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Neurobiological correlates of theory of mind in psychosis proneness

Gemma Modinos, Remco Renken, Simone G. Shamay-Tsoory, Johan Ormel, André Aleman
2010 Neuropsychologia  
Theory of mind (ToM) refers to the capacity to infer one's own and other persons' mental states.  ...  Prior behavioral studies have also suggested ToM deficits in healthy individuals with psychosis proneness (PP), although no study to date had investigated the associated neural mechanisms in such a sample  ...  We would like to thank Lisette van der Meer for help with the translation of the task into Dutch, and Anita Kuiper for assistance with MRI scanning.  ... 
doi:10.1016/j.neuropsychologia.2010.09.030 pmid:20888847 fatcat:d5pndi3jlrdvdipeoqtdeprtbe

Simulation and social behavior: An fMRI study of neural processing during simulation in individuals with and without risk for psychosis

Sarah Hope Lincoln, Laura T Germine, Patrick Mair, Christine I Hooker
2020 Social Cognitive and Affective Neuroscience  
This study investigates the neural process of simulation in healthy individuals and individuals at risk for psychosis.  ...  Social dysfunction is a risk indicator for schizophrenia spectrum disorders, with at-risk individuals demonstrating a range of social behavior impairments.  ...  Funding This study was supported by the Sackler Scholar Programme in Psychobiology (to S.H.L.).  ... 
doi:10.1093/scan/nsaa047 pmid:32248225 pmcid:PMC7304514 fatcat:fsjwj2qaubeh5hwuk3f3jlqgcq

Further Evidence for the Impact of a Genome-Wide-Supported Psychosis Risk Variant in ZNF804A on the Theory of Mind Network

Sebastian Mohnke, Susanne Erk, Knut Schnell, Claudia Schütz, Nina Romanczuk-Seiferth, Oliver Grimm, Leila Haddad, Lydia Pöhland, Maria Garbusow, Mike M Schmitgen, Peter Kirsch, Christine Esslinger (+12 others)
2013 Neuropsychopharmacology  
This skill, commonly referred to as Theory of Mind (ToM), has consistently been found to be impaired in schizophrenia.  ...  We aimed to replicate these results in an independent sample of 188 healthy German volunteers.  ...  ACKNOWLEDGEMENTS We thank Josephine Klaembt, Phöbe Schmierer, Carola Opitz von Boberfeld, Beate Newport, and Dagmar Gass for help with data acquisition and Torsten Wüstenberg for technical support.  ... 
doi:10.1038/npp.2013.321 pmid:24247043 pmcid:PMC3957114 fatcat:kwi52wjjcne4nmters4n3xulfa

Neural Correlates of Aberrant Salience and Source Monitoring in Schizophrenia and At-Risk Mental States—A Systematic Review of fMRI Studies

Joachim Kowalski, Adrianna Aleksandrowicz, Małgorzata Dąbkowska, Łukasz Gawęda
2021 Journal of Clinical Medicine  
Various brain regions are associated with aberrant salience and source monitoring in individuals with schizophrenia and the risk of psychosis.  ...  We conducted a systematic search of fMRI studies of said cognitive biases. Eight studies on aberrant salience and eleven studies on source monitoring were included in the review.  ...  The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.  ... 
doi:10.3390/jcm10184126 pmid:34575237 pmcid:PMC8468329 fatcat:xjulk4kptzghzptiaoqhygrjda

Neural disruption to theory of mind predicts daily social functioning in individuals at familial high-risk for schizophrenia

David Dodell-Feder, Lynn E. DeLisi, Christine I. Hooker
2014 Social Cognitive and Affective Neuroscience  
Importantly, the social consequences of ToM deficits could create an additional vulnerability factor for individuals at familial high risk (FHR).  ...  Schizophrenia is associated with ToM impairments, and initial studies demonstrate similar, though more subtle deficits, in unaffected first-degree relatives, indicating that ToM deficits are a potential  ...  FHR status was defined as between 15 and 32 years of age (age-range of greatest psychosis-risk) with two or more affected relatives (at least one first-degree relative with schizophrenia or schizoaffective  ... 
doi:10.1093/scan/nst186 pmid:24396009 pmcid:PMC4249465 fatcat:t5p4dvjxy5coxasszqo5vvdlea

Neural circuit of verbal humor comprehension in schizophrenia - an fMRI study

Przemysław Adamczyk, Miroslaw Wyczesany, Aleksandra Domagalik, Artur Daren, Kamil Cepuch, Piotr Błądziński, Andrzej Cechnicki, Tadeusz Marek
2017 NeuroImage: Clinical  
The study included chronic schizophrenia (SCH) outpatients (n = 20), and sex, age and education level matched healthy controls (n = 20).  ...  This study evaluates neural correlates of diminished humor comprehension observed in schizophrenia.  ...  Our thanks go also to the staff at "U Pana Cogito" and Occupational Therapy Workshops in Krakow for their assistance in coordinating the participants from the clinical group.  ... 
doi:10.1016/j.nicl.2017.06.005 pmid:28652967 pmcid:PMC5473647 fatcat:fgymianwvjgmxiqhmerkhaw4iu

Altered Neural Activity during Irony Comprehension in Unaffected First-Degree Relatives of Schizophrenia Patients—An fMRI Study

Róbert Herold, Eszter Varga, András Hajnal, Edina Hamvas, Hajnalka Berecz, Borbála Tóth, Tamás Tényi
2018 Frontiers in Psychology  
We examined 12 schizophrenic patients, 12 first-degree relatives of schizophrenia patients and 12 healthy controls with functional MRI while they were performing irony and control tasks.  ...  In the present study, we examined the neural correlates of irony understanding in schizophrenic patients and in unaffected first-degree relatives of patients compared to healthy adults with functional  ...  The study was supported by the National Excellence Program Kiválósági Program NKP_17 and the National Brain Research Program 2.0.  ... 
doi:10.3389/fpsyg.2017.02309 pmid:29375430 pmcid:PMC5767266 fatcat:de6ydv7cnrh5xib24leavwftdq

Theory of Mind Skills Are Related to Gray Matter Volume in the Ventromedial Prefrontal Cortex in Schizophrenia

Christine I. Hooker, Lori Bruce, Sarah Hope Lincoln, Melissa Fisher, Sophia Vinogradov
2011 Biological Psychiatry  
Among individuals with schizophrenia, deficits in theory of mind (ToM) skills predict poor social functioning.  ...  Twenty-one schizophrenia and 17 healthy control subjects participated.  ...  and the behavioral ToM deficits associated with risk, manifestation, and severity of schizophrenia disorder.  ... 
doi:10.1016/j.biopsych.2011.07.027 pmid:21917239 pmcid:PMC3432316 fatcat:utxnodruzrd3rakup2a6wiush4

Examining the Psychosis Continuum

Pamela DeRosse, Katherine H. Karlsgodt
2015 Current Behavioral Neuroscience Reports  
adversity is substantially associated with an increased risk for psychosis with a population attributable risk of ∼33 %.  ...  There have been relatively few functional investigations; these have demonstrated differences in functional magnetic resonance imaging (fMRI) activation during theory of mind [109] , emotional processing  ... 
doi:10.1007/s40473-015-0040-7 pmid:26052479 pmcid:PMC4454466 fatcat:2ebglngtpreh3moshhitrxh6lu

Altered resting-state connectivity in subjects at ultra-high risk for psychosis: an fMRI study

Geumsook Shim, Jungsu S Oh, Wi Jung, Joon Jang, Chi-Hoon Choi, Euitae Kim, Hye-Yoon Park, Jung-Seok Choi, Myung Jung, Jun Kwon
2010 Behavioral and Brain Functions  
Individuals at ultra-high risk (UHR) for psychosis have self-disturbances and deficits in social cognition and functioning.  ...  Methods: This study utilized functional magnetic resonance imaging (fMRI) to investigate resting-state DMN and task-related network (TRN) functional connectivity in 19 UHR subjects and 20 matched healthy  ...  grant from the Seoul Figure 4 Default mode areas in which ultra-high risk subjects showed significantly greater positive correlation with the posterior cingulate cortex than healthy controls.  ... 
doi:10.1186/1744-9081-6-58 pmid:20932348 pmcid:PMC2959003 fatcat:3rlouactvja6xkxoulgwuoyoti

Empathy in individuals clinically at risk for psychosis: Brain and behaviour

Birgit Derntl, Tanja Maria Michel, Pamela Prempeh, Volker Backes, Andreas Finkelmeyer, Frank Schneider, Ute Habel
2015 British Journal of Psychiatry  
Method Using functional magnetic resonance imaging, we measured 15 individuals at clinical high risk of psychosis (CHR group) and compared their empathy performance with 15 healthy volunteers and 15 patients  ...  Aims These dysfunctions may precede the onset of illness; thus, it seems mandatory to examine the empathic abilities in individuals at clinical high risk for psychosis.  ...  Greater activation in people at clinical high risk of psychosis in regions known to be essential for emotion and sociocognitive processing were also reported in studies addressing theory of mind. 44,  ... 
doi:10.1192/bjp.bp.114.159004 pmid:26294367 fatcat:4weeoxmg4vhghp5zlhnajndu7y

The Fragile Brain: Stress Vulnerability, Negative Affect and GABAergic Neurocircuits in Psychosis

2019 Schizophrenia Bulletin  
Persons with schizophrenia exhibit sensitivity to stress and negative affect (NA), both strongly correlated with poor functional outcome.  ...  Based on postmortem evidence of altered gamma-aminobutyric acid (GABA) function in parvalbumin positive interneurons (PVI), animal models of PVI abnormalities and neuroimaging data with GABAergic challenge  ...  Acknowledgment The authors have declared that there are no conflicts of interest in relation to the subject of this study.  ... 
doi:10.1093/schbul/sbz046 pmid:31150555 pmcid:PMC6811817 fatcat:ooisdejjivcmdjk2kuhqov53su

Psychosis and autism as diametrical disorders of the social brain

Bernard Crespi, Christopher Badcock
2008 Behavioral and Brain Sciences  
We describe evidence that a large set of phenotypic traits exhibit diametrically opposite phenotypes in autistic-spectrum versus psychotic-spectrum conditions, with a focus on schizophrenia.  ...  This suite of traits is inter-correlated, in that autism involves a general pattern of constrained overgrowth, whereas schizophrenia involves undergrowth.  ...  In the case of paranoid or delusional schizophrenia, we observe theory of mind impairments that result from an over-attribution of mental states to self or others (i.e., hyper-theory of mind) (Abu-Akel  ... 
doi:10.1017/s0140525x08004214 pmid:18578904 fatcat:oyr2qndsrbf5fa5pp34sxwiiee

Do Subjects at Clinical High Risk for Psychosis Differ from those with a Genetic High Risk? - A Systematic Review of Structural and Functional Brain Abnormalities

R. Smieskova, J. Marmy, A. Schmidt, K. Bendfeldt, A. Riecher-Rossler, M. Walter, U. E. Lang, S. Borgwardt
2013 Current Medicinal Chemistry  
= at risk stage of schizophrenia -basic symptoms; SC, social cognition; SCZ, schizophrenia patients; SoP, speed of processing; ToM, "Theory of mind"; VL&M, verbal learning and memory; WM, working memory  ...  , longitudinal sMRI, fMRI, neuroimaging (high risk psychosis & fMRI, high risk schizophrenia & fMRI, high risk psychosis & sMRI longitudinal, high risk schizophrenia & sMRI follow-up).  ... 
doi:10.2174/0929867311320030018 pmid:23157639 pmcid:PMC3580804 fatcat:sxqazkq25jesbkj3lc2lzrbxkm

Do Subjects at Clinical High Risk for Psychosis Differ from those with a Genetic High Risk? - A Systematic Review of Structural and Functional Brain Abnormalities

R. Smieskova, J. Marmy, A. Schmidt, K. Bendfeldt, A. Riecher-Rossler, M. Walter, U. E. Lang, S. Borgwardt
2013 Current Medicinal Chemistry  
= at risk stage of schizophrenia -basic symptoms; SC, social cognition; SCZ, schizophrenia patients; SoP, speed of processing; ToM, "Theory of mind"; VL&M, verbal learning and memory; WM, working memory  ...  , longitudinal sMRI, fMRI, neuroimaging (high risk psychosis & fMRI, high risk schizophrenia & fMRI, high risk psychosis & sMRI longitudinal, high risk schizophrenia & sMRI follow-up).  ... 
doi:10.2174/092986713804870756 pmid:23157639 pmcid:PMC3580804 fatcat:5qa45b5itncqrdigwkqpyk5nca
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