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Nano(Q)SAR: Challenges, pitfalls and perspectives

Ratna Tantra, Ceyda Oksel, Tomasz Puzyn, Jian Wang, Kenneth N. Robinson, Xue Z. Wang, Cai Y. Ma, Terry Wilkins
2014 Nanotoxicology  
TP is grateful for the financial support of the European Commission through Marie Curie IRSES program, NanoBRIDGES project (FP7-PEOPLE-2011-IRSES, Grant Agreement Number 295128), COST action TD1204: Modelling  ...  Acknowledgements The authors would like to thank the European Commission for financial support via the FP7 NanoReg and DEFRA UK (Department for Environment, Food and Rural Affairs).  ...  The purpose of the paper is to understand the pitfalls and challenges associated with nano(Q)SAR and research requirements in order to develop reliable nanomaterial categories.  ... 
doi:10.3109/17435390.2014.952698 pmid:25211549 fatcat:isljowzh2rdwzl4rxutlskmx2i

Imaging of retinal ganglion cells in glaucoma: pitfalls and challenges

R. M. Werkmeister, A. Popa Cherecheanu, G. Garhofer, D. Schmidl, L. Schmetterer
2013 Cell and Tissue Research  
However, the visualization of retinal ganglion cells and their dendrites has been achieved in animal models.  ...  Implementation of these techniques in clinical practice will probably improve glaucoma care and facilitate the development of neuroprotective strategies.  ...  FA607A0502 and the Christian Doppler Laboratory for Laser Development and their Application in Medicine.  ... 
doi:10.1007/s00441-013-1600-3 pmid:23512142 pmcid:PMC3714556 fatcat:n5l6eiy5gvf75kdluklsfoblr4

Periprosthetic fractures around the femoral stem: overcoming challenges and avoiding pitfalls

Andrew N Fleischman, Antonia F Chen
2015 Annals of Translational Medicine  
Management of periprosthetic fractures around the femoral stem after total hip arthroplasty (THA) represents a significant challenge and optimal treatment remains controversial.  ...  We review the appropriate methods for evaluation and treatment of Vancouver type B fractures with particular emphasis on avoiding missteps that can lead to failure.  ...  Acknowledgements We would like to thank Katherine Huff for her assistance with editing and formatting the manuscript.  ... 
doi:10.3978/j.issn.2305-5839.2015.09.32 pmid:26539451 pmcid:PMC4598449 fatcat:4zhyrfqhhvexlgckgnsmmaemsq

Challenges and Pitfalls: Performing Clinical Trials in Patients With Congenital Diaphragmatic Hernia

Suzan Cochius - den Otter, Jan A. Deprest, Laurent Storme, Anne Greenough, Dick Tibboel
2022 Frontiers in Pediatrics  
Herein, we discuss major challenges and pitfalls when performing a clinical trial in infants with CDH.  ...  Congenital diaphragmatic hernia (CDH) is a rare developmental defect of the lungs and diaphragm, with substantial morbidity and mortality.  ...  New RCTs are recruiting, and those focus on the reduction in PH, a major contributor to mortality in CDH patients. Our experience learns that performing an RCT in CDH patients is challenging.  ... 
doi:10.3389/fped.2022.852843 pmid:35498783 pmcid:PMC9051320 fatcat:6oyysty2xfhczpm45inye3sbsq

Mouse Genetic Analysis of Bone Marrow Stem Cell Niches: Technological Pitfalls, Challenges, and Translational Considerations

Kevin G. Chen, Kory R. Johnson, Pamela G. Robey
2017 Stem Cell Reports  
ACKNOWLEDGMENTS This work was supported by the Intramural Research Program of the NIH at the National Institute of Neurological Disorders and Stroke (to K.G.C. and K.R.J.) and the National Institute of  ...  McKay for discussion and support of this work.  ...  We aim to do the following: (1) briefly discuss the advantages of mouse genetic models and try to resolve inconsistencies, (2) shed light on the technological advantages, pitfalls, and challenges in the  ... 
doi:10.1016/j.stemcr.2017.09.014 pmid:29056332 pmcid:PMC5829346 fatcat:c7nlo64yuja47dq63zf7wdwzya

Formal Methods in Industrial Practice - Bridging the Gap (Track Summary) [chapter]

Michael Felderer, Dilian Gurov, Marieke Huisman, Björn Lisper, Rupert Schlick
2018 Lecture Notes in Computer Science  
We invited speakers that have collaborated with industry, and asked them for their experiences and recommendations on what should be done to close the gap.  ...  and industrial practice, which also exists in other areas of software engineering like testing [10] .  ...  [15] (Model-based Testing for Avionic Systems Proven Benefits and Further Challenges) report on the transition of model-based testing (MBT) from a widely discussed research discipline to an accepted  ... 
doi:10.1007/978-3-030-03427-6_10 fatcat:tkpk7wmnrjgqjn3v6brvr5mca4

Tips for successful practice of simulation

Deborah A. Sadowski, Mark R. Grabau
1999 Proceedings of the 31st conference on Winter simulation Simulation---a bridge to the future - WSC '99  
Remember back in school what it was like to learn new concepts? At the time, it probably seemed challenging, even intimidating.  ...  And, of course, you need to do a responsible job of those "easy" parts-building the model, verifying and validating it, and analyzing your results-as well!  ...  multiple design points in an experiment, let alone the appropriate analyses to determine all of the above.  ... 
doi:10.1145/324138.324153 fatcat:gd6cv5o56valxi44qhccebc2x4

Software analytics as a learning case in practice

Dongmei Zhang, Yingnong Dang, Jian-Guang Lou, Shi Han, Haidong Zhang, Tao Xie
2011 Proceedings of the International Workshop on Machine Learning Technologies in Software Engineering - MALETS '11  
In this position paper, we advocate that when applying analytic technologies in practice of software analytics, one should (1) incorporate a broad spectrum of domain knowledge and expertise, e.g., management  ...  Our position is based on our experiences of successful technology transfer on software analytics at Microsoft Research Asia.  ...  We thank Ira Baxter, Judith Bishop, Prem Devanbu, Harald Gall, Mark Harman, David Notkin, Sriram Rajamani, Wolfram Schulte, David Weiss, and Minghui Zhou for their feedback on an earlier version of this  ... 
doi:10.1145/2070821.2070829 fatcat:gkdsmpgmd5ftrck7wmqdbkfrvu

Standard Practices of Reticular Chemistry

Cornelius Gropp, Stefano Canossa, Stefan Wuttke, Felipe Gándara, Qiaowei Li, Laura Gagliardi, Omar M. Yaghi
2020 ACS Central Science  
Reticular chemistry is a growing field of science with a multitude of practitioners with diverse frames of thinking, making the need for standard practices and quality indicators ever more compelling.  ...  Our purpose here is to provide guidelines to avoid common pitfalls during the characterization process, and to report results and necessary information in a useful and sensible manner.  ...  However, one should bear in mind that experiments and calculations may be carried out under different conditions.  ... 
doi:10.1021/acscentsci.0c00592 pmid:32875067 pmcid:PMC7453418 fatcat:uvwc5mvfzbgmhg7fmuqo2qsw6a

Leading DevOps Practice and Principle Adoption [article]

Krikor Maroukian, Stephen R. Gulliver
2020 arXiv   pre-print
This research, undertaken in highly structured software-intensive organizations, outlines challenges associated to agile, lean and DevOps practices and principles adoption.  ...  A set of agile, lean and DevOps practices and principles, which organizations choose to include in their DevOps adoption journeys were identified.  ...  ACKNOWLEDGEMENTS The authors would like to thank the interview participants for all the time and committed efforts to contribute to the results and outcomes towards research questions.  ... 
arXiv:2008.10515v1 fatcat:y4h6tijjdzd53imndn4i2jasgu

Next generation sequencing--implications for clinical practice

E. Raffan, R. K. Semple
2011 British Medical Bulletin  
Next-generation sequencing in clinical practice British Medical Bulletin 2011;99 Table 1 1 Some novel and/or unexpected genetic defects discovered NGS (AR, autosomal recessive; AD, autosomal dominant  ...  A sizable majority of these have been previously reported in many other individuals and are in dbSNP (Fig. 3 ).  ... 
doi:10.1093/bmb/ldr029 pmid:21705347 fatcat:rlpfh7emijggff2bnl4fub3md4

A progression model of software engineering goals, challenges, and practices in start-ups

Eriks Klotins, Michael Unterkalmsteiner, Panagiota Chatzipetrou, Tony Gorschek, Rafael Prikladniki, Nirnaya Tripathi, Leandro Pompermaier
2019 IEEE Transactions on Software Engineering  
Objective: We aim to collect data related to engineering goals, challenges, and practices in start-up companies to ascertain trends and patterns characterizing engineering work in start-ups.  ...  However, traditional software engineering practices are not evaluated in the context, nor adopted to goals and challenges of start-ups.  ...  The authors of this paper would like to thank all practitioners who found time and motivation to share their experiences.  ... 
doi:10.1109/tse.2019.2900213 fatcat:s5u7qqll7fg4jovqte7hlnjw5q

On Studying Bad Practices in Configuration UIs

Tony Leclercq, Maxime Cordy, Bruno Dumas, Patrick Heymans
2018 International Conference on Intelligent User Interfaces  
In this paper, we focus instead on HCI and analyse the occurrence of 11 design flaws that occur in 28 car configurators.  ...  Being often the first contact between the retailer and the customer, it is important for a configurator to provide a smooth user experience.  ...  For each manufacturer we choose the best selling car model, and for every model we consider the configurator of the US, UK and Belgium websites.  ... 
dblp:conf/iui/LeclercqCDH18 fatcat:hdax7mjdgfeknaadesmfdbucpe

Toward a practical solution for capturing knowledge for software projects

S. Komi-Sirvio, A. Mantyniemi, V. Seppanen
2002 IEEE Software  
Seppänen has published about a hundred scientific and practical publications. He was an Asla Fulbright scholar at UC Irvine in 1986-87 and a JSPS Postdoctoral Fellow at Kyoto University in 1991-93.  ...  An analysis of the database revealed that a number of entries were incomplete and only one of the four thematic sections was in active use.  ... 
doi:10.1109/ms.2002.1003457 fatcat:f6ztugm675eyhnhi4ibcmmj2na

A Security Practices Evaluation Framework

Patrick Morrison
2015 2015 IEEE/ACM 37th IEEE International Conference on Software Engineering  
We identified use of all of the practices specified in SP-EF by one or more survey participants.  ...  We conducted a case study in which we collected all SP-EF data from an industrial software development project.  ...  Bitcoin provides an open defect repository and version control system, both based on a public Github repository 3 .  ... 
doi:10.1109/icse.2015.296 dblp:conf/icse/Morrison15 fatcat:oghtjdeecbednhf5bzrwy22f5i
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