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Microarray Techniques to Analyze Copy-Number Alterations in Genomic DNA: Array Comparative Genomic Hybridization and Single-Nucleotide Polymorphism Array

Károly Szuhai, Maarten Vermeer
<span title="">2015</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/hxva2c3v7rgxffw6x5wzadfdrm" style="color: black;">Journal of Investigative Dermatology</a> </i> &nbsp;
A higher density allows more precise detection of small genomic changes, but may increase cost per analyzed sample and background, such as detection of chromosomal copy-number variations with unknown clinical  ...  Array CGH and SNP arrays have been used extensively to analyze copy-number alterations in tumor DNA.  ...  A wide dynamic range in copy-number estimation allows for detection of gains and losses. C. Array CGH can be performed on heterogeneous cell populations. D.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/jid.2015.308">doi:10.1038/jid.2015.308</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/26358390">pmid:26358390</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/obj4lvdhm5gnrggrbjhlvr7gna">fatcat:obj4lvdhm5gnrggrbjhlvr7gna</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190416044515/https://core.ac.uk/download/pdf/81183259.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/f7/b0/f7b0af96cacd26817d85c743fb95b0e7969ad399.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/jid.2015.308"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a>

Next generation sequencing and array-based comparative genomic hybridization for molecular diagnosis of pediatric endocrine disorders

Maki Fukami, Mami Miyado
<span title="">2017</span> <i title="Korean Society of Pediatric Endocrinology"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/2vu45q3sivf6jjgk7zxjyrdnry" style="color: black;">Annals of Pediatric Endocrinology &amp; Metabolism</a> </i> &nbsp;
Next-generation sequencing (NGS) and array-based comparative genomic hybridization (array CGH) have enabled us to perform high-throughput mutation screening and genome-wide copy number analysis, respectively  ...  Array CGH can detect various submicroscopic genomic rearrangements involving exons or enhancers of disease-associated genes.  ...  Acknowledgments This study was supported by the Grants-in-Aid from the Japan Society for the Promotion of Science; and by the Grants from the Ministry of Health, Labor and Welfare, the Japan Agency for  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.6065/apem.2017.22.2.90">doi:10.6065/apem.2017.22.2.90</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/28690986">pmid:28690986</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC5495984/">pmcid:PMC5495984</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/sqkv5jgskjfp3oxx6htawzjun4">fatcat:sqkv5jgskjfp3oxx6htawzjun4</a> </span>
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Clinical implementation of whole-genome array CGH as a first-tier test in 5080 pre and postnatal cases

Sang-Jin Park, Eun Jung, Ran-Suk Ryu, Hyun Kang, Jung-Min Ko, Hyon J Kim, Chong Cheon, Sang-Hyun Hwang, Ho-Young Kang
<span title="">2011</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/kwb5msf5nbfdhiyw6knc2gckfq" style="color: black;">Molecular Cytogenetics</a> </i> &nbsp;
In this study, we developed a BAC based array CGH analysis platform for detecting whole genome DNA copy number changes including specific micro deletion and duplication chromosomal disorders.  ...  Among 75 positive prenatal cases with DNA copy number variations, 60 had an aneuploidy, seven had a deletion, and eight had a duplication.  ...  He doo Chung for his contribution to clinical validation and our clinical colleagues for supporting this work. We are grateful to other laboratory members for their enthusiastic participation.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/1755-8166-4-12">doi:10.1186/1755-8166-4-12</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/21549014">pmid:21549014</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3114015/">pmcid:PMC3114015</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/nnqzuvrqofh53p4uhwugn4g6wm">fatcat:nnqzuvrqofh53p4uhwugn4g6wm</a> </span>
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Array CGH in Fetal Medicine Diagnosis [chapter]

Ricardo Barini, Isabela Nelly, Juliana Karina R. Heinrich
<span title="2012-03-02">2012</span> <i title="InTech"> Recent Trends in Cytogenetic Studies - Methodologies and Applications </i> &nbsp;
Number of fetuses with copy number abnormalities and copy number variation (CNV) in recent prenatal array CGH studies Regardless of array CGH techniques have a theoretical principle and common molecular  ...  However, at this point in time, genome-wide arrays will detect many copy number variants of unknown clinical significance.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.5772/34316">doi:10.5772/34316</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/yyglffrhujh57nldovs55qp22i">fatcat:yyglffrhujh57nldovs55qp22i</a> </span>
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Whole-Genome Scanning by Array Comparative Genomic Hybridization as a Clinical Tool for Risk Assessment in Chronic Lymphocytic Leukemia

Shelly R. Gunn, Mansoor S. Mohammed, Mercedes E. Gorre, Philip D. Cotter, Jaeweon Kim, David W. Bahler, Sergey N. Preobrazhensky, Russell A. Higgins, Aswani R. Bolla, Sahar H. Ismail, Daphne de Jong, Eric Eldering (+6 others)
<span title="">2008</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/mj3bzt4f4rdenm2p4fih7aw2c4" style="color: black;">Journal of Molecular Diagnostics</a> </i> &nbsp;
Array CGH is a powerful, costeffective tool for genome-wide risk assessment in the clinical evaluation of CLL.  ...  test. 2-4 A number of arraybased studies analyzing copy number imbalances in CLL have been recently reported, including array CGH using bacterial artificial chromosome (BAC) and oligonucleotide microarrays  ...  Acknowledgment We thank Kathryn Miller for critically reading the manuscript before publication.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.2353/jmoldx.2008.080033">doi:10.2353/jmoldx.2008.080033</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/18687794">pmid:18687794</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC2518739/">pmcid:PMC2518739</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/27rskjsc3fbtrjprhd53ivubhq">fatcat:27rskjsc3fbtrjprhd53ivubhq</a> </span>
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Comparative genomic hybridization (CGH)-arrays pave the way for identification of novel cancer-related genes

Johji Inazawa, Jun Inoue, Issei Imoto
<span title="">2004</span> <i title="Wiley"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/rnoo45wedrc6toyzxy2l7ullbi" style="color: black;">Cancer Science</a> </i> &nbsp;
High-density CGH-array therefore paves the way for identification of disease-related genetic aberrations that have not yet been detected by existing technologies, and array-based CGH technology should  ...  copy-number aberrations.  ...  Prospects for improvement Recently Bignell et al. 35) showed that an SNP array could be used to detect copy-number variations in cancer-cell lines.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1111/j.1349-7006.2004.tb02486.x">doi:10.1111/j.1349-7006.2004.tb02486.x</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/15245590">pmid:15245590</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/gomdu2ndbjhcdlqg5l4r7xm2vq">fatcat:gomdu2ndbjhcdlqg5l4r7xm2vq</a> </span>
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Application of Array-Based Comparative Genomic Hybridization to Clinical Diagnostics

Bassem A. Bejjani, Lisa G. Shaffer
<span title="">2006</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/mj3bzt4f4rdenm2p4fih7aw2c4" style="color: black;">Journal of Molecular Diagnostics</a> </i> &nbsp;
It allows for a high-resolution evaluation of DNA copy number alterations associated with chromosome abnormalities.  ...  Microarray-based comparative genomic hybridization (array CGH) is a revolutionary platform that was recently adopted in the clinical laboratory.  ...  Array CGH has proven useful in providing DNA copy number "signatures" or profiles for various cancers.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.2353/jmoldx.2006.060029">doi:10.2353/jmoldx.2006.060029</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/17065418">pmid:17065418</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC1876176/">pmcid:PMC1876176</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/az2ull22bjdrrb6a3k24gc2mwq">fatcat:az2ull22bjdrrb6a3k24gc2mwq</a> </span>
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Microarray-based comparative genomic hybridization analysis in neonates with congenital anomalies: detection of chromosomal imbalances

Luiza Emy Dorfman, Júlio César L. Leite, Roberto Giugliani, Mariluce Riegel
<span title="">2015</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/ipmafkxguvgaroi3kgjef4652e" style="color: black;">Jornal de Pediatria</a> </i> &nbsp;
All potential DNA copy number variations detected (CNVs) were matched with those reported in public genomic databases, and their clinical significance was evaluated.  ...  Conclusions: Array-CGH analysis allowed for a higher rate of detection of chromosomal anomalies, and this determination is especially valuable in neonates with congenital anomalies of unknown etiology,  ...  Acknowledgments The authors would like to thank the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) for financial support (grant 402012/2010-0).  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.jped.2014.05.007">doi:10.1016/j.jped.2014.05.007</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/25203518">pmid:25203518</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/l7lz6gk6q5d4pkjdzgfkcb4aom">fatcat:l7lz6gk6q5d4pkjdzgfkcb4aom</a> </span>
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Genomic microarrays in the spotlight

Kiran K Mantripragada, Patrick G Buckley, Teresita Diaz de Ståhl, Jan P Dumanski
<span title="">2004</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/alw4ab5u3vdqlgfh3smvbfnjqu" style="color: black;">Trends in Genetics</a> </i> &nbsp;
Microarray-based comparative genomic hybridization (array-CGH) has emerged as a revolutionary platform, enabling the high-resolution detection of DNA copy number aberrations.  ...  Furthermore, the applications and future aspects of these arrays for DNA copy number analysis in research and diagnostics, epigenetic profiling and gene annotation are discussed.  ...  Acknowledgements We thank Ian Dunham, Lore Zech, Anna Wedell, Nils-Erik Heldin and Magnus Nordenskjöld for helpful comments. We also thank the anonymous referees for their constructive criticism.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.tig.2003.12.008">doi:10.1016/j.tig.2003.12.008</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/14746990">pmid:14746990</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/ri3wymlovjfolf3ddofumugmfa">fatcat:ri3wymlovjfolf3ddofumugmfa</a> </span>
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Prenatal diagnosis of chromosomal abnormalities using array-based comparative genomic hybridization

Trilochan Sahoo, Sau Wai Cheung, Patricia Ward, Sandra Darilek, Ankita Patel, Daniela del Gaudio, Sung Hae L Kang, Seema R Lalani, Jiangzhen Li, Sallie McAdoo, Audrey Burke, Chad A Shaw (+6 others)
<span title="">2006</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/h2z5pwtf7veqbi7mqc2bhke44a" style="color: black;">Genetics in Medicine</a> </i> &nbsp;
In 12 cases, the array detected copy number variation requiring testing of parental samples for optimal interpretation.  ...  Use of array-CGH should increase the detection of abnormalities relative to the risk, and is an option for an enhanced level of screening for chromosomal abnormalities in high risk pregnancies.  ...  Copy number variants (CNV) In 30 cases, array-CGH detected a gain or loss of copy number in a fetus with a clone (or clones) which was known to show a frequent normal variation in copy number based on  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1097/01.gim.0000245576.47154.63">doi:10.1097/01.gim.0000245576.47154.63</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/17108764">pmid:17108764</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/r3hgdub2xve4fhx76ujym262pm">fatcat:r3hgdub2xve4fhx76ujym262pm</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200510153312/https://www.nature.com/articles/gim2006117.pdf?error=cookies_not_supported&amp;code=74d756b5-5e16-4b09-af13-874a2ea518c7" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/0e/9e/0e9e21096551a52d849e312bdb137714facc1f08.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1097/01.gim.0000245576.47154.63"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a>

Methods to detect and analyze copy number variations at the genome-wide and locus-specific levels

J.H. Lee, J.T. Jeon
<span title="">2008</span> <i title="S. Karger AG"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/t3hajbt3cre27lrm3i235w3xie" style="color: black;">Cytogenetic and Genome Research</a> </i> &nbsp;
Copy number variations (CNVs) have effects on phenotypes by altering transcription levels of genes and may have major impacts on protein sequence, structure and function.  ...  RFLP followed by Southern blot analysis, quantitative real-time PCR, pyrosequencing, ligation detection reaction and the invader assay have become the main tools for locus-specific analysis so far.  ...  This CGH method was originally developed for detecting copy number variations and their chromosomal locations in tumor and normal samples (Kallioniemi et al., 1995) .  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1159/000184725">doi:10.1159/000184725</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/19287172">pmid:19287172</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/ggcmj4eutzgphj6olonjlbhddy">fatcat:ggcmj4eutzgphj6olonjlbhddy</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170810153632/http://gene-quantification.net/lee-leon-cnv-methods-2008.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/fd/24/fd24abb09c02e950ecc76ac75f7e341d1795ab6f.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1159/000184725"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a>

Copy number variants (CNVs) in primate species using array-based comparative genomic hybridization

Ömer Gökçümen, Charles Lee
<span title="">2009</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/3jmevtg2ajcdnpgyntimblv7iu" style="color: black;">Methods</a> </i> &nbsp;
The importance of copy number variants (CNVs) was unknown for a long time, primarily because it was assumed that CNVs represented only a very small fraction of genomic variation.  ...  Copy Number Variation Copy number variants are DNA segments that are duplicated or deleted in the genomes of organisms and vary in copy number among individuals.  ...  For instance, the same BAC-based probes initially used to determine the widespread copy number variation in humans (3) were later utilized to detect copy number variation among 20 unrelated chimpanzees  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.ymeth.2009.06.001">doi:10.1016/j.ymeth.2009.06.001</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/19545629">pmid:19545629</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC2796453/">pmcid:PMC2796453</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/tf6qvansb5gsjgoiyhpjycs3mu">fatcat:tf6qvansb5gsjgoiyhpjycs3mu</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20191029025011/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC2796453&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/70/78/707837859930c7a7b3fe853a65ba9d9a3432ead7.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.ymeth.2009.06.001"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> elsevier.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2796453" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Genomic Microarray in Intellectual Disability: The Usefulness of Existing Systems in the Interpretation of Copy Number Variation

Najla Soyah, Audrey Labalme, Helene Guilbert, Damien Sanlaville, Ali Saad, Soumaya Mougou-Zerelli, Hela Ben Khelifa
<span title="2016-09-08">2016</span> <i title="Georg Thieme Verlag KG"> Journal of Pediatric Genetics </i> &nbsp;
Acknowledgments The authors thank the patients and their family for their cooperation.  ...  essential tool for the detection of a large number of copy number variants (CNVs) in patients with ID and/or multiple congenital anomalies.  ...  Table 4 4 Scoring for novel copy number variants revealed by oligo-CGH 180K Abbreviations: CGH, comparative genomic hybridization; CNV, copy number variants, DGV, Database of Genomic Variants; ID, intellectual  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1055/s-0036-1588027">doi:10.1055/s-0036-1588027</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/28496995">pmid:28496995</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC5423794/">pmcid:PMC5423794</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/yruugtlx4zbathtmdcf3s6zkly">fatcat:yruugtlx4zbathtmdcf3s6zkly</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200209104515/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC5423794&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/d5/72/d572f5d48457bc01a1c5801e449607c74de42f10.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1055/s-0036-1588027"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423794" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Genetic Copy Number Variations in Colon Mucosa Indicating Risk for Colorectal Cancer

Annika Gustafsson Asting, Kristina K. Lagerstedt, Erik Kristiansson, Christina Lönnroth, Marianne Andersson, Elham Rekabdar, Elisabeth Hansson, Ulf Kressner, Fredrik Enlund, Kent Lundholm
<span title="">2014</span> <i title="Scientific Research Publishing, Inc,"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/62oqrfbkpjemzpq2pxtujoyjoq" style="color: black;">Journal of Cancer Therapy</a> </i> &nbsp;
The aim of the present study was therefore to search for DNA regions (copy number variations, CNVs) as biomarkers associated to genetic susceptibility for early risk predictions of colorectal cancer.  ...  Array-detected CNVs were confirmed by Multiplex ligation-dependent probe amplification (MLPA).  ...  Conclusion In conclusion, oligonucleotide-based array CGH appears as a sensitive tool for screening for identification of CNVs related to tumor development, complementary to the use of SNP arrays.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.4236/jct.2014.514135">doi:10.4236/jct.2014.514135</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/tqbt55gdjbdrvj6ybyvrrzx5sa">fatcat:tqbt55gdjbdrvj6ybyvrrzx5sa</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20151225080846/http://www.scirp.org/journal/PaperDownload.aspx?paperID=52041" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/04/48/04485003eaf811e5b150217be4b6df348422384f.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.4236/jct.2014.514135"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a>

Sertoli Cell-Only Syndrome: Behind the Genetic Scenes

Katrien Stouffs, Alexander Gheldof, Herman Tournaye, Deborah Vandermaelen, Maryse Bonduelle, Willy Lissens, Sara Seneca
<span title="">2016</span> <i title="Hindawi Limited"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/icbhosh775h7bgzgot6avm3cua" style="color: black;">BioMed Research International</a> </i> &nbsp;
Array comparative genomic hybridization in a selected group of "idiopathic patients" showed no known infertility related copy number variations.  ...  Our results show that, for a large part of the patients (>23% in an unselected group), the sex chromosomes are involved.  ...  In order to detect copy number variations, array CGH analysis was performed on the nine patient samples described above. Together with these patients, we have also analyzed 23 control samples.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1155/2016/6191307">doi:10.1155/2016/6191307</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/26925412">pmid:26925412</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4746273/">pmcid:PMC4746273</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/mr46kjz7ibhevlnennbohbqptm">fatcat:mr46kjz7ibhevlnennbohbqptm</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190303105619/http://pdfs.semanticscholar.org/b449/0963feaec74641c09967fa75a4a58ce11b66.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/b4/49/b4490963feaec74641c09967fa75a4a58ce11b66.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1155/2016/6191307"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> hindawi.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4746273" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>
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