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An agent-based model of dengue virus transmission shows how uncertainty about breakthrough infections influences vaccination impact projections

T. Alex Perkins, Robert C. Reiner, Guido España, Quirine A. ten Bosch, Amit Verma, Kelly A. Liebman, Valerie A. Paz-Soldan, John P. Elder, Amy C. Morrison, Steven T. Stoddard, Uriel Kitron, Gonzalo M. Vazquez-Prokopec (+3 others)
2019 PLoS Computational Biology  
Our goal in this study was to quantify the extent to which uncertainty about breakthrough infections results in uncertainty about vaccination impact, with a focus on vaccines for dengue.  ...  To realistically account for the many forms of heterogeneity in dengue virus (DENV) transmission, which could have implications for the dynamics of indirect protection, we used a stochastic, agent-based  ...  Acknowledgments This research made extensive use of computing resources provided by the Center for Research Computing at the University of Notre Dame. Author Contributions Conceptualization: T.  ... 
doi:10.1371/journal.pcbi.1006710 pmid:30893294 pmcid:PMC6443188 fatcat:xbbpspz7svc6np4mzpnwvqf2ra

Vaccines and Antivirals: Grand Challenges and Great Opportunities

Graciela Andrei
2021 Frontiers in Virology  
The virus infected about one-third of the planet's population (∼500 million people at that time) and made an estimated 50 million victims.  ...  Zoonotic viruses may show limited variability in their natural hosts; however, these viruses have the potential to infect humans (an immunological naïve population).  ...  This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).  ... 
doi:10.3389/fviro.2021.666548 fatcat:qth6e42pe5d2vmjuwprvj3oidu

Projections of zoster incidence in Australia based on demographic and transmission models of varicella-zoster virus infection

Valentina Costantino, Heather F Gidding, James G Wood
2017 Vaccine  
Title: Projections of zoster incidence in Australia based on demographic and transmission models of varicella-zoster virus infection Other name/s: Faculty: Medicine Varicella Zoster Virus (VZV) firstly  ...  However, following age-standardisation, HZ trends showed an increase of 8.11% over the same period.  ...  How demographic changes in the Australian population have influenced the epidemiology of varicella infection over the 20 th century and 2. How these changes could impact on HZ epidemiology.  ... 
doi:10.1016/j.vaccine.2017.09.090 pmid:29050801 fatcat:xre5obpv5zdcpeaaqm3pdndxlu

ISAR News

2019 Antiviral Research  
This collective, deliberative and collaborative methodology can be not only enriching in the implementation of strategies, but it is also an efficient way to triangulate research techniques and strategies  ...  to obtain more solid results and broader consensus, in this case, on priorities in the field of vector control of AA in this region.  ...  What is the focus of your research now? Belgium during your Postdoc. Could you please tell us about this experience and how your stay abroad influenced your career?  ... 
doi:10.1016/s0166-3542(18)30746-0 fatcat:esn5r75mbzevthf3xyec3uuuti

SEVERE COINFECTIONS OF DENGUE AND PANDEMIC INFLUENZA A H1N1 VIRUSES

Maria Angeles Perez, Aubree Gordon, Felix Sanchez, Federico Narvaez, Gamaliel Gutierrez, Oscar Ortega, Andrea Nuñez, Eva Harris, Angel Balmaseda
2010 The Pediatric Infectious Disease Journal  
, An. koliensis, An. farauti s.s., An. farauti 4 and An. hinesorum (formerly An 1 SPATIAL SCALE OF DENGUE VIRUS TRANSMISSION IN IQUITOS, PERU Kelly A.  ...  We studied the dynamics of both virus replication when dengue-2 virus (DENV-2) and yellow fever virus vaccine strain 17D (YFV-17D) infected the same culture of mammalian cells (Vero cells).  ...  The results demonstrated an exacerbation of the parasitism in infected mice, as result of the immunosuppressive chemical agent activity during the course of infection by T. cruzi.  ... 
doi:10.1097/inf.0b013e3181e6c69b pmid:20811315 pmcid:PMC5614439 fatcat:h764ud7zjnamlprplnjdogffza

Abstracts for Supplement

2010 International Journal of Infectious Diseases  
Travel medicine has emerged as a new field of medicine, moving to an evidence based body of knowledge concerning risk assessment and measures to protect the health of travellers.  ...  All will influence travelers' health and pose new challenges to travel medicine in the forthcoming decades.  ...  Background: A combination of geographical features makes Mongolia an ideal location for understanding the epidemiology of avian influenza viruses in wild birds.  ... 
doi:10.1016/j.ijid.2010.02.003 fatcat:quufwjql2ncdtdtcqhyspvncaa

Zika e Aedes aegypti: antigos e novos desafios

Flávia Thedim Costa Bueno, Mónica García, José Moya, Ilana Löwy, Jaime L. Benchimol, Roberta C. Cerqueira, Marcos Cueto
2017 História, Ciências, Saúde: Manguinhos  
O objetivo deste texto é identificar esse impacto e as mudanças históricas, sociais e sanitárias da doença e o legado do vírus zika.  ...  I've been amazed at how many rumors have circulated in Brazil about zika, relating the disease to vaccines, the use of insecticides and pesticides.  ...  How do you see the zika epidemic impacting on the debate about contraception and maternal and infant health?  ... 
doi:10.1590/s0104-59702017000500017 pmid:29412263 fatcat:6rd6mxytkfddhkdfc2u2pmx3oa

Evolution and public health

G. S. Omenn
2009 Proceedings of the National Academy of Sciences of the United States of America  
sources of exposures to infectious agents and chemicals, diverse causes of migration of populations, and climate change.  ...  The substrate for the study of evolution in public health includes international patterns of incidence and prevalence of disease, influences of human and animal behavior, dramatic changes in diet, environmental  ...  (28) have created a community-based vaccine ontology to standardize vaccine annotation, integrate information about vaccine types, and support computer-assisted reasoning (www.violinet.org/vaccineontology  ... 
doi:10.1073/pnas.0906198106 pmid:19966311 pmcid:PMC2868289 fatcat:kmqzrqtobfahvhxzw4l23xctgy

Communicable Diseases [chapter]

Theodore H. Tulchinsky, Elena A. Varavikova
2014 The New Public Health  
An official apology was subsequently rendered to the government of Guatemala.  ...  The US Presidential Commission on Bioethics has highlighted this case as an awakener to ensure that something of this magnitude, grossly violating the rights of study participants, is never repeated.  ...  Studies showing equivocal benefit of BCG in preventing TB have added to the dispute and uncertainty.  ... 
doi:10.1016/b978-0-12-415766-8.00004-5 fatcat:o7bowmzvf5ch3anp3qyrz3xzxi

Statistical physics of vaccination

Zhen Wang, Chris T. Bauch, Samit Bhattacharyya, Alberto d'Onofrio, Piero Manfredi, Matjaž Perc, Nicola Perra, Marcel Salathé, Dawei Zhao
2016 Physics reports  
To help reduce their impact, mathematical models of disease transmission have been studied to help understand disease dynamics and inform prevention strategies.  ...  Vaccination - one of the most important preventive measures of modern times - is of great interest both theoretically and empirically.  ...  infected agent could influence more neighbors.  ... 
doi:10.1016/j.physrep.2016.10.006 fatcat:hxq7di4j4zfilfv3m4ogbkzovu

Fast detection of Southern tomato virus by one-step transcription loop-mediated isothermal amplification (RT-LAMP)

L. Elvira-González, A.V. Puchades, C. Carpino, A. Alfaro-Fernandez, M.I. Font-San-Ambrosio, L. Rubio, L Galipienso
2017 Journal of Virological Methods  
together with dengue virus.  ...  However,little attention has been devoted in many cases to the possible impact of mixed infections on the transmission of viruses by their natural vector organisms.  ...  To perform an exhaustive study of the effect of size (or generations) of a battery of polyanionic carbosilane dendrimers (PCDs) containing a polyphenolic core for the prevention of HIV-1 transmission as  ... 
doi:10.1016/j.jviromet.2016.12.004 pmid:27965036 fatcat:5vqbhusk7vajhkvtl7wkufo2na

Infectious disease epidemiology [chapter]

Marc Lipsitch
2015 Teaching Epidemiology  
Working group TS057 "Sexual risk behavior having an impact on blood donor management". Chair: Rut Norda (Sweden)  ...  agents such as hepatitis E virus, hantavirus, leptospirosis, and vector-borne pathogens (e.g., Borrelia burgdorferi, Plasmodium species, Dengue virus, West Nile virus).  ...  for a transmission modelling project(2012-14, rotavirus transmission).  ... 
doi:10.1093/acprof:oso/9780199685004.003.0016 fatcat:olecp4fdzvdi3orrnnqusbbs6i

Infectious disease epidemiology [chapter]

Marc Lipsitch
2010 Teaching Epidemiology  
Working group TS057 "Sexual risk behavior having an impact on blood donor management". Chair: Rut Norda (Sweden)  ...  agents such as hepatitis E virus, hantavirus, leptospirosis, and vector-borne pathogens (e.g., Borrelia burgdorferi, Plasmodium species, Dengue virus, West Nile virus).  ...  for a transmission modelling project(2012-14, rotavirus transmission).  ... 
doi:10.1093/acprof:oso/9780199239481.003.016 fatcat:6wcltfzcifacjjwoc3lorblabq

Infectious Disease Epidemiology

N. Nathanson, E. R. Alexander
1996 American Journal of Epidemiology  
Working group TS057 "Sexual risk behavior having an impact on blood donor management". Chair: Rut Norda (Sweden)  ...  agents such as hepatitis E virus, hantavirus, leptospirosis, and vector-borne pathogens (e.g., Borrelia burgdorferi, Plasmodium species, Dengue virus, West Nile virus).  ...  for a transmission modelling project(2012-14, rotavirus transmission).  ... 
doi:10.1093/aje/144.supplement_8.s34 pmid:8857840 fatcat:6x5ban3wr5fshanwarosanwjwq

Infectious Disease Epidemiology [chapter]

Susanne Straif-Bourgeois, Raoult Ratard, Mirjam Kretzschmar
2014 Handbook of Epidemiology  
Working group TS057 "Sexual risk behavior having an impact on blood donor management". Chair: Rut Norda (Sweden)  ...  agents such as hepatitis E virus, hantavirus, leptospirosis, and vector-borne pathogens (e.g., Borrelia burgdorferi, Plasmodium species, Dengue virus, West Nile virus).  ...  for a transmission modelling project(2012-14, rotavirus transmission).  ... 
doi:10.1007/978-0-387-09834-0_34 fatcat:moiem6wgpjcjfmk62aoxhgkl7i
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