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A METHODOLOGY FOR DESIGNING HIGH CONFIDENCE PATTERN VIA EVENT B

E.K Elsayed, A Ibrahim
2017 International Journal of Intelligent Computing and Information Sciences  
In this paper we discuss these two types on Insulin Infusion Pump (IIP) and sample of UML class diagrams. The proposed approach to formalize IIP is based on using event B.  ...  Finally, we could verify that the code generated from the proposed approach is correct and formal to use as a pattern.  ...  Ref3: This refinement introduce the time issues and the corresponding solutions for them prob2 by applying several timing patterns to the infusion process in the IIP.  ... 
doi:10.21608/ijicis.2017.9149 fatcat:gcustkk4afhbvlrulfdt7egm7i

Stepwise Formal Modelling and Reasoning of Insulin Infusion Pump Requirements [chapter]

Neeraj Kumar Singh, Hao Wang, Mark Lawford, Thomas S. E. Maibaum, Alan Wassyng
2015 Lecture Notes in Computer Science  
An insulin infusion pump (IIP) is a critical software-intensive medical device that infuses insulin satisfying patient needs under safety and timing constraints that are appropriate for the treatment of  ...  This paper presents an incremental proof-based development of an IIP. We use the Event-B modelling language to formalize the given system requirements.  ...  Moreover, we have plans to a closed-loop system using our gluhomeostasis model [3] to verify the correctness of system behaviour, to analyze system operations, and to provide the required safety assurances  ... 
doi:10.1007/978-3-319-21070-4_39 fatcat:yo2gbbw4jrdebdlrhagrcgkf4a

Insulin Pump Risks and Benefits: A Clinical Appraisal of Pump Safety Standards, Adverse Event Reporting, and Research Needs

Lutz Heinemann, G. Alexander Fleming, John R. Petrie, Reinhard W. Holl, Richard M. Bergenstal, Anne L. Peters
2015 Diabetes Care  
However, even with modern insulin pumps, errors of insulin infusion can occur due to pump failure, insulin infusion set (IIS) blockage, infusion site problems, insulin stability issues, user error, or  ...  Insulin pump therapy, also known as continuous subcutaneous insulin infusion (CSII), is an important and evolving form of insulin delivery, which is mainly used for people with type 1 diabetes.  ...  We would like to thank Viktor Jörgens (Executive Director, EASD), Monika Grüsser (Vice Director, EASD), and Robert Ratner (Chief Scientific and Medical Officer, ADA) for  ... 
doi:10.2337/dc15-0168 pmid:25776138 fatcat:vzjm6xfrenaoljw23fxovl3rt4

Real-Time Hypoglycemia Prediction Suite Using Continuous Glucose Monitoring: A safety net for the artificial pancreas

E. Dassau, F. Cameron, H. Lee, B. W. Bequette, H. Zisser, L. Jovanovic, H. P. Chase, D. M. Wilson, B. A. Buckingham, F. J. Doyle
2010 Diabetes Care  
CONCLUSIONS -The HPA will enable automated insulin-pump suspension in response to a pending event that has been detected prior to severe immediate complications.  ...  During these admissions, hypoglycemia was induced by gradual increases in the basal insulin infusion rate up to 180% from the subject's own baseline infusion rate.  ...  On one hand, longer prediction time may provide greater ability to prevent hypoglycemia events; on the other hand, it may be impractical to suspend a pump too far from an event that may not happen due  ... 
doi:10.2337/dc09-1487 pmid:20508231 pmcid:PMC2875433 fatcat:3nf3iivp6zgcjdzerui4cwl2v4

Insulin pump risks and benefits: a clinical appraisal of pump safety standards, adverse event reporting and research needs. A Joint Statement of the European Association for the Study of Diabetes and the American Diabetes Association Diabetes Technology Working Group

Lutz Heinemann, G. Alexander Fleming, John R. Petrie, Reinhard W. Holl, Richard M. Bergenstal, Anne L. Peters
2015 Diabetologia  
Insulin pump therapy, also known as continuous subcutaneous insulin infusion (CSII), is an important and evolving form of insulin delivery, which is mainly used for people with type 1 diabetes.  ...  This statement concludes with a series of recommended specific actions for 'meknovigilance' (i.e. a standardised safety approach to technology) which could be implemented to address the shortcomings we  ...  All authors approved the final version to be published.  ... 
doi:10.1007/s00125-015-3513-z pmid:25784563 fatcat:efyzwqdaavdkvoav72jqkyfrie

Continuous Glucose Monitoring Enables the Detection of Losses in Infusion Set Actuation (LISAs)

Daniel Howsmon, Faye Cameron, Nihat Baysal, Trang Ly, Gregory Forlenza, David Maahs, Bruce Buckingham, Juergen Hahn, B. Bequette
2017 Sensors  
Therefore, an algorithm for the detection of LISAs based on CGM and CSII signals was developed to improve patient safety.  ...  In addition to artificial pancreas algorithms that use CGM to automate continuous subcutaneous insulin infusion (CSII), CGM can also inform fault detection algorithms that alert patients to problems in  ...  Time points with retrospective alarms are shaded in red; (B) the basal and bolus insulin administration is passed to a second-order filter to determine the plasma insulin estimate (PIE); (C) the IFM calculated  ... 
doi:10.3390/s17010161 pmid:28098839 pmcid:PMC5298734 fatcat:h74sjn3a6veshoaj5prh5km4em

Early Detection of Infusion Set Failure During Insulin Pump Therapy in Type 1 Diabetes

Marzia Cescon, Daniel J. DeSalvo, Trang T. Ly, David M. Maahs, Laurel H. Messer, Bruce A. Buckingham, Francis J. Doyle, Eyal Dassau
2016 Journal of Diabetes Science and Technology  
Declaration of Conflicting Interests The author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: Funding The author  ...  (s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: JDRF Grant 17-2013-471 and National Institutes of Health Grant DP3DK094331.  ...  To the best of the authors knowledge this is the first time that a method with these features has been applied to actual outpatient data.  ... 
doi:10.1177/1932296816663962 pmid:27621142 pmcid:PMC5094340 fatcat:hgzmzj2brjfbzoaqpsjcw6hs2i

Guidelines for Application of Continuous Subcutaneous Insulin Infusion (Insulin Pump) Therapy in the Perioperative Period

Mary E. Boyle, Karen M. Seifert, Karen A. Beer, Heidi A. Apsey, Adrienne A. Nassar, Stephanie D. Littman, Janice M. Magallanez, Richard T. Schlinkert, Joshua D. Stearns, Michael J. Hovan, Curtiss B. Cook
2012 Journal of Diabetes Science and Technology  
Although the work group identified safety issues specific to surgical scenarios, it believed that with the use of standardized guidelines and a checklist, continuation of insulin pump therapy during the  ...  Abbreviations: (CSII) continuous subcutaneous insulin infusion, (PACU) postanesthesia care unit Abstract Case reports indicate that diabetes patients receiving outpatient insulin pump therapy have been  ...  Similar to the approach taken to implementing an inpatient insulin pump policy, a successful approach to perioperative insulin pump use will depend on a collaborative relationship among the patient, the  ... 
doi:10.1177/193229681200600123 pmid:22401338 pmcid:PMC3320837 fatcat:xrofdt5gefcfzafqlfeaofrk2e

A Hazard Analysis of Class I Recalls of Infusion Pump (Preprint)

Xuemei Gao, Qiang Wen, Xiaolian Duan, Wei Jin, Xiaohong Tang, Ling Zhong, Shitao Xia, Hailing Feng, Daidi Zhong
2018 JMIR Human Factors  
This study aimed to establish a hazard classification framework of medical devices and to apply it over practical adverse event data on infusion pumps.  ...  According to the analytical results, an important source of product technical risk was that the infusion pumps did not infuse accurate dosage (ie, over- or underdelivery of fluid).  ...  Multimedia Appendix 1: [The hazard classification of 2001 ~ 2017 class Ⅰ infusion pump recalls extracted from FDA website.]  ... 
doi:10.2196/10366 pmid:31066695 pmcid:PMC6524450 fatcat:uewivk7bofatvmvi4a223gbope

Insulin Infusion Set Use: European Perspectives and Recommendations

Dorothee Deiss, Peter Adolfsson, Marije Alkemade-van Zomeren, Geremia B. Bolli, Guillaume Charpentier, Claudio Cobelli, Thomas Danne, Angela Girelli, Heiko Mueller, Carol A. Verderese, Eric Renard
2016 Diabetes Technology & Therapeutics  
Insulin pump users worldwide depend on insulin infusion sets (IISs) for predictable delivery of insulin to the subcutaneous tissue.  ...  Yet emerging data indicates that IISs are associated with many pump-related adverse events and may contribute to potentially life-threatening problem of unexplained hyperglycemia.  ...  C.C. has patent applications related to glucose sensors and the artificial pancreas; he has received non-financial support from Roche and Dexcom, and received research support, managed by University of  ... 
doi:10.1089/dia.2016.07281.sf pmid:27526329 pmcid:PMC5040072 fatcat:rpwa25xgr5ctbfi55bfvbnhmme

Patient Infusion Pattern based Access Control Schemes for Wireless Insulin Pump System

Xiali Hei, Xiaojiang Du, Shan Lin, Insup Lee, Oleg Sokolsky
2015 IEEE Transactions on Parallel and Distributed Systems  
This scheme employs supervised learning approaches to learn normal patient infusion patterns in terms of the dosage amount, rate, and time of infusion, which are automatically recorded in insulin pump  ...  The generated regression models are used to dynamically configure a safe infusion range for abnormal infusion identification.  ...  ACKNOWLEDGMENTS This work was supported in part by the US NSF under grants CNS-0963578, CNS-1022552, CNS-1065444, IIS-1231680, CNS-1239108, as well as CNS-1035715.  ... 
doi:10.1109/tpds.2014.2370045 fatcat:l5tpyzxuovbdpf6zwmp32klrp4

Update on a Quality Initiative to Standardize Perioperative Care for Continuous Subcutaneous Insulin Infusion Therapy

Patricia A. Mackey, Bithika M. Thompson, Mary E. Boyle, Heidi A. Apsey, Karen M. Seifert, Richard T. Schlinkert, Joshua D. Stearns, Curtiss B. Cook
2015 Journal of Diabetes Science and Technology  
Preoperative contact is an opportune time to educate the patient on the inpatient insulin pump policy outside of the surgical day which is often accompanied by increased stress, unfamiliar transitions,  ...  Patients are asked about their diabetes type and duration, their current glucose control, length of time that they have been using an insulin pump, the pump brand, current pump rates, settings, and brand  ... 
doi:10.1177/1932296815592027 pmid:26092687 pmcid:PMC4667318 fatcat:p5ecob3wqbhcvhzqqizzau6hyi

Confusion Regarding Duration of Insulin Action

John Walsh, Ruth Roberts, Lutz Heinemann
2014 Journal of Diabetes Science and Technology  
; IAT, insulin action time; IOB, insulin on board; PD, pharmacodynamic; PK, pharmacokinetic; SC, subcutaneous.  ...  Abbreviations BC, bolus calculator; BOB, bolus insulin on board; carb, carbohydrate; CGM, continuous glucose monitor; DIA, duration of insulin action; GIR, glucose infusion rate; HGP, hepatic glucose production  ...  from an insulin pump) before the test insulin is applied.  ... 
doi:10.1177/1932296813514319 pmid:24876553 pmcid:PMC4454113 fatcat:7eiux7tnjzgcvfjrsw235jpfrq

Preclinically assessed optimal control of postprandial glucose excursions for type 1 patients with diabetes

Thierry Prud'homme, Alain Bock, Gregory Francois, Denis Gillet
2011 2011 IEEE International Conference on Automation Science and Engineering  
Model parameters are identified for every couple (Patient, Meal) of interest and optimal control is applied to generate individualized meal specific insulin profiles.  ...  The method does not require the use of a continuous BG meter, the profiles being infused in an open-loop manner. Results from a preliminary clinical study are presented.  ...  Important safety issues related to the automatically changing insulin infusion generated by an AP are another drawback.  ... 
doi:10.1109/case.2011.6042510 dblp:conf/case/PrudhommeBFG11 fatcat:egixnrjgljhsxhi372sgie2aay

SMARTDIAB: A Communication and Information Technology Approach for the Intelligent Monitoring, Management and Follow-up of Type 1 Diabetes Patients

Stavroula G. Mougiakakou, Christos S. Bartsocas, Evangelos Bozas, Nikos Chaniotakis, Dimitra Iliopoulou, Ioannis Kouris, Sotiris Pavlopoulos, Aikaterini Prountzou, Marios Skevofilakas, Alexandre Tsoukalis, Kostas Varotsis, Andrianni Vazeou (+2 others)
2010 IEEE Transactions on Information Technology in Biomedicine  
The PU consists of an insulin pump for subcutaneous insulin infusion to the patient and a continuous glucose measurement system.  ...  The IIAS is used to close the loop between the insulin pump and the continuous glucose monitoring system, by providing the pump with the appropriate insulin infusion rate in order to keep the patient's  ...  Furthermore, they would like to thank Medtronic (Athens, Greece) for the provision of the continuous glucose systems (CGMS and Guardian RT) and the insulin pumps.  ... 
doi:10.1109/titb.2009.2039711 pmid:20123578 fatcat:lo5jc5qc6jdq5pt2ilbbwa6qdi
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