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Fault-tolerant valve-based microfluidic routing fabric for droplet barcoding in single-cell analysis

Yasamin Moradi, Mohamed Ibrahim, Krishnendu Chakrabarty, Ulf Schlichtmann
2018 2018 Design, Automation & Test in Europe Conference & Exhibition (DATE)  
In this design, a valve-based routing fabric based on transposers is used to label/barcode the target cells.  ...  We address the above limitation by investigating the fault tolerance of the valve-based routing fabric.  ...  In this work, we are focused on droplet barcoding and a valve-based fabric that is utilized as a crossbar to route a barcoding droplet from the reservoirs to the point where it is mixed with sample/reagents  ... 
doi:10.23919/date.2018.8342247 dblp:conf/date/MoradiICS18 fatcat:ysfpco4qmvhfzdmg4januir6si

Synthesis of a Cyberphysical Hybrid Microfluidic Platform for Single-Cell Analysis

Mohamed Ibrahim, Krishnendu Chakrabarty, Ulf Schlichtmann
2018 IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems  
To overcome these challenges, we present a hybrid microfluidic platform that enables complete single-cell analysis on a heterogeneous pool of cells.  ...  Microfluidic solutions have recently been developed to classify cell types or perform singlecell biochemical analysis on pre-isolated types of cells.  ...  valve-based fabric used for barcoding.  ... 
doi:10.1109/tcad.2018.2846662 fatcat:w7zqsv53i5gkphewmbcpfs5twe

Security Trade-Offs in Microfluidic Routing Fabrics

Jack Tang, Mohamed Ibrahim, Krishnendu Chakrabarty, Ramesh Karri
2017 2017 IEEE International Conference on Computer Design (ICCD)  
Many applications in microfluidics, such as DNA barcoding for single-cell analysis, are expected to benefit from these new devices.  ...  Microfluidic routing fabrics, or crossbars, based on transposer primitives provide benefits in manufacturability, performance, and on-the-fly reconfigurability.  ...  The transposer-based microfluidic routing fabrics described in this paper were recently proposed as part of a hybrid single-cell analysis platform [7] for its ability to barcode cells in a space-efficient  ... 
doi:10.1109/iccd.2017.13 dblp:conf/iccd/TangICK17 fatcat:nsikappl6fdo3dckfrbxn53dom

BioCyBig: A Cyberphysical System for Integrative Microfluidics-Driven Analysis of Genomic Association Studies

Mohamed Ibrahim, Krishnendu Chakrabarty, Jun Zeng
2016 IEEE Transactions on Big Data  
This framework will be based on the integration of CPS with microfluidic biochips and cloud computing.  ...  A case study from cancer research is discussed to explain the significance of our framework in promoting coordinated genomic studies.  ...  Various microfluidic technologies (e.g., flow-based, droplet-based, and digital microfluidics) have been presented in the literature for genomic association analysis, targeting epigenome [5] , transcriptome  ... 
doi:10.1109/tbdata.2016.2643683 fatcat:u5ws25dwdnbmbj4bb4qyppbl2a

2020 Index IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems Vol. 39

2020 IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems  
., +, TCAD Nov. 2020 3698-3710 Drops An Efficient Fault-Tolerant Valve-Based Microfluidic Routing Fabric for Droplet Barcoding in Single-Cell Analysis.  ...  ., +, TCAD Nov. 2020 3458-3466 Cancer An Efficient Fault-Tolerant Valve-Based Microfluidic Routing Fabric for Droplet Barcoding in Single-Cell Analysis.  ...  Entropy-Directed Scheduling for FPGA High-Level Synthesis. Shen, M., +, TCAD Oct. 2020 2588 -2601 FLASH: Fast, Parallel, and Accurate Simulator for HLS.  ... 
doi:10.1109/tcad.2021.3054536 fatcat:wsw3olpxzbeclenhex3f73qlw4

Roadmap for optofluidics

Paolo Minzioni, Roberto Osellame, Cinzia Sada, S Zhao, F G Omenetto, Kristinn B Gylfason, Tommy Haraldsson, Yibo Zhang, Aydogan Ozcan, Adam Wax, Frieder Mugele, Holger Schmidt (+13 others)
2017 Journal of Optics  
Nowadays optofluidics applications include, without being limited to, lab-on-chip devices, fluid-based and controlled lenses, optical sensors for fluids and for suspended particles, biosensors, imaging  ...  in different fields, ranging from materials science to photonics, from microfluidics to molecular biology and biophysics.  ...  As shown in Figure 2(d) , the single-cell barcoding microchips consist of thousands of individually addressed micro chambers for single-cell trapping, followed by cell lysis, capture of targeted proteins  ... 
doi:10.1088/2040-8986/aa783b fatcat:p4bxkftdv5anzkc66amuibh6zm

Synthesis of a Cyberphysical Hybrid Microfluidic Platform for Single-Cell Analysis

Mohamed, Krishnendu Chakrabarty, Ulf Schlichtmann
unpublished
Microfluidic solutions have recently been developed to classify cell types or perform single-cell biochemical analysis on pre-isolated types of cells.  ...  To overcome these challenges, we present a hybrid microfluidic platform that enables complete single-cell analysis on a heterogeneous pool of cells.  ...  Kristin Scott from the Department of Molecular Genetics and Microbiology at Duke University for providing the data related to the performance of the ChIP protocol.  ... 
fatcat:innm2vcyargc5igw4m5gfzhoii

Abstracts of Papers Presented at the 2005 Pittsburgh Conference

Peter B. Stockwell
2005 Journal of automated methods & management in chemistry (Print)  
I feel sure that past Pittcon organizers would have been more persistent in getting the required details for the audience.  ...  No doubt I will be there making it a straight 31 in a row; in Pittsburgh Conference terms I am just a beginner with many of the attendees making more shows in a run than that.  ...  Here, we describe the fabrication of electrically actuated micropumps for microfluidic applications.  ... 
doi:10.1155/jammc.2005.59 pmid:18924631 pmcid:PMC2548401 fatcat:xqreduq3ibdwdkzh4l7xtj4f3e