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S-phase progression stimulates both the mutagenic KU-independent pathway and mutagenic processing of KU-dependent intermediates, for nonhomologous end joining

J Guirouilh-Barbat, S Huck, B S Lopez
2007 Oncogene  
We used intrachromosomal substrates to directly monitor the effect of the cell cycle on the efficiency and the accuracy of nonhomologous end joining (NHEJ) in mammalian cells.  ...  In addition, the accuracy of NHEJ is barely altered when the cells are blocked in G 1 /S or in G 2 /M.  ...  *Data from Guirouilh-Barbat et al. (2004). (c) Distribution of the size of deletions in asynchronous cells and mimosine-or nocodazole-blocked cells. *Data from Guirouilh-Barbat et al. (2004).  ... 
doi:10.1038/sj.onc.1210807 pmid:17891177 fatcat:4rywudifcrbapet2vb42lvbpe4

Replication fork passage drives asymmetric dynamics of a critical nucleoid‐associated protein in Caulobacter

Rodrigo Arias‐Cartin, Genevieve S Dobihal, Manuel Campos, Ivan V Surovtsev, Bradley Parry, Christine Jacobs‐Wagner
2016 EMBO Journal  
Strikingly, this asymmetric localization cannot be explained by the distribution of GapR binding sites on the chromosome.  ...  Instead, we present a mechanistic model in which the spatiotemporal dynamics of GapR are primarily driven by the progression of the replication forks.  ...  To simulate the average GapR distribution over the chromosome in asynchronous populations, we used demograph data on DnaN-CFP for an asynchronous culture to estimate the fraction of the cells in G1 (before  ... 
doi:10.15252/embj.201695513 pmid:28011580 pmcid:PMC5286365 fatcat:tkn3zinm3jawlm4dpy7ticb4y4

DOLCLAN – Middleware Support for Peer-to-Peer Distributed Shared Objects [chapter]

Jakob E. Bardram, Martin Mogensen
2007 Lecture Notes in Computer Science  
In this paper we present an approach to support distributed programming, which rely on local object replicas keeping themselves synchronized using an underlying peer-to-peer infrastructure.  ...  An evaluation demonstrates that DOLCLAN can be utilized to create a real distributed collaborative system for ad-hoc collaboration in hospitals, which demonstrates that the approach can support the creation  ...  Acknowledgments Jonathan Bunde-Pedersen provided valuable feedback on the ideas and language support presented in this paper. This work is partly funded by the Competence Centre ISIS Katrinebjerg.  ... 
doi:10.1007/978-3-540-72883-2_9 fatcat:nfwb6k4p75hchcgxdyjm35fztu

Have Your Data and Query It Too

Dipti Borkar, Ravi Mayuram, Gerald Sangudi, Michael Carey
2016 Proceedings of the 2016 International Conference on Management of Data - SIGMOD '16  
Today's Couchbase Server is a memory-and network-centric, shared-nothing, auto-partitioned, and distributed NoSQL database system that offers both key-based and secondary index-based data access paths  ...  In addition, it details the implementation of such an architecture using Couchbase Server and explains the evolution of Couchbase Server from its early roots to its present form.  ...  to handle workload spikes at memory-first speeds, and asynchronous data replication within a cluster to achieve high availability.  ... 
doi:10.1145/2882903.2904443 dblp:conf/sigmod/BorkarMSC16 fatcat:drhqy62livgdjd7pnjs4nhjvgi

Locality Aware Networked Join Evaluation

Y. Ahmad, U. Cetintemel, J. Jannotti, A. Zgolinski
2005 21st International Conference on Data Engineering Workshops (ICDEW'05)  
We first argue that distributed joins arise naturally in a variety of networked applications.  ...  We then discuss the key challenges involved in the distribution, namely how to partition the join operator and how to place the resulting partitions on the network, in order to minimize output latencies  ...  Replicating join partitions and executing them in concert present an opportunity to further optimize the expected tuple delay, as we describe below.  ... 
doi:10.1109/icde.2005.237 dblp:conf/icde/AhmadCJZ05 fatcat:cbsvwlvh6zbktajzgnzqllxo5m

In the higher plantPisum sallvummaturation of nascent DNA is blocked by cycloheximide, but only after 4-8 replicons are joined

J.B. Schvartzman, J.Van't Hof
1982 Nucleic Acids Research  
that replicate early in the S phase.  ...  The experiments also showed that the joining of nascent replicons is not an absolute function of late S or G2 phase of the cell cycle, since cells treated with cycloheximide and blocked in mid-S phase  ...  A unique feature of eukaryotic DNA replication, however, is the joining of nascent replicons once their replication is completed.  ... 
doi:10.1093/nar/10.19.6191 pmid:7145718 pmcid:PMC320960 fatcat:mva4z33vtbcidpk4l6h6ztqhom

Asynchronous Replication Timing: A Mechanism for Monoallelic Choice During Development

Yehudit Bergman, Itamar Simon, Howard Cedar
2021 Frontiers in Cell and Developmental Biology  
In this perspective, we propose that asynchronous replication timing (ASRT) serves as the basis for a sophisticated universal mechanism for mediating and maintaining these decisions.  ...  allele in each cell.  ...  for generating genomic data.  ... 
doi:10.3389/fcell.2021.737681 pmid:34660595 pmcid:PMC8517340 fatcat:76iv6tv2ijahlhbx37siohh224

A multistage collaborative 3D GIS to support public participation

Yingjie Hu, Zhenhua Lv, Jianping Wu, Krzysztof Janowicz, Xizhi Zhao, Bailang Yu
2013 International Journal of Digital Earth  
Such an interface integrates a variety of data, functions, and services into a unified virtual environment which is delivered to both experts and public participants through the Internet.  ...  We differentiate ubiquitous participation and intensive participation and identify their suitable application stages.  ...  Such an environment requires a design choice among centralized, replicated, or semi-replicated architecture to handle the distributed data and functions.  ... 
doi:10.1080/17538947.2013.866172 fatcat:6nt4u6zjujhkzctrg62nyrsvdu

DNA replication timing, genome stability and cancer

Nathan Donley, Mathew J. Thayer
2013 Seminars in Cancer Biology  
Aberrant DNA replication timing is associated with changes in gene expression, changes in epigenetic modifications and an increased frequency of structural rearrangements.  ...  This influence has helped shape the genomes of humans and other multicellular organisms and can affect the distribution of mutations in somatic cells.  ...  This can explain a switch in replication timing of an individual locus and aberrant asynchronous replication.  ... 
doi:10.1016/j.semcancer.2013.01.001 pmid:23327985 pmcid:PMC3615080 fatcat:n5uvhbj72nfjfhskpmd6xhw33y

A Classification of NoSQL Data Stores Based on Key Design Characteristics

Antonios Makris, Konstantinos Tserpes, Vassiliki Andronikou, Dimosthenis Anagnostopoulos
2016 Procedia Computer Science  
Traditional Relational Database Management Systems are continuously being replaced by NoSQL data stores as a result of the growing demand for big data applications.  ...  It supports a multi-master, asynchronous replication and the communication conducted by using an agent-based P2P framework 12 .  ...  In general, there is a trade-off between consistency and high availability of data in NoSQL data stores. Redis is not able to guarantee strong consistency because it uses asynchronous replication.  ... 
doi:10.1016/j.procs.2016.08.284 fatcat:pp5sdg4thzg2lhriyo46xztgkm

Chemical foundations of distributed aspects

Nicolas Tabareau, Éric Tanter
2018 Distributed computing  
We propose the Aspect Join Calculus, an aspectoriented and distributed variant of the join calculus that addresses crosscutting and provides a formal foundation for distributed AOP.  ...  It is used as the basis of concurrency and distribution features in several mainstream languages like C# (Polyphonic C#, now Cω), OCaml (JoCaml), and Scala Joins.  ...  For instance, data replication, transactions, security, and fault tolerance often crosscut the business code of a distributed application.  ... 
doi:10.1007/s00446-018-0334-6 fatcat:gczozwcylfgyldijiaw4zo2jky

Self-replication, Evolvability and Asynchronicity in Stochastic Worlds [chapter]

Chrystopher L. Nehaniv
2005 Lecture Notes in Computer Science  
We consider temporal aspects of self-replication and evolvability -in particular, the massively asynchronous parallel and distributed nature of living systems.  ...  Individuals in a finite computer memory are self-replicating programs running on a Darwinian operating systems (one in which mutations in data and flaws in computational operations occur with certain low  ...  The biological modelling work involving NETBUILDER is supported in part by an grant from the Wellcome Trust.  ... 
doi:10.1007/11571155_13 fatcat:4cdihrzr5reljbhedfxh67v47y

Scaling and Continuous Availability in Database Server Clusters through Multiversion Replication

Kaloian Manassiev, Cristiana Amza
2007 37th Annual IEEE/IFIP International Conference on Dependable Systems and Networks (DSN'07)  
In this paper, we study replication techniques for scaling and continuous operation for a dynamic content server.  ...  At the same time, updates are handled by an on-disk database back-end that is in charge of making them persistent.  ...  Our in-memory replication scheme is asynchronous in order to provide scaling.  ... 
doi:10.1109/dsn.2007.86 dblp:conf/dsn/ManassievA07 fatcat:wdgnsax4rvgttoiks7qqbr4qnu

A Differentiation-Aware Fault-Tolerant Framework for Web Services [chapter]

Gerald Kotonya, Stephen Hall
2010 Lecture Notes in Computer Science  
However, FT techniques are yet to be adopted in a systematic way within service oriented computing.  ...  This paper describes a service differentiation-aware, FT framework based on the FT process model that can be used to support serviceoriented computing.  ...  This is a distributed version of ubiquitous recovery block protocol for passive replication, as also found in [4] , [5] , [8] .  ... 
doi:10.1007/978-3-642-17358-5_10 fatcat:2h6v3axt2fdtdd7pxlvlhe5qiq

Design and Implementation of a Corba Fault-Tolerant Object Group Service [chapter]

Graham Morgan, Santosh Shrivastava, Paul Ezhilchelvan, Mark Little
1999 Distributed Applications and Interoperable Systems II  
Many fault-tolerant distributed applications can be structured as one or more groups of objects that cooperate by multicasting invocations on member objects.  ...  Both symmetric and asymmetric total order protocols are supported, permitting a member to use say symmetric version in one group and asymmetric version in another group simultaneously.  ...  As an example, these properties are ideal for replicated data management: each member manages a copy of data, and given atomic delivery and total order, it can be ensured that copies of data do not diverge  ... 
doi:10.1007/978-0-387-35565-8_29 fatcat:w43zpplgbndujmccq6mkbrxt5e
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