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S-phase progression stimulates both the mutagenic KU-independent pathway and mutagenic processing of KU-dependent intermediates, for nonhomologous end joining
2007
Oncogene
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We used intrachromosomal substrates to directly monitor the effect of the cell cycle on the efficiency and the accuracy of nonhomologous end joining (NHEJ) in mammalian cells. ...
In addition, the accuracy of NHEJ is barely altered when the cells are blocked in G 1 /S or in G 2 /M. ...
*Data from Guirouilh-Barbat et al. (2004). (c) Distribution of the size of deletions in asynchronous cells and mimosine-or nocodazole-blocked cells. *Data from Guirouilh-Barbat et al. (2004). ...
doi:10.1038/sj.onc.1210807
pmid:17891177
fatcat:4rywudifcrbapet2vb42lvbpe4
Replication fork passage drives asymmetric dynamics of a critical nucleoid‐associated protein in Caulobacter
2016
EMBO Journal
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Strikingly, this asymmetric localization cannot be explained by the distribution of GapR binding sites on the chromosome. ...
Instead, we present a mechanistic model in which the spatiotemporal dynamics of GapR are primarily driven by the progression of the replication forks. ...
To simulate the average GapR distribution over the chromosome in asynchronous populations, we used demograph data on DnaN-CFP for an asynchronous culture to estimate the fraction of the cells in G1 (before ...
doi:10.15252/embj.201695513
pmid:28011580
pmcid:PMC5286365
fatcat:tkn3zinm3jawlm4dpy7ticb4y4
DOLCLAN – Middleware Support for Peer-to-Peer Distributed Shared Objects
[chapter]
2007
Lecture Notes in Computer Science
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In this paper we present an approach to support distributed programming, which rely on local object replicas keeping themselves synchronized using an underlying peer-to-peer infrastructure. ...
An evaluation demonstrates that DOLCLAN can be utilized to create a real distributed collaborative system for ad-hoc collaboration in hospitals, which demonstrates that the approach can support the creation ...
Acknowledgments Jonathan Bunde-Pedersen provided valuable feedback on the ideas and language support presented in this paper. This work is partly funded by the Competence Centre ISIS Katrinebjerg. ...
doi:10.1007/978-3-540-72883-2_9
fatcat:nfwb6k4p75hchcgxdyjm35fztu
Have Your Data and Query It Too
2016
Proceedings of the 2016 International Conference on Management of Data - SIGMOD '16
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Today's Couchbase Server is a memory-and network-centric, shared-nothing, auto-partitioned, and distributed NoSQL database system that offers both key-based and secondary index-based data access paths ...
In addition, it details the implementation of such an architecture using Couchbase Server and explains the evolution of Couchbase Server from its early roots to its present form. ...
to handle workload spikes at memory-first speeds, and asynchronous data replication within a cluster to achieve high availability. ...
doi:10.1145/2882903.2904443
dblp:conf/sigmod/BorkarMSC16
fatcat:drhqy62livgdjd7pnjs4nhjvgi
Locality Aware Networked Join Evaluation
2005
21st International Conference on Data Engineering Workshops (ICDEW'05)
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We first argue that distributed joins arise naturally in a variety of networked applications. ...
We then discuss the key challenges involved in the distribution, namely how to partition the join operator and how to place the resulting partitions on the network, in order to minimize output latencies ...
Replicating join partitions and executing them in concert present an opportunity to further optimize the expected tuple delay, as we describe below. ...
doi:10.1109/icde.2005.237
dblp:conf/icde/AhmadCJZ05
fatcat:cbsvwlvh6zbktajzgnzqllxo5m
In the higher plantPisum sallvummaturation of nascent DNA is blocked by cycloheximide, but only after 4-8 replicons are joined
1982
Nucleic Acids Research
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that replicate early in the S phase. ...
The experiments also showed that the joining of nascent replicons is not an absolute function of late S or G2 phase of the cell cycle, since cells treated with cycloheximide and blocked in mid-S phase ...
A unique feature of eukaryotic DNA replication, however, is the joining of nascent replicons once their replication is completed. ...
doi:10.1093/nar/10.19.6191
pmid:7145718
pmcid:PMC320960
fatcat:mva4z33vtbcidpk4l6h6ztqhom
Asynchronous Replication Timing: A Mechanism for Monoallelic Choice During Development
2021
Frontiers in Cell and Developmental Biology
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In this perspective, we propose that asynchronous replication timing (ASRT) serves as the basis for a sophisticated universal mechanism for mediating and maintaining these decisions. ...
allele in each cell. ...
for generating genomic data. ...
doi:10.3389/fcell.2021.737681
pmid:34660595
pmcid:PMC8517340
fatcat:76iv6tv2ijahlhbx37siohh224
A multistage collaborative 3D GIS to support public participation
2013
International Journal of Digital Earth
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Such an interface integrates a variety of data, functions, and services into a unified virtual environment which is delivered to both experts and public participants through the Internet. ...
We differentiate ubiquitous participation and intensive participation and identify their suitable application stages. ...
Such an environment requires a design choice among centralized, replicated, or semi-replicated architecture to handle the distributed data and functions. ...
doi:10.1080/17538947.2013.866172
fatcat:6nt4u6zjujhkzctrg62nyrsvdu
DNA replication timing, genome stability and cancer
2013
Seminars in Cancer Biology
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Aberrant DNA replication timing is associated with changes in gene expression, changes in epigenetic modifications and an increased frequency of structural rearrangements. ...
This influence has helped shape the genomes of humans and other multicellular organisms and can affect the distribution of mutations in somatic cells. ...
This can explain a switch in replication timing of an individual locus and aberrant asynchronous replication. ...
doi:10.1016/j.semcancer.2013.01.001
pmid:23327985
pmcid:PMC3615080
fatcat:n5uvhbj72nfjfhskpmd6xhw33y
A Classification of NoSQL Data Stores Based on Key Design Characteristics
2016
Procedia Computer Science
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Traditional Relational Database Management Systems are continuously being replaced by NoSQL data stores as a result of the growing demand for big data applications. ...
It supports a multi-master, asynchronous replication and the communication conducted by using an agent-based P2P framework 12 . ...
In general, there is a trade-off between consistency and high availability of data in NoSQL data stores. Redis is not able to guarantee strong consistency because it uses asynchronous replication. ...
doi:10.1016/j.procs.2016.08.284
fatcat:pp5sdg4thzg2lhriyo46xztgkm
Chemical foundations of distributed aspects
2018
Distributed computing
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We propose the Aspect Join Calculus, an aspectoriented and distributed variant of the join calculus that addresses crosscutting and provides a formal foundation for distributed AOP. ...
It is used as the basis of concurrency and distribution features in several mainstream languages like C# (Polyphonic C#, now Cω), OCaml (JoCaml), and Scala Joins. ...
For instance, data replication, transactions, security, and fault tolerance often crosscut the business code of a distributed application. ...
doi:10.1007/s00446-018-0334-6
fatcat:gczozwcylfgyldijiaw4zo2jky
Self-replication, Evolvability and Asynchronicity in Stochastic Worlds
[chapter]
2005
Lecture Notes in Computer Science
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We consider temporal aspects of self-replication and evolvability -in particular, the massively asynchronous parallel and distributed nature of living systems. ...
Individuals in a finite computer memory are self-replicating programs running on a Darwinian operating systems (one in which mutations in data and flaws in computational operations occur with certain low ...
The biological modelling work involving NETBUILDER is supported in part by an grant from the Wellcome Trust. ...
doi:10.1007/11571155_13
fatcat:4cdihrzr5reljbhedfxh67v47y
Scaling and Continuous Availability in Database Server Clusters through Multiversion Replication
2007
37th Annual IEEE/IFIP International Conference on Dependable Systems and Networks (DSN'07)
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In this paper, we study replication techniques for scaling and continuous operation for a dynamic content server. ...
At the same time, updates are handled by an on-disk database back-end that is in charge of making them persistent. ...
Our in-memory replication scheme is asynchronous in order to provide scaling. ...
doi:10.1109/dsn.2007.86
dblp:conf/dsn/ManassievA07
fatcat:wdgnsax4rvgttoiks7qqbr4qnu
A Differentiation-Aware Fault-Tolerant Framework for Web Services
[chapter]
2010
Lecture Notes in Computer Science
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However, FT techniques are yet to be adopted in a systematic way within service oriented computing. ...
This paper describes a service differentiation-aware, FT framework based on the FT process model that can be used to support serviceoriented computing. ...
This is a distributed version of ubiquitous recovery block protocol for passive replication, as also found in [4] , [5] , [8] . ...
doi:10.1007/978-3-642-17358-5_10
fatcat:2h6v3axt2fdtdd7pxlvlhe5qiq
Design and Implementation of a Corba Fault-Tolerant Object Group Service
[chapter]
1999
Distributed Applications and Interoperable Systems II
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Many fault-tolerant distributed applications can be structured as one or more groups of objects that cooperate by multicasting invocations on member objects. ...
Both symmetric and asymmetric total order protocols are supported, permitting a member to use say symmetric version in one group and asymmetric version in another group simultaneously. ...
As an example, these properties are ideal for replicated data management: each member manages a copy of data, and given atomic delivery and total order, it can be ensured that copies of data do not diverge ...
doi:10.1007/978-0-387-35565-8_29
fatcat:w43zpplgbndujmccq6mkbrxt5e
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