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Amygdala volume in depressed patients with bipolar disorder assessed using high resolution 3T MRI: The impact of medication

Jonathan Savitz, Allison C. Nugent, Wendy Bogers, Alice Liu, Rebecca Sills, David A. Luckenbaugh, Earle E. Bain, Joseph L. Price, Carlos Zarate, Husseini K. Manji, Dara M. Cannon, Sean Marrett (+2 others)
2010 NeuroImage  
MRI-based reports of both abnormally increased and decreased amygdala volume in bipolar disorder (BD) have surfaced in the literature.  ...  Here, we acquired high-resolution images (voxel size=0.55×0.55×0.60mm) using a GE 3T MRI scanner, and a pulse sequence optimized for tissue contrast resolution.  ...  Here we resolve this problem with high-resolution 3T MRI images (volumetric resolution=0.4 mm 3 ) that allowed us to segment the amygdala in a reliable and accurate manner.  ... 
doi:10.1016/j.neuroimage.2009.11.025 pmid:19931399 pmcid:PMC2818548 fatcat:43aourpu6ncbtptkaqmjju5tu4

Childhood trauma is associated with reduced frontal gray matter volume: a large transdiagnostic structural MRI study

Marieke J. H. Begemann, Maya J. L. Schutte, Edwin van Dellen, Lucija Abramovic, Marco P. Boks, Neeltje E. M. van Haren, Rene C. W. Mandl, Christiaan H. Vinkers, Marc M. Bohlken, Iris E. C. Sommer
2021 Psychological Medicine  
Participants filled in the Childhood Trauma Questionnaire. Anatomical T1 MRI scans were acquired at 3T, regional brain morphology was assessed using Freesurfer.  ...  No trauma-related volume reductions were observed in any other (sub)cortical lobes nor the hippocampus or amygdala, trauma-by-group (i.e. both patient groups and healthy subjects) interaction effects were  ...  The authors have declared that there are no conflicts of interest in relation to the subject of this study.  ... 
doi:10.1017/s0033291721002087 fatcat:h4vfypxk5rahvoickff5bdgxai

In Vivo Amygdala Nuclei Volumes in Schizophrenia and Bipolar Disorders

Claudia Barth, Stener Nerland, Ann-Marie G de Lange, Laura A Wortinger, Eva Hilland, Ole A Andreassen, Kjetil N Jørgensen, Ingrid Agartz
2021 Schizophrenia Bulletin  
Our study is the first to demonstrate distinct patterns of amygdala nuclei volume reductions in a well-powered sample of patients with schizophrenia and bipolar disorders.  ...  Abnormalities in amygdala volume are well-established in schizophrenia and commonly reported in bipolar disorders.  ...  Acknowledgments We thank the study participants, and the clinicians as well as research assistants involved in recruitment and assessment at the Norwegian Centre for Mental Disorders (NORMENT).  ... 
doi:10.1093/schbul/sbaa192 pmid:33479754 pmcid:PMC8379533 fatcat:6mpkgw7bn5gvbm74y3gupkd5bq

Fronto-temporal dysregulation in asymptomatic bipolar I patients: A paired associate functional MRI study

David C. Glahn, Jennifer L. Robinson, Diana Tordesillas-Gutierrez, E. Serap Monkul, M. Kathleen Holmes, Melissa J. Green, Carrie E. Bearden
2010 Human Brain Mapping  
Bipolar disorder is associated with persistent declarative memory disturbances, but the neural basis of these deficits is not well understood.  ...  These findings suggest a neural basis for the long-term memory deficits consistently observed in patients with bipolar disorder; further, as these patterns appear in symptomatically remitted patients,  ...  Acknowledgments The authors thank Sharon Primeaux for help recruiting and assessing patients.  ... 
doi:10.1002/hbm.20918 pmid:20063304 pmcid:PMC3660318 fatcat:qmxrv5vqbba33b3lwjwbo4gkji

Reward Processing in Unipolar and Bipolar Depression: A Functional MRI Study

Ronny Redlich, Katharina Dohm, Dominik Grotegerd, Nils Opel, Pienie Zwitserlood, Walter Heindel, Volker Arolt, Harald Kugel, Udo Dannlowski
2015 Neuropsychopharmacology  
Differentiating bipolar disorders (BD) from unipolar depression (UD) remains a major clinical challenge.  ...  These results may help to refine the understanding of neural correlates of reward processing in both disorders, and to understand the neural underpinnings of anhedonia, a core symptom of depressive episodes  ...  The study was supported by grants of the German Research Foundation (DFG; grant FOR 2107; DA1151/5-1 to UD), Innovative Medizinische Forschung (DA120903 to UD, DA111107 to UD, and DA211012 to UD), and  ... 
doi:10.1038/npp.2015.110 pmid:25881114 pmcid:PMC4569953 fatcat:oyw7bz5nrncavd4lxxkujsista

Anatomical and Neurochemical Correlates of Parental Verbal Abuse: A Combined MRS—Diffusion MRI Study

Dohyun Kim, Jae Hyun Yoo, Young Woo Park, Minchul Kim, Dong Woo Shin, Bumseok Jeong
2019 Frontiers in Human Neuroscience  
Despite the critical impact of parental dialog on children who remain physically and psychologically dependent, most studies have focused on brain alterations in people exposed to moderate-to-high levels  ...  We measured metabolites in the pregenual anterior cingulate cortex (pgACC) acquired with single-voxel proton magnetic resonance spectroscopy and anatomical connectivity assessed with probabilistic tractography  ...  Childhood trauma and the limbic network: a multimodal MRI study in patients with bipolar disorder and controls. J. Affect.  ... 
doi:10.3389/fnhum.2019.00012 pmid:30760992 pmcid:PMC6361791 fatcat:7iyh5hqsurezzakxuynqee4x7u

In vivo amygdala nuclei volumes in schizophrenia and bipolar disorders [article]

Claudia Barth, Stener Nerland, Ann-Marie G de Lange, Laura Anne Wortinger, Eva Hilland, Ole Andreassen, Kjetil N. Jorgensen, Ingrid Agartz
2020 medRxiv   pre-print
Conclusions: Our study is the first to demonstrate distinct patterns of amygdala nuclei volume reductions in a well-powered sample of patients with schizophrenia and bipolar disorders.  ...  Abnormalities in amygdala volume are well-established in schizophrenia and commonly reported in bipolar disorders.  ...  *** * ** Acknowledgments We thank the study participants, and the clinicians as well as research assistants involved in recruitment and assessment at the Norwegian Centre for Mental Disorders (NORMENT  ... 
doi:10.1101/2020.09.30.20204602 fatcat:dzwdsjeflnhwriujvmjw66ajkm

Machine learning techniques in a structural and functional MRI diagnostic approach in schizophrenia: a systematic review

Renato de Filippis, Elvira Anna Carbone, Raffaele Gaetano, Antonella Bruni, Valentina Pugliese, Cristina Segura-Garcia, Pasquale De Fazio
2019 Neuropsychiatric Disease and Treatment  
of the treatment response and to establish the prognosis of patients with SCZ.  ...  Machine learning (ML) represents a promising approach that could support clinicians in the diagnosis of mental disorders.  ...  Disclosure The authors report no conflicts of interest in this work. References  ... 
doi:10.2147/ndt.s202418 pmid:31354276 pmcid:PMC6590624 fatcat:wubpr7zpubhp3nf7wy2yqhgsg4

The Limbic System in Youth Depression: Brain Structural and Functional Alterations in Adolescent In-patients with Severe Depression

Ronny Redlich, Nils Opel, Christian Bürger, Katharina Dohm, Dominik Grotegerd, Katharina Förster, Dario Zaremba, Susanne Meinert, Jonathan Repple, Verena Enneking, Elisabeth Leehr, Joscha Böhnlein (+10 others)
2017 Neuropsychopharmacology  
Higher levels of childhood maltreatment were associated with smaller hippocampal volumes in both depressed patients and healthy controls, whereby no associations between amygdala reactivity and childhood  ...  Adolescent-onset major depressive disorder (MDD) is associated with an increased risk of recurrent depressive episodes, suicidal behaviors, and psychiatric morbidity throughout the lifespan.  ...  Third, high levels of childhood maltreatment are associated with smaller hippocampal volumes in both depressed patient and healthy controls.  ... 
doi:10.1038/npp.2017.246 pmid:29039414 fatcat:bp5iuur36reztb5xmifrrlj2e4

Structural Plasticity of the Hippocampus and Amygdala Induced by Electroconvulsive Therapy in Major Depression

Shantanu H. Joshi, Randall T. Espinoza, Tara Pirnia, Jie Shi, Yalin Wang, Brandon Ayers, Amber Leaver, Roger P. Woods, Katherine L. Narr
2016 Biological Psychiatry  
changes in hippocampal and amygdala structure were examined in patients with major depression (N= 43, scanned thrice; prior to ECT, after the 2 nd ECT session, and within one week of completing the ECT  ...  Background-Electroconvulsive therapy (ECT) elicits a rapid and robust clinical response in patients with refractory depression.  ...  The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Mental Health or the National Institutes of Health.  ... 
doi:10.1016/j.biopsych.2015.02.029 pmid:25842202 pmcid:PMC4561035 fatcat:ggt5apwj4jhbtmbibmtgkzxmz4

Normal amygdala activation but deficient ventrolateral prefrontal activation in adults with bipolar disorder during euthymia

Lara C. Foland-Ross, Susan Y. Bookheimer, Matthew D. Lieberman, Catherine A. Sugar, Jennifer D. Townsend, Jeffrey Fischer, Salvatore Torrisi, Conor Penfold, Sarah K. Madsen, Paul M. Thompson, Lori L. Altshuler
2012 NeuroImage  
Additional support for algorithm development was provided by the National Institute on Aging (NIA), the National Institute of Biomedical  ...  Acknowledgements This work was supported by grants from the National Institute of Mental Health (MH078556 to LCFR, and MH075944 and MH01848 to LLA).  ...  Until recently, it was believed that between episodes of depression and mania, patients with bipolar disorder experience symptom resolution and return to a state of relative "normality" (Malhi et al.,  ... 
doi:10.1016/j.neuroimage.2011.07.054 pmid:21854858 pmcid:PMC3216485 fatcat:cfqgf75qxnd3lm35gcyejwrrle

Abnormal Amygdala and Prefrontal Cortex Activation to Facial Expressions in Pediatric Bipolar Disorder

Amy S. Garrett, Allan L. Reiss, Meghan E. Howe, Ryan G. Kelley, Manpreet K. Singh, Nancy E. Adleman, Asya Karchemskiy, Kiki D. Chang
2012 Journal of the American Academy of Child and Adolescent Psychiatry  
Objective: Previous functional magnetic resonance imaging (fMRI) studies in pediatric bipolar disorder (BD) have reported greater amygdala and less dorsolateral prefrontal cortex (DLPFC) activation to  ...  Significant activation from the main effect of group included greater DLPFC activation in the HC group, and greater amygdala/ hippocampal activation in the BD group.  ...  The authors thank Vinod Menon, Ph.D., of Stanford University for his assistance with task design.  ... 
doi:10.1016/j.jaac.2012.06.005 pmid:22840553 pmcid:PMC3408885 fatcat:czjjfplfyvfqvhri6ix4v2m5ey

Hippocampal and Hippocampal-Subfield Volumes From Early-Onset Major Depression and Bipolar Disorder to Cognitive Decline

Niels Hansen, Aditya Singh, Claudia Bartels, Frederic Brosseron, Katharina Buerger, Arda C Cetindag, Laura Dobisch, Peter Dechent, Birgit B Ertl-Wagner, Klaus Fliessbach, John D Haynes, Michael T Heneka (+19 others)
2021 Frontiers in Aging Neuroscience  
The hippocampus and its subfields (HippSub) are reported to be diminished in patients with Alzheimer's disease (AD), bipolar disorder (BD), and major depressive disorder (MDD).  ...  Methods: We segmented 3T-MRI T2-weighted hippocampal images of 67 HC, 58 BD, and MDD patients from the AFFDIS study and 137 patients from the DELCODE study assessing cognitive decline, including subjective  ...  ACKNOWLEDGMENTS This work was promoted by the University Medical Center Göttingen (UMG) and the German Federal Ministry of Education and Research (Bundesministerium fuer Bildung und Forschung, BMBF: 01  ... 
doi:10.3389/fnagi.2021.626974 pmid:33967736 pmcid:PMC8097178 fatcat:wfjivn3v5rfnjeprgss5yvbprq

Relationships Between Altered Functional Magnetic Resonance Imaging Activation and Cortical Thickness in Patients With Euthymic Bipolar I Disorder

Shantanu H. Joshi, Nathalie Vizueta, Lara Foland-Ross, Jennifer D. Townsend, Susan Y. Bookheimer, Paul M. Thompson, Katherine L. Narr, Lori L. Altshuler
2016 Biological Psychiatry: Cognitive Neuroscience and Neuroimaging  
Methods-In a sample of ninety adults (45 with inter-episode Bipolar I disorder and 45 healthy controls), we explored whether abnormal functional activation patterns in bipolar euthymic subjects during  ...  Background-Performance during cognitive control functional magnetic resonance imaging (fMRI) tasks are associated with frontal lobe hypoactivation in patients with bipolar disorder, even while euthymic  ...  Aquino, Jeffrey Fischer and the UCLA Deutsch Mood Disorders Fellows for diagnostic interviewing and assessment; Jacquelyn Dang and Isabella Cordova for assistance with data entry; and Tara Pirnia for assistance  ... 
doi:10.1016/j.bpsc.2016.06.006 pmid:27990494 pmcid:PMC5157843 fatcat:nt6ho2vd4vhqhes2i66q5g6fo4

Limbic hyperactivation during processing of neutral facial expressions in children with bipolar disorder

B. A. Rich, D. T. Vinton, R. Roberson-Nay, R. E. Hommer, L. H. Berghorst, E. B. McClure, S. J. Fromm, D. S. Pine, E. Leibenluft
2006 Proceedings of the National Academy of Sciences of the United States of America  
Also, compared with controls, patients had greater activation in the left amygdala, accumbens, putamen, and ventral prefrontal cortex when rating face hostility, and greater activation in the left amygdala  ...  However, most work in this area focuses on schizophrenia. Here, we extend this paradigm to pediatric bipolar disorder (BD), thus demonstrating traction in the developmental psychobiology perspective.  ...  Structural MRI (sMRI) studies in bipolar adults find either increased or unchanged amygdala volume relative to controls (8) (9) (10) , whereas functional MRI (fMRI) studies find that adults with BD, relative  ... 
doi:10.1073/pnas.0603246103 pmid:16735472 pmcid:PMC1482675 fatcat:a3flkcloxzcdjiu7utofmqp5bi
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