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Amygdala volume in depressed patients with bipolar disorder assessed using high resolution 3T MRI: The impact of medication
2010
NeuroImage
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MRI-based reports of both abnormally increased and decreased amygdala volume in bipolar disorder (BD) have surfaced in the literature. ...
Here, we acquired high-resolution images (voxel size=0.55×0.55×0.60mm) using a GE 3T MRI scanner, and a pulse sequence optimized for tissue contrast resolution. ...
Here we resolve this problem with high-resolution 3T MRI images (volumetric resolution=0.4 mm 3 ) that allowed us to segment the amygdala in a reliable and accurate manner. ...
doi:10.1016/j.neuroimage.2009.11.025
pmid:19931399
pmcid:PMC2818548
fatcat:43aourpu6ncbtptkaqmjju5tu4
Childhood trauma is associated with reduced frontal gray matter volume: a large transdiagnostic structural MRI study
2021
Psychological Medicine
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Participants filled in the Childhood Trauma Questionnaire. Anatomical T1 MRI scans were acquired at 3T, regional brain morphology was assessed using Freesurfer. ...
No trauma-related volume reductions were observed in any other (sub)cortical lobes nor the hippocampus or amygdala, trauma-by-group (i.e. both patient groups and healthy subjects) interaction effects were ...
The authors have declared that there are no conflicts of interest in relation to the subject of this study. ...
doi:10.1017/s0033291721002087
fatcat:h4vfypxk5rahvoickff5bdgxai
In Vivo Amygdala Nuclei Volumes in Schizophrenia and Bipolar Disorders
2021
Schizophrenia Bulletin
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Our study is the first to demonstrate distinct patterns of amygdala nuclei volume reductions in a well-powered sample of patients with schizophrenia and bipolar disorders. ...
Abnormalities in amygdala volume are well-established in schizophrenia and commonly reported in bipolar disorders. ...
Acknowledgments We thank the study participants, and the clinicians as well as research assistants involved in recruitment and assessment at the Norwegian Centre for Mental Disorders (NORMENT). ...
doi:10.1093/schbul/sbaa192
pmid:33479754
pmcid:PMC8379533
fatcat:6mpkgw7bn5gvbm74y3gupkd5bq
Fronto-temporal dysregulation in asymptomatic bipolar I patients: A paired associate functional MRI study
2010
Human Brain Mapping
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Bipolar disorder is associated with persistent declarative memory disturbances, but the neural basis of these deficits is not well understood. ...
These findings suggest a neural basis for the long-term memory deficits consistently observed in patients with bipolar disorder; further, as these patterns appear in symptomatically remitted patients, ...
Acknowledgments The authors thank Sharon Primeaux for help recruiting and assessing patients. ...
doi:10.1002/hbm.20918
pmid:20063304
pmcid:PMC3660318
fatcat:qmxrv5vqbba33b3lwjwbo4gkji
Reward Processing in Unipolar and Bipolar Depression: A Functional MRI Study
2015
Neuropsychopharmacology
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Differentiating bipolar disorders (BD) from unipolar depression (UD) remains a major clinical challenge. ...
These results may help to refine the understanding of neural correlates of reward processing in both disorders, and to understand the neural underpinnings of anhedonia, a core symptom of depressive episodes ...
The study was supported by grants of the German Research Foundation (DFG; grant FOR 2107; DA1151/5-1 to UD), Innovative Medizinische Forschung (DA120903 to UD, DA111107 to UD, and DA211012 to UD), and ...
doi:10.1038/npp.2015.110
pmid:25881114
pmcid:PMC4569953
fatcat:oyw7bz5nrncavd4lxxkujsista
Anatomical and Neurochemical Correlates of Parental Verbal Abuse: A Combined MRS—Diffusion MRI Study
2019
Frontiers in Human Neuroscience
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Despite the critical impact of parental dialog on children who remain physically and psychologically dependent, most studies have focused on brain alterations in people exposed to moderate-to-high levels ...
We measured metabolites in the pregenual anterior cingulate cortex (pgACC) acquired with single-voxel proton magnetic resonance spectroscopy and anatomical connectivity assessed with probabilistic tractography ...
Childhood trauma and the limbic network: a multimodal MRI study in patients with bipolar disorder and controls. J. Affect. ...
doi:10.3389/fnhum.2019.00012
pmid:30760992
pmcid:PMC6361791
fatcat:7iyh5hqsurezzakxuynqee4x7u
In vivo amygdala nuclei volumes in schizophrenia and bipolar disorders
[article]
2020
medRxiv
pre-print
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Conclusions: Our study is the first to demonstrate distinct patterns of amygdala nuclei volume reductions in a well-powered sample of patients with schizophrenia and bipolar disorders. ...
Abnormalities in amygdala volume are well-established in schizophrenia and commonly reported in bipolar disorders. ...
*** * **
Acknowledgments We thank the study participants, and the clinicians as well as research assistants involved in recruitment and assessment at the Norwegian Centre for Mental Disorders (NORMENT ...
doi:10.1101/2020.09.30.20204602
fatcat:dzwdsjeflnhwriujvmjw66ajkm
Machine learning techniques in a structural and functional MRI diagnostic approach in schizophrenia: a systematic review
2019
Neuropsychiatric Disease and Treatment
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of the treatment response and to establish the prognosis of patients with SCZ. ...
Machine learning (ML) represents a promising approach that could support clinicians in the diagnosis of mental disorders. ...
Disclosure The authors report no conflicts of interest in this work.
References ...
doi:10.2147/ndt.s202418
pmid:31354276
pmcid:PMC6590624
fatcat:wubpr7zpubhp3nf7wy2yqhgsg4
The Limbic System in Youth Depression: Brain Structural and Functional Alterations in Adolescent In-patients with Severe Depression
2017
Neuropsychopharmacology
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Higher levels of childhood maltreatment were associated with smaller hippocampal volumes in both depressed patients and healthy controls, whereby no associations between amygdala reactivity and childhood ...
Adolescent-onset major depressive disorder (MDD) is associated with an increased risk of recurrent depressive episodes, suicidal behaviors, and psychiatric morbidity throughout the lifespan. ...
Third, high levels of childhood maltreatment are associated with smaller hippocampal volumes in both depressed patient and healthy controls. ...
doi:10.1038/npp.2017.246
pmid:29039414
fatcat:bp5iuur36reztb5xmifrrlj2e4
Structural Plasticity of the Hippocampus and Amygdala Induced by Electroconvulsive Therapy in Major Depression
2016
Biological Psychiatry
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changes in hippocampal and amygdala structure were examined in patients with major depression (N= 43, scanned thrice; prior to ECT, after the 2 nd ECT session, and within one week of completing the ECT ...
Background-Electroconvulsive therapy (ECT) elicits a rapid and robust clinical response in patients with refractory depression. ...
The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Mental Health or the National Institutes of Health. ...
doi:10.1016/j.biopsych.2015.02.029
pmid:25842202
pmcid:PMC4561035
fatcat:ggt5apwj4jhbtmbibmtgkzxmz4
Normal amygdala activation but deficient ventrolateral prefrontal activation in adults with bipolar disorder during euthymia
2012
NeuroImage
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Additional support for algorithm development was provided by the National Institute on Aging (NIA), the National Institute of Biomedical ...
Acknowledgements This work was supported by grants from the National Institute of Mental Health (MH078556 to LCFR, and MH075944 and MH01848 to LLA). ...
Until recently, it was believed that between episodes of depression and mania, patients with bipolar disorder experience symptom resolution and return to a state of relative "normality" (Malhi et al., ...
doi:10.1016/j.neuroimage.2011.07.054
pmid:21854858
pmcid:PMC3216485
fatcat:cfqgf75qxnd3lm35gcyejwrrle
Abnormal Amygdala and Prefrontal Cortex Activation to Facial Expressions in Pediatric Bipolar Disorder
2012
Journal of the American Academy of Child and Adolescent Psychiatry
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Objective: Previous functional magnetic resonance imaging (fMRI) studies in pediatric bipolar disorder (BD) have reported greater amygdala and less dorsolateral prefrontal cortex (DLPFC) activation to ...
Significant activation from the main effect of group included greater DLPFC activation in the HC group, and greater amygdala/ hippocampal activation in the BD group. ...
The authors thank Vinod Menon, Ph.D., of Stanford University for his assistance with task design. ...
doi:10.1016/j.jaac.2012.06.005
pmid:22840553
pmcid:PMC3408885
fatcat:czjjfplfyvfqvhri6ix4v2m5ey
Hippocampal and Hippocampal-Subfield Volumes From Early-Onset Major Depression and Bipolar Disorder to Cognitive Decline
2021
Frontiers in Aging Neuroscience
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The hippocampus and its subfields (HippSub) are reported to be diminished in patients with Alzheimer's disease (AD), bipolar disorder (BD), and major depressive disorder (MDD). ...
Methods: We segmented 3T-MRI T2-weighted hippocampal images of 67 HC, 58 BD, and MDD patients from the AFFDIS study and 137 patients from the DELCODE study assessing cognitive decline, including subjective ...
ACKNOWLEDGMENTS This work was promoted by the University Medical Center Göttingen (UMG) and the German Federal Ministry of Education and Research (Bundesministerium fuer Bildung und Forschung, BMBF: 01 ...
doi:10.3389/fnagi.2021.626974
pmid:33967736
pmcid:PMC8097178
fatcat:wfjivn3v5rfnjeprgss5yvbprq
Relationships Between Altered Functional Magnetic Resonance Imaging Activation and Cortical Thickness in Patients With Euthymic Bipolar I Disorder
2016
Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
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Methods-In a sample of ninety adults (45 with inter-episode Bipolar I disorder and 45 healthy controls), we explored whether abnormal functional activation patterns in bipolar euthymic subjects during ...
Background-Performance during cognitive control functional magnetic resonance imaging (fMRI) tasks are associated with frontal lobe hypoactivation in patients with bipolar disorder, even while euthymic ...
Aquino, Jeffrey Fischer and the UCLA Deutsch Mood Disorders Fellows for diagnostic interviewing and assessment; Jacquelyn Dang and Isabella Cordova for assistance with data entry; and Tara Pirnia for assistance ...
doi:10.1016/j.bpsc.2016.06.006
pmid:27990494
pmcid:PMC5157843
fatcat:nt6ho2vd4vhqhes2i66q5g6fo4
Limbic hyperactivation during processing of neutral facial expressions in children with bipolar disorder
2006
Proceedings of the National Academy of Sciences of the United States of America
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Also, compared with controls, patients had greater activation in the left amygdala, accumbens, putamen, and ventral prefrontal cortex when rating face hostility, and greater activation in the left amygdala ...
However, most work in this area focuses on schizophrenia. Here, we extend this paradigm to pediatric bipolar disorder (BD), thus demonstrating traction in the developmental psychobiology perspective. ...
Structural MRI (sMRI) studies in bipolar adults find either increased or unchanged amygdala volume relative to controls (8) (9) (10) , whereas functional MRI (fMRI) studies find that adults with BD, relative ...
doi:10.1073/pnas.0603246103
pmid:16735472
pmcid:PMC1482675
fatcat:a3flkcloxzcdjiu7utofmqp5bi
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