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White matter involvement after TBI: Clues to axon and myelin repair capacity

Regina C. Armstrong, Amanda J. Mierzwa, Christina M. Marion, Genevieve M. Sullivan
2016 Experimental Neurology  
forces to the head cause traumatic brain injury (TBI) with damage in white matter tracts comprised of long axons traversing the brain.  ...  White matter injury after TBI involves both traumatic axonal injury (TAI) and myelin pathology that evolves throughout the post-injury time course.  ...  White matter injury is a major component of TBI White matter atrophy dramatically demonstrates significant white matter involvement in moderate-severe forms of TBI in patients who survive to a chronic  ... 
doi:10.1016/j.expneurol.2015.02.011 pmid:25697845 fatcat:3khlgkffmrbszj6ggfojj3cqze

Transfer of orbital angular momentum from a super-continuum, white-light beam

Amanda J. Wright, John M. Girkin, Graham M. Gibson, Jonathan Leach, Miles J. Padgett
2008 Optics Express  
2008) Transfer of orbital angular momentum from a supercontinuum, white-light beam. Optics Express, 16 (13). pp. 9495-9500.  ...  We illustrate the achromatic, helical phase structure of a white-light beam by observing the transfer of its orbital angular momentum to particles held in optical tweezers.  ...  To axially confine the 1μm diameter polystyrene particles we prepared the sample cell as a thin (< 100μm) water layer between a microscope slide and cover slip.  ... 
doi:10.1364/oe.16.009495 pmid:18575514 fatcat:3mv4qfxlb5gy3gq72hfvxerv4y

Relationship between abdominal fat and bone mineral density in white and African American adults

Peter T. Katzmarzyk, Tiago V. Barreira, Deirdre M. Harrington, Amanda E. Staiano, Steven B. Heymsfield, Jeffrey M. Gimble
2012 Bone  
The sample included 330 white women, 328 African American women, 307 white men, and 116 African American men 18-74 years of age.  ...  In conclusion, BMD was inversely related to abdominal VAT and SAT in white and African American adults after adjustment for LBM.  ...  The average age of the sample was 42.1 years (range, 18-74 years) and the average BMI was 31 kg/m 2 (range, 17-45 kg/m 2 ).  ... 
doi:10.1016/j.bone.2011.04.012 pmid:21549867 pmcid:PMC3936414 fatcat:5ytzhmmtvjccdbplpaoq5atb4q

Engineered bromodomains to explore the acetylproteome

Bryan D. Bryson, Amanda M. Del Rosario, Jonathan S. Gootenberg, Michael B. Yaffe, Forest M. White
2015 Proteomics  
Acknowledgments The author would like to thank the White Lab for valuable conversations and Duaa Muhammad for supplying yeast DNA.  ...  Table 1 1 K D Measurements of Engineered Bromodomain-Containing Proteins Protein K D (M) BDF1-A 1.11×10 −6 BDF1-B 2.14×10 −7 BDF1 1.67×10 −8 GCN5 2.25×10 −5 GLB 1.08×10 −7  ... 
doi:10.1002/pmic.201400401 pmid:25641834 pmcid:PMC4535431 fatcat:3n6jzdyuazgqjedz5iczhltpgy

Associations of postpartum sleep, stress, and depressive symptoms with LPS-stimulated cytokine production among African American and White women

Lisa M. Christian, Jennifer M. Kowalsky, Amanda M. Mitchell, Kyle Porter
2018 Journal of Neuroimmunology  
., depressive symptoms), serum cytokine levels, and LPS-stimulated proinflammatory cytokine production among 69 women (32 African American, 37 White) assessed at 7-10 weeks postpartum.  ...  In African American women, but not Whites, poorer sleep quality, greater parenting stress, and greater depressive symptoms were associated with greater LPSstimulated IL-6 and IL-8 production (ps ≤ 0.05  ...  Maternal body mass index (BMI; kg/m 2 ) was calculated using weight and height measured by nursing staff at the study visit.  ... 
doi:10.1016/j.jneuroim.2017.12.020 pmid:29406850 pmcid:PMC5806133 fatcat:grwzkm6vvnce3pojxazdkvnuwq

Complementary and Alternative Medicine for Mental Disorders Among African Americans, Black Caribbeans, and Whites

Amanda T. Woodward, Kai M. Bullard, Robert J. Taylor, Linda M. Chatters, Raymond E. Baser, Brian E. Perron, James S. Jackson
2009 Psychiatric Services  
K Ka ai i M M. . B Bu ul ll la ar rd d, , P Ph h. .D D. . R Ro ob be er rt t J J. . T Ta ay yl lo or r, , P Ph h. .D D. . L Li in nd da a M M. . C Ch ha at tt te er rs s, , P Ph h. .D D. .  ...  B Ba as se er r, , M M. .S S. . B Br ri ia an n E E. . P Pe er rr ro on n, , P Ph h. .D D. . J Ja am me es s S S. . J Ja ac ck ks so on n, , P Ph h.  ...  Jackson JS, Torres M, Caldwell CH, et al: The National Survey of American Life: a study of racial, ethnic, and cultural influences on mental disorders and mental health.  ... 
doi:10.1176/ps.2009.60.10.1342 pmid:19797374 pmcid:PMC3058881 fatcat:tohudrtmm5c5zk74futfaxh2b4

White Matter Injury in Term Newborns With Neonatal Encephalopathy

Amanda M Li, Vann Chau, Kenneth J Poskitt, Michael A Sargent, Brian A Lupton, Alan Hill, Elke Roland, Steven P Miller
2009 Pediatric Research  
White matter injury (WMI) is the characteristic pattern of brain injury detected on magnetic resonance imaging in the premature newborn.  ...  Figure 1 . 1 Severity of acute white matter injury. White matter injury (WMI) has a wide range of severity in the term newborn.  ...  Figure 2 . 2 Acute focal white matter injury and acute stroke. T 1 -weighted sequence of patient 5 (A) shows a focal area of white matter injury (WMI) (arrow) in the right frontal lobe.  ... 
doi:10.1203/pdr.0b013e31818912d2 pmid:18787422 fatcat:dvzpmyt2njeetiaa5ywhey7y5e

Myelin and oligodendrocyte lineage cells in white matter pathology and plasticity after traumatic brain injury

Regina C. Armstrong, Amanda J. Mierzwa, Genevieve M. Sullivan, Maria A. Sanchez
2016 Neuropharmacology  
TAI occurs in a pattern of damaged axons dispersed among intact axons in white matter tracts.  ...  White matter pathology after TBI depends on the extent and distribution of axon damage, microhemorrhages and/or neuroinflammation.  ...  With TAI, damaged axons are dispersed among intact axons within white matter tracts.  ... 
doi:10.1016/j.neuropharm.2015.04.029 pmid:25963414 fatcat:megkoouolfhjzhwfdkdnl62v5u

Time Constraints Limit Group Sizes and Distribution in Red and Black-and-White Colobus

Amanda H. Korstjens, R. I. M. Dunbar
2007 International journal of primatology  
doi:10.1007/s10764-007-9148-2 fatcat:ut5pxyzigjdqvlkxqpdlmxm7py

Psychosocial costs of racism to whites: Exploring patterns through cluster analysis

Lisa B. Spanierman, V. Paul Poteat, Amanda M. Beer, Patrick Ian Armstrong
2006 Journal of Counseling Psychology  
Participants (230 White college students) completed the Psychosocial Costs of Racism to Whites (PCRW) Scale.  ...  S D M S D M S D M S D M S D CoBRAS Racial Privilege 26.90 6.55 26.02 5.38 21.81 5.90 22.31 6.36 28.28 5.72 9.38* .15 C, D Ͻ A, B, E Institutional Racism 26.98 5.76 24.54 5.02  ...  Method Participants Participants were 230 self-identified White undergraduate students (36% men, 64% women) aged 18 -44 years (M ϭ 29.42, SD ϭ 2.15) attending a large Midwestern university.  ... 
doi:10.1037/0022-0167.53.4.434 fatcat:gvfzpasi35ao5jkl6uxdy2g4n4

Cerebellar Purkinje cell microcircuits are essential for tremor [article]

Amanda M Brown, Joshua J White, Meike E van der Heijden, Tao Lin, Roy V Sillitoe
2019 bioRxiv   pre-print
White J.J., Arancillo M., Stay T.L., et al. (2014) Cerebellar Zonal Patterning Relies on Purkinje Cell Neurotransmission. J Neurosci 34(24), 8231-8245.  ...  Arancillo M., White J.J., Lin T., et al. (2015) In vivo analysis of Purkinje cell firing properties during postnatal mouse development. J Neurophysiol 113(2), 578-591. .  ... 
doi:10.1101/770321 fatcat:qaiwi2cmdnaprb73gb5w64pmui

Influence of age on peripheral refraction

David A. Atchison, Nicola Pritchard, Shane D. White, Amanda M. Griffiths
2005 Vision Research  
are usually asymmetrical about fixation, and in the case of the horizontal visual field, the astigmatic refractive errors are usually higher in the nasal side than the temporal side (Dunne, Misson, White  ...  Table 1 1 Subject numbers, age and M (mean spherical refraction) for the young and older refractive error groups Young Older n Age (years) M (D) n Age (years) M (D) Low hyperopes - - - 17 59  ... 
doi:10.1016/j.visres.2004.09.028 pmid:15639498 fatcat:3s7p7po2obdpvmyaviso7vkq3a

Quantifying oncogenic phosphotyrosine signaling networks through systems biology

Amanda M Del Rosario, Forest M White
2010 Current Opinion in Genetics and Development  
Acknowledgments We would like to thank members of the Forest White lab for helpful discussions regarding this review. This work was supported by National Cancer Institute Grant CA118705.  ... 
doi:10.1016/j.gde.2009.12.005 pmid:20074929 pmcid:PMC3694410 fatcat:4qvncjthhjf5hnky3ydtrkoqdy

Evaluating concentration estimation errors in ELISA microarray experiments

Don Simone Daly, Amanda M White, Susan M Varnum, Kevin K Anderson, Richard C Zangar
2005 BMC Bioinformatics  
Enzyme-linked immunosorbent assay (ELISA) is a standard immunoassay to estimate a protein's concentration in a sample. Deploying ELISA in a microarray format permits simultaneous estimation of the concentrations of numerous proteins in a small sample. These estimates, however, are uncertain due to processing error and biological variability. Evaluating estimation error is critical to interpreting biological significance and improving the ELISA microarray process. Estimation error evaluation
more » ... be automated to realize a reliable high-throughput ELISA microarray system. In this paper, we present a statistical method based on propagation of error to evaluate concentration estimation errors in the ELISA microarray process. Although propagation of error is central to this method and the focus of this paper, it is most effective only when comparable data are available. Therefore, we briefly discuss the roles of experimental design, data screening, normalization, and statistical diagnostics when evaluating ELISA microarray concentration estimation errors. We use an ELISA microarray investigation of breast cancer biomarkers to illustrate the evaluation of concentration estimation errors. The illustration begins with a description of the design and resulting data, followed by a brief discussion of data screening and normalization. In our illustration, we fit a standard curve to the screened and normalized data, review the modeling diagnostics, and apply propagation of error. We summarize the results with a simple, three-panel diagnostic visualization featuring a scatterplot of the standard data with logistic standard curve and 95% confidence intervals, an annotated histogram of sample measurements, and a plot of the 95% concentration coefficient of variation, or relative error, as a function of concentration. This statistical method should be of value in the rapid evaluation and quality control of high-throughput ELISA microarray analyses. Applying propagation of error to a variety of ELISA microarray concentration estimation models is straightforward. Displaying the results in the three-panel layout succinctly summarizes both the standard and sample data while providing an informative critique of applicability of the fitted model, the uncertainty in concentration estimates, and the quality of both the experiment and the ELISA microarray process.
doi:10.1186/1471-2105-6-17 pmid:15673468 pmcid:PMC549203 fatcat:wpaa2utbwrejzfet6pxz6564c4

Pathophysiology of Dyt1 dystonia is mediated by spinal cord dysfunction [article]

Amanda M Pocratsky, Filipe Nascimento, M Görkem Özyurt, Ian J White, Roisin Sullivan, Calvin Chad Smith, Sunaina Surana, Marco Beato, Robert M Brownstone
2022 bioRxiv   pre-print
Scale: 1s (M), 0.1s (N-O). 513 Fig. 3 514Figure 3 . 33 Fig. 3 Fig. 4 .Fig. 4 44 Fig. 4. Fig. 5 .Fig. 5 55 Fig. 5.  ...  Thus, we recorded L4 and L5 dorsal root volleys in response to root stimulation (Fig. 5K ), and found slower afferent conduction velocities in spinal Tor1a d-cko mice compared to controls (Fig. 5L-M  ... 
doi:10.1101/2022.05.05.490750 fatcat:nmyotovq3zcadd6urr6jgnxadm
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