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Regional Cerebral Blood Flow Single Photon Emission Computed Tomography for detection of Frontotemporal dementia in people with suspected dementia

Hilary A Archer, Nadja Smailagic, Christeena John, Robin B Holmes, Yemisi Takwoingi, Elizabeth J Coulthard, Sarah Cullum
2015 The Cochrane library  
Eight of the 11 studies which used SPECT to differentiate FTD from Alzheimer's disease used multiple-headed camera SPECT.  ...  Background This review focused on one type of dementia, frontotemporal dementia (FTD).  ...  Reference standards We considered a diagnosis of FTD based on any of the following recognised diagnostic criteria as acceptable. Lund-Manchester (Lund and Manchester Groups 1994) 1.  ... 
doi:10.1002/14651858.cd010896.pub2 pmid:26102272 fatcat:ztvhdfvczffttmnqvrmuvpe2l4

Behavioral variant frontotemporal dementia with dominant gait disturbances - case report
Wariant behawioralny otępienia czołowo-skroniowego z dominującymi zaburzeniami chodu w obrazie klinicznym – opis przypadku

Wojciech Guenter, Ewa Betscher, Paweł Bochniak, Robert Bonek
2016 Psychiatria Polska  
It is the second most common neurodegenerative cause of dementia after Alzheimer's type dementia.  ...  However, it is not a predominant symptom of behavioural variant frontotemporal dementia excluding terminal stage of the disease. Conclusions.  ...  SCEPT image of the brain: A -axial SPECT/CT fused image; B -sagittal SPECT image state that gait is not an automatic motor activity independent of cognitive processes.  ... 
doi:10.12740/pp/58937 pmid:27288678 fatcat:vl4dh7z2mvblfoh6mh6lzt6fra

Single-photon emission computed tomography perfusion imaging in the differential diagnosis of dementia: a retrospective regional audit

M. Doran, S. Vinjamuri, J. Collins, D. Parker, A. J. Larner
2005 International journal of clinical practice  
Application of easy Z score imaging system (eZIS) on brain perfusion SPECT images for quantitative evaluation of rCBF has attempted to explore the differential diagnosis of dementia with various degenerative  ...  diseases and to evaluate discrimination of early Alzheimer's disease (AD) from other types of dementia.  ...  Waragai et al. revealed that eZIS analysis of SPECT images could be convenient for the early and differential diagnosis of patients with neurodegenerative disease, including dementing diseases, AD, frontotemporal  ... 
doi:10.1111/j.1368-5031.2005.00499.x pmid:15853870 fatcat:gpy64iuggne5zfvuizriw2grla

Alzheimer's disease and frontotemporal dementia are differentiated by discriminant analysis applied to 99mTc HmPAO SPECT data

P Charpentier
2000 Journal of Neurology, Neurosurgery and Psychiatry  
Objective-Alzheimer's disease (AD) and frontotemporal dementia (FTD) are the most frequent neurodegenerative cognitive disorders. However, FTD remains poorly recognised clinically.  ...  Automatic classification based on a decision rule deduced from factorial discriminant analysis could enhance its performance.  ...  The frontotemporal dementia (FTD) concept still needs clinical and non-clinical tools to enable better discrimination. The main diVerential diagnosis remains Alzheimer's disease (AD).  ... 
doi:10.1136/jnnp.69.5.661 pmid:11032624 pmcid:PMC1763418 fatcat:4tepghmssfhfzg6jehyuw3gsyq

Evaluation of brain perfusion in specific Brodmann areas in Frontotemporal dementia and Alzheimer disease using automated 3-D voxel based analysis

V Valotassiou, J Papatriantafyllou, N Sifakis, C Karageorgiou, I Tsougos, C Tzavara, C Zerva, P Georgoulias
2009 Journal of Instrumentation  
diagnosis of the dementia subtype is based on the postmortem examination of the brain [7] .  ...  Introduction Frontotemporal dementia (FTD) and Alzheimer's disease (AD) have been recognized as distinct clinical syndromes for a number of years, the former considered to be one of the most common neurodegenerative  ... 
doi:10.1088/1748-0221/4/05/p05020 fatcat:n3nwsodqyzfz5cofcibbu5j7om

Diagnostic imaging of dementia with Lewy bodies, frontotemporal lobar degeneration, and normal pressure hydrocephalus

Kazunari Ishii
2019 Japanese Journal of Radiology  
Neuroimaging can provide important biomarkers and is very useful for supporting dementia diagnosis.  ...  In DLB, medial temporal atrophy is milder than that of Alzheimer's disease. 2-fluoro-2-deoxy-D-glucose-positron emission tomography and brain perfusion single-photon emission computed tomography demonstrate  ...  (FP-CIT) single-photon emission computed tomography (SPECT) images of DLB and Alzheimer's disease.  ... 
doi:10.1007/s11604-019-00881-9 pmid:31549279 fatcat:dr4ao34npbdvtmasd74qnhxbbm

Differential Diagnosis Between Neurodegenerative Dementia Disorders and Parkinson's Disease Using 99mTc-HMPAO SPECT

Barbara Palumbo, Donatella Siepi, Serena Amici, Helmut Sinzinger
2014 The Open Nuclear Medicine Journal  
Materials and Methods: We retrospectively evaluated 104 patients, 30 with Alzheimer's disease (AD), 26 with frontotemporal dementia (FTD), 25 with mild cognitive impairment (MCI), 23 with PD, undergoing  ...  Introduction and Objective: To investigate perfusion in dementia and Parkinson's disease (PD) we performed 99m Tc-HMPAO brain SPECT with semiquantitative analysis of Brodmann areas in different aged patients  ...  to the differential diagnosis.  ... 
doi:10.2174/1876388x01406010001 fatcat:erjagtze3rbhjhgbhecjsaxtti

Dementia: a brief review

Hillel Grossman, Christine Bergmann, Susan Parker
2006 The Mount Sinai journal of medicine  
Alzheimer's disease alone now affects 4.5 million people in the US, while millions more are currently affected by vascular dementia, Lewy Body disease and frontotemporal dementia.  ...  We are entering an era of dementia care that will be based upon the identification of potentially modifiable risk factors and early disease markers, and the application of new disease-specific diagnostic  ...  Diagnostic patterns of regional atrophy on MRI and regional cerebral blood flow change on SPECT in young onset patients with Alzheimer’s disease, frontotemporal dementia and vascular dementia Acta Neurol  ... 
pmid:17195884 fatcat:q5o5unfbu5f2zjwpbaynzqneny

Neuroimaging characteristics of dementia with Lewy bodies

Elijah Mak, Li Su, Guy B Williams, John T O'Brien
2014 Alzheimer's Research & Therapy  
DLB shares common clinical, neuropsychological and pathological features with Parkinson's disease dementia and other dementia subtypes, such as Alzheimer's disease.  ...  We also discuss the increasingly important role of imaging biomarkers in differential diagnosis and outline promising areas for future research in DLB.  ...  Acknowledgements This work was supported by the NIHR Biomedical Research Unit in Dementia and the Biomedical Research Centre awarded to Cambridge University Hospitals NHS Foundation Trust and the University  ... 
doi:10.1186/alzrt248 pmid:25031634 pmcid:PMC4055038 fatcat:c7tko6q7tjafjkb7dtmjz2mfn4

Usefulness of [123I]metaiodobenzylguanidine ([123I]MIBG) Myocardial Scintigraphy in Differentiating between Alzheimer's Disease and Dementia with Lewy Bodies

Takashi OIDE, Takahiko TOKUDA, Mitsuhiro MOMOSE, Kazuhiro OGUCHI, Akinori NAKAMURA, Shinji OHARA, Shu-ichi IKEDA
2003 Internal medicine (Tokyo. 1992)  
(Internal Medicine 42: 686-690, 2003) Key words: Alzheimer's disease, dementia with Lewy bodies, [123I]metaiodobenzyl guanidine, myocardial scintigraphy, tau protein, differential diagnosis studies using  ...  Objective To confirm the clinical usefulness of [123I] metaiodobenzylguanidine ([123I]MIBG) myocardial scintigraphy in the antemortem differential diagnosis between patients with Alzheimer's disease (AD  ...  Planar car- diac imaging for 2 minutes in the anterior and left anterior oblique projection was performed automatically during SPECT.  ... 
doi:10.2169/internalmedicine.42.686 fatcat:qwwijdboc5ddbcwyrb24pojw3e

Neuroimaging in Lewy body dementia

Tayyabah Yousaf, George Dervenoulas, Polytimi-Eleni Valkimadi, Marios Politis
2018 Journal of Neurology  
Early diagnosis of DLB has been challenging; particularly in the context of differentiation with Parkinson's disease dementia and other forms of dementias, such as Alzheimer's disease and rapidly progressive  ...  Structural imaging techniques have an essential role for excluding structural causes, which could lead to a DLBlike phenotype, as well as aiding differential diagnosis through illustrating disease-specific  ...  , AD Alzheimer's disease, HC healthy controls, PD Parkinson's disease, PDD Parkinson's disease dementia, FTD frontotemporal dementia, MCI mild cognitive impairment, VaD vascular dementia,  ... 
doi:10.1007/s00415-018-8892-x pmid:29761296 fatcat:4aaplvy7bjcitcsigarc5rswhi

Neuronuclear Imaging in the Evaluation of Dementia and Mild Decline in Cognition

Nare Torosyan, Daniel H.S. Silverman
2012 Seminars in nuclear medicine  
in the human brain --especially, processes that herald impending dementia due to Alzheimer's disease (AD), in its prodromal form.  ...  Recently, the National Institute on Aging (NIA) and the Alzheimer's Association (AA), identified specific structural and functional neuroimaging findings as valuable markers of biological processes occurring  ...  Levels of specific proteins in CSF, and scans obtained with MRI, SPECT, and PET, serve as biomarkers with varying degrees of utility for predicting subsequent cognitive decline, as discussed in detail  ... 
doi:10.1053/j.semnuclmed.2012.06.004 pmid:23026363 pmcid:PMC4309799 fatcat:npndyl4arvgz5ni47qbm7wzwqq

123I-2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl) nortropane single photon emission computed tomography and123I-metaiodobenzylguanidine myocardial scintigraphy in differentiating dementia with lewy bodies from other dementias: A comparative study

Pietro Tiraboschi, Angelo Corso, Ugo Paolo Guerra, Flavio Nobili, Arnoldo Piccardo, Maria Lucia Calcagni, Duccio Volterrani, Diego Cecchin, Mauro Tettamanti, Luigi Antelmi, Simone Vidale, Leonardo Sacco (+10 others)
2016 Annals of Neurology  
Methods: This prospective longitudinal study included 30 patients with a clinical diagnosis of DLB and 29 patients with non-DLB dementia (Alzheimer disease, n 5 16; behavioral variant frontotemporal dementia  ...  All patients underwent 123 I-FP-CIT SPECT and 123 I-MIBG myocardial scintigraphy within a few weeks of clinical diagnosis.  ...  [14] [15] [16] Nonetheless, specificity of DAT imaging is expected to decrease when the differential diagnosis is not between DLB and AD, but between DLB and disorders, such as vascular or frontotemporal  ... 
doi:10.1002/ana.24717 pmid:27398636 fatcat:a7yvkbg2gzecxest7xjup5if44

Logopenic aphasia or Alzheimer's disease: Different phases of the same disease?

Bárbara Costa Beber, Renata Kochhann, Bruna Matias da Silva, Marcia L. F. Chaves
2014 Dementia & Neuropsychologia  
This article reports the clinical case of a patient for whom it proved difficult to define a clinical diagnosis, being split between the logopenic variant and Alzheimer's disease at different phases of  ...  Using this case as an example and drawing on the latest evidence from the literature on the logopenic variant, we postulate the hypothesis that this variant may present as an initial symptom of Alzheimer's  ...  The authors would like to thank CAPES for providing the Doctoral (BCB) and Post-doctoral (RK) scholarships, and Dr.  ... 
doi:10.1590/s1980-57642014dn83000016 pmid:29213918 pmcid:PMC5619409 fatcat:u45rognzwndgfntsjksptpfdea

Application of Artificial Neural Networks to Identify Alzheimer's Disease Using Cerebral Perfusion SPECT Data

Dariusz Świetlik, Jacek Białowąs
2019 International Journal of Environmental Research and Public Health  
The aim of this study was to demonstrate the usefulness of artificial neural networks in Alzheimer disease diagnosis (AD) using data of brain single photon emission computed tomography (SPECT).  ...  The sensitivity of Alzheimer disease diagnosis detection by artificial neural network and discriminant analysis were 93.8% and 86.1%, respectively, and the corresponding specificity was 100% and 95%.  ...  Introduction Alzheimer's disease is one of the most common causes of dementia in the growing population of elderly people.  ... 
doi:10.3390/ijerph16071303 pmid:30979022 pmcid:PMC6479441 fatcat:k5x74wl5sncujnga2xmalcffky
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