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Alternative Splicing in the Differentiation of Human Embryonic Stem Cells into Cardiac Precursors
2009
PLoS Computational Biology
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The role of alternative splicing in self-renewal, pluripotency and tissue lineage specification of human embryonic stem cells (hESCs) is largely unknown. ...
These included an enrichment of splice isoforms that oppose cell-cycle arrest in hESCs and that promote calcium signaling and cardiac development in cardiac precursors. ...
In loving memory of Karen Vranizan and Milo Salomonis.
Author Contributions ...
doi:10.1371/journal.pcbi.1000553
pmid:19893621
pmcid:PMC2764345
fatcat:jgthhwg3hjgyrevs7ibybqvwea
α6-Integrin alternative splicing: distinct cytoplasmic variants in stem cell fate specification and niche interaction
2018
Stem Cell Research & Therapy
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Understanding of the distinct functions of α6 splicing variants in stem cell biology may inform the rational design of novel stem cell-based therapies for a range of human diseases. ...
In this review, we summarize the current knowledge on the structural variants of the α6integrin subunit and spatiotemporal expression of α6 cytoplasmic variants in embryonic and adult stem/progenitor cells ...
Alternative splicing impacts the function of α6 in the regulation of the stem cell propensity and niche interaction. ...
doi:10.1186/s13287-018-0868-3
pmid:29720266
pmcid:PMC5930856
fatcat:6kdfbv44ffahnob5b5usvcqukm
Small and long non-coding RNAs in cardiac homeostasis and regeneration
2013
BBA - Molecular Cell Research
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This article is part of a Special Issue entitled: Cardiomyocyte Biology: Cardiac Pathways of Differentiation, Metabolism and Contraction. ...
Recently, the notion of promoting cardiac regeneration as a means to replace lost cardiomyocytes in the damaged heart has engendered considerable research interest. ...
Acknowledgement We are grateful to the Swiss National Science Foundation for their support (National Research Program 63 "Stem Cells and Regenerative Medicine"; Grant no: 406340-128129). ...
doi:10.1016/j.bbamcr.2012.08.010
pmid:22951218
fatcat:bl6dojzynbdcrg6boklt3zlg3i
Alternative splicing: An important mechanism in stem cell biology
2015
World Journal of Stem Cells
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It has been shown that AS is prevalent in metazoan genomes, and the splicing pattern is dynamically regulated in different tissues and cell types, including embryonic stem cells. ...
However, most of the studies focused on the expression of a core set of transcription factors and regulatory RNAs. The role of AS in stem cell differentiation was not clear. ...
Pervasive splicing in embryonic stem cells Embryonic stem cells (ESCs) are pluripotent cells which can self-renew and has the ability to differentiate into all three germ layers [59, 60] . ...
doi:10.4252/wjsc.v7.i1.1
pmid:25621101
pmcid:PMC4300919
fatcat:wtxuqxgs4bghvmduzuwkos4myi
Alternative Splicing in Neurogenesis and Brain Development
2018
Frontiers in Molecular Biosciences
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Genetic manipulation and RNA sequencing have provided insights into the molecular mechanisms underlying the effects of alternative splicing in stem cell self-renewal and neuronal fate specification. ...
Alternative splicing of many key transcription regulators or epigenetic factors reprograms the transcriptome and hence contributes to stem cell fate determination. ...
ACKNOWLEDGMENTS The work from our laboratory that is reported in this review was supported by the Ministry of Science and Technology grant 106-2311-B-001-015. ...
doi:10.3389/fmolb.2018.00012
pmid:29484299
pmcid:PMC5816070
fatcat:bybazza6gve3hfcmgzddrsj24e
Alternative splicing switching in stem cell lineages
2012
Frontiers in Biology
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In addition, recent publications have revealed another interesting molecular feature of stem cells-a distinct alternative splicing pattern. ...
In this review, we will discuss the generality of mRNA isoform switching and its interaction with other molecular mechanisms to regulate stem cell pluripotency, as well as the reprogramming process in ...
The work in the Chen lab has been supported by Research Grant No. 05-FY09-88 from the March of Dimes Foundation, the R00HD055052 NIH Pathway to Independence Award, R21 HD065089 and R01HD065816 from NICHD ...
doi:10.1007/s11515-012-1198-y
pmid:23399987
pmcid:PMC3566875
fatcat:aozryy4osbegjekpzc3xhkiguu
Embryonic Stem Cells as a Model System to Elucidate Early Events in Cardiac Specification and Determination
[chapter]
2011
Embryonic Stem Cells: The Hormonal Regulation of Pluripotency and Embryogenesis
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However, the scenario of the heart inducer morphogens is still incomplete, and several hints may come from in vitro study of the embryonic stem cell (ESC) differentiation process. ...
Embryonic Stem Cells as a Model System to Elucidate Early Events in Cardiac Specification and Determination 495 as endothelial cells. ...
Pluripotency is a prerequisite for the subsequent coordinated differentiation of embryonic stem cells into all tissues of the body. ...
doi:10.5772/14304
fatcat:2rfyij63c5hhbihnws2rvkw6dq
RNA binding proteins in the regulation of heart development
2013
International Journal of Biochemistry and Cell Biology
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A fuller understanding of the roles and substrates of these proteins could ultimately provide attractive targets for the design of therapies for congenital heart defects, cardiovascular disease, or cardiac ...
Since the targets and functions of most RBPs -in the heart and at large -are not fully understood, this review focuses on the expression and roles of RBPs that have been implicated in specific stages of ...
In a comparison of human embryonic stem cells before and after differentiation into either cardiac or neural progenitors, Salomonis and colleagues identified alternative splicing events common to both ...
doi:10.1016/j.biocel.2013.08.008
pmid:23973289
pmcid:PMC3804413
fatcat:jp7hadvr4ngothxnly6c7pyygu
Nitric oxide–cyclic GMP signaling in stem cell differentiation
2011
Free Radical Biology & Medicine
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This review will focus on some of the work pertaining to the role of NO-cGMP in differentiation of stem cells into cells of various lineages particularly into myocardial cells and stem cell based therapy ...
in regulation of stem cell differentiation. ...
Acknowledgments This work was supported in part by National Institutes of Health (GM076695) and grants from the Dunn foundation, the Welch foundation, Mathers foundation, NASA and the University of Texas ...
doi:10.1016/j.freeradbiomed.2011.09.037
pmid:22019632
pmcid:PMC3232180
fatcat:h7mi4shm4ndd5lrqombvdyh3rq
LncRNAs in Stem Cells
2016
Stem Cells International
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We discuss some of the known ncRNAs in stem cells such as embryonic stem cells, induced pluripotent stem cells, mesenchymal stem cells, adult stem cells, and cancer stem cells with a focus on long ncRNAs ...
Stem cells occupy a special position in cell biology and Biomedicine, and emerging results show that multiple ncRNAs play essential roles in stem cells. ...
Conflict of Interests The authors declare that there is no conflict of interests regarding the publication of this paper. ...
doi:10.1155/2016/2681925
pmid:26880946
pmcid:PMC4736767
fatcat:mvuq2nq75jaajpxfve6vkjjtne
Regulation of Cardiac Cell Fate by microRNAs: Implications for Heart Regeneration
2014
Cells
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Here we review the role of microRNAs in the control of stem cell and cardiomyocyte dependent cardiac regeneration processes, and discuss potential applications for the treatment of cardiac injury. ...
Both the proliferation of adult cardiac stem cells and the ability of cardiomyocytes to re-enter the cell cycle have been proposed to sustain these regenerative processes. ...
Luis Brás-Rosário contributed to the outline of the manuscript and in manuscript revision.
Conflicts of Interest The authors declare no conflict of interest. ...
doi:10.3390/cells3040996
pmid:25358052
pmcid:PMC4276912
fatcat:kty3ztxgvrdkxiqplgobk5ylru
The promise of enhancer-associated long noncoding RNAs in cardiac regeneration
2015
Trends in cardiovascular medicine
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New strategies envisage the transfer of stem cells into the damaged myocardium, the mobilization of cardiac precursor cells, the promotion of cardiomyocyte proliferation in situ and direct reprogramming ...
of non-cardiac cells into electromechanically coupled cardiomyocytes. ...
Embryonic stem (ES) cells and induced pluripotent stem (iPS) cells are unlimited sources of precursors [2] . ...
doi:10.1016/j.tcm.2015.01.014
pmid:25753179
fatcat:tsosrmzpnfcmjbhj5lh7sbviee
The Emerging Role of the RBM20 and PTBP1 Ribonucleoproteins in Heart Development and Cardiovascular Diseases
2020
Genes
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More than 90% of human genes are regulated by alternative splicing events, which participate in cell fate determination. ...
Alternative splicing is a regulatory mechanism essential for cell differentiation and tissue organization. ...
In human embryonic stem-cell-derived cardiomyocytes, the knockout of RBM20 affects the choice of alternative exons for both the TTN-associated genes CACNA1C and CAMK2D. ...
doi:10.3390/genes11040402
pmid:32276354
fatcat:xr4j2hniebfkzilyk3y2kdx524
Divergent roles of tumor suppressor gene Klf6 in ES cell differentiation
2008
Journal of Electrophoresis
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The aim of this study was to more clearly define the roles of Klf6 in tissue specification using tissue-specific ES cell differentiation systems. ...
We previously reported that Klf6 -/mice are embryonic lethal because of impaired hematopoietic differentiation. In that study, we also found Klf6 -/mice have undefinable livers. ...
We confirmed this role of Klf6 in differentiation using Klf6 -/embryonic stem (ES) cells, which displayed broad defects in differentiaton 4) . ...
doi:10.2198/jelectroph.52.65
fatcat:aolrjvujnvbftdn2rc2igr6o3a
Myotonic Muscular Dystrophy, RNA Toxicity, and the Brain: Trouble Making the Connection?
2011
Cell Stem Cell
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Using human embryonic stem cells (hESCs) derived from embryos with the DM1 mutation, Marteyn et al. (2011) found that after differentiation into neural precursor cells, SLITRK4 expression was decreased ...
In this issue of Cell Stem Cell, Marteyn et al. (2011) use human embryonic stem cells to identify deficits in neuritic outgrowth in myotonic dystrophy type 1. ...
In this issue of Cell Stem Cell, Loffredo et al. (2011) provide evidence that hematopoietic precursors do not differentiate into new cardiomyocytes but, rather, stimulate production of new cardiomyocytes ...
doi:10.1016/j.stem.2011.03.007
pmid:21474094
fatcat:iimn4hnlx5ctdm7svxbrdlnltm
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