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Altered temporal stability in dynamic neural networks underlies connectivity changes in neurodevelopment

Matthew J. Brookes, Madeleine J. Groom, Lucrezia Liuzzi, Ryan M. Hill, Helen J.F. Smith, Paul M. Briley, Emma L. Hall, Benjamin A.E. Hunt, Lauren E. Gascoyne, Margot J. Taylor, Peter F. Liddle, Peter G. Morris (+2 others)
2018 NeuroImage  
Changing network dynamics underlies changes in time averaged functional connectivity  ...  Significant overlap was found between age-modulated dynamic networks and inter-regional oscillatory coordination, implying that altered network dynamics underlie age related changes in functional connectivity  ...  ) Altered network dynamics will underlie changes in functional connectivity: Specifically, the spatial signature of changing stationary connectivity will agree with one or more dynamic networks, whose  ... 
doi:10.1016/j.neuroimage.2018.03.008 pmid:29524625 fatcat:ykr7m2leqjbybccusuxuvfriqm

Neurodynamics and Schizophrenia Research: Editors' Introduction

R. E. Hoffman, T. H. McGlashan
1993 Schizophrenia Bulletin  
term, use this information to alter their own architectures.  ...  The term, "neurodynamics," refers to interactions of large numbers of neurons that, in the short term, transform input information derived from their environments into meaningful outputs and, in the long  ...  How Spatially and Temporally Localized Are Brain Disturbances Underlying Schizophrenia?  ... 
doi:10.1093/schbul/19.1.15 pmid:8451609 fatcat:d2y766uqgnalhcbtzikckn6xiy

Network Analysis: Applications for the Developing Brain

Catherine J. Chu-Shore, Mark A. Kramer, Matt T. Bianchi, Verne S. Caviness, Sydney S. Cash
2011 Journal of Child Neurology  
Upon this framework, we describe early work revealing the evolution of agespecific functional brain networks in normal neurodevelopment.  ...  Finally, we review how these relationships can be altered in disease and perhaps even rectified with treatment.  ...  funding from the Department of Neurology, Massachusetts General Hospital, and the Clinical Investigator Training Program: Harvard/MIT Health Sciences and Technology-Beth Israel Deaconess Medical Center, in  ... 
doi:10.1177/0883073810385345 pmid:21303762 pmcid:PMC3124081 fatcat:gy67n76fo5hpblvjp63qhogifq

Microtubule Dynamics and Neuronal Excitability: Advances on Cytoskeletal Components Implicated in Epileptic Phenomena

Giuditta Gambino, Valerio Rizzo, Giuseppe Giglia, Giuseppe Ferraro, Pierangelo Sardo
2020 Cellular and molecular neurobiology  
Pathophysiological alterations of microtubule dynamics inducing neurodegeneration, network remodeling and relative impairment on synaptic transmission were overviewed.  ...  and excitability, in order to suggest a potential role for microtubule dynamics in the processes turning a normal neuronal network in a hyperexcited one.  ...  2009 ), a clear understanding of mechanisms underlying structural changes in epilepsy has not been achieved yet.  ... 
doi:10.1007/s10571-020-00963-7 pmid:32929563 pmcid:PMC8891195 fatcat:breebm4k45azzkrjxa6xpfgk34

Circadian rhythms and mood: Opportunities for multi-level analyses in genomics and neuroscience

Jun Z. Li
2013 Bioessays  
In the healthy state, both circadian rhythm and mood are stable against perturbations, yet they are capable of adjusting to altered internal cues or ongoing changes in external conditions.  ...  The dual demands of stability and flexibility are met by the collective properties of complex neural networks.  ...  Neural dynamics: The circadian system provides an ideal model to study temporal organization In the SCN, adaptation to seasonal changes of day length or temperature is achieved not by changed oscillating  ... 
doi:10.1002/bies.201300141 pmid:24853393 pmcid:PMC4033528 fatcat:lp3fkg6nojdnvhoamydsqcgxyu

Neurological Foundation of Unconscious and Higher Thinking Processes and the Dynamic Variability of Clinical Presentations

Lawrence Greenman
2018 Open Journal of Psychiatry  
This article reviews selected neuroscientific and psychoanalytic writings with a focus on dynamic variability, unconscious processes and their presence in clinical venues. Two objects are pursued.  ...  The goal is to describe the stated objectives and the theme of variability represented in clinical presentations and venues.  ...  Acknowledgements The author would like to thank Robert and Jax Kovacs for their assistance in the preparation of the manuscript.  ... 
doi:10.4236/ojpsych.2018.81006 fatcat:x2dvnom7jrdwfa3uhbktvwynua

Imbalance of Functional Connectivity and Temporal Entropy in Resting-State Networks in Autism Spectrum Disorder: A Machine Learning Approach

Robert X. Smith, Kay Jann, Mirella Dapretto, Danny J. J. Wang
2018 Frontiers in Neuroscience  
Conclusions: Imbalanced brain connectivity and dynamics at the network level coincides with their decoupling in ASD.  ...  Two approaches to understanding the etiology of neurodevelopmental disorders such as Autism Spectrum Disorder (ASD) involve network level functional connectivity (FC) and the dynamics of neuronal signaling  ...  This suggests that changes in network dynamics largely follow local FC changes.  ... 
doi:10.3389/fnins.2018.00869 pmid:30542259 pmcid:PMC6277800 fatcat:n5wcabikm5dzdp37exhhjdkapm

Microbiota and neurodevelopmental windows: implications for brain disorders

Yuliya E. Borre, Gerard W. O'Keeffe, Gerard Clarke, Catherine Stanton, Timothy G. Dinan, John F. Cryan
2014 Trends in Molecular Medicine  
Temporal profile of neurodevelopmental sequences in relation to the age of onset of mental disorders and degree of microbiota stability/diversity throughout life.Gut microbiota is essential to human health  ...  Importantly, childhood and adolescence are the most dynamic periods of change in relation to microbiota and brain development.  ... 
doi:10.1016/j.molmed.2014.05.002 pmid:24956966 fatcat:uhzarfrlqrfi5ln2fwmqx5suo4

Non-Coding RNAs in Neural Networks, REST-Assured

Michael Rossbach
2011 Frontiers in Genetics  
The importance of the correct regulation within the ncRNA network, the ncRNAome, is demonstrated when it comes to a deregulation of REST and/or ncRNAs associated with molecular pathophysiology underlying  ...  In the nervous system, several key steps in cellular complexity and development are regulated by non-coding RNAs (ncRNAs) and the repressor element-1 silencing transcription factor/neuron-restrictive silencing  ...  Within the network regulated by REST and CoREST, neural genes are connecting points and this network is highly integrated with the ncRNAome that orchestrates aspects as diverse as lineage restriction,  ... 
doi:10.3389/fgene.2011.00008 pmid:22303307 pmcid:PMC3268567 fatcat:gyj7nsffynee3kdwynwcoj67by

Early Childhood Developmental Functional Connectivity of Autistic Brains with Non-Negative Matrix Factorization

Tianyi Zhou, Jiannan Kang, Fengyu Cong, Dr. Xiaoli Li
2020 NeuroImage: Clinical  
Age-related changes in neural connectivities remain unclear for autistic children as compared with normal children.  ...  Autism spectrum disorder (ASD) is associated with altered patterns of over- and under-connectivity of neural circuits.  ...  Neurodevelopmental changes in salient connectivity patterns Considerable changes in the patterns of functional brain networks occur throughout neurodevelopment.  ... 
doi:10.1016/j.nicl.2020.102251 pmid:32403087 pmcid:PMC7218077 fatcat:bk5jwzuy55gnvffhxegxaacmhm

Autism as an adaptive common variant pathway for human brain development

Mark H. Johnson
2017 Developmental Cognitive Neuroscience  
processing over the early years (such as alterations in synaptic efficiency).  ...  From this perspective, autism is not appropriately described as a disorder of neurodevelopment, but rather as an adaptive common variant pathway of human functional brain development.  ...  in underlying structural networks.  ... 
doi:10.1016/j.dcn.2017.02.004 pmid:28233663 pmcid:PMC6987822 fatcat:cqrqc3tzn5gs7mc7vlag37drzy

Ontogeny of small RNA in the regulation of mammalian brain development

Sharon L Hollins, Belinda J Goldie, Adam P Carroll, Elizabeth A Mason, Frederick R Walker, Darryl W Eyles, Murray J Cairns
2014 BMC Genomics  
MicroRNAs (miRNAs) play a pivotal role in coordinating messenger RNA (mRNA) transcription and stability in almost all known biological processes, including the development of the central nervous system  ...  Conclusions: Our findings suggest that miRNA have significant implications for the development of neural structure and support important mechanisms that if disrupted, may contribute to or drive neurodevelopmental  ...  Ainsworth Research Fellowship in Epigenetics (MC); and a National Health and Medical Research Council project grant (631057).  ... 
doi:10.1186/1471-2164-15-777 pmid:25204312 pmcid:PMC4171549 fatcat:6rzkteosz5eazhji6bmjulzmku

Predictive Modeling of Neurobehavioral State and Trait Variation Across Development

Sara Sanchez-Alonso, Richard N. Aslin
2020 Developmental Cognitive Neuroscience  
We discuss this framework in the context of mapping language neurodevelopmental changes in early childhood, with an emphasis on measures of functional connectivity and their reliability for establishing  ...  We focus on mapping variation across a range of neural and behavioral measurements and consider concurrent alterations of state and trait variation across development.  ...  Acknowledgment Research reported in this publication was supported by National Institutes of Health Grant HD-037082 (R.N.A).  ... 
doi:10.1016/j.dcn.2020.100855 pmid:32942148 pmcid:PMC7501421 fatcat:ub4tyyenhrbh5fyispb6dvbufy

Deep brain stimulation for severe autism: from pathophysiology to procedure

Saurabh Sinha, Robert A. McGovern, Sameer A. Sheth
2015 Neurosurgical Focus  
The authors review recent developments in the understanding of the pathophysiology of autism. Specifically, they describe the genetic and environmental alterations that affect neurodevelopment.  ...  The authors also highlight the resultant microstructural, macrostructural, and functional abnormalities that emerge during brain development, which create a pattern of dysfunctional neural networks involved  ...  These changes also appear to underlie gross structural alterations that ultimately have implications for the characteristic neural network dysfunction underlying autism.  ... 
doi:10.3171/2015.3.focus1548 pmid:26030703 fatcat:wtxmb2k4vzh25czlysvmbfopki

Atypical core-periphery brain dynamics in autism

Dipanjan Roy, Lucina Q. Uddin
2021 Network Neuroscience  
Core-periphery dynamical changes associated with macroscale brain network dynamics span multiple timescales and may lead to atypical behavior and clinical symptoms.  ...  In this review, we summarize a large body of converging evidence derived from timeresolved fMRI studies in autism to characterize atypical core-periphery brain dynamics and how they relate to core and  ...  reporting brain connectivity and dynamic alterations observed in ASD.  ... 
doi:10.1162/netn_a_00181 pmid:34189366 pmcid:PMC8233106 fatcat:gjg45ue6pvce5cgzfxdd4skcpq
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