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Can Online Discussion Sites Generate Quality Data for Research Purposes?

Helen Smith, Alpaslan Bulbul, Christina J. Jones
2017 Frontiers in Public Health  
doi:10.3389/fpubh.2017.00156 pmid:28730148 pmcid:PMC5499632 fatcat:j2kvpog4yfafzapmpa7ynf5vf4

Measurement properties of asthma-specific quality-of-life measures: protocol for a systematic review

Christian Apfelbacher, Priya Paudyal, Alpaslan Bülbül, Helen Smith
2014 Systematic Reviews  
Asthma is a frequent chronic inflammatory disease of the airways, and the assessment of health-related quality of life (HrQoL) is important in both research and routine care. Various asthma-specific measures of HrQoL exist but there is uncertainty which measures are best suited for use in research and routine care. Therefore, the aim of the proposed research is a comprehensive systematic assessment of the measurement properties of the existing measures that were developed to measure
more » ... fic quality of life. Methods/design This study is a systematic review of the measurement properties of asthma-specific measures of health-related quality of life. PubMed and Embase will be searched using a selection of relevant search terms. Eligible studies will be primary empirical studies evaluating, describing or comparing measurement properties of asthma-specific HRQL tools. Eligibility assessment and data abstraction will be performed independently by two reviewers. Evidence tables will be generated for study characteristics, instrument characteristics, measurement properties and interpretability. The quality of the measurement properties will be assessed using predefined criteria. Methodological quality of studies will be assessed using the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) checklist. A best evidence synthesis will be undertaken if more than one study have investigated a particular measurement property. Discussion The proposed systematic review will produce a comprehensive assessment of measurement properties of existing measures of asthma-specific health-related quality of life. We also aim to derive recommendations in order to help researchers and practitioners alike in the choice of instrument. Trial registration PROSPERO registration number: CRD42014010491.
doi:10.1186/2046-4053-3-83 pmid:25060719 pmcid:PMC4124509 fatcat:t2csawdfkzhijagqfrbb2biqam

Automatic identification of variables in epidemiological datasets using logic regression

Matthias W. Lorenz, Negin Ashtiani Abdi, Frank Scheckenbach, Anja Pflug, Alpaslan Bülbül, Alberico L. Catapano, Stefan Agewall, Marat Ezhov, Michiel L. Bots, Stefan Kiechl, Andreas Orth
2017 BMC Medical Informatics and Decision Making  
For an individual participant data (IPD) meta-analysis, multiple datasets must be transformed in a consistent format, e.g. using uniform variable names. When large numbers of datasets have to be processed, this can be a time-consuming and error-prone task. Automated or semi-automated identification of variables can help to reduce the workload and improve the data quality. For semi-automation high sensitivity in the recognition of matching variables is particularly important, because it allows
more » ... eating software which for a target variable presents a choice of source variables, from which a user can choose the matching one, with only low risk of having missed a correct source variable. Methods: For each variable in a set of target variables, a number of simple rules were manually created. With logic regression, an optimal Boolean combination of these rules was searched for every target variable, using a random subset of a large database of epidemiological and clinical cohort data (construction subset). In a second subset of this database (validation subset), this optimal combination rules were validated. Results: In the construction sample, 41 target variables were allocated on average with a positive predictive value (PPV) of 34%, and a negative predictive value (NPV) of 95%. In the validation sample, PPV was 33%, whereas NPV remained at 94%. In the construction sample, PPV was 50% or less in 63% of all variables, in the validation sample in 71% of all variables. Conclusions: We demonstrated that the application of logic regression in a complex data management task in large epidemiological IPD meta-analyses is feasible. However, the performance of the algorithm is poor, which may require backup strategies.
doi:10.1186/s12911-017-0429-1 pmid:28407816 pmcid:PMC5390441 fatcat:vrbivhnujrc6lbx63elf3da44q

'The mean mummy way' – experiences of parents instilling eye drops to their young children as described in online forums and blogs

Gloria C. Law, Alpaslan Bülbül, Christina J. Jones, Helen Smith
2020 BMC Pediatrics  
Background Adults often have difficulty instilling eye drops in their own eyes, but little has been documented about the difficulties experienced by parents when administering eye drops to their young children, where the challenges of instillation are accentuated by their inability to cooperate. This qualitative study explores parents' experiences of administering eye drops to their children as described in online forum discussions and blog posts. Methods This was an exploratory study using
more » ... itative methods. We thematically analysed the written exchanges between parents participating in online forum discussions and blog posts about the administration of eye drops to their young children. Results We found 64 forum discussion threads and 4 blog posts, representing 464 unique contributors expressing their experiences of eye drop administration to young children. Three major themes were identified – administration challenges, administration methods and role of health care professionals. Besides describing their children's distress, parents discussed their own discomfort and anxiety when administering eye drops. Parents used a variety of techniques to facilitate adherence with medication, including restraining the child, role-play, reassurance, distraction, or reward. The ideas exchanged about eye drop administration occasionally included reiteration of professional advice, but were dominated by parents' own ideas/suggestions; interestingly health care professionals were considered diagnosticians and prescribers, rather than sources of practical advice on administration. Conclusions Parents struggling to deliver eye drops to their young children may seek advice on how to administer treatment from parental on-line discussion forums. The distress experienced by the young child and their parents is a powerful reminder to clinicians that procedures common and routine in health care may be challenging to parents. The advice given to parents needs to go beyond the instillation of the eye drops, and include advice on child restraint, distraction techniques and allaying distress. Forewarned of the potential difficulties and provided with coping strategies parents can employ when the child resists, could alleviate their own and their child's distress.
doi:10.1186/s12887-020-02410-4 pmid:33167925 fatcat:hezmxip6jvamnbqfvibymtok3e

Carotid Intima-Media Thickness Progression and Risk of Vascular Events in People With Diabetes: Results From the PROG-IMT Collaboration

Matthias W. Lorenz, Jackie F. Price, Christine Robertson, Michiel L. Bots, Joseph F. Polak, Holger Poppert, Maryam Kavousi, Marcus Dörr, Eva Stensland, Pierre Ducimetiere, Kimmo Ronkainen, Stefan Kiechl (+41 others)
2015 Diabetes Care  
OBJECTIVE Carotid intima media thickness (CIMT) is a marker of subclinical organ damage and predicts cardiovascular disease (CVD) events in the general population. It has also been associated with vascular risk in people with diabetes. However, the association of CIMT change in repeated examinations with subsequent CVD events is uncertain, and its use as a surrogate end point in clinical trials is controversial. We aimed at determining the relation of CIMT change with CVD events in people with
more » ... iabetes. RESEARCH DESIGN AND METHODS In a comprehensive meta-analysis of individual participant data, we collated data from 3,902 adults (age 33-92 years) with type 2 diabetes from 21 populationbased cohorts. We calculated the hazard ratio (HR) per standard deviation (SD) difference in mean common carotid artery intima media thickness (CCA-IMT) or in CCA-IMT progression, both calculated from two examinations on average 3.6 years apart, for each cohort, and combined the estimates with random-effects meta-analysis. RESULTS Average mean CCA-IMT ranged from 0.72 to 0.97 mm across cohorts in people with diabetes. The HR of CVD events was 1.22 (95% CI 1.12-1.33) per SD difference in mean CCA-IMT, after adjustment for age, sex, and cardiometabolic risk factors. Average mean CCA-IMT progression in people with diabetes ranged between 20.09 and 0.04 mm/year. The HR per SD difference in mean CCA-IMT progression was 0.99 (0.91-1.08). CONCLUSIONS Despite reproducing the association between CIMT level and vascular risk in subjects with diabetes, we did not find an association between CIMT change and vascular risk. These results do not support the use of CIMT progression as a surrogate end point in clinical trials in people with diabetes.
doi:10.2337/dc14-2732 pmid:26180107 pmcid:PMC4580609 fatcat:vwbgyurfo5hulb72hins2bpnrq

Inflammatory markers and extent and progression of early atherosclerosis: Meta-analysis of individual-participant-data from 20 prospective studies of the PROG-IMT collaboration

Peter Willeit, Simon G Thompson, Stefan Agewall, Göran Bergström, Horst Bickel, Alberico L Catapano, Kuo-Liong Chien, Eric de Groot, Jean-Philippe Empana, Thorleif Etgen, Oscar H Franco, Bernhard Iglseder (+42 others)
2014 European Journal of Preventive Cardiology  
Background-Large-scale epidemiological evidence on the role of inflammation in early atherosclerosis, assessed by carotid ultrasound, is lacking. We aimed to quantify cross-sectional and longitudinal associations of inflammatory markers with common-carotid-artery intima-media thickness (CCA-IMT) in the general population. Methods-Information on high-sensitivity C-reactive protein, fibrinogen, leucocyte count and CCA-IMT was available in 20 prospective cohort studies of the PROG-IMT
more » ... involving 49,097 participants free of pre-existing cardiovascular disease. Estimates of associations were calculated within each study and then combined using random-effects meta-analyses. Results-Mean baseline CCA-IMT amounted to 0.74mm (SD = 0.18) and mean CCA-IMT progression over a mean of 3.9 years to 0.011 mm/year (SD = 0.039). Cross-sectional analyses showed positive linear associations between inflammatory markers and baseline CCA-IMT. After adjustment for traditional cardiovascular risk factors, mean differences in baseline CCA-IMT per one-SD higher inflammatory marker were: 0.0082mm for high-sensitivity C-reactive protein (p < 0.001); 0.0072mm for fibrinogen (p < 0.001); and 0.0025mm for leucocyte count (p = 0.033). 'Inflammatory load', defined as the number of elevated inflammatory markers (i.e. in upper two quintiles), showed a positive linear association with baseline CCA-IMT (p < 0.001). Longitudinal associations of baseline inflammatory markers and changes therein with CCA-IMT progression were null or at most weak. Participants with the highest 'inflammatory load' had a greater CCA-IMT progression (p = 0.015). Conclusion-Inflammation was independently associated with CCA-IMT cross-sectionally. The lack of clear associations with CCA-IMT progression may be explained by imprecision in its Reprints and permissions: sagepub.co.uk/journalsPermissions.nav
doi:10.1177/2047487314560664 pmid:25416041 pmcid:PMC4544641 fatcat:y45orgn2bfgw5ny2rdy5c3xrw4

1980 SONRASI ÂŞIK ŞİİRİNDE SİYASİ SÖYLEMLER

Salahaddin BEKKi
2016 Littera Turca Journal of Turkish Language and Literature  
Kemâlî Bülbül, Alpaslan Türkeş'in siyasete dönmesiyle ANAP'tan vazgeçerek ona övgüler dizer: "Yediden yetmişe müjdeler olsun Samsun ilimize Başbuğ geliyor Caddeler sokaklar coşkuyla dolsun Sevgi selimize  ...  1998: 101) 1997 yılı, 28 Şubatta gerçekleşen ve ileride "28 Şubat Süreci" olarak anılacak tarihi Millî Güvenlik Kurulu toplantısı ile açılır. 4 Nisanda ülkücü hareketin kurucusu ve MHP genel başkanı Alpaslan  ... 
doi:10.20322/lt.66351 fatcat:vlxl2ryq7rgjdpec5jpl2ptcse

Çocuk İstismarı ve İhmalini Anlamak: Ekolojik Bir Yaklaşım

Tuğba TÜRKKAN, Hatice ODACI, Kenan BÜLBÜL
2021 Toplum ve sosyal hizmet(Online)  
Alpaslan, A.H. (2014). Çocukluk döneminde cinsel istismar. Kocatepe Tıp Dergisi, 15(2), 194-201. Sosyal Çalışma Dergisi, 4(1), 12-20.  ...  Bu olumsuz sonuçlar ve yaygınlık oranları göz önüne alındığında çocuk istismarının anlaşılması, risk faktörlerinin belirlenmesi, gelecekteki müdahale ve önleme Türkkan, Odacı ve Bülbül 711 araştırmalarının  ... 
doi:10.33417/tsh.847467 fatcat:i7gmcdtf75erbduop5uvl6k3bq

KADI BURHANEDDİN ve NESÎMÎ'NİN ŞİİRLERİNDE GEÇEN BİTKİ VE HAYVAN ADLARI ÜZERİNE

Sibel Murad
2019 Littera Turca Journal of Turkish Language and Literature  
egele vü cânumuza ur İllâ sahın ciger tovşanı rîş olmasun KB G 884/5 SONUÇ Kadı Burhâneddin'in hayatı ve eserleriyle ilgili ayrıntılı bilgi için bk.İz ve Kut 1985; Özaydın 2001; Tören 2001; Alpaslan  ...  [bülbül] G 604/9 G 62/6 'anka (Ar.) [zümrüdüanka, simurg] G 1232/6 G 50/14 cedy (Ar.) [oğlak] G 8/9 dürrâc (Ar.) [turaç] G 342/1 ebâbil (Ar.) G 935/1 ef'î (Ar.)  ... 
doi:10.20322/littera.529633 fatcat:26a262q6yvd6dkcp5mnoqxmya4

Kadı Burhaneddin'in Düşünce Dünyasında Tasavvuf

Kadir Özköse
2016 Cumhuriyet Üniversitesi İlahiyat Fakültesi Dergisi  
, "Giriş", Kadı Burhaneddin Divanı'ndan Seçmeler, Ankara: Kültür Bakanlığı, 1977, xxxıx. 11 Alpaslan, "Giriş", Kadı Burhaneddin Divanı'ndan Seçmeler, xxıx. 12 Alpaslan, "Giriş", Kadı Burhaneddin Divanı'ndan  ...  Tanrı-İnsan-Ȃlem ilişkisi Ki bülbül-i divâne dahi perde-serâdur".Bk.Kadı Burhaneddin, Divandan Seçmeler, 225.Allah'a içten yakarışlarda bulunan şair, günahının çokluğundan üzüntüsünü belirtirken, Allah'tan  ... 
doi:10.18505/cuifd.70833 fatcat:mufsflcwqfcarcr2yilc66wmsa

Localization And Nedim's Songs

Rasih ERKUL
2009 Turkish Studies  
Bülbül, keyfe gelip meclise gazel okuyarak geldiğine göre, Çırağan vakti gelmiĢtir; gül bahçesine müjdeler osun!"  ...  Fuat Köprülü, Saz ġairler, C.II, Ġstanbul, 1940 Ġpekten, a.g.e., s.118 12 Ġpekten, a.g.e., s.110 13 Ali Alpaslan, Ahmet PaĢa,Ankara, 1987, s.14 Nedim"in yaĢadığı devir, Ģairleri Ģarkılar yazmaya yöneltir  ... 
doi:10.7827/turkishstudies.857 fatcat:qcla5je7s5fy5knczodanjwygq

Tuz Stresi Altında Çimlendirilen Arpa Tohumlarında Borik Asit Uygulamasının Sitogenetik Etkisi

Dilek ÇAVUŞOĞLU, Selma TABUR
2015 Süleyman Demirel Üniversitesi Fen Bilimleri Enstitüsü Dergisi  
'Bülbül 89') seeds germinated under salt stress was investigated.  ...  ., Alpaslan, M., Özcan, H., Çıkılı, Y., 2000. Türkiye’de Yaygın Olarak Yetiştirilen Mısır (Zea mays L.) Çeşitlerinin Bor Toksisitesine Duyarlılıkları.  ... 
doi:10.19113/sdufbed.79527 doaj:c90a2606b94e4c16bfee1605aac83fbe fatcat:tcovj33b4nftzmnuiuma4n5y5u

Sindbâdnâmelerden Hareketle Çerçeve Hikâye Geleneğinde Metinlerarasılık: Tûtî Hikâyesi Örneği

Gülşah Gaye FİDAN
2012 Divan Edebiyatı Araştırmaları Dergisi  
Sindbâd'da yer alan, kocasını aldatan kadın ve evde olup bitenleri sahibine anlatan papağan motiflerinin işlendiği Tûtî hikâyesinde olay örgüsü şu şekildedir: Zamanında bir adamın hafif meşrep bir karısı ve bülbül  ...  Bakthin'e göre "saf metin yoktur" ve "her metin kendinden önceki veya kendi dönemindeki diğer metinlerle kaçınılmaz bir ilişki içerisindedir" (Gökalp-Alpaslan, 2007: 9).  ... 
doi:10.15247/dev.87 fatcat:7vync5wrsvbu5kwu77iahroohm

Carotid intima-media thickness progression and risk of vascular events in people with diabetes: results from the PROG-IMT collaboration

Matthias W Lorenz, Jackie F Price, Christine Robertson, Michiel L Bots, Joseph F Polak, Holger Poppert, Maryam Kavousi, Marcus Dörr, Eva Stensland, Pierre Ducimetiere, Kimmo Ronkainen, Stefan Kiechl (+43 others)
2019
OBJECTIVE: Carotid intima-media thickness (CIMT) is a marker of subclinical organ damage and predicts cardiovascular disease (CVD) events in the general population. It has also been associated with vascular risk in people with diabetes. However, the association of CIMT change in repeated examinations with subsequent CVD events is uncertain, and its use as a surrogate end point in clinical trials is controversial. We aimed at determining the relation of CIMT change to CVD events in people with
more » ... abetes. RESEARCH DESIGN AND METHODS: In a comprehensive meta-analysis of individual participant data, we collated data from 3,902 adults (age 33-92 years) with type 2 diabetes from 21 population-based cohorts. We calculated the hazard ratio (HR) per standard deviation (SD) difference in mean common carotid artery intima-media thickness (CCA-IMT) or in CCA-IMT progression, both calculated from two examinations on average 3.6 years apart, for each cohort, and combined the estimates with random-effects meta-analysis. RESULTS: Average mean CCA-IMT ranged from 0.72 to 0.97 mm across cohorts in people with diabetes. The HR of CVD events was 1.22 (95% CI 1.12-1.33) per SD difference in mean CCA-IMT, after adjustment for age, sex, and cardiometabolic risk factors. Average mean CCA-IMT progression in people with diabetes ranged between -0.09 and 0.04 mm/year. The HR per SD difference in mean CCA-IMT progression was 0.99 (0.91-1.08). CONCLUSIONS: Despite reproducing the association between CIMT level and vascular risk in subjects with diabetes, we did not find an association between CIMT change and vascular risk. These results do not support the use of CIMT progression as a surrogate end point in clinical trials in people with diabetes.
doi:10.17863/cam.25232 fatcat:uaj4jm337vffvbwlk55ezjiug4

Tarih'ten Mesnevi'ye Bir Koşuklaştırma Örneği: Âşık Molla Rahim'in Manzum Hazret

Özkan Daşdemir
2014 International Journal Of Turkish Literature Culture Education  
Marry Orr, metinlerarasılığın uzamını genişleterek onu türler arası bir ilişki olarak tanımlamaktadır (Alpaslan, 2007: 14) .  ...  Örneğin, Öcal Oğuz, Âşık Efgan Hikâyesi'nin Gül-Bülbül Efsanesi'nden yola çıkılarak tasnif edildiğini, hikâyedeki semboller ve içeriğin bu sembollerle gösterdiği koşutluklar yoluyla saptamıştır.  ... 
doi:10.7884/teke.231 fatcat:57pvwugwincaha77odtgnt5iee
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