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Small animal fluorescence and bioluminescence tomography: a review of approaches, algorithms and technology update

Chinmay Darne, Yujie Lu, Eva M Sevick-Muraca
2013 Physics in Medicine and Biology  
The authors thank Jessica Nollkamper for her assistance in manuscript preparation.  ...  As shown in table 4, bioluminescence and Cerenkov tomography are conducted using non-contact CCD measurements and require no external illumination for emission.  ...  With the transition of optical tomography from contact to non-contact techniques, changes to instrumentation along with the necessary modifications for corresponding reconstruction algorithms were made  ... 
doi:10.1088/0031-9155/59/1/r1 pmid:24334634 fatcat:tm7nvbyx4rdxlnhy37nojp7hwe

Experimental bioluminescence tomography with fully parallel radiative-transfer-based reconstruction framework

Yujie Lu, Hidevaldo B. Machado, Ali Douraghy, David Stout, Harvey Herschman, Arion F. Chatziioannou
2009 Optics Express  
In contrast, bioluminescence tomography (BLT) promises to provide three dimensional quantitative source information.  ...  Bioluminescence imaging is a very sensitive imaging modality, used in preclinical molecular imaging. However, in its planar projection form, it is non-quantitative and has poor spatial resolution.  ...  We are grateful to Judy Edwards and Waldemar Ladno at the small-animal imaging facility of the Crump Institute for Molecular Imaging for their assistance with mouse experiments.  ... 
doi:10.1364/oe.17.016681 pmid:19770883 pmcid:PMC2790868 fatcat:wby6a7x34ne2jgoi6q6e5tryhu

Adaptive improved element free Galerkin method for quasi- or multi-spectral bioluminescence tomography

Chenghu Qin, Jie Tian, Xin Yang, Jinchao Feng, Kai Liu, Junting Liu, Guorui Yan, Shouping Zhu, Min Xu
2009 Optics Express  
Bioluminescence tomography (BLT) has become a powerful tool for whole-body small animal imaging.  ...  In this contribution, an adaptive improved element free Galerkin method (IEFGM) is presented to perform a quantitative reconstruction of the internal light source using quasi-or multi-spectral information  ...  Thus, this contribution presents an adaptive improved element free Galerkin method (IEFGM) for bioluminescence tomography using quasi-or multi-spectral measurement, and the algorithm performance is validated  ... 
doi:10.1364/oe.17.021925 pmid:19997437 fatcat:3ko7wvmv6jfabfhh2ositlqwxu

Quantitative Bioluminescence Tomography-guided System for Conformal Irradiation In Vivo [article]

Xiangkun Xu, Zijian Deng, Hamid Dehghani, Iulian Iordachita, Michael Lim, John W. Wong, Ken Kang-Hsin Wang
2020 arXiv   pre-print
Recognition of this need led us to develop quantitative bioluminescence tomography (QBLT), which provides strong imaging contrast to localize optical targets.  ...  With multi-projection and multi-spectral bioluminescence imaging and a novel spectral derivative method, our QBLT system is able to reconstruct GBM with localization accuracy <1mm.  ...  Thus, the spatial distribution of bioluminescent tumor is not directly accessible for quantitation with 2D BLI.  ... 
arXiv:2010.02492v1 fatcat:tps4d2z7kngxrk66nknr2xwlgm

Image Guided Biodistribution and Pharmacokinetic Studies of Theranostics

Hong Ding, Fang Wu
2012 Theranostics  
The quantitative measurement of the bio-distribution and pharmacokinetics of theranostics in the fields of new drug/probe development, diagnosis and treatment process monitoring as well as tracking the  ...  Besides anatomical imaging modalities such as computed tomography (CT), magnetic resonance imaging (MRI), molecular imaging strategy including optical imaging, positron emission tomography (PET) and single-photon  ...  several methods for in vivo applications such as bioluminescence imaging, fluorescence imaging, ultrasound, dark field, diffused optical tomography, and optical coherence tomography, etc.  ... 
doi:10.7150/thno.4652 pmid:23227121 pmcid:PMC3516836 fatcat:btayy7av5vb4pf3bp3spooqlta

Bioluminescence tomography with optimized optical parameters

Weimin Han, Kamran Kazmi, Wenxiang Cong, Ge Wang
2007 Inverse Problems  
The goal of BLT is to produce a quantitative reconstruction of a bioluminescent source distribution within a living mouse from bioluminescent signals measured on the body surface of the mouse.  ...  Bioluminescence tomography (BLT) is a rapidly developing new area of molecular imaging.  ...  The authors thank the editorial board member in charge and anonymous referees for the valuable comments.  ... 
doi:10.1088/0266-5611/23/3/022 fatcat:pwxueshyqbh3hgpvfgan2356ku

Single pixel hyperspectral bioluminescence tomography based on compressive sensing

Alexander Bentley, Jonathan E. Rowe, Hamid Dehghani
2019 Biomedical Optics Express  
Specifically, bioluminescence imaging is a sensitive non-invasive and non-contact optical imaging technique that is able to detect distributed (biologically informative) visible and near-infrared activated  ...  Photonics based imaging is a widely utilised technique for the study of biological functions within pre-clinical studies.  ...  Acknowledgments The author would like to acknowledge financial support from EPSRC through a studentship from the Physical Sciences for Health Centre for Doctoral Training (EP/L016346/1).  ... 
doi:10.1364/boe.10.005549 pmid:31799030 pmcid:PMC6865106 fatcat:7dpfsgroh5ajlfspfdmdiz56ju

Fluorescence Molecular Tomography: Principles and Potential for Pharmaceutical Research

Florian Stuker, Jorge Ripoll, Markus Rudin
2011 Pharmaceutics  
Acknowledgements We all acknowledge Swiss National Foundation under Grant SNF 3100-112835 and Grant 310030-126029 and FMT-XCT EU FP7 Grant. J.R. acknowledges the Bill and Melinda Gates Foundation.  ...  Progress in understanding and developing models for describing the light/tissue interaction allowed constructing a framework towards three-dimensional quantitative fluorescence tomography.  ...  (b), Quantitative image analysis of all 20 tumors.  ... 
doi:10.3390/pharmaceutics3020229 pmid:24310495 pmcid:PMC3864234 fatcat:oyflhcyu4rbaflinrekxvddiiy

Multi-modal molecular diffuse optical tomography system for small animal imaging

James A Guggenheim, Hector R A Basevi, Jon Frampton, Iain B Styles, Hamid Dehghani
2013 Measurement science and technology  
A multi-modal optical imaging system for quantitative 3D bioluminescence and functional diffuse imaging is presented, which has no moving parts and uses mirrors to provide multi-view tomographic data for  ...  be used as prior knowledge for bioluminescence imaging within the visible spectrum.  ...  Here an all-optical, multi-modal imaging system is presented for performing quantitative volumetric and spatially resolved BLI via BLT alongside spectral diffuse optical tomography (DOT) for the reconstruction  ... 
doi:10.1088/0957-0233/24/10/105405 pmid:24954977 pmcid:PMC4061700 fatcat:tiberx6ivjeqbfuffi6frmm4wm

Image reconstruction for bioluminescence tomography from partial measurement

Ming Jiang, Tie Zhou, Jiantao Cheng, Wenxiang Cong, Ge Wang
2007 Optics Express  
The bioluminescence tomography is a novel molecular imaging technology for small animal studies.  ...  Known reconstruction methods require the completely measured data on the external surface, although only partially measured data is available in practice.  ...  More advanced techniques should be used to improve this process, such as the recently proposed non-contact measurement technique for fluorescence tomography [56] .  ... 
doi:10.1364/oe.15.011095 pmid:19547465 fatcat:vblf6rf6drde3ouzc5uzk5ua6u

Front Matter: Volume 10251

2017 Biomedical Imaging and Sensing Conference  
Publication of record for individual papers is online in the SPIE Digital Library. SPIEDigitalLibrary.org Paper Numbering: Proceedings of SPIE follow an e-First publication model.  ...  These two-number sets start with 00, 01, 02, 03, 04, 05, 06, 07, 08, 09, 0A, 0B ... 0Z, followed by 10-1Z, 20-2Z, etc. The CID Number appears on each page of the manuscript.  ...  the position tolerance of intraocular lenses in a model eye [10251-41] Holographic 3D multi-spot two-photon excitation for fast optical stimulation in brain [10251-42] 10251 18 Non-contact local  ... 
doi:10.1117/12.2280106 fatcat:ckg5k47r4ndjxjzlu36riy45nu

3D reconstruction of light flux distribution on arbitrary surfaces from 2D multi-photographic images

Xueli Chen, Xinbo Gao, Duofang Chen, Xiaopeng Ma, Xiaohui Zhao, Man Shen, Xiangsi Li, Xiaochao Qu, Jimin Liang, Jorge Ripoll, Jie Tian
2010 Optics Express  
Optical tomography can demonstrate accurate three-dimensional (3D) imaging that recovers the 3D spatial distribution and concentration of the luminescent probes in biological tissues, compared with planar  ...  To handle this problem, a novel and effective method is proposed in this paper to determine the surface flux distribution from multi-view 2D photographic images acquired by a set of non-contact detectors  ...  Lastly, quantitative reconstruction (for example for bioluminescent sources) is still lacking in this approach both for the reconstruction of the surface flux and for the internal light source, since they  ... 
doi:10.1364/oe.18.019876 pmid:20940879 fatcat:vnehbff5ozahvbyghrnhcudita

An integrated solution and analysis of bioluminescence tomography and diffuse optical tomography

Weimin Han, Wenxiang Cong, Kamran Kazmi, Ge Wang
2009 Communications in Numerical Methods in Engineering  
While diffuse optical tomography (DOT) has been studied for years, bioluminescence tomography (BLT) is emerging as a promising optical molecular imaging tool.  ...  BLT is for reconstruction of a bioluminescent source distribution in a medium such as a mouse from surface measurements induced by internal bioluminescent sources.  ...  Bioluminescence tomography (BLT) we have been developing since 2002 is an emerging optical molecular imaging tool.  ... 
doi:10.1002/cnm.1163 pmid:21709770 pmcid:PMC3121333 fatcat:doo2atez2zfv5kk7osggmldpc4

ESTRO ACROP: Technology for precision small animal radiotherapy research: Optimal use and challenges

Frank Verhaegen, Ludwig Dubois, Stefano Gianolini, Mark A. Hill, Christian P. Karger, Kirsten Lauber, Kevin M. Prise, David Sarrut, Daniela Thorwarth, Christian Vanhove, Boris Vojnovic, Robert Weersink (+2 others)
2018 Radiotherapy and Oncology  
It also provides guidelines for reporting on studies.  ...  radiotherapy research centers have recently installed novel research platforms enabling the investigation of the radiation response of tumors and normal tissues in small animal models, possibly in combination with  ...  Acknowledgements The authors would like to thank Dr Julia Mannheim and Dr Lucas Persoon for comments on the manuscript. Appendix A.  ... 
doi:10.1016/j.radonc.2017.11.016 pmid:29269093 fatcat:ky3fvvu6ojhmvkavhms2zlzvsi

Feasibility study of near-infrared fluorescence tomography using a positron emission tomograph equipped with depth-of-interaction PET detectors

Hideaki Tashima, Takashi Obi, Taiga Yamaya, Hideo Murayama, Keishi Kitamura, Ichiro Oda, Masahiro Yamaguchi, Nagaaki Ohyama
2009 Radiological Physics and Technology  
We are currently developing an imaging system that combines simultaneous positron emission tomography (PET) with near-infrared (NIR) optical tomography, thus supporting two different types of molecular  ...  We then evaluated imaging systems for 3D fluorescence tomography with different detector resolutions and excitation light arrangements using singular-value analysis and imaging simulation.  ...  Acknowledgment Some of this work was supported by the Japan Society for the Promotion of Science (JSPS) within the framework of the Global COE Program ''Photonics Integration-Core Electronics'' and the  ... 
doi:10.1007/s12194-009-0065-2 pmid:20821119 fatcat:y76hbgwjb5ffbc2i4qwrxmaile
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