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Financial stability, along with the improvement of stress resistance of financial sector and efficient distribution of resources in the real economy, is important for the sustainable development of the economy. The central bank together with other state institutions supervises financial stability, but this cannot be just a national matter if we consider an open economy. Systemic risk affects the financial stability and this can be defined as a state of being in which systemic risk occurrence isdoaj:d08d4bb988ac40718b1b027dd411ceb1 fatcat:vtjeprvlvvhghhefrw7nfm3t5q
more »... prevented. Identification and proper assessment of systemic risk are the foundation for appropriate macro prudential instrument and progress were made after the financial crises. The paper follows theoretical aspects present in the literature and the enhancement of the practice used for the systemic risk analysis and the insurance of the financial stability in our country.
The current literature available on databases in medicine and related areas clearly shows a remarkable growth of knowledge in neuro-degenerative and cerebrovascular diseases. However, it shows an equally remarkable gap between the 'neurodegenerative field' and the 'vascular field'. Research ondoi:10.17925/enr.2008.03.01.52 fatcat:hwojkluoxff5xkh7tjiainoiji
Computer, Intelligent Computing and Education Technology
SOLOMON 1 , *S. ALINA 2 & W. ETA 3 , M. A. ... @uthm.edu.my, 3 email@example.com and 4 firstname.lastname@example.org *Corresponding author: email@example.com ...doi:10.1201/b16698-190 fatcat:4cfxm7uuhfbyrcb662dfdncye4
Alzheimer's disease is the most common cause of dementia in elderly people. Research into Alzheimer's disease therapy has been at least partly successful in terms of developing symptomatic treatments, but has also had several failures in terms of developing disease-modifying therapies. These successes and failures have led to debate about the potential defi ciencies in our understanding of the pathogenesis of Alzheimer's disease and potential pitfalls in diagnosis, choice of therapeuticdoi:10.1016/s1474-4422(10)70119-8 pmid:20610346 fatcat:s4ds5yvra5eijpbpsq3ej6ymiu
more »... development of drug candidates, and design of clinical trials. Many clinical and experimental studies are ongoing, but we need to acknowledge that a single cure for Alzheimer's disease is unlikely to be found and that the approach to drug development for this disorder needs to be reconsidered. Preclinical research is constantly providing us with new information on pieces of the complex Alzheimer's disease puzzle, and an analysis of this information might reveal patterns of pharmacological interactions instead of single potential drug targets. Several promising randomised controlled trials are ongoing, and the increased collaboration between pharmaceutical companies, basic researchers, and clinical researchers has the potential to bring us closer to developing an optimum pharmaceutical approach for the treatment of Alzheimer's disease. Disease stage Symptomatic activity* Potential neuroprotective activity AChEIs: improve cognition, behaviour, and functional and global clinical state Donepezil † All stages 3,4,15 Huperzine-A ‡ Approved in China for mild-to-moderate stages; dietary supplement in some countries 5 AChEI Modulates APP processing by enhancing soluble APPα secretion; antioxidant, anti-apoptotic eff ects; mitochondrial protection 2,6 NMDA receptor antagonists: improve cognition, behaviour, and functional state Memantine Moderate to severe (monotherapy and in combination with AChEI) 10-14 Uncompetitive, voltage-dependent NMDA receptor antagonist Decreases Aβ toxicity; prevents hyperphosphorylation of tau; decreases microglia-associated infl ammation; increases release of neurotrophic factors from astroglia 7-9 The proposed mechanisms of activity for the diff erent drugs and the indicated disease stage for treatment are shown. 2-15 Aβ=amyloid β. APP=amyloid precursor protein. AChEI=acetylcholinesterase inhibitor. BChEI=butyrylcholinesterase inhibitor. *Donepezil, rivastigmine, galantamine, and huperzine-A all increase cholinergic transmission, whereas memantine decreases glutamate excitotoxicity. †Approved for all stages of Alzheimer's disease in several countries, including the USA, but not in Europe. ‡Published results on randomised controlled trials outside China are not available; optimum therapeutic dosages not yet clear.
Dementia is an acquired disabling syndrome characterized by progressive deterioration in multiple cognitive domains and is severe enough to interfere with daily functioning. Alzheimer's disease (AD) is the most common cause of dementia, but increasing evidence from population-based neuropathological and neuroimaging studies shows that mixed brain pathologies (neurodegenerative and vascular) account for most dementia cases, especially in very old people [1, 2] . Both prevalence and incidence ofdoi:10.1186/alzrt104 pmid:22339927 pmcid:PMC3471409 fatcat:vxyyoy76trd5hod7iaxbtscs4u
more »... ementia rise exponentially with advancing age, and 70% of all dementia cases occur in people who are at least 75 years old  . Th e worldwide increase in the number of older adults, more pronounced in those who are at least 80 years old, explains the epidemic proportions assumed by dementia. Because dementia is a major cause of disability in and institutionalization of older people, the increased preva lence of this syndrome places enormous pressures on health-care systems and society. Th e World Alzheimer Report estimates that, in 2010, the number of people with dementia worldwide was 35.6 million and that this will increase to 65.7 million by 2030 and 115.4 million by 2050 unless eff ective means of reducing the incidence of this disease are introduced  . In 2010, the total estimated worldwide costs of dementia were USD $604 billion, including the costs of informal care (unpaid care provided by family and others), direct costs of social care (provided by community care professionals and in residential home settings), and the direct costs of medical care (the costs of treating Abstract Dementia, a major cause of disability and institutionalization in older people, poses a serious threat to public health and to the social and economic development of modern society. Alzheimer's disease (AD) and cerebrovascular diseases are the main causes of dementia; most dementia cases are attributable to both vascular and neurodegenerative brain damage. No curative treatment is available, but epidemiological research provides a substantial amount of evidence of modifi able risk and protective factors that can be addressed to prevent or delay onset of AD and dementia. Risk of late-life dementia is determined by exposures to multiple factors experienced over the life course, and the eff ect of specifi c risk/protective factors depends largely on age. Moreover, cumulative and combined exposure to diff erent risk/protective factors can modify their eff ect on dementia/AD risk. Multidisciplinary research involving epidemiology, neuropathology, and neuroimaging has provided suffi cient evidence that vascular risk factors signifi cantly contribute to the expression and progression of cognitive decline (including dementia) but that active engagement in social, physical, and mentally stimulating activities may delay the onset of dementia. However, these fi ndings need to be confi rmed by randomized controlled trials (RCTs). A promising strategy for preventing dementia is to implement intervention programs that take into account both the life-course model and the multifactorial nature of this syndrome. In Europe, there are three ongoing multidomain interventional RCTs that focus on the optimal management of vascular risk factors and vascular diseases. The RCTs include medical and lifestyle interventions and promote social, mental, and physical activities aimed at increasing the cognitive reserve. These studies will provide new insights into prevention of cognitive impairment and dementia. Such knowledge can help researchers plan larger, international prevention trials that could provide robust evidence on dementia/AD prevention. Taking a step in this direction, researchers involved in these European RCTs recently started the European Dementia Prevention Initiative, an international collaboration aiming to improve strategies for preventing dementia.
et al., 2013; Solomon, 2015] . ... ., 2013; Hayden, 2014 , Solomon, 2015 . ...doi:10.1159/000438732 pmid:26778943 pmcid:PMC4702011 fatcat:s6acrox2gvgcrlbpfcj4wtbuti
Journal of Alzheimer's Disease & Parkinsonism
ARS Medica Tomitana
Molar pregnancies results from a tainted fertilization process. Trophoblastic thyroidian hyper function is an unusual complication of a molar pregnancy. The degree of thyroid stimulation and the severity of clinical hyperthyroidism is directly proportional to HCG concentration. Human chorionic gonadotrophin is almost identical with TSH, luteinizing hormone (LH) and follicle-stimulating hormone, this analogy in the structure will cause cross-reactivity with their receptors. Hyperthyroid statusdoi:10.1515/arsm-2017-0021 fatcat:crwukq7jqba6rklqzpvo6w4nne
more »... n vary from asymptomatic hyper function to thyroid storm. Dilation and curettage represents the treatment for hyperthyroidism in molar pregnancy. Awareness of this condition is important for diagnosis and treatment.
Innovation in aging
WORLD-WIDE FINGERS: AN INTERNATIONAL NETWORK OF LINKED MULTIDOMAIN TRIALS Francesca Mangialasche, 1 Alina Solomon, 2 Tiia Ngandu, 3 and Miia Kivipelto, 2 1. ...doi:10.1093/geroni/igab046.259 fatcat:e2j5hbobj5dznlptppd627enee
Beginning with the traditional methods of cooperation between states, as of 1962, on the suggestion of the European Commission the grounds were set for a project of particular importance, respectively the achievement of the Economic and Monetary Union, a project that may be regarded as a modern approach of the European construction.Starting from this hypothesis, in the paper we have made an analysis of the outcomes achieved as result of the measures adopted by Romania in view of integrationdoi:10.1016/j.sbspro.2012.09.124 fatcat:5th4v2ja5vbirgh4tyq7j446i4
more »... the Euro-area, highlighting the special impact that this process generates on the national fiscal and budgetary policy, on the business and social environment at large.Yet, the Eurothe targets established in the Maastricht Treaty, by instruments of fiscal-budgetary and monetary policy, as this justifies the comparative analysis of the development of earnings level and budgetary expenditures of Romania with the ones recorded in the European Union, by particularising the Euro-area, but also the analysis of budgetary prospects on medium-and long-term, realised in the present work.
This perspective calling into question the maintenance of a state of fiscal sustainability; in other words, a new design concept macroeconomic solvency linked to the government (Solomon, 2015) . ...doi:10.6007/ijarafms/v7-i1/2703 fatcat:sgcrix6jifgbvmvolqabcwnqsu
it is well accepted that expression of mutant p53 involves the gain of oncogenic-specific activities accentuating the malignant phenotype. Depending on the specific cancer type, mutant p53 can contribute to either the early or the late events of the multiphase process underlying the transformation of a normal cell into a cancerous one. This multifactorial system is evident in ~50% of human cancers. Mutant p53 was shown to interfere with a variety of cellular functions that lead to augmenteddoi:10.1093/carcin/bgu073 pmid:24658181 fatcat:trofwtod6nczzkjxvpcj6m3o2q
more »... survival, cellular plasticity, aberration of DNA repair machinery and other effects. All these effects culminate in the acquisition of drug resistance often seen in cancer cells. interestingly, drug resistance has also been suggested to be associated with cancer stem cells (CSCs), which reside within growing tumors. The notion that p53 plays a regulatory role in the life of stem cells, coupled with the observations that p53 mutations may contribute to the evolvement of CSCs makes it challenging to speculate that drug resistance and cancer recurrence are mediated by CSCs expressing mutant p53.
Journal of Neurology
performance on global cognition [β-coefficient, −0.02; 95% confidence interval (CI), −0.05 to −0.00], and processing speed [β −0.03, CI −0.05 to −0.01]. Results remained significant after adjusting for potential confounders. Workrelated stress was not significantly associated with episodic memory, executive functioning, verbal fluency or manual dexterity. This study shows that global cognition and processing speed may be particularly susceptible to the effects of midlife work-related stress.doi:10.1007/s00415-017-8571-3 pmid:28821958 pmcid:PMC5587634 fatcat:s74nx6mf5rfgjgeaq5k35cmluq
Protected by copyright. 7 Solomon A, et al. ... BMJ Open 2018;8:e021017. doi:10.1136/bmjopen-2017-021017 4 Solomon A, et al. ...doi:10.1136/bmjopen-2017-021017 pmid:30782589 pmcid:PMC6318591 fatcat:skr4xm7su5bithearfaulhrka4
In honor of John Tarbell, herein, I and Solomon Mensah, along with our research team member Alina Nersesyan, provide a brief review of research that took place shortly after we moved on from John Tarbell's ... I am honored to have been selected to contribute to this issue with an article that summarizes the dissertation of one of my first PhD students, Solomon Mensah, who I initially met in Dr. ...doi:10.1007/s13239-020-00487-7 pmid:33000443 fatcat:4koadjt2dragve7wxnfsucxq3a
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