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Sources and implications of deep uncertainties surrounding sea-level projections

Alexander M. R. Bakker, Domitille Louchard, Klaus Keller
2016 Climatic Change  
The continuous lines are fitted beta-distributions assuming an 3.3-m (i.e., total disintegration) upper limit.  ...  From a robust decision-making perspective, conservative projections may be preferable to overconfident projections (see for example the discussions in Herman et al. 2015 and Bakker et al. 2016 Fig.  ... 
doi:10.1007/s10584-016-1864-1 fatcat:k22ml5dfefc4pkd7o3tbnaptsa

Slow fertilization of stickleback eggs: the result of sexual conflict?

Theo C M Bakker, Marc Zbinden, Joachim G Frommen, Alexander Weiss, Carlo R Largiadèr
2006 BMC Ecology  
TCMB & M.  ...  In fish of the Texel population sperm number in left and right testes were not significantly different (paired t test, t = 0.90, df = 12, P = 0.39) and correlated well (r p = 0.72, N = 12, P = 0.009) (  ... 
doi:10.1186/1472-6785-6-7 pmid:16712724 pmcid:PMC1481549 fatcat:ebfwkdsv2bggtibxyox3pq456m

The effects of time-varying observation errors on semi-empirical sea-level projections

Kelsey L. Ruckert, Yawen Guan, Alexander M. R. Bakker, Chris E. Forest, Klaus Keller
2016 Climatic Change  
The projected 90% probability ranges in 2050 differ by up to 0.11 m; Bootstrap (0.23-0.33 m), homoskedastic Bayesian (0.19-0.32 m), to heteroskedastic Bayesian (0.14-0.35 m) (Fig. 2c) .  ...  0.42 m; this difference corresponds to a 40% increase (Fig. 4f) .  ... 
doi:10.1007/s10584-016-1858-z fatcat:3y6pmg5eafa6pmaegwxucpdqke

Estimation of persistence and trends in geostrophic wind speed for the assessment of wind energy yields in Northwest Europe

Alexander M. R. Bakker, Bart J. J. M. van den Hurk
2011 Climate Dynamics  
M. R. Bakker, B. J. J. M van den Hurk: Persistence and trends in wind climate in Northwest Europe 771 using the slp-gradient between the four surrounding grid points.  ...  A distinct increase has been reported from the 1960s until the mid 1990s (Pryor and Barthelmie 2003; Alexander et al. 2005) .  ... 
doi:10.1007/s00382-011-1248-1 fatcat:rlyme72a3rb77fmf5cyvpexmmm

Sea-level projections representing the deeply uncertain contribution of the West Antarctic ice sheet

Alexander M. R. Bakker, Tony E. Wong, Kelsey L. Ruckert, Klaus Keller
2017 Scientific Reports  
The probabilistic part of the sea-level projections for 2050 yields 90% credible ranges of 0.19-0.32 m (RCP2.6), 0.21-0.34 m (RCP4.5), and 0.23-0.37 m (RCP8.5) sea level relative to 1986-2005 mean sea  ...  This GIS contribution increases the 90% credible ranges for 2100 to 0.40-0.71 m (RCP2.6), 0.54-0.97 m (RCP4.5), and 0.85-1.59 m (RCP8.5) sea level in 2100, relative to 1986-2005 mean sea level (Fig. 2  ...  Bakker and K. Keller designed the research. A. Bakker designed the initial figures and wrote the first draft. T. Wong and K. Ruckert took care of the major part of the coding.  ... 
doi:10.1038/s41598-017-04134-5 pmid:28634375 pmcid:PMC5478629 fatcat:5xgyz2wm55ey3md4b2mxfj5zsy

IR photofragmentation of the Phenyl Cation: Spectroscopy and Fragmentation Pathways

Sandra Denise Wiersma, Alessandra Candian, Joost M. Bakker, Giel Berden, John R Eyler, Jos Oomens, Alexander G. G. M. Tielens, Annemieke Petrignani
2021 Physical Chemistry, Chemical Physics - PCCP  
We present the gas-phase infrared spectra of the phenyl cation, phenylium, in its perprotio C6H5+ and perdeutero C6D5+ forms, in the 260--1925 cm-1 (5.2-38 μm) spectral range, and investigate the...  ...  The m/z = 50 and 49 channels appear mostly along this dominant m/z = 51 mass, while the m/z = 37 channel only appears at the most intense resonances.  ...  Four fragment ions are observed at m/z =51, 50, 49 and 37 in addition to the parent ion at m/z = 77.  ... 
doi:10.1039/d0cp05554a pmid:33587740 fatcat:umnisuzwq5gkjld4mjfsgqt3ky

BRICK v0.2, a simple, accessible, and transparent model framework for climate and regional sea-level projections

Tony E. Wong, Alexander M. R. Bakker, Kelsey Ruckert, Patrick Applegate, Aimée B. A. Slangen, Klaus Keller
2017 Geoscientific Model Development  
BRICK is written in R and Fortran.  ...  R Core Team, 2016).  ...  of mass on the Antarctic Ice Sheet (m 3 yr −1 ), T A is the Antarctic surface temperature reduced to sea level ( • C), S is the sea level (m), R is the Antarctic Ice Sheet radius (m), and F is the ice  ... 
doi:10.5194/gmd-10-2741-2017 fatcat:mzvklxihd5emvgtnihymxfjguq

Large-scale winds in the southern North Sea region: the wind part of the KNMI'14 climate change scenarios

Andreas Sterl, Alexander M R Bakker, Henk W van den Brink, Rein Haarsma, Andrew Stepek, Ine L Wijnant, Renske C de Winter
2015 Environmental Research Letters  
Res. 14 71-3 Bakker A M R and van den Hurk B J J M 2012 Estimation of persistence and trends in geostrophic wind speed for theassessment of wind energy yields in Northwest Europe Clim.  ...  Dyn. 39 767-82 Bakker A M R, van den Hurk B J J M and Coelingh J P 2013 Decomposition of the windiness index in the Netherlands for the assessment of future long-term wind supply Wind Energy 16 927-36  ... 
doi:10.1088/1748-9326/10/3/035004 fatcat:bz75q4qypfhozigi7z6wol655e

Translational PK-PD modeling analysis of MCLA-128, a HER2/HER3 bispecific monoclonal antibody, to predict clinical efficacious exposure and dose

Aurelia H. M. de Vries Schultink, Robert P. Doornbos, Alexander B. H. Bakker, Kees Bol, Mark Throsby, Cecile Geuijen, David Maussang, Jan H. M. Schellens, Jos H. Beijnen, Alwin D. R. Huitema
2018 Investigational new drugs  
Software Data management, graphical evaluation and simulations were performed using R (version 3.0.1) [16] .  ...  This K m is in the same order of magnitude as the K m of MCLA-128 used in the sensitivity analysis (2.19 mg/L).  ...  Compliance with ethical standards Conflict of interest Robert Doornbos, Alexander Bakker, Kees Bol, Mark Throsby, Cecile Geuijen and David Maussang are employees of Merus N.V.  ... 
doi:10.1007/s10637-018-0593-x pmid:29728897 fatcat:nmnjlhmws5avvhgnevu6xvkhme

Evaluation of dextran(ethylene glycol) hydrogel films for giant unilamellar lipid vesicle production and their application for the encapsulation of polymersomes

Nestor Lopez Mora, Yue Gao, M. Gertrude Gutierrez, Justin Peruzzi, Ivan Bakker, Ruud J. R. W. Peters, Bianka Siewert, Sylvestre Bonnet, Roxanne E. Kieltyka, Jan C. M. van Hest, Noah Malmstadt, Alexander Kros
2017 Soft Matter  
As a comparison, we also determined the T m of DOPC in the presence of a gel consisting solely of disulphide crosslinked PEG (2 wt% of 5).  ...  The melting temperature (T m ) of DOPC lipids in the presence and absence of the DexPEG film was determined by differential scanning calorimetry (DSC).  ... 
doi:10.1039/c7sm00551b pmid:28730206 pmcid:PMC5586486 fatcat:4i5ecanhurgubp73auznqkba3q

Packaging signals in single-stranded RNA viruses: nature's alternative to a purely electrostatic assembly mechanism

Peter G. Stockley, Reidun Twarock, Saskia E. Bakker, Amy M. Barker, Alexander Borodavka, Eric Dykeman, Robert J. Ford, Arwen R. Pearson, Simon E. V. Phillips, Neil A. Ranson, Roman Tuma
2013 Journal of biological physics (Print)  
This effect is reduced when we compare discrimination of MS2 and STNV RNAs at typical in vitro reassembly concentrations (≥10 μM) [14] .  ...  nanomolar concentrations range (∼1 nM for RNA & ∼100 nM for CP), which are much more reflective of early concentrations within infected cells than most in vitro assays where CP concentrations of ≥10 μM  ... 
doi:10.1007/s10867-013-9313-0 pmid:23704797 pmcid:PMC3662417 fatcat:sobmmfbknfg7dj3kxj7gdpx3xm

Snake Venom Gland Organoids

Yorick Post, Jens Puschhof, Joep Beumer, Harald M. Kerkkamp, Merijn A.G. de Bakker, Julien Slagboom, Buys de Barbanson, Nienke R. Wevers, Xandor M. Spijkers, Thomas Olivier, Taline D. Kazandjian, Stuart Ainsworth (+19 others)
2020 Cell  
g a n o id s : d if f e r e n t ia t io n O r g a n o id s : e x p a n s io n O r g a n o id s : e a r ly p a s s a g e V e n o m g la n d t is s u e L iv e r t is  ...  Maimets, M., Rocchi, C., Bron, R., Pringle, S., Kuipers, J., Giepmans, B.N., Vries, R.G., Clevers, H., de Haan, G., van Os, R., and Coppes, R.P. (2016).  ... 
doi:10.1016/j.cell.2019.11.038 pmid:31978343 fatcat:2zsqrasdhjfkvdqadabu7oy5nq

Impacts of Antarctic fast dynamics on sea-level projections and coastal flood defense

Tony E. Wong, Alexander M. R. Bakker, Klaus Keller
2017 Climatic Change  
The physical models are coded in Fortran 90 and called from driver scripts coded in the R Programming Language. The analysis was performed using RStudio (Version 0.99.903).  ...  ,000 years BCE, -11.35 m SLE, 2.23 m SLE; 4,000 years BCE, -2.63 m SLE, 0.68 m SLE; and 2002 CE, 0.00197 m SLE, 0.00046 m SLE Table .  ...  (a) surface temperature anomaly (C), (b) ocean heat uptake (10 22 J), (c) glaciers and small ice caps (m SLE), (d) Greenland Ice Sheet (m SLE), (e) thermal expansion (m SLE), (f) total sea level (m SLE  ... 
doi:10.1007/s10584-017-2039-4 fatcat:b7zevqiopnfmtoil4sgdvvzvze

Pancreatitis, very early compared with normal start of enteral feeding (PYTHON trial): design and rationale of a randomised controlled multicenter trial

Olaf J Bakker, Hjalmar C van Santvoort, Sandra van Brunschot, Usama Ahmed Ali, Marc G Besselink, Marja A Boermeester, Thomas L Bollen, Koop Bosscha, Menno A Brink, Cornelis H Dejong, Erwin J van Geenen, Harry van Goor (+16 others)
2011 Trials  
Dutch Pancreatitis Study Grp (2011). Pancreatitis, very early compared with normal start of enteral feeding (PYTHON trial): design and rationale of a randomised controlled multicenter trial. TRIALS, 12, [73]. Abstract Background: In predicted severe acute pancreatitis, infections have a negative effect on clinical outcome. A start of enteral nutrition (EN) within 24 hours of onset may reduce the number of infections as compared to the current practice of starting an oral diet and EN if
more » ... at 3-4 days after admission. Methods/Design: The PYTHON trial is a randomised controlled, parallel-group, superiority multicenter trial. Patients with predicted severe acute pancreatitis (Imrie-score ≥ 3 or APACHE-II score ≥ 8 or CRP > 150 mg/L) will be randomised to EN within 24 hours or an oral diet and EN if necessary, after 72 hours after hospital admission. During a 3-year period, 208 patients will be enrolled from 20 hospitals of the Dutch Pancreatitis Study Group. The primary endpoint is a composite of mortality or infections (bacteraemia, infected pancreatic or peripancreatic necrosis, pneumonia) during hospital stay or within 6 months following randomisation. Secondary endpoints include other major morbidity (e.g. new onset organ failure, need for intervention), intolerance of enteral feeding and total costs from a societal perspective. Discussion: The PYTHON trial is designed to show that a very early (< 24 h) start of EN reduces the combined endpoint of mortality or infections as compared to the current practice of an oral diet and EN if necessary at around 72 hours after admission for predicted severe acute pancreatitis.
doi:10.1186/1745-6215-12-73 pmid:21392395 pmcid:PMC3068962 fatcat:v2j7u6d5sran7bq67rlpk2ihuq

A cryogenic imaging x-ray spectrometer for XEUS readout by frequency-division SQUID multiplexers

Piet A. J. de Korte, John J. van Baar, Norman H. R. Baars, Frank E. Bakker, Wouter M. Bergmann Tiest, Marcel P. Bruijn, Alexander Germeau, Henk F. C. Hoevers, Mikko Kiviranta, Eric Krouwer, Jan van der Kuur, Marco P. Lubbers (+5 others)
2004 High-Energy Detectors in Astronomy  
Measurements indicate that the phonon mfp is 110 µm for a 40 µm wide Si-beam.  ...  For R ESR ≈ 1 mΩ the Q-factor (1/Q = ωCR ESR ) of the capacitors has to be between 670 and 6700 for carrier frequencies between 1 and 10 MHz, respectively.  ... 
doi:10.1117/12.552933 fatcat:6z53qg6htzgp7lt6n6py5pcfiy
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