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Recursive Monte Carlo and Variational Inference with Auxiliary Variables
[article]
2022
arXiv
pre-print
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We adapt the generative model of Lew et al. [18] . ...
agglomerative clustering algorithm as a proposal, outperforming strong baselines on a standard benchmark from astronomy [15] and a challenging data-cleaning problem using Medicare data [22] , adapted from Lew ...
The meta-posterior approximation must solve two new challenges: recovering the rejected q samples x 1:K from the posterior approximation, and recovering the many unused rejection loops (and the suffix ...
arXiv:2203.02836v1
fatcat:l4iwitv55nfsrot6frsasyqv4y
Automating Involutive MCMC using Probabilistic and Differentiable Programming
[article]
2020
arXiv
pre-print
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For each finite set of keys K, we make V K a measure space using the standard product σ-algebra Σ K = ⊗ k∈K Σ k and the product measure µ K = × k∈K µ k . ...
The probability mass is distributed among the finite sets of keys K ⊆ K: 1 = K⊆K |K|<∞ x1 R d K p((K, (x 1 , x 2 )))dx 2 (1) where d K := k∈K∩J d k is the total continuous dimension for keys K, and where ...
z (A)µ(dz) = K π(z)k z (Z)µ(dz) = K π(z)µ(dz) for all A ∈ Σ ...
arXiv:2007.09871v2
fatcat:bbfgkqnfszexxkr2kxysw5oz7u
Towards Denotational Semantics of AD for Higher-Order, Recursive, Probabilistic Languages
[article]
2021
arXiv
pre-print
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Marco F Cusumano-Towner, Feras A Saad, Alexander K Lew, and Vikash K Mansinghka. Gen: a
general-purpose probabilistic programming system with programmable inference. ...
Marco Cusumano-Towner, Alexander K Lew, and Vikash K Mansinghka. Automating involutive
mcmc using probabilistic and differentiable programming. arXiv preprint arXiv:2007.09871, 2020. ...
arXiv:2111.15456v2
fatcat:3nhzpfr5u5cstonw7slwrz7co4
Trace types and denotational semantics for sound programmable inference in probabilistic languages
2019
Proceedings of the ACM on Programming Languages (PACMPL)
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⊢ mix K p k 1 k 2 : K τ I ∪J σ j Γ ⊢ n : N Γ ⊢ k : K τ σ Γ ⊢ repeat K n k : K τ σ Γ ⊢ b : τ → B Γ ⊢ k : K (τ + + σ ) σ Γ ⊢ if K b k : K τ σ seq K k 1 k 2 = λ µ t . ...
Composition of Stationary Kernels for Custom MCMC Schedules Γ ⊢ k 1 : K τ ( I σ i ) Γ ⊢ k 2 : K τ ( J σ j ) Γ ⊢ seq K k 1 k 2 : K τ I ∪J σ j Γ ⊢ p : U Γ ⊢ k 1 : K τ ( I σ i ) Γ ⊢ k 2 : K τ ( J σ j ) Γ ...
doi:10.1145/3371087
fatcat:kf4vfvzt7rdvzencdtksbk3moq
Gen: a general-purpose probabilistic programming system with programmable inference
2019
Proceedings of the 40th ACM SIGPLAN Conference on Programming Language Design and Implementation - PLDI 2019
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The kernel G k maps (y, z) ∈ Y × Z to a new state y ′ ∈ Y. ...
Each application of G k is assigned an address namespace i ∈ {1 . . . n}. ...
doi:10.1145/3314221.3314642
dblp:conf/pldi/Cusumano-Towner19
fatcat:bmjwmh7jhjf33gg6dywrdjop7y
PClean: Bayesian Data Cleaning at Scale with Domain-Specific Probabilistic Programming
[article]
2020
arXiv
pre-print
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F., Lew, A. K., Saad, F. A., and Mansinghka,
V. K. (2019). Gen: A general-purpose proba-
bilistic programming system with programmable
inference. ...
K)} Set φ u (v u | {v u } u ∈P a(u) ) = 1[v u = v K .X] v K ∈ R (i−1) φ Π T (C obs .K).X (v u | {v u } u ∈P a Π (T (C obs .K).X) ) v K = new K 1[v u = v u .X ] v K = new u , u = K else Set P ...
arXiv:2007.11838v4
fatcat:navjwv7vpfbzhaq4mugkbucvve
A Bidirectional System for the Dynamic Small Molecule Control of Intracellular Fusion Proteins
2013
ACS Chemical Biology
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We found that HALTS1 binds HaloTag7 in vitro with a K d of 143 nM, an enthalpy of −10.7 kcal/mol, and entropy of −4.8 cal/mol/deg. ...
doi:10.1021/cb400569k
pmid:23978068
pmcid:PMC4113957
fatcat:5wa7dtvrifdtfi2pj56zvnz66q
Platelet PD-L1 suppresses anti-cancer immune cell activity in PD-L1 negative tumors
2020
Scientific Reports
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Strategies that interfere with the binding of the receptor programmed cell death protein-1 (PD-1) to programmed death ligand-1 (PD-L1) have shown marked efficacy against many advanced cancers, including those that are negative for PD-L1. Precisely why patients with PD-L1 negative tumors respond to PD-1/PD-L1 checkpoint inhibition remains unclear. Here, we show that platelet-derived PD-L1 regulates the growth of PD-L1 negative tumors and that interference with platelet binding to PD-L1 negative
doi:10.1038/s41598-020-76351-4
pmid:33168847
fatcat:utnavuofg5abplz3jr3u4tftdi
more »
... ancer cells promotes T cell-induced cancer cytotoxicity. These results suggest that the successful outcomes of PD-L1 based therapies in patients with PD-L1 negative tumors may be explained, in part, by the presence of intra-tumoral platelets. Altogether, our findings demonstrate the impact of non-cancer/non-immune cell sources of PD-L1 in the tumor microenvironment in the promotion of cancer cell immune evasion. Our study also provides a compelling rationale for future testing of PD-L1 checkpoint inhibitor therapies in combination with antiplatelet agents, in patients with PD-L1 negative tumors.
Page 260 of The Russian Review Vol. 11, Issue 4
[page]
1952
The Russian Review
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Rev. by Vladimir Petrov Micklesen, Lew R.: W. K. Matthews’ Languages of the U.S.S.R..
Moscow Students’ Movement, The Reminiscences of. Ivan Kheraskov ...
K.: Languages of the U.S.S.R. Rev. by Lew R. Micklesen Mazour, A. G.: Russia, Past and Present. Rev. by C. E. Black. . Mead, Margaret: Soviet Attitudes Toward Authority. ...
Page 260 of The Russian Review Vol. 11, Issue 4
[page]
1952
The Russian Review
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Micklesen, Lew R.: W. K. Matthews’ Languages of the U.S.S.R..
Moscow Students’ Movement, The Reminiscences of. Ivan
Kheraskov ...
K.: Languages of the U. S.8.R. Rev. by Lew R. Micklesen
Mazour, A. G.: Russia, Past and Present. Rev. by C. E. Black.
Mead, Margaret: Soviet Attitudes Toward Authority. Rev. by Vladimir Petrov. . ...
The diversity of CM carbonaceous chondrite parent bodies explored using Lewis Cliff 85311
2019
Geochimica et Cosmochimica Acta
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The chemical composition of LEW 85311 matrix, fine-grained rims, tochilinite and P-rich sulphides is similar to mildly aqueously altered CMs. ...
Lewis Cliff (LEW) 85311 is classified as a Mighei-like (CM) carbonaceous chondrite, yet it has some unusual properties that highlight an unrealised diversity within the CMs, and also questions how many ...
ACKNOWLEDGEMENTS We thank Peter Chung for help with the SEM work, and are grateful to ANSMET for providing the samples of LEW 85311. ...
doi:10.1016/j.gca.2019.07.027
fatcat:usis3ju6ebgwpjyazup2rsmun4
Page 183 of Delaware Medical Journal Vol. 9, Issue 9
[page]
1937
Delaware Medical Journal
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Russo, Alexander Smith.
Delegates—Kent County W. T. Chipman, Harrington; J. 8S. MeDan- iel, Dover; C. J. Prickett, Smyrna.
Delegates—Sussex County Bruce Barnes, Howard Le Cates, K. J. Hocker. ...
Stambaugh, Lewes
Committee on Hospitals.
James Beebe, Lewes W. E. Bird, Wilmington H. V. P. Wilson, Dover
Committee on Necrology
O. V. James, Milford J. D. Niles, Townsend W. T. ...
Page 501 of National Union Catalog Vol. 142, Issue
[page]
1942
National Union Catalog
Preserved Fulltext
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Preface signed by Charles Lee Lewes.
1, Characters and characteristics. 2. Sa:
1. Lewes, Charles Lee, 1740-1803. 1. ...
Library of Congress PR3717.82H5 (a34b1, 823.6
Stevens, George Alexander, 1710-1784.
A lecture on heads, by Geo, Alex. Stevens, with additions by Mr. Pilon; as delivered by Mr. Charles Lée Lewes. ...
Page 51 of Delaware Medical Journal Vol. 10, Issue 3
[page]
1938
Delaware Medical Journal
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Hocker, Lewes
COMMITTEE ON HOSPITALS H. V’P. Wilson, Dover N. S. Washburn, Milford C. L. Munson, Wilmington
COMMITTEE ON NECROLOGY
G. W. K. Forrest, Wilmington C. G@. Harmonson, Smyrna J. B. ...
Beebe, Lewes V. James, Milford
bm
Ong iP ORS
COMMITTEE ON MEDICAL ECONOMICS W. E. Bird, Wilmington
G. W. K. Forrest, Wilmington
W. O. La Motte, ‘Wilmington
H. L. Springer, Wilmington
D. W. ...
Page 33 of Delaware Medical Journal Vol. 10, Issue 2
[page]
1938
Delaware Medical Journal
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Hocker, Lewes
COMMITTEE ON HOSPITALS V’P. Wilson, Dover S. Washburn, Milford L. Munson, Wilmington
COMMITTEE ON NECROLOGY
W. K. Forrest, Wilmington . G@. Harmonson, Smyrna . B. ...
Beebe, Lewes
O. V. James, Milford
COMMITTEE ON MEDICAL ECONOMICS
W. E. Bird, Wilmington G.
Ww. O.
W. K. Forrest, Wilmington La Motte, Wilmington
H. L. Springer, Wilmington D. W. Lewis, Middletown C. ...
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