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Recursive Monte Carlo and Variational Inference with Auxiliary Variables [article]

Alexander K. Lew, Marco Cusumano-Towner, Vikash K. Mansinghka
2022 arXiv   pre-print
We adapt the generative model of Lew et al. [18] .  ...  agglomerative clustering algorithm as a proposal, outperforming strong baselines on a standard benchmark from astronomy [15] and a challenging data-cleaning problem using Medicare data [22] , adapted from Lew  ...  The meta-posterior approximation must solve two new challenges: recovering the rejected q samples x 1:K from the posterior approximation, and recovering the many unused rejection loops (and the suffix  ... 
arXiv:2203.02836v1 fatcat:l4iwitv55nfsrot6frsasyqv4y

Automating Involutive MCMC using Probabilistic and Differentiable Programming [article]

Marco Cusumano-Towner, Alexander K. Lew, Vikash K. Mansinghka
2020 arXiv   pre-print
For each finite set of keys K, we make V K a measure space using the standard product σ-algebra Σ K = ⊗ kK Σ k and the product measure µ K = × kK µ k .  ...  The probability mass is distributed among the finite sets of keys KK: 1 = KK |K|<∞ x1 R d K p((K, (x 1 , x 2 )))dx 2 (1) where d K := kK∩J d k is the total continuous dimension for keys K, and where  ...  z (A)µ(dz) = K π(z)k z (Z)µ(dz) = K π(z)µ(dz) for all A ∈ Σ  ... 
arXiv:2007.09871v2 fatcat:bbfgkqnfszexxkr2kxysw5oz7u

Towards Denotational Semantics of AD for Higher-Order, Recursive, Probabilistic Languages [article]

Alexander K. Lew, Mathieu Huot, Vikash K. Mansinghka
2021 arXiv   pre-print
Marco F Cusumano-Towner, Feras A Saad, Alexander K Lew, and Vikash K Mansinghka. Gen: a general-purpose probabilistic programming system with programmable inference.  ...  Marco Cusumano-Towner, Alexander K Lew, and Vikash K Mansinghka. Automating involutive mcmc using probabilistic and differentiable programming. arXiv preprint arXiv:2007.09871, 2020.  ... 
arXiv:2111.15456v2 fatcat:3nhzpfr5u5cstonw7slwrz7co4

Trace types and denotational semantics for sound programmable inference in probabilistic languages

Alexander K. Lew, Marco F. Cusumano-Towner, Benjamin Sherman, Michael Carbin, Vikash K. Mansinghka
2019 Proceedings of the ACM on Programming Languages (PACMPL)  
⊢ mix K p k 1 k 2 : K τ I ∪J σ j Γ ⊢ n : N Γ ⊢ k : K τ σ Γ ⊢ repeat K n k : K τ σ Γ ⊢ b : τ → B Γ ⊢ k : K (τ + + σ ) σ Γ ⊢ if K b k : K τ σ seq K k 1 k 2 = λ µ t .  ...  Composition of Stationary Kernels for Custom MCMC Schedules Γ ⊢ k 1 : K τ ( I σ i ) Γ ⊢ k 2 : K τ ( J σ j ) Γ ⊢ seq K k 1 k 2 : K τ I ∪J σ j Γ ⊢ p : U Γ ⊢ k 1 : K τ ( I σ i ) Γ ⊢ k 2 : K τ ( J σ j ) Γ  ... 
doi:10.1145/3371087 fatcat:kf4vfvzt7rdvzencdtksbk3moq

Gen: a general-purpose probabilistic programming system with programmable inference

Marco F. Cusumano-Towner, Feras A. Saad, Alexander K. Lew, Vikash K. Mansinghka
2019 Proceedings of the 40th ACM SIGPLAN Conference on Programming Language Design and Implementation - PLDI 2019  
The kernel G k maps (y, z) ∈ Y × Z to a new state y ′ ∈ Y.  ...  Each application of G k is assigned an address namespace i ∈ {1 . . . n}.  ... 
doi:10.1145/3314221.3314642 dblp:conf/pldi/Cusumano-Towner19 fatcat:bmjwmh7jhjf33gg6dywrdjop7y

PClean: Bayesian Data Cleaning at Scale with Domain-Specific Probabilistic Programming [article]

Alexander K. Lew, Monica Agrawal, David Sontag, Vikash K. Mansinghka
2020 arXiv   pre-print
F., Lew, A. K., Saad, F. A., and Mansinghka, V. K. (2019). Gen: A general-purpose proba- bilistic programming system with programmable inference.  ...  K)} Set φ u (v u | {v u } u ∈P a(u) ) =      1[v u = v K .X] v K ∈ R (i−1) φ Π T (C obs .K).X (v u | {v u } u ∈P a Π (T (C obs .K).X) ) v K = new K 1[v u = v u .X ] v K = new u , u = K else Set P  ... 
arXiv:2007.11838v4 fatcat:navjwv7vpfbzhaq4mugkbucvve

A Bidirectional System for the Dynamic Small Molecule Control of Intracellular Fusion Proteins

Taavi K. Neklesa, Devin J. Noblin, Alexander Kuzin, Scott Lew, Jayaraman Seetharaman, Thomas B. Acton, Gregory Kornhaber, Rong Xiao, Gaetano T. Montelione, Liang Tong, Craig M. Crews
2013 ACS Chemical Biology  
We found that HALTS1 binds HaloTag7 in vitro with a K d of 143 nM, an enthalpy of −10.7 kcal/mol, and entropy of −4.8 cal/mol/deg.  ... 
doi:10.1021/cb400569k pmid:23978068 pmcid:PMC4113957 fatcat:5wa7dtvrifdtfi2pj56zvnz66q

Platelet PD-L1 suppresses anti-cancer immune cell activity in PD-L1 negative tumors

Alexander B. Zaslavsky, M. P. Adams, X. Cao, T. Maj, J. E. Choi, J. Stangl-Kremser, S. Patel, A. Putelo, S. K. Lee, S. Nallandhighal, A. Kasputis, A. Alva (+9 others)
2020 Scientific Reports  
Strategies that interfere with the binding of the receptor programmed cell death protein-1 (PD-1) to programmed death ligand-1 (PD-L1) have shown marked efficacy against many advanced cancers, including those that are negative for PD-L1. Precisely why patients with PD-L1 negative tumors respond to PD-1/PD-L1 checkpoint inhibition remains unclear. Here, we show that platelet-derived PD-L1 regulates the growth of PD-L1 negative tumors and that interference with platelet binding to PD-L1 negative
more » ... ancer cells promotes T cell-induced cancer cytotoxicity. These results suggest that the successful outcomes of PD-L1 based therapies in patients with PD-L1 negative tumors may be explained, in part, by the presence of intra-tumoral platelets. Altogether, our findings demonstrate the impact of non-cancer/non-immune cell sources of PD-L1 in the tumor microenvironment in the promotion of cancer cell immune evasion. Our study also provides a compelling rationale for future testing of PD-L1 checkpoint inhibitor therapies in combination with antiplatelet agents, in patients with PD-L1 negative tumors.
doi:10.1038/s41598-020-76351-4 pmid:33168847 fatcat:utnavuofg5abplz3jr3u4tftdi

Page 260 of The Russian Review Vol. 11, Issue 4 [page]

1952 The Russian Review  
Rev. by Vladimir Petrov Micklesen, Lew R.: W. K. Matthews’ Languages of the U.S.S.R.. Moscow Students’ Movement, The Reminiscences of. Ivan Kheraskov  ...  K.: Languages of the U.S.S.R. Rev. by Lew R. Micklesen Mazour, A. G.: Russia, Past and Present. Rev. by C. E. Black. . Mead, Margaret: Soviet Attitudes Toward Authority.  ... 

Page 260 of The Russian Review Vol. 11, Issue 4 [page]

1952 The Russian Review  
Micklesen, Lew R.: W. K. Matthews’ Languages of the U.S.S.R.. Moscow Students’ Movement, The Reminiscences of. Ivan Kheraskov  ...  K.: Languages of the U. S.8.R. Rev. by Lew R. Micklesen Mazour, A. G.: Russia, Past and Present. Rev. by C. E. Black. Mead, Margaret: Soviet Attitudes Toward Authority. Rev. by Vladimir Petrov. .  ... 

The diversity of CM carbonaceous chondrite parent bodies explored using Lewis Cliff 85311

Martin R. Lee, Benjamin E. Cohen, Ashley J. King, Richard C. Greenwood
2019 Geochimica et Cosmochimica Acta  
The chemical composition of LEW 85311 matrix, fine-grained rims, tochilinite and P-rich sulphides is similar to mildly aqueously altered CMs.  ...  Lewis Cliff (LEW) 85311 is classified as a Mighei-like (CM) carbonaceous chondrite, yet it has some unusual properties that highlight an unrealised diversity within the CMs, and also questions how many  ...  ACKNOWLEDGEMENTS We thank Peter Chung for help with the SEM work, and are grateful to ANSMET for providing the samples of LEW 85311.  ... 
doi:10.1016/j.gca.2019.07.027 fatcat:usis3ju6ebgwpjyazup2rsmun4

Page 183 of Delaware Medical Journal Vol. 9, Issue 9 [page]

1937 Delaware Medical Journal  
Russo, Alexander Smith. Delegates—Kent County W. T. Chipman, Harrington; J. 8S. MeDan- iel, Dover; C. J. Prickett, Smyrna. Delegates—Sussex County Bruce Barnes, Howard Le Cates, K. J. Hocker.  ...  Stambaugh, Lewes Committee on Hospitals. James Beebe, Lewes W. E. Bird, Wilmington H. V. P. Wilson, Dover Committee on Necrology O. V. James, Milford J. D. Niles, Townsend W. T.  ... 

Page 501 of National Union Catalog Vol. 142, Issue [page]

1942 National Union Catalog  
Preface signed by Charles Lee Lewes. 1, Characters and characteristics. 2. Sa: 1. Lewes, Charles Lee, 1740-1803. 1.  ...  Library of Congress PR3717.82H5 (a34b1, 823.6 Stevens, George Alexander, 1710-1784. A lecture on heads, by Geo, Alex. Stevens, with additions by Mr. Pilon; as delivered by Mr. Charles Lée Lewes.  ... 

Page 51 of Delaware Medical Journal Vol. 10, Issue 3 [page]

1938 Delaware Medical Journal  
Hocker, Lewes COMMITTEE ON HOSPITALS H. V’P. Wilson, Dover N. S. Washburn, Milford C. L. Munson, Wilmington COMMITTEE ON NECROLOGY G. W. K. Forrest, Wilmington C. G@. Harmonson, Smyrna J. B.  ...  Beebe, Lewes V. James, Milford bm Ong iP ORS COMMITTEE ON MEDICAL ECONOMICS W. E. Bird, Wilmington G. W. K. Forrest, Wilmington W. O. La Motte, ‘Wilmington H. L. Springer, Wilmington D. W.  ... 

Page 33 of Delaware Medical Journal Vol. 10, Issue 2 [page]

1938 Delaware Medical Journal  
Hocker, Lewes COMMITTEE ON HOSPITALS V’P. Wilson, Dover S. Washburn, Milford L. Munson, Wilmington COMMITTEE ON NECROLOGY W. K. Forrest, Wilmington . G@. Harmonson, Smyrna . B.  ...  Beebe, Lewes O. V. James, Milford COMMITTEE ON MEDICAL ECONOMICS W. E. Bird, Wilmington G. Ww. O. W. K. Forrest, Wilmington La Motte, Wilmington H. L. Springer, Wilmington D. W. Lewis, Middletown C.  ... 
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