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Lecture Notes in Computer Science
Recent research has focused on the concept of product family architecture. We address the more specific case of legacy product families, whose life spans across several years and product generations. We illustrate the method we use to describe legacy product family architecture and manage its evolution. To describe of the family architecture we use two separate documents. The reference architecture, which describes the abstract architecture that is instantiated in every product, and containsdoi:10.1007/3-540-47833-7_7 fatcat:7yt4pti7ujbsvnq3buw4mg72ea
more »... hitecturally significant rules for adding new components to the system. And the configuration architecture, which maps the product family features into the various products, thus, allowing to model commonality and variability. The concept of a family is an abstraction that automatically generates a new layer in every product. This layer includes all the software that is common to other products in the family, and is, naturally, less prone to change than the layer constituted by software which is specific to the product. In certain domains like mobile telecommunications, when new products are added to the family, they tend to share most of the stable features that belong to legacy products. This phenomenon abstracts the issues of architectural evolution from the single products to the entire family scope. We also sketch the process we follow to maintain the documents that model the product family architecture. Our approach combines reverse and forward architecting activities, and is currently applied in Nokia Mobile Phones. Research on the issues of architectural modelling is still insufficient: we propose some hints for future work.
IFIP Advances in Information and Communication Technology
Managing evolution of complex software architecture is a continuous challenge in industry. Systems such as mobile handsets undergo a continuous increase in complexity, while the fast market evolution imposes quick integration of new features. Being able to easily manage software architecture evolution is the basis for shorter time-to-market and faster product release. The term "viewpoint" has become familiar with the publication of the IEEE standard 1471-2000 on recommended practices fordoi:10.1007/978-0-387-35607-5_11 fatcat:byf7g3l7gbg33oymwcxrzq42qi
more »... ctural modelling. Based on the classical 4+1 view model, we have elaborated our own set of viewpoints in order to support our domain-specific architectural modelling needs. We hereby justify the introduction of the architectonic viewpoint, which models the evolutionary aspects of software architecture. The term, as well as the rationale behind it, is inspired from architecture as in buildings. We describe the viewpoint and the way it links to the others we use. Additionally, we briefly elaborate on the other viewpoints that we use for architectural modelling of mobile telephone software architecture. We provide basis for discussion and further research into the matter.
Lecture Notes in Computer Science
In spite of the abundant research that promotes different methods for software development, and the current method war amidst agile and disciplined methods, little research is done to actually figure out whether real projects, carried out in industrial environments, benefit more from either approach. This paper analyses a real project team's opinions and feelings about project management techniques, software development methods and cultural difference in a multi-site project where traveling anddoi:10.1007/978-3-540-85279-7_14 fatcat:bisjx6jzlnbv7nfghgmzkmd2ye
more »... communication are made difficult by restrictions and low-quality infrastructure. The different sites also worked in different time zones and with different working week patterns. The project team members almost unanimously indicated that the presence of a local team leader with authority and flexibility to cover a role that is not exactly as assigned in the beginning, is key factor for the success of this sort of projects. While there was no consensus on whether the project was agile or disciplined, evidence seems to hint towards a more disciplined approach, probably as a compensation for the higher degree of uncertainty that derives from the distributed setup. While the findings of the case study cannot be extended to other organizations without caution, we do infer a number of conclusions on cultural differences, project management tools and techniques.
10 : 910 Software splatting visualized with elevation plots Software splatting visualized with elevation plots Figure 11 : 11 Software visualizations in reverse engineering applications c Telea, Maccari ...doi:10.2312/vissym/vissym02/241-249 fatcat:r7mpa6gbonbxri7hdchfl45vxy
doi:10.1145/581339.581414 dblp:conf/icse/Maccari02 fatcat:ycwgm274y5asrnwb37xmmq2voq
Proceedings of the 24th international conference on Software engineering - ICSE '02
This paper presents an assessment case study on the evolutionary capability of a large software system using a knowledge-based approach. The knowledge-based assessment is based on interviews with selected stakeholders of a software system. We have used this to assess the capability of the software architecture to evolve in one large Nokia software system. We have found that this approach proves to be effective in large organizations where development teams are distributed in differentdoi:10.1109/wicsa.2007.17 dblp:conf/wicsa/RossoM07 fatcat:w5fu4pnxbrf4digxmhtlfzfvza
more »... , with cultural differences and with limited person-to person communication. The lessons learned and the advantages of using this approach are presented.
and Morley-Fletcher, 2007; Darnaudéry and Maccari, 2008; Vallée et al, 1999; McCormick et al, 1995) . ... Control dams were left undisturbed throughout gestation, whereas stressed dams were subjected to repeated episodes of restraint stress, as described previously in rats (Maccari et al, 1995) , and here ...doi:10.1038/npp.2011.274 pmid:22089319 pmcid:PMC3280642 fatcat:dvchtiojyfa75ia5ctqrb6kv4i
Conflict of interest: COI declared -see note COI notes: PG reports speaker honoraria from Novartis and Abbvie and fees from Novartis and Abbvie for participation on advisory boards. AMV has personal fees as advisory bord and speaker fee from AOP Orphan Pharmaceuticals and Novartis. AR has personal fees as advisory board from Astellas, Amgen, Celgene BMS, Gilead, Italfarmaco, Novartis, Omeros, Roche, and Sanofi. TB declares personal fees as advisory bord from AOP Orphan Pharmaceuticals,doi:10.1182/bloodadvances.2021006006 pmid:34753179 pmcid:PMC8791590 fatcat:5ehgy6bj2bbqdk6l74mf7bepy4
more »... co, and Novartis, outside the submitted work. The remaining authors declare no competing financial interests. Preprint server: No; Author contributions and disclosures: PG interpreted the data, and wrote the brief report. TB conceived and designed the study, supervised the analysis and critically revised the brief report. AG and AC contributed to dataset preparation, planned and performed statistical analyses. AM directed the project. AMV interpreted the data and critically revised the brief report.
Multiple myeloma is a malignant neoplasm of plasma cells that usually invades the bone marrow replacing normal bone marrow and producing large amounts of light chains of immunoglobulins (Ig) . Clinical manifestations are related to the accumulation of these proteins in vital organs such as kidney and heart. Pleural effusion may be a sign of chest involvement that occurs in approximately 6% of patients with Known multiple myeloma [2,3]. We present the case of an 80-year- old man with pleuraldoi:10.1016/j.rmcr.2020.101013 pmid:32071852 pmcid:PMC7013170 fatcat:7u42weungrebpnppyiy57dp6tq
more »... ffusion as first extra-medullary clinical presentation of an occult multiple myeloma.
Maccari). 1 These two authors contributed equally to the work. ... ., 2005; Maccari et al., 2003) which is sensitive to antidepressant treatment evidenced by the Porsolt test (Morley-Fletcher et al., 2004) . ... This might result from a decreased number of high and low-affinity glucocorticoid receptors (Maccari et al., 1995) and a decreased neurogenesis (Lemaire et al., 2006) . ...doi:10.1016/j.psyneuen.2007.03.013 pmid:17666188 fatcat:2bi26ydwhva3lkm5uquwm3sas4
doi:10.1517/14656566.2013.765859 pmid:23356509 fatcat:6ckkrbwkbvbj3onrosthcwu3ya
(Chiara Maccari) and M.Z.; Funding acquisition, R.M.; Investigation, M.M. (Margherita Mirabile), E.B., F.B., M.M. (Monica Maccaferri), T.O. and A.M.V.; Methodology, S.F., S.S. (Stefano Sartini), M.M. ...doi:10.3390/cancers13194744 pmid:34638230 pmcid:PMC8507546 fatcat:qjs6am57svcgfhpb3hrjd6pbxa
Enhancement of cellular senescence in tumours triggers a stable cell growth arrest and activation of an antitumour immune response that can be exploited for cancer therapy. Currently, there are only a limited number of targeted therapies that act by increasing senescence in cancers, but the majority of them are not selective and also target healthy cells. Here we developed a chemogenomic screening to identify compounds that enhance senescence in PTEN-deficient cells without affecting normaldoi:10.1038/ncomms8227 pmid:26085373 fatcat:opg2m7mjdjhm3mlhu3euysryea
more »... s. By using this approach, we identified casein kinase 2 (CK2) as a pro-senescent target. Mechanistically, we show that Pten loss increases CK2 levels by activating STAT3. CK2 upregulation in Pten null tumours affects the stability of Pml, an essential regulator of senescence. However, CK2 inhibition stabilizes Pml levels enhancing senescence in Pten null tumours. Taken together, our screening strategy has identified a novel STAT3-CK2-PML network that can be targeted for pro-senescence therapy for cancer.
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