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Spatial heterogeneity of the relation between resting-state connectivity and blood flow: An important consideration for pharmacological studies

Najmeh Khalili-Mahani, Matthias J. van Osch, Mark de Rooij, Christian F. Beckmann, Mark A. van Buchem, Albert Dahan, Johannes M. van Gerven, Serge A.R.B. Rombouts
2012 Human Brain Mapping  
Functional connectivity reflects the degree of synchrony or correlation of spontaneous fluctuations-mostly in the blood oxygen level dependent (BOLD) signal-across brain networks; but CBF reflects mean  ...  The BOLD and CBF signals are linked to common neurovascular and hemodynamic mechanisms that necessitate increased oxygen transportation to the site of neuronal activation; however, the scale and the sources  ...  ACKNOWLEDGMENTS The authors thank Evelinda Baerends and Remco Zoethout for the study design and execution; and Jordan Gross and Rene Post (CHDR) for assisting with the data acquisition.  ... 
doi:10.1002/hbm.22224 pmid:23281174 fatcat:6bs6ie6yiba7dondlbp2dsmpzy

Loss of Coherence of Low Frequency Fluctuations of BOLD FMRI in Visual Cortex of Healthy Aged Subjects

Lirong Yan, Yan Zhuo, Bo Wang, Danny J.J Wang
2011 The Open Neuroimaging Journal  
The present study systematically investigated the normal aging effect in the visual cortex using 3 indices of low frequency fluctuations of resting state BOLD fMRI, i.e., amplitude of low frequency fluctuations  ...  These data suggest that normal aging may be associated with "loss of coherence" of low frequency fluctuations of resting state BOLD fMRI in the visual cortex, and may affect task induced BOLD response  ...  This observation suggests a shared mechanism underlying the BOLD contrast and spontaneous fluctuations in BOLD fMRI, such as aerobic glycolysis [29] .  ... 
doi:10.2174/1874440001105010105 pmid:22216081 pmcid:PMC3245404 fatcat:ztaoxasuara3lhyx2idn66rqmy

Spontaneous Low-Frequency Fluctuations in the BOLD Signal in Schizophrenic Patients: Anomalies in the Default Network

R. L. Bluhm, J. Miller, R. A. Lanius, E. A. Osuch, K. Boksman, R. Neufeld, J. Theberge, B. Schaefer, P. Williamson
2007 Schizophrenia Bulletin  
patients may show some anomalies in spontaneous slow fluctuations in the BOLD signal in default network associated with the resting state.  ...  To our knowledge, this is the first report of anomalies in spontaneous slow fluctuations of the BOLD signal associated with the resting-state default network in schizophrenic patients.  ... 
doi:10.1093/schbul/sbm052 pmid:17556752 pmcid:PMC2632312 fatcat:5thgi2pa6bckvdz5fcbwrdwcge

Reduced Dynamic Coupling Between Spontaneous BOLD-CBF Fluctuations in Older Adults: A Dual-Echo pCASL Study

Piero Chiacchiaretta, Francesco Cerritelli, Giovanna Bubbico, Mauro Gianni Perrucci, Antonio Ferretti
2018 Frontiers in Aging Neuroscience  
Moreover, correcting for temporal shift between BOLD and CBF timecourses resulted in an increased correlation of the two signals for both groups, but with a larger increase for elderlies.  ...  Measurement of the dynamic coupling between spontaneous Blood Oxygenation Level Dependent (BOLD) and cerebral blood flow (CBF) fluctuations has been recently proposed as a method to probe resting-state  ...  INTRODUCTION Since the first observation that spontaneous Blood Oxygenation Level Dependent (BOLD) signal fluctuations in the left and right motor cortex are correlated in the absence of a task (Biswal  ... 
doi:10.3389/fnagi.2018.00115 pmid:29740310 pmcid:PMC5925323 fatcat:xxmqzkxrrnhtjf7wnzq2rt6ihe

Vigilance Effects in Resting-State fMRI

Thomas T. Liu, Maryam Falahpour
2020 Frontiers in Neuroscience  
In this paper, we examine in detail the link between vigilance and rsfMRI measures, such as signal variance and functional connectivity.  ...  However, there is growing evidence that variations in vigilance can lead to pronounced and spatially widespread differences in resting-state brain activity.  ...  FUNDING This work was supported in part by NIH grant R21MH112155.  ... 
doi:10.3389/fnins.2020.00321 pmid:32390792 pmcid:PMC7190789 fatcat:byw2gwbasfbhvczuqpi4xaoy7i

Altered Amplitude of Low-Frequency Fluctuation in Primary Open-Angle Glaucoma: A Resting-State fMRI Study

T. Li, Z. Liu, J. Li, Z. Liu, Z. Tang, X. Xie, D. Yang, N. Wang, J. Tian, J. Xian
2014 Investigative Ophthalmology and Visual Science  
Moreover, the alterations in some of these networks are correlated with the progression of POAG; for the abnormal spontaneous neural activities in the left cuneus, bilateral MTG and right prefrontal cortex  ...  Compared with controls, POAG patients showed significantly decreased ALFF/fALFF values in the visual cortices, posterior regions of the default-mode network (DMN), and motor and sensory cortices.  ...  With monocular visual stimulation, the attenuation of the blood oxygenation level dependent (BOLD) signal in the PVA is consistent with the visual defect in POAG patients. 15, 16 Furthermore, Qing et  ... 
doi:10.1167/iovs.14-14974 pmid:25525176 fatcat:q7zfn576kfbsjn3steyl7yic2i

Altered Intrinsic Brain Activities in Patients with Diabetic Retinopathy Using Amplitude of Low-frequency Fluctuation: A Resting-state fMRI Study

Chen-Xing Qi, Xin Huang, Yin Shen
2020 Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy  
The current study aimed to apply the amplitude of low-frequency fluctuation (ALFF) method for investigating the spontaneous brain activity alterations and their relationships with clinical features in  ...  The ALFF method was used to assess the spontaneous brain activity, while the mean ALFF signal values of patients with DR and HCs were classified by the receiver operating characteristic (ROC) curve.  ...  The Hipp is a critical hub in the default mode network (DMN), a network responsible for spontaneous cognition.  ... 
doi:10.2147/dmso.s259476 pmid:32884311 pmcid:PMC7434521 fatcat:tc53xgorkbb77kywxnlvo54vsu

Correlated Low-Frequency BOLD Fluctuations in the Resting Human Brain Are Modulated by Recent Experience in Category-Preferential Visual Regions

W. Dale Stevens, Randy L. Buckner, Daniel L. Schacter
2009 Cerebral Cortex  
Coupling of LF-BOLD fluctuations in the rIFG with category-preferential visual regions during rest predicts subsequent memory.  ...  The resting brain is associated with significant intrinsic activity fluctuations, such as the correlated low-frequency (LF) blood oxygen level--dependent (BOLD) fluctuations measured by functional magnetic  ...  Gilmore for assistance in preparation of the manuscript. Conflict of Interest : None declared. Address correspondence to W.  ... 
doi:10.1093/cercor/bhp270 pmid:20026486 pmcid:PMC2901023 fatcat:6uuonqhi2jh2nho5gcidp5jqbq

Biomarkers, designs, and interpretations of resting-state fMRI in translational pharmacological research: A review of state-of-the-Art, challenges, and opportunities for studying brain chemistry

Najmeh Khalili-Mahani, Serge A.R.B. Rombouts, Matthias J.P. van Osch, Eugene P. Duff, Felix Carbonell, Lisa D. Nickerson, Lino Becerra, Albert Dahan, Alan C Evans, Jean-Paul Soucy, Richard Wise, Alex P. Zijdenbos (+1 others)
2017 Human Brain Mapping  
Common biomarkers in these studies include functional connectivity, graph metrics, cerebral blood flow and the amplitude and spectrum of BOLD fluctuations.  ...  About 85 pharma-RSfMRI studies using BOLD signal (75% of all) or arterial spin labeling (ASL) were surveyed to investigate the acute effects of psychoactive drugs.  ...  Spontaneous BOLD Signal Fluctuations and Functional Networks In RSfMRI, slow fluctuations in the BOLD signal (around 0.1 Hz frequency) serve as a proxy to regional spontaneous neuronal activity.  ... 
doi:10.1002/hbm.23516 pmid:28145075 fatcat:o6h7ahdzerbbngzx6vcfsvbn3q

Isoflurane-Induced Burst Suppression Increases Intrinsic Functional Connectivity of the Monkey Brain

Zhao Zhang, Dan-Chao Cai, Zhiwei Wang, Kristina Zeljic, Zheng Wang, Yingwei Wang
2019 Frontiers in Neuroscience  
In datasets with BS activity, we observed robust coupling between the BS pattern (the binary alternation between burst and suppression activity in EEG signal) and filtered BOLD signals in most brain areas  ...  After eliminating the BS coupling effect by regressing out the BS pattern, we detected an overall increase in FC with a few decreased connectivity compared to datasets with SW activity.  ...  RESULTS Brain-Wide BOLD Fluctuations Are Coupled With BS Activity Figure 1 shows robust coupling between the BS pattern in EEG signals ( Figure 1A ) and the spontaneous fluctuations in BOLD signals  ... 
doi:10.3389/fnins.2019.00296 pmid:31031580 pmcid:PMC6470287 fatcat:ltoinjhqkvdehob2h6jp5zabri

Default Mode Network Functional Reorganization During Early Abstinence in Polysubstance-Using Emerging Adults Treated for Opioid Dependence

Marc L. Copersino, Jenessa S. Price, Katherine H. Frost, Gordana D. Vitaliano, Blaise deB. Frederick, Scott E. Lukas, Roger D. Weiss, Amy C. Janes
2016 The Journal of Neuropsychiatry and Clinical Neurosciences  
We examined default mode network connectivity within the first 30 days of abstinence in emerging adults entering treatment for opioid dependence.  ...  There were significant associations between abstinence duration and coupling strength with brain regions within and outside of the network.  ...  Using FSL, an ICA was conducted to identify the DMN. Spontaneous resting-state BOLD signal fluctuations ascribable to the DMN were detected in our sample.  ... 
doi:10.1176/appi.neuropsych.15090240 pmid:26792100 pmcid:PMC4956593 fatcat:youbdn5chbbjdihssf2jl6r3pa

The alteration of spontaneous low frequency oscillations caused by acute electromagnetic fields exposure

Bin Lv, Zhiye Chen, Tongning Wu, Qing Shao, Duo Yan, Lin Ma, Ke Lu, Yi Xie
2014 Clinical Neurophysiology  
Conclusions: The study provided the evidences that 30 min LTE RF-EMF exposure modulated the spontaneous low frequency fluctuations in some brain regions.  ...  The radiation source was close to the right ear. Then the resting state fMRI signals of human brain were collected before and after the exposure in both sessions.  ...  Acknowledgements We would like to thank all the participants enrolled in this study.  ... 
doi:10.1016/j.clinph.2013.07.018 pmid:24012322 fatcat:zs2lyd7ws5hlnkgcvshbbnfkbe

Altered intrinsic brain activity in patients with toothaches using the amplitude of low-frequency fluctuations: a resting-state fMRI study

Jun Yang, Bin Li, Qiu-Yue Yu, Lei Ye, Pei-Wen Zhu, Wen-Qing Shi, Qing Yuan, You-Lan Min, Yu-Lin He, Yi Shao
2019 Neuropsychiatric Disease and Treatment  
In the TA group, the visual analog scale of the left side was positively correlated with the ALFF signal values of the right paracentral lobule (r=0.639, P=0.025).  ...  However, differences in spontaneous brain activity occurring in toothache (TA) patients remain unclear.  ...  Acknowledgment The study was funded by the National Natural Science Disclosure The authors report no conflicts of interest in this work.  ... 
doi:10.2147/ndt.s189962 pmid:30697053 pmcid:PMC6342150 fatcat:yld2j5dldnadteuqxb2fdjysrm

Stomach-brain synchrony reveals a novel, delayed-connectivity resting-state network in humans

Ignacio Rebollo, Anne-Dominique Devauchelle, Benoît Béranger, Catherine Tallon-Baudry
2018 eLife  
Here, we describe a novel resting-state network based on the delayed connectivity between the brain and the slow electrical rhythm (0.05 Hz) generated in the stomach.  ...  This network is composed of regions with convergent functional properties involved in mapping bodily space through touch, action or vision, as well as mapping external space in bodily coordinates.  ...  Acknowledgements This work was supported by the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program (grant agreement No 670325) to CT-B, as well as by  ... 
doi:10.7554/elife.33321 pmid:29561263 pmcid:PMC5935486 fatcat:6lkxkz6dsregfbafqw5pfwfxry

The Contribution of Resting State Networks to the Study of Cortical Reorganization in MS

Rosaria Sacco, Simona Bonavita, Fabrizio Esposito, Gioacchino Tedeschi, Antonio Gallo
2013 Multiple Sclerosis International  
Compared to activation/task-related fMRI, RS-fMRI has the advantages that (i) BOLD fMRI signals are self-generated and independent of subject's performance during the task and (ii) a single dataset is  ...  The most interesting results, in particular, regard the default-mode network (DMN), whose FC changes have been correlated with cognitive status of MS patients, and the visual RSN (V-RSN) whose FC changes  ...  RS-FC can be assessed noninvasively in vivo by analyzing the spatiotemporal distribution of spontaneous lowfrequency (<0.1 Hz) BOLD (blood-oxygen-level dependent) fMRI signals fluctuations during resting  ... 
doi:10.1155/2013/857807 pmid:24288613 pmcid:PMC3833123 fatcat:hrzxsoul3zcqrewflfvs3wr55q
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