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T-1982の基礎的, 臨床的検討

1982 Chemotherapy  
Experimental and clinical studies on T-1982 were performed to evaluate usefulness in the field of oral surgery. T-1982 was administered to rabbits at a dose of 33 mg/kg by 2 hour i.v. drip infusion.  ...  Twenty patients with oral purulent inflammation were treated with T-1982 at a daily dose of 1 to 2 g for 4 to 11 days. Clinical results were good in 19 cases and poor in 1 case.  ...  T-1982は1回19,1日2回 点 滴 静 注 し,初 診 時 の 症 状 評 点30点 で あ っ た もの が,投 与3日 後 の 評 点20点 (評 点 比0.67)と 効 果 が み られ た 。 本 症 例 で は,T-1982は11日 間22gが 使 用 さ れ た 。  ... 
doi:10.11250/chemotherapy1953.30.supplement3_961 fatcat:455ulu3ofrh25c6rvczh263ifa

Ubiquinol-10 Intake Is Effective in Relieving Mild Fatigue in Healthy Individuals

Kei Mizuno, Akihiro T. Sasaki, Kyosuke Watanabe, Yasuyoshi Watanabe
2020 Nutrients  
Our double-blind, placebo-controlled study evaluated effects of ubiquinol, the reduced form of coenzyme Q10, on mild fatigue in healthy individuals experiencing fatigue in daily life that had continued for more than 1 and less than 6 months. The participants received 100-mg/day (Ubq100; age 44.0 ± 9.8 years; 14 females and 6 males) or 150-mg/day ubiquinol (Ubq150; age 40.4 ± 11.8 years; 14 females and 8 males) or placebo (Plc; age 41.3 ± 13.4 years; 13 females and 7 males) daily for 12 weeks.
more » ... asurements of subjective and objective fatigue were conducted by using questionnaires-based fatigue scales/visual analogue scales and autonomic nerve function/biological oxidation index, respectively, prior to the first dosing and every 4 weeks thereafter. Serum ubiquinol level increased three- to four-fold after 4 weeks and remained significantly higher than that after Plc administration throughout the intake period. Although a higher blood level of ubiquinol was observed with Ubq150 than with Ubq100, the difference was not statistically significant. In both Ubq100 and Ubq150 groups, subjective levels of fatigue sensation and sleepiness after cognitive tasks, which consisted of the modified Advanced Trail Making Test, the modified Stroop Color-Word Test, and the Digit Symbol Substitution Test, improved significantly compared with those in the placebo group, suggesting an anti-fatigue effect. The Ubq150 group demonstrated significant improvement compared with the Plc group regarding subjective level of relaxation after task, sleepiness before and after task, motivation for task, and serum level of oxidative stress. Correlation analysis between blood level of ubiquinol and each evaluated effect suggested a positive relationship with relaxation after task, motivation for cognitive task, and parasympathetic activity. The results of the study suggest that ubiquinol intake relieves mild fatigue in healthy individuals.
doi:10.3390/nu12061640 pmid:32498248 fatcat:lyhsyc2y45de3gesexvhuhuosq

口腔外科領域におけるT-3262の基礎的, 臨床的検討

1988 Chemotherapy  
Clinical response of T-3262 classified by diagnosis Table 7. Clinical response of T-3262 classified by daily dose  ...  血 清 中 濃 度 のparameter は 食 後 投 与 の 場 合T顯 。xは1.42hr,Cmaxは0.67 μ91ml,T(1/2)は3.28hr,Aucは4.17μ9・hr/mlで あ り,空 腹 時 投 与 で は 各 々1.67,0.61,2.36,3.30で あ っ た 。  ... 
doi:10.11250/chemotherapy1953.36.supplement9-clinical_1488 fatcat:dde3yexdfbhebbmv2dhkxvokze

Mental fatigue is linked with attentional bias for sad stimuli

Kyosuke Watanabe, Akihiro T. Sasaki, Kanako Tajima, Kenji Mizuseki, Kei Mizuno, Yasuyoshi Watanabe
2019 Scientific Reports  
The design of the present study was dependent (paired), so that we used the equation advocated by Dunlap et al. 48 where t was the t statistic from paired samples t-test and r was the correlation across  ...  The data from the paired samples t-test for each measure are also shown. df, degrees of freedom.  ... 
doi:10.1038/s41598-019-45428-0 pmid:31217505 pmcid:PMC6584697 fatcat:svtmbw2bencbncjhtrikukejqy

Frequency-specific network topologies in the resting human brain

Shuntaro Sasai, Fumitaka Homae, Hama Watanabe, Akihiro T. Sasaki, Hiroki C. Tanabe, Norihiro Sadato, Gentaro Taga
2014 Frontiers in Human Neuroscience  
We then conducted two-tailed t-tests against the null-hypothesis that there were no group-level differences between I VLF and I LF in the calculated graph metrics.  ...  Statistical comparisons For each threshold level, we conducted a two-tailed t-test with subjects (random effects analysis) against the null hypothesis, defined as no significant group-level difference  ... 
doi:10.3389/fnhum.2014.01022 pmid:25566037 pmcid:PMC4273625 fatcat:uvbgnoqpufcczohw4nym4vso7e

Bacteriological evaluation of T-3262(Tosufloxacin tosilate in the oral
口腔領域感染症に対するT‐3262(Tosufloxacin tosilate)の細菌学的検討

T-3262 demonstrated high effectiveness on the isolated organisms. NFLX and ENX had little effectiveness on the isolated organisms.  ...  Their susceptibilities to T-3262 (tosufloxacin tosilate), norfloxacine (NFLX), ofloxacin (OFLX) and enoxacin (ENX) were determined. The results were as follows. 1.  ...  MICの 測 定 は 日 本 化 学 療 法 学 会 標 準 法1・2)に従 い,新 キ ノ ロ ン系 抗 菌 剤T。  ... 
doi:10.11263/jsotp1982.8.16 fatcat:kdvpumehhjhk7boutqlcbycnty

Imaging the passionate stage of romantic love by dopamine dynamics

Kayo Takahashi, Kei Mizuno, Akihiro T. Sasaki, Yasuhiro Wada, Masaaki Tanaka, Akira Ishii, Kanako Tajima, Naohiro Tsuyuguchi, Kyosuke Watanabe, Semir Zeki, Yasuyoshi Watanabe
2015 Frontiers in Human Neuroscience  
The mean and standard deviation is shown in (B) and the P values resulted from statistical analysis by two-tailed paired t-test.  ...  Statistical Analysis Differences between conditions for VAS parameters, physiological responses and BP ND (plots) were analyzed using a paired t-test.  ...  Copyright © 2015 Takahashi, Mizuno, Sasaki, Wada, Tanaka, Ishii, Tajima, Tsuyuguchi, Watanabe, Zeki and Watanabe.  ... 
doi:10.3389/fnhum.2015.00191 pmid:25914637 pmcid:PMC4391262 fatcat:ucj65gc3hreflfjgvaqd7nkase

Neural networks for action representation: a functional magnetic-resonance imaging and dynamic causal modeling study

Akihiro T. Sasaki, Takanori Kochiyama, Motoaki Sugiura, Hiroki C. Tanabe, Norihiro Sadato
2012 Frontiers in Human Neuroscience  
T.  ...  Sasaki) and by Scientific Research on Innovative Areas grant number 22101007 (Hiroki C.  ...  STIMULUS PREPARATION Original video clip An original video clip was recorded in which a ball was rotated once by the investigator (Akihiro T.  ... 
doi:10.3389/fnhum.2012.00236 pmid:22912611 pmcid:PMC3418609 fatcat:xxjc2yooergmtcmxu3phtpja2m

The role of prosody and context in sarcasm comprehension: Behavioral and fMRI evidence

Tomoko Matsui, Tagiru Nakamura, Akira Utsumi, Akihiro T. Sasaki, Takahiko Koike, Yumiko Yoshida, Tokiko Harada, Hiroki C. Tanabe, Norihiro Sadato
2016 Neuropsychologia  
processing affective prosody in sarcasm comprehension, we created the following contrasts: the in- The resulting set of voxel values for each contrast constituted a statistical parametric mapping (SPM) of the t  ... 
doi:10.1016/j.neuropsychologia.2016.04.031 pmid:27157883 fatcat:gdfeyq3a3fecvppqkr2633fcha

Discovery of African bat polyomaviruses and infrequent recombination in the large T antigen in the Polyomaviridae

Michael Carr, Gabriel Gonzalez, Michihito Sasaki, Kimihito Ito, Akihiro Ishii, Bernard M Hang'ombe, Aaron S Mweene, Yasuko Orba, Hirofumi Sawa
2017 Journal of General Virology  
Predicted coding regions for STAg (small T antigen), ALTO (alternate frame of the large T open reading frame), LTAg (large T antigen) and the variable protein (VP) 1-3 genes are indicated.  ...  The PyV genome is functionally divided into an early region, encoding the small T antigen (STAg) and large T antigen (LTAg) nonstructural proteins, and a late region harbouring, minimally, the genes encoding  ... 
doi:10.1099/jgv.0.000737 pmid:28430100 fatcat:4jq6wr4p2bf3dnqz54jug6aium

Medial Prefrontal Cortex Activation Is Commonly Invoked by Reputation of Self and Romantic Partners

Hiroaki Kawamichi, Akihiro T. Sasaki, Masahiro Matsunaga, Kazufumi Yoshihara, Haruka K. Takahashi, Hiroki C. Tanabe, Norihiro Sadato, Mitchell Valdes-Sosa
2013 PLoS ONE  
Izuma for providing experimental material and T. Kochiyama for helping with fMRI data analysis. Author Contributions  ... 
doi:10.1371/journal.pone.0074958 pmid:24086409 pmcid:PMC3781163 fatcat:ndzdiexmfrdc5mphj56o5z6ck4

Low putamen activity associated with poor reward sensitivity in childhood chronic fatigue syndrome

Kei Mizuno, Junko Kawatani, Kanako Tajima, Akihiro T. Sasaki, Tetsuya Yoneda, Masanori Komi, Toshinori Hirai, Akemi Tomoda, Takako Joudoi, Yasuyoshi Watanabe
2016 NeuroImage: Clinical  
The resulting set of voxel values for each comparison constituted a statistical parametric map of t statistics [SPM(t)].  ...  P values were obtained using Student's t-test.  ... 
doi:10.1016/j.nicl.2016.09.016 pmid:27709065 pmcid:PMC5043413 fatcat:ir5bq2k7t5huhkax7igjmdnjuy

The anterior insular and anterior cingulate cortices in emotional processing for self-face recognition

Tomoyo Morita, Hiroki C. Tanabe, Akihiro T. Sasaki, Koji Shimada, Ryusuke Kakigi, Norihiro Sadato
2013 Social Cognitive and Affective Neuroscience  
30) ¼ 0.81, P ¼ 0.43; private: t(30) ¼ 1.50, P ¼ 0.14].  ...  increase of embarrassment when viewing face images of a partner [t(31) ¼ 1.88, P ¼ 0.07] or an unfamiliar person [t(31) ¼ 0.87, P ¼ 0.39] ( Figure 2B ).  ... 
doi:10.1093/scan/nst011 pmid:23377900 pmcid:PMC4014092 fatcat:lroxdjfjajg4tcpof22af3uiye

The Brain Mechanisms Underlying the Perception of Pungent Taste of Capsaicin and the Subsequent Autonomic Responses

Shinpei Kawakami, Hajime Sato, Akihiro T. Sasaki, Hiroki C. Tanabe, Yumiko Yoshida, Mitsuru Saito, Hiroki Toyoda, Norihiro Sadato, Youngnam Kang
2016 Frontiers in Human Neuroscience  
., 2003; Sasaki et al., 2013) .  ...  statistic[SPM{t}].  ... 
doi:10.3389/fnhum.2015.00720 pmid:26834613 pmcid:PMC4717328 fatcat:g4oubsyyrnf37n3i7xwuplveda

Perceiving active listening activates the reward system and improves the impression of relevant experiences

Hiroaki Kawamichi, Kazufumi Yoshihara, Akihiro T. Sasaki, Sho K. Sugawara, Hiroki C. Tanabe, Ryoji Shinohara, Yuka Sugisawa, Kentaro Tokutake, Yukiko Mochizuki, Tokie Anme, Norihiro Sadato
2014 Social Neuroscience  
test; t(9) = 16.47, p < .001).  ...  Subjects rated greater willingness to cooperate with evaluators who had demonstrated active, compared to non-active, listening behavior (paired t test; t(17) = 6.10, p < .001).  ... 
doi:10.1080/17470919.2014.954732 pmid:25188354 pmcid:PMC4270393 fatcat:cctffwuzxbf4noft4nqlamwtvm
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