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Integration of fluidic channels and total internal reflection excitation with supercritical angle fluorescence detection

Kirsi Tappura, Aki Mäyrä, Markku Alamäki, Annukka Kokkonen, Sanna Aikio, Marianne Hiltunen, O. Fähnle, A. Vasdekis
2019 EPJ Web of Conferences  
In many diagnostic applications, there is a growing demand for small cost effective portable devices that enable fast on-site analysis. For this target, we are developing an integrated approach of a previously reported surface-sensitive measurement system based on total internal reflection excitation and supercritical angle fluorescence detection. The integrated measurement platform includes a polystyrene substrate on which the fluidic channels for sample transport, waveguides for fluorescence
more » ... xcitation and the readout optics are fabricated. In addition, thin layers with dielectric properties differing from those of polystyrene may be needed on the fluidic channels for optimal sample transport or biomolecule immobilisation. Here, special attention is paid to the influence of the dielectric environment near the solid-liquid interface on the fluorescence distribution and to the design of the readout optics. The first version of the designed readout optics of the integrated measurement platform is presented.
doi:10.1051/epjconf/201921515002 fatcat:t3mshbd4evbbbp6w52lum7p7zq

A passive, fully-staring THz video camera based on kinetic inductance bolometer arrays

Juho Luomahaara, Hannu Sipola, Leif Gronberg, Aki Mayra, Mika Aikio, Andrey Timofeev, Kirsi Tappura, Anssi Rautiainen, Aleksi Tamminen, Visa Vesterinen, Mikko Leivo, Feng Gao (+3 others)
2020 IEEE Transactions on Terahertz Science and Technology  
Aki  ... 
doi:10.1109/tthz.2020.3029949 fatcat:rnxwu7p4jrfh5owgdvv2eqd7fq

Early mortality risk factors at the beginning of continuous renal replacement therapy for acute kidney injury

Camilo Alberto Gonzalez, Jessica Liliana Pinto, Viviana Orozco, Kateir Contreras, Paola Garcia, Patricia Rodriguez, Juan Patiño, Jorge Echeverri, Udo Schumacher
2018 Cogent Medicine  
Results: 214 AKI patient required CRRT, The mean age was 61.5 years (± 15.47), 57.73% men. The most frequent cause of AKI was sepsis in 30.9% of cases.  ...  Acute kidney injury (AKI) occurs in more than 50% of critically ill patients, 23% need renal replacement therapy.  ...  Acknowledgements We thank to Lisseth Rincon, Juliana Rios and Mayra Tejada nurses of the critical nephrology service of the Hospital Universitario San Ignacio were contributing to patient selection and  ... 
doi:10.1080/2331205x.2017.1407485 fatcat:fixrspz3fvaufa63ip4szqibfm

Therapeutic effects of micro-RNAs in preclinical studies of acute kidney injury: a systematic review and meta-analysis

Sarah Zankar, Mayra Trentin-Sonoda, Jose L Viñas, Rosendo A Rodriguez, Adrian Bailey, David Allan, Kevin D Burns
2021 Scientific Reports  
AKI has a high mortality rate, may lead to chronic kidney disease, and effective therapies are lacking.  ...  Micro-RNAs (miRNAs) regulate biologic processes by potently inhibiting protein expression, and pre-clinical studies have explored their roles in AKI.  ...  in human AKI.  ... 
doi:10.1038/s41598-021-88746-y pmid:33907298 fatcat:zzo3wnp76vdhrjyfo5euvfa6pa

Acute kidney injury in 3182 patients admitted with COVID-19: a single center retrospective case-control study

Fabio L Procaccini, Roberto Alcázar Arroyo, Marta Albalate Ramón, Esther Torres Aguilera, Juan Martín Navarro, Pablo Ryan Murua, Melissa Cintra Cabrera, Mayra Ortega Díaz, Marta Puerta Carretero, Patricia de Sequera Ortiz
2021 Clinical Kidney Journal  
Baseline kidney function was not recovered in 45.73% of overall AKI cases and in 52.75% of AKI patients with prior chronic kidney disease.  ...  Results AKI incidence was 17.22% among 3182 admitted COVID-19 patients and acute kidney disease (AKD) incidence was 6.82%. The most frequent causes of AKI were prerenal (68.8%) and sepsis (21.9%).  ...  of AKI.  ... 
doi:10.1093/ckj/sfab021 pmid:34079618 pmcid:PMC7929007 fatcat:5kfhtsefd5fttlmez3txet6qhu

Abrogation of Plasminogen Activator Inhibitor-1-Vitronectin Interaction Ameliorates Acute Kidney Injury in Murine Endotoxemia

Kamlesh K. Gupta, Deborah L. Donahue, Mayra J. Sandoval-Cooper, Francis J. Castellino, Victoria A. Ploplis, Jian Fu
2015 PLoS ONE  
Schematic representation demonstrating functional roles of PAI-1 during LPS-induced AKI. LPS induces AKI in mice by enhancing PAI-1 expression in kidneys.  ...  Although the pathogenesis of AKI during sepsis is poorly understood, it is well accepted that plasminogen activator inhibitor-1 (PAI-1) and vitronectin (Vn) are involved in AKI.  ...  Apoptosis is known to play an important role in septic AKI [31] .  ... 
doi:10.1371/journal.pone.0120728 pmid:25799354 pmcid:PMC4370643 fatcat:zq36b4jym5elpfx5be3ztix6ce

Hypercalcemia: A Metabolic Complication of an AIDS-Defining Illness

Dorothy E Bennett, Ruba Riachy, Lucas S Blanton, L Maria Belalcazar
2021 Journal of the Endocrine Society  
He was found to have a high serum calcium (13.4 mg/dL, n 8.6–10.6 mg/dL) and acute kidney injury (AKI) (creatinine 4 mg/dL, n 0.6–1.25 mg/dL).  ...  Patient was discharged with an 8-day prednisone taper, but readmitted to the hospital 3 weeks later with recurrent hypercalcemia (13.8 mg/dL) and AKI.  ...  He was found to have a high serum calcium (13.4 mg/ dL, n 8.6-10.6 mg/dL) and acute kidney injury (AKI) (creatinine 4 mg/dL, n 0.6-1.25 mg/dL).  ... 
doi:10.1210/jendso/bvab048.403 fatcat:igpll6ley5ckxnoanhp26fbryi

Could dysnatremias play a role as independent factors to predict mortality in surgical critically ill patients?

Edson A. Nicolini, Roosevelt S. Nunes, Gabriela V. Santos, Silvana Lia da Silva, Mariana M. Carreira, Fernanda G. Pellison, Mayra G. Menegueti, Maria Auxiliadora-Martins, Fernando Bellissimo-Rodrigues, Marcus A. Feres, Anibal Basile-Filho
2017 Medicine  
AKI = acute kidney failure, CI = confidence interval, SAPS III = simplified acute physiology score.  ...  It was observed that the need for vasopressors, blood transfusions, dialysis-requiring acute kidney injury (AKI), mechanical ventilation, and cases of severe sepsis and septic shock were independent factors  ... 
doi:10.1097/md.0000000000006182 pmid:28248872 pmcid:PMC5340445 fatcat:uw6uadcnkbdjjjqqb3kbfpoh2u

Bernard Perron & Mark J.P. Wolf (Eds.): The Video Game Theory Reader 2. New York & London: Routledge. 2009

Ole Ertløv Hansen
2010 MedieKultur: Journal of Media and Communication Research  
Frans Mäyräs afsluttende artikel om hans syn på spilforskningens nødvendige interdisciplinaere metodik laeses langt bedre i hans bog (anmeldt i MedieKultur 46).  ...  Aki Järvinens efterfølgende forsøg på at systematisere de mulige emotionelle reaktioner, der kan optraede i forbindelse med computerspil, baerer tydeligt praeg af at vaere et koncentrat af forfatterens  ... 
doi:10.7146/mediekultur.v26i49.3012 fatcat:sinmgsr4rjeetexpagtkeptsau

Page 565 of National Union Catalog Vol. 37, Issue [page]

1963 National Union Catalog  
—— yy, re ie aki 20 XUM The National Union Catalog Moscow. Institut agrolesomelioratsii see Vv. ~ V ch led. V’skii institut agroleso- Moscow.  ...  Mayra, Mocxea, Hayna, : Axagemna wayx CCCP. Munncrepcrso HMR, cpeacts aBTOMaTHSauMH HW CHCTeEM ynpaBjcHH® CP. Plhacraryt SACKTPOHHEX YNPABARIOULMX MALUHH. Includes bibliograph 1.  ... 

Persistent shallow background microseismicity on Hekla volcano, Iceland: A potential monitoring tool

Eva P.S. Eibl, Christopher J. Bean, Kristín Vogfjörd, Aoife Braiden
2014 Journal of Volcanology and Geothermal Research  
, 2003; Aki and Ferrazzini, 2000b).  ...  We used a time window that 208 started at a time that was twice the arrival of the S phase (Aki and Ferrazzini, 2000a; 209 Aki and Chouet, 1975).  ... 
doi:10.1016/j.jvolgeores.2014.11.004 fatcat:haea6p3gkvhzrbxxxoousyp4kq

Ludology as Game Research in Language Pedagogy Studies / Ludologie als Spielforschung – angewandt in der Fremdsprachendidaktik

Augustyn Surdyk
2008 Kalbotyra  
The first president of DiGRA was professor Frans Mäyrä, followed by professor Tanya Krzywinska in 2006.  ...  The only exception to the current trend seems to be represented by Aki game studies evolved from the work of the Norwegian games academic Espen J. Aarseth.  ... 
doi:10.15388/klbt.2008.7614 fatcat:vngbamgvore5nn32drom6enc2q

Digitaalisen pelaamisen historiantutkimus Suomessa

Jaakko Suominen
2019 Lähikuva – audiovisuaalisen kulttuurin tieteellinen julkaisu  
Mäyrä 2008) on ollut myös jonkinlaisia historiaosuuksia, mutta en käsittele niitä tässä.  ...  Muista varhaisista digipelihistoriaan liittyvistä suomalaisten tutkijoiden artikkeleista mainittakoon Aki Järvisen Mariosofia-kirjassa julkaistu artikkeli pelien audiovisuaalisten tyylien kehityksestä  ... 
doi:10.23994/lk.87958 fatcat:dmbmybzgzfbkpkcig7whivnuau

Resúmenes de Trabajos Orales

2020 Revista Mexicana de Trasplantes  
Sin lesión n = 15 (33.3%) AKI 1 n = 12 (26.7%) AKI 2 n = 6 (13.3%) AKI 3 n = 12 (26.7%) Características clínicas y demográficas, n (%) Edad, mediana [IQR] 50 [43-62] 39.5 [(29.2-52.7  ...  Se documentó lesión renal aguda en 30 casos (66.6%), de los cuales 18/30 (60%) fueron AKI 2 o 3.  ... 
doi:10.35366/96231 fatcat:nmmkl7tes5chppdlbuxisc6pcu

K jednému pokusu o evolučné vysvetlenie morálky

Stanislav Spodniak
2020 Filozofia  
Napríklad podľa Mayra (2002, 140) selekcia neprebieha na úrovni génov, ale na úrovni genotypu, keďže miera, do akej sa jedinec prispôsobí prostrediu, má závisieť od toho, ako jeho jednotlivé gény navzájom  ...  Realisti by totiž vďaka tomu stáli pred neľahkou úlohou vysvetliť, " ... aký je vzťah (ak vôbec nejaký je) medzi selektívnymi mechanizmami, ktoré ovplyvnili podobu našich normatívnych postojov a nezávisle  ... 
doi:10.31577/filozofia.2020.75.7.6 fatcat:y62nyx3aircjpihx4lpvmgsmb4
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