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International Journal of Medicine and Biomedical Research
Since its founding indoi:10.14194/ijmbr.2212 fatcat:kwdddqvzk5emzifmepbbuqic4m
Anil Kumar, Dr. Rishi Raj, and Dr. C.B. Singh for their valuable contribution in implementing the study. Additionally, sincere thanks to U.C. ... Pandey and Sanjay Kumar for their valuable field assistance. ... Ajay Kumar: Investigation, Writing -review & editing. S.P. Poonia: Data curation, Writing -review & editing. Vipin Kumar: Writing -review & editing. Anurag Ajay: Writing -review & editing. ...doi:10.1016/j.fcr.2020.107776 pmid:32362715 pmcid:PMC7171704 fatcat:niwtmfvl4jcixks5vqaa2u5rt4
The world has faced the challenges of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) for the last two years, first diagnosed at the end of 2019 in Wuhan and widely distributed worldwide. As a result, the WHO has proclaimed the illness brought on by this virus to be a global pandemic. To combat COVID-19, researcher communities continuously develop and implement rapid diagnoses, safe and effective vaccinations and other alternative therapeutic procedures. However, syntheticdoi:10.3390/antiox11030452 pmid:35326102 pmcid:PMC8944855 fatcat:4mw23s6vd5ao3dbjo62nbsqbmu
more »... ted side effects and high costs have piqued scientists' interest in natural product-based therapies and medicines. In this regard, antiviral substances derived from natural resources and some medicines have seen a boom in popularity. For instance, algae are a rich source of compounds such as lectins and sulfated polysaccharides, which have potent antiviral and immunity-boosting properties. Moreover, Algae-derived compounds or metabolites can be used as antibodies and vaccine raw materials against COVID-19. Furthermore, some algal species can boost immunity, reduce viral activity in humans and be recommended for usage as a COVID-19 preventative measure. However, this field of study is still in its early stages of development. Therefore, this review addresses critical characteristics of algal metabolites, their antioxidant potential and therapeutic potential in COVID-19.
Interestingly more than 50% of the world's area is rainfed and approximately 80% of maize is cultivated under rainfed condition where selection of cultivar and management of nitrogen have major impact on production. The aim of this study was to evaluate the growth, phenology, yield and quality parameters of maize as influenced by variety and nitrogen scheduling under rainfed condition. For this, a field experiment having two factors was laid out in a factorial randomised block design anddoi:10.3390/su14053116 fatcat:6uhraem2fvarhio44sl2h3lkdm
more »... ted three times. The first factor was variety, i.e., V1 (JM 216) and V2 (JM 218), and the second was six nitrogen scheduling, i.e., N1 to N6, in which nitrogen splitting was done based on 30-years of average rainfall data. Variety JM 218 and N5 [40 kg N as basal followed by (fb) 2 splits of 40 kg N and 38.8 kg N at 30 and 52 days after sowing (DAS) and 1% N foliar spray at 40 DAS] nitrogen scheduling were found promising under rainfed situation because it recorded maximum value of growth parameters, yield attributes, grain yield and quality parameters (protein, mineral and dickson quality index). Thus, it can be inferred that JM 218 and N5 nitrogen schedule would be a better choice than alternative options.
We are also very much thankful to Santosh Kumar Rai and Rita Sharma who manually helped us throughout this whole research works. ... A case of cyanide poisoning of a 14 year old female with a history of consumption of bamboo shoot juice in JSS Hospital, Mysore, India was reported recently (Pramod Kumar et al., 2011) which confirms ... Fermentation is one of the most economic and effective method for the reduction of these detrimental components (Sarangthem & Singh, 2013) . ...doi:10.18006/2019.7(2).128.137 fatcat:sede3yboybb57dstgihswcak7e
Data in Brief
The first draft of the pigeonpea (Cajanus cajan (L.) Millsp. cv. Asha) genome with 511 Mbp of assembled sequence information has low genome coverage of about sixty percent. Here we present an improved version of this genome with 648.2 Mbp of assembled sequence of this popular pigeonpea variety, which is liked by the millers and has resistance to fusarium wilt and sterility mosaic diseases. With the addition of 137 Mb of assembled sequence information the present version has the highestdoi:10.1016/j.dib.2017.11.066 pmid:29234695 pmcid:PMC5723258 fatcat:ntbzmua57na5fnjrcf34vhxu7y
more »... genome coverage of pigeonpea till date. We predicted 56,888 protein-coding genes of which 54,286 (96.7%) were functionally annotated. In the improved genome assembly we identified 158,432 SSR loci, designed flanking primers for 85,296 of these and validated them in-silico by e-PCR. The raw data used for the improvement of genome assembly are available in the SRA database of NCBI with accession numbers SRR5922904, SRR5922905, SRR5922906, SRR5922907. The genome sequence update has been deposited at DDBJ/EMBL/GenBank under the accession AFSP00000000, and the version described in this paper is the second version (AFSP02000000).
Theorem 6. 1 ( 1 Singh and Thukral,  ). Let α 1 , . . . , α n ∈ D, and B(z) Blaschke factor of order n. We assume that α 1 = 0. Define e j,. ...arXiv:1602.05729v1 fatcat:q364ic7pxbggbgy6u6ki2x4vua
Indian Heart Journal
To compare the outcome of suture mediated vascular closure device Perclose Proglide (PP) with manual compression (MC) following transfemoral access for coronary interventions (CI). It is a retrospective, observational, single centre study from January 2018 to September 2019. Consecutive patients undergoing interventions through transfemoral access were divided into PP and MC groups. Those with less than 3 months follow up were excluded. Two groups were compared for baseline characteristics anddoi:10.1016/j.ihj.2020.12.014 pmid:33865515 pmcid:PMC8065371 fatcat:5gm5znhxvfb3farj3okegqzwg4
more »... arious complications at 24 h and at 30 days. Out of 1743 patients studied, PP group included 1343 and MC group, 400 patients. Both groups were comparable in baseline characteristics, sheath size and use of antiplatelets and anticoagulation. PP group had significantly less minor bleeding (P = .01, CI 0.34-4.03) and hematoma (P = .0007, CI 0.95-5.10) at 24 h. At 30 days, minor bleeding (P < .0001, CI 0.97-4.25), hematoma (P = .0002, CI 1.05-4.93) and pseudo-aneurysm (P = .0095, CI 0.03-1.18) were also significantly less in PP group. Obesity (OR 3.5, CI 1.29-9.49) and hypertension (OR 2.41, CI 1.12-5.19) were associated with increased minor bleeding at 24 h. Device failure rate was 2.38%. PP device is safe, effective and is associated with fewer complications than MC in CI. Device failure rate is low. Obesity and hypertension are associated with increased minor bleeding in both groups.
This study aimed to evaluate the epidemiological and clinicopathological spectrum of ocular malignancies among patients presenting to a teaching hospital in Northern India. A total of 246 histopathologically diagnosed patients with ocular malignancies were included in the study. Tumor type and size, primary origin and location of tumor, clinical staging, radiological findings, histopathological type, and treatment outcomes were assessed. Overall, males over 55 years of age were most commonlydoi:10.2147/opth.s287087 pmid:33542619 pmcid:PMC7853408 fatcat:u7mrygfgjfe7ndrpfhoxqsk634
more »... ected and the majority of cases were primary ocular or adnexal malignancies (n = 226; 91.87%). The eyelids and periocular structures (n = 92; 37.40%) were the most commonly involved site, followed by the orbit (n = 72; 29.27%), ocular surface (n = 46; 18.70%) and intraocular region (n = 36; 14.63%). The majority of the patients (n = 68; 27.64%) were managed by primary surgical excision and reconstruction. However, 46 patients (18.70%) with advanced lesions underwent neoadjuvant chemotherapy followed by surgical excision and more extensive orbital lesions were treated by exenteration followed by adjuvant chemotherapy (n=48; 19.51%), while patients with metastatic tumor were given palliative chemotherapy/external beam radiation therapy (n= 46; 18.70%). Overall, 45.12% of patients were cured completely, 15.45% showed a partial response to the treatment, 13.04% had progressive disease and 16.67% demonstrated disease recurrence. A clinicopathological analysis of ocular malignancies at a teaching hospital in Northern India indicated the preponderance of primary ocular malignancies, with eyelid sebaceous gland carcinomas being the most common pathological diagnosis. Most of our patients had advanced and extensive disease among them majority belonged to the rural background and poor socio-economic status.
Highly water dispersible boron based compounds are innovative and advanced materials which can be used in Boron Neutron Capture Therapy for cancer treatment (BNCT). Present study deals with the synthesis of highly water dispersible nanostructured Boron Nitride (BN). Unique and relatively low temperature synthesis route is the soul of present study. The morphological examinations (Scanning/ transmission electron microscopy) of synthesized nanostructures showed that they are in transient phasedoi:10.1038/srep35535 pmid:27759052 pmcid:PMC5069687 fatcat:fh2mm7pt5vf4xf6l672xirmefy
more »... m two dimensional hexagonal sheets to nanotubes. It is also supported by dual energy band gap of these materials calculated from UV-visible spectrum of the material. The theoretically calculated band gap also supports the same (calculated by virtual nano lab Software). X-ray diffraction (XRD) analysis shows that the synthesized material has deformed structure which is further supported by Raman spectroscopy. The structural aspect of high water disperse ability of BN is also studied. The ultra-high disperse ability which is a result of structural deformation make these nanostructures very useful in BNCT. Cytotoxicity studies on various cell lines (Hela(cervical cancer), human embryonic kidney (HEK-293) and human breast adenocarcinoma (MCF-7)) show that the synthesized nanostructures can be used for BNCT.
The study was performed to check the chemical, antioxidant, antimicrobial and protein binding qualities of the hydro-ethanolic extract of Tinospora cordifolia (TC). In qualitative and quantitative analysis of extract, the major compounds were tinocordioside, cordifolide A, palmatine, quercetin, β-sitosterol, heptacosanol, and syringin. Hydro-ethanolic extract of TC exhibited low antibacterial and antifungal activities. Excellent antioxidant activities (60–80 %) were noticed for variousdoi:10.6084/m9.figshare.6741368.v1 fatcat:zolr2cb7sze4lno4reuaxkeljm
more »... nt assays viz DPPH (2,2-diphenyl-1-picrylhydrazyl), MC (Metal chelating), FRAP (Ferric reducing), SA (Superoxide radical), and NO (Nitric oxide). Total phenolic content (TPC) and total flavanoids content (TFC) of the extract was 2.38±0.15 mg/g (expressed in equivalents to gallic acid) and 18.91±0.21 mg (expressed in equivalents quercetin) respectively. Moreover, at p < 0.05, significant linear correlation was noticed between the TFC/TPC and antioxidant activities favoured which highlights the medicinal property of TC. Protein binding assay was performed and an observed binding constant (1.03±0.92×10-5 μM-1) was almost close to control (aspirin). Anti-inflammatory assay revealed potent anti-inflammatory activity of hydro-alcoholic extract of TC. These significant findings of TC may provide compelling scientific evidence of its therapeutic potential.
., 2009) , anti-stress agent (Singh et al., 2003) , anti-neoplastic and anti-carcinogenic (Dikshit et al., 2000) , anti-spasmodic, anti-allergic, anti-leprotic (Asthana et al., 2001) , antidote (Nadkarni ... Also, SSR markers developed in peppermint (Mentha piperita) showed transferability among four different species of mentha, with maximum in Mentha arvensis (87.0%) and minimum in Mentha citrata (37.0%) (Kumar ...doi:10.1016/j.plgene.2016.02.001 fatcat:mtthbswgxvbt5ppbqgwhe4wl5u
Type 2 Diabetes Mellitus (T2DM) is associated with a high risk of atherosclerotic cardiovascular disease (ASCVD). Intensive blood glucose reduction with antidiabetic drugs significantly reduce microvascular complications but there is no strong evidence of reduction in cardiovascular (CV) events. In 2008, the US Food and Drug Administration (FDA) issued guidance to demonstrate cardiovascular safety of newer antidiabetic drugs in addition to reduction in blood glucose level. After which a numberdoi:10.3126/ajms.v12i3.32477 doaj:9fc3b7e94306434890ed71c551202820 fatcat:bnrvmpypyncvhmwvwubjkh6lwa
more »... f CVOTs were conducted involving newer antidiabetic drugs. The newer drugs (e.g. GLP-1 RAs, SGLT2 inhibitors and DPP 4 inhibitors) might have potential effects on body weight, lipid parameters and blood pressure, as well as endothelial dysfunctions, inflammatory markers and oxidative stress. The current review summarizes the results of the main trials focused on the cardiovascular outcomes of traditional as well as newer antidiabetic drugs.
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