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Nanopolymeric Therapeutics

Rong Tong, David A. Christian, Li Tang, Horacio Cabral, James R. Baker, Kazunori Kataoka, Dennis E. Discher, Jianjun Cheng
2009 MRS bulletin  
This review describes the progress that has been made in the field of polymeric nanomedicine that brings the science closer to clinical realization of nanopolymeric therapeutics for its application in  ...  Polymeric nanoparticulate delivery vehicles, with chemotherapeutics being either conjugated or encapsulated, have been developed into a variety of different architectures, including polymer-drug conjugates  ...  Science Foundation (Career Program DMR-0748834), the Siteman Center for Cancer Nanotechnology Excellence (SCCNE, Washington University), the Center for Nanoscale Science and Technology (CNST, University of  ... 
doi:10.1557/mrs2009.118 fatcat:yi55hvqiwbaetmcciaqkirq4wy

Engineering Polymeric Drug Delivery Systems For Cancer Therapeutics Using Multi-scale Modeling

Lili X. Peng, Anthony Ivetac, Sang Van, Lei Yu, Stephen B. Howell, J. Andrew McCammon, David A. Gough
2009 Biophysical Journal  
Our polymeric DDS is poly-L-glutamyl-glutamine (PGG) covalently bound to Paclitaxel, a widely used anticancer therapeutic.  ...  We have developed coarse-grained models of PGG Paclitaxel in effort to achieve a variety of sizes and shapes by varying the Paclitaxel % weight loading (18%, 24%, 37% of total wt) and distribution (even  ...  Our polymeric DDS is poly-L-glutamyl-glutamine (PGG) covalently bound to Paclitaxel, a widely used anticancer therapeutic.  ... 
doi:10.1016/j.bpj.2008.12.1583 fatcat:243wfxa44bcojox6chz3i2lg5u

Highway to Success—Developing Advanced Polymer Therapeutics

Marianne B. Ashford, Richard M. England, Nadim Akhtar
2021 Advanced Therapeutics  
This approach together with improved pathophysiological disease knowledge and critical developability considerations, imperative given the size and complexity of polymer therapeutics, provides a structured  ...  Polymer therapeutics are advancing as an important class of drugs. Polymers have already demonstrated their value in extending the half-life of proteins.  ...  of polymer therapeutics.  ... 
doi:10.1002/adtp.202000285 fatcat:6bww47uidre4jam523pfjok7a4

Polymersome carriers: From self-assembly to siRNA and protein therapeutics

David A. Christian, Shenshen Cai, Diana M. Bowen, Younghoon Kim, J. David Pajerowski, Dennis E. Discher
2009 European journal of pharmaceutics and biopharmaceutics  
These high molecular weight amphiphiles impart physicochemical properties that allow polymersomes to stably encapsulate or integrate a broad range of active molecules.  ...  Here we summarize the assembly and development of controlled release polymersomes to encapsulate therapeutics ranging from small molecule anti-cancer drugs to siRNA and therapeutic proteins.  ...  using coarse-grained molecular dynamics (Srinivas 2005) .  ... 
doi:10.1016/j.ejpb.2008.09.025 pmid:18977437 pmcid:PMC2702089 fatcat:pnsela7qz5fyjla75yvoqktk2q

Targeted polymeric therapeutic nanoparticles: design, development and clinical translation

Nazila Kamaly, Zeyu Xiao, Pedro M. Valencia, Aleksandar F. Radovic-Moreno, Omid C. Farokhzad
2012 Chemical Society Reviews  
Polymeric materials have been used in a range of pharmaceutical and biotechnology products for more than 40 years.  ...  In this regard, polymeric NPs have the potential to result in a highly differentiated new class of therapeutics, distinct from the original active drugs used in their composition, and distinct from first  ...  This work was also supported by the National Heart, Lung, and Blood Institute, (NIH), as a Program of Excellence in Nanotechnology (PEN) Award, Contract #HHSN268201000045C.  ... 
doi:10.1039/c2cs15344k pmid:22388185 pmcid:PMC3684255 fatcat:o5pkptet7vdfrlbxmw5d4ewy4m

The shape of things to come: importance of design in nanotechnology for drug delivery

Yaling Liu, Jifu Tan, Antony Thomas, Daniel Ou-Yang, Vladimir R Muzykantov
2012 Therapeutic delivery  
Based on an all-atom molecular dynamics simulation, a rational coarse grain model of nanoworms and nanospheres has been generated to study the shape-dependent effects on drug delivery.  ...  A few mathematical models have been developed to study the adhesion properties for NPs of various shapes.  ... 
doi:10.4155/tde.11.156 pmid:22834196 pmcid:PMC3408634 fatcat:rvbu7vzvgvgunkgyqqecd2mjse

Mechanotransduction in Single Cardiac Myocyte Studied Using Laser Tweezers and FRET

Amy L. Hsieh, Yingxiao Wang, Robert S. Ross, Michael W. Berns, Andrew D. McCulloch
2009 Biophysical Journal  
Our polymeric DDS is poly-L-glutamyl-glutamine (PGG) covalently bound to Paclitaxel, a widely used anticancer therapeutic.  ...  We have developed coarse-grained models of PGG Paclitaxel in effort to achieve a variety of sizes and shapes by varying the Paclitaxel % weight loading (18%, 24%, 37% of total wt) and distribution (even  ...  Our polymeric DDS is poly-L-glutamyl-glutamine (PGG) covalently bound to Paclitaxel, a widely used anticancer therapeutic.  ... 
doi:10.1016/j.bpj.2008.12.1582 fatcat:b3sdd3wz5fhypmh74xvutdsdp4

Nanopore Sequencing with MspA

Ian Derrington, Tom Butler, M. Pavlenok, Marcus Collins, Michael Niederweis, Jens Gundlach
2009 Biophysical Journal  
Our polymeric DDS is poly-L-glutamyl-glutamine (PGG) covalently bound to Paclitaxel, a widely used anticancer therapeutic.  ...  We have developed coarse-grained models of PGG Paclitaxel in effort to achieve a variety of sizes and shapes by varying the Paclitaxel % weight loading (18%, 24%, 37% of total wt) and distribution (even  ...  Our polymeric DDS is poly-L-glutamyl-glutamine (PGG) covalently bound to Paclitaxel, a widely used anticancer therapeutic.  ... 
doi:10.1016/j.bpj.2008.12.1581 fatcat:yi3sfidtnjeojinlr264znf7qy

Multivariable Parameter Optimization Of Microfluidic Post Arrays For DNA Fractionation

Robert H. Meltzer, Lisa W. Kwok, Daniel Trahan, Bryan Crane, Amanda Edmonson, Wolf Mesadieu, Jonathan Larson, Patrick Doyle, Rudolf Gilmanshin
2009 Biophysical Journal  
Our polymeric DDS is poly-L-glutamyl-glutamine (PGG) covalently bound to Paclitaxel, a widely used anticancer therapeutic.  ...  We have developed coarse-grained models of PGG Paclitaxel in effort to achieve a variety of sizes and shapes by varying the Paclitaxel % weight loading (18%, 24%, 37% of total wt) and distribution (even  ...  Our polymeric DDS is poly-L-glutamyl-glutamine (PGG) covalently bound to Paclitaxel, a widely used anticancer therapeutic.  ... 
doi:10.1016/j.bpj.2008.12.1580 fatcat:3e5hg76sovdali5miaawxvkqc4

Hydrogel-Based Drug Delivery Nanosystems for the Treatment of Brain Tumors

João Basso, Ana Miranda, Sandra Nunes, Tânia Cova, João Sousa, Carla Vitorino, Alberto Pais
2018 Gels  
The former, as a local delivery approach, have the ability to confine the release of anticancer drugs near tumor cells over a long period of time, without compromising healthy cells and tissues.  ...  In brain tumors, the existence of both physiological barriers that protect tumor cells and complex resistance mechanisms to anticancer drugs are additional obstacles that hamper a successful course of  ...  Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/gels4030062 pmid:30674838 pmcid:PMC6209281 fatcat:56uv4qzthbh6boypttzf6r3i64

Molecular Modelling Guided Modulation of Molecular Shape and Charge for Design of Smart Self-Assembled Polymeric Drug Transporters

Sousa Javan Nikkhah, Damien Thompson
2021 Pharmaceutics  
Multi-scale modeling and simulations provide a valuable ally to experiment by mapping the potential energy landscape of self-assembly, translocation, and delivery of smart drug-loaded NPs.  ...  We provide a roadmap outlining the opportunities and challenges for the effective use of predictive multiscale molecular modeling techniques to accelerate the development of smart polymer-based drug delivery  ...  Data Availability Statement: Data available in a publicly accessible repository. Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/pharmaceutics13020141 pmid:33499130 fatcat:ezlm6khwhzf5lo2awnsbpr5upa

Multiscale Modeling for Host-Guest Chemistry of Dendrimers in Solution

Seung Ha Kim, Monica H. Lamm
2012 Polymers  
This review focuses on computational studies aimed at providing a better understanding of the relevant physicochemical parameters at play in the binding and release mechanisms between polyamidoamine (PAMAM  ...  The role of solvent effects on dendrimer-guest interactions and the importance of relating model parameters across multiple scales is discussed.  ...  Our group has studied the interactions between G5 PAMAM dendrimers and phenanthrene molecules using a new coarse-grained modeling scheme that combines a systematic, solvent-free multiscale coarse-graining  ... 
doi:10.3390/polym4010463 fatcat:bzfrejyogfakvckgt5fvylbs64

Mitigating Alzheimer`s Disease by Natural Polyphenols : A Review

Roger Gaudreault, Normand Mousseau
2019 Current Alzheimer Research  
These include therapeutic strategies for decreasing amyloid-β (Aβ) production, preventing and/or altering Aβ aggregation, and reducing oligomers cytotoxicity such as curcumin, (-)-epigallocatechin-3-gallate  ...  We also examine whether consideration should be given to potential candidates used outside of medicine and nutrition, through a discussion of two intermediate-sized green molecules, with very similar molecular  ...  Recently, a coarse grain model was used to investigate the aggregation of 75mer A $& oligomer, and the salt effect [69] .  ... 
doi:10.2174/1567205016666190315093520 pmid:30873922 fatcat:2wvsr4xevrhhne5qo3bpvo6uhm

Impact Of Oxysterols On Endothelial Elastic Properties, Contractility And Morphogenesis

Tzu-Pin Shentu, Igor Titushkin, Michael Cho, Irena Levitan
2009 Biophysical Journal  
Our polymeric DDS is poly-L-glutamyl-glutamine (PGG) covalently bound to Paclitaxel, a widely used anticancer therapeutic.  ...  We have developed coarse-grained models of PGG Paclitaxel in effort to achieve a variety of sizes and shapes by varying the Paclitaxel % weight loading (18%, 24%, 37% of total wt) and distribution (even  ...  Our polymeric DDS is poly-L-glutamyl-glutamine (PGG) covalently bound to Paclitaxel, a widely used anticancer therapeutic.  ... 
doi:10.1016/j.bpj.2008.12.1584 fatcat:wzp7bde76fbntp6mhobpkmexfu

Nanoparticle drug delivery systems: an excellent carrier for tumor peptide vaccines

Jiemin Wang, Xiongbin Hu, Daxiong Xiang
2018 Drug Delivery  
In the past 40 years, the nanoparticle drug delivery system for tumor peptide vaccines has been widely studied which also reached a splendid result.  ...  Currently, several categories of nanopreparation, such as liposome, polymeric micelle, polymeric nanoparticle, gold nanoparticle and so on, are proved that they are appropriate for peptide vaccines.  ...  For animal models, the principle also exist. To study Leishmania panamensis, researcher set a model of mice, which treated with free CpG, empty NPs and NP-CpG.  ... 
doi:10.1080/10717544.2018.1477857 pmid:29869539 pmcid:PMC6058474 fatcat:74se2jzlyfgnzf4sylvizb6awm
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