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Identification of Therapeutic Targets in Rhabdomyosarcoma through Integrated Genomic, Epigenomic, and Proteomic Analyses
2018
Cancer Cell
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We integrated transcriptomic, epigenomic, and proteomic/phosphoproteomic data to elucidate the cellular origins and therapeutic vulnerabilities of rhabdomyosarcoma (RMS). ...
Comprehensive preclinical testing revealed that targeting the WEE1 kinase in the G 2 /M pathway is the most effective approach in vivo for high-risk RMS. ...
This work was supported, in part, by Cancer Center Support (CA21765) from the NCI, grants to M.A.D from the NIH (EY014867 and EY018599 and CA168875) and ALSAC. ...
doi:10.1016/j.ccell.2018.07.012
pmid:30146332
pmcid:PMC6158019
fatcat:txxtgwgeobbbdj2zrivcn7z6d4
(So) Big Data and the transformation of the city
2020
International Journal of Data Science and Analytics
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We conclude the paper outlining the main research challenges that urban data science has yet to address in order to help make the smart city vision a reality. ...
The truth is that we have just scratched the surface of the research challenges that should be tackled in order to make this vision a reality. ...
Availability of data and materials The data and methods that support the findings described in this paper can be found in the SoBigData catalogue at https://sobigdata.d4science.org/catalogue-sobigdata. ...
doi:10.1007/s41060-020-00207-3
fatcat:k4eh5k2epjblzf6myc7tiw5gam
Chalcogenides and Carbon Nanostructures: Great Applications for PEM Fuel Cells
[chapter]
2018
Proton Exchange Membrane Fuel Cell
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In this context, new synthesis routes are designed under moderate conditions, which are definitely needed in order to simplify the process, reduce costs, and allow the production of NMCs at lower temperatures ...
have a significant oxygen reduction activity and remarkable superconducting properties. ...
Paraguay Delgado for TEM analysis and to Marco Ovalle, student of Nanotechnology Engineering, for their technical support and design of figures and to the National Institute of Technology of México/Technological ...
doi:10.5772/intechopen.71994
fatcat:vfto6nw7crcepppxnwq5nqq2xy
Electrophysiological responses to sugars and amino acids in the nucleus of the solitary tract of type 1 taste receptor double knockout mice
2020
Journal of Neurophysiology
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Strong evidence supports a major role for heterodimers of the Type 1 taste receptor (T1R) family in the taste transduction of sugars (T1R2+T1R3) and amino acids (T1R1+T1R3), but there are also neural and ...
In both double-KO strains, responses to sugars and a moderate concentration of an MSG+amiloride+IMP cocktail (0.1M, i.e, umami) were profoundly depressed, whereas a panel of 0.6M amino acids were mostly ...
GRANTS This work was supported by National Institute of Deafness and Other Communications Disorders Grant DC-004574 (to A. C. Spector). ...
doi:10.1152/jn.00584.2019
pmid:31913749
pmcid:PMC7052635
fatcat:qf24tijgkrgklofo4ausgv25je
Occupational cancer in the oncogene era
1990
British Journal of Industrial Medicine
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The putative oncogene is to be known as "gsp" (pronounced "gasp" for G, protein) and promises to be the first of a new family of oncogenes that will contribute another dimension to cellular mischief. ...
expertise in order to take part in such multidisciplinary approaches to occupational cancer in the oncogene era. ...
pmid:2159771
pmcid:PMC1035140
fatcat:5mmytuq6tbgnlb4aytnsw2ga6m
Some aspects of toxic contaminants in herbal medicines
2003
Chemosphere
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The paper also summarises how modernization and progress are being carried out to get the best out of Chinese medicines for public healthcare. ...
Practice (GSP) and Good Manufacturing Practice (GMP) for producing these medicinal products from herbal or natural sources. ...
diagnostic agents (Chan, 1996) . ...
doi:10.1016/s0045-6535(03)00471-5
pmid:12867165
fatcat:vv2gejuf7vcszpqilktupir3ae
Evaluation of Biological Activity of Natural Compounds: Current Trends and Methods
2022
Molecules
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These emerging technologies continue to appear due to the urgent need to expand the analysis capacity of a growing number of reported biomolecules. ...
Metabolites such as tannins, anthocyanins, and alkaloids, among others, serve as a defense mechanism in live organisms and are undoubtedly compounds of interest for the food, cosmetic, and pharmaceutical ...
Figures 3 and 7 were created with BioRender.com.
Conflicts of Interest: The authors declare no conflict of interest. ...
doi:10.3390/molecules27144490
pmid:35889361
pmcid:PMC9324072
fatcat:x2pbtvfkh5gulmqr6rfumvm32e
Exploring the genomic traits of fungus-feeding bacterial genus Collimonas
2015
BMC Genomics
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Collimonas is a genus belonging to the class of Betaproteobacteria and consists mostly of soil bacteria with the ability to exploit living fungi as food source (mycophagy). ...
(PKS-NRPS), nonribosomal peptide synthetase (NRPS) gene clusters, a new lipopeptide and type III and type VI secretion systems. ...
Acknowledgements This research was supported in part by funds from Ecolink (260-45140) and by The Netherlands Organization for Scientific Research (NWO) VIDI personal grant to P.G (864.11.015). ...
doi:10.1186/s12864-015-2289-3
pmid:26704531
pmcid:PMC4690342
fatcat:gdv5rraa7jecjor47dghzvp6g4
Gold Nanoparticles in Cancer Theranostics
2021
Frontiers in Bioengineering and Biotechnology
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Their small size and surface characteristics enable them to extravasate and access the tumor microenvironment (TME), which is a promising solution to realize highly effective treatments. ...
Moreover, stimuli-responsive properties (respond to hypoxia and acidic pH) of nanoparticles to TME enable GNPs' unrivaled control for effective transport of therapeutic cargos. ...
The ZIF-8 layer, providing a porous character, was coated onto a self-assembly of gold superparticles (GSPs) to form a GSPs@ZIF-8 SERS substrate, could affect the traveled fashion and process of gaseous ...
doi:10.3389/fbioe.2021.647905
pmid:33928072
pmcid:PMC8076689
fatcat:xpue354msnc6xi2tsfkmdgilom
Plant Extracts for Type 2 Diabetes: From Traditional Medicine to Modern Drug Discovery
2021
Antioxidants
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As numerous plant extracts with antidiabetic effects have been widely reported, they have the potential to be a great therapeutic agent for type 2 diabetes with less side effects. ...
The anti-inflammatory and antioxidant properties of plant extracts suppressed c-Jun amino terminal kinase (JNK) and nuclear factor kappa B (NF-κB) pathways, which induce insulin resistance. ...
As such, additional examination is necessary to confirm whether the natural components played a synergistic role. ...
doi:10.3390/antiox10010081
pmid:33435282
fatcat:sxvwiplqqzfhtegwd4h32fk7km
Proteomics-based identification of differentially abundant proteins reveals adaptation mechanisms of Xanthomonas citri subsp. citri during Citrus sinensis infection
2017
BMC Microbiology
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Conclusions: This is the first time that a protein repertoire is shown to be active and working in an integrated manner during the infection process in a compatible host, pointing to an elaborate mechanism ...
Xanthomonas citri subsp. citri (Xac) is the causal agent of citrus canker. ...
Acknowledgements We acknowledge the Mass Spectrometry Laboratory at Brazilian Biosciences National Laboratory, CNPEM-ABTLuS, Campinas, Brazil for its support with the mass spectrometry analysis. ...
doi:10.1186/s12866-017-1063-x
pmid:28693412
pmcid:PMC5504864
fatcat:gy5ymzcvgnbrxfdmlji3aoqcom
A Study on Technology Competition of Graphene Biomedical Technology Based on Patent Analysis
2019
Applied Sciences
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The main objective of this study is to develop a new and comprehensive method to investigate TC in a given technology field by conducting a patent review and then employing a patent roadmap to dig out ...
The effectiveness of the approach is verified with the case study on graphene biomedical technology. Compared to previous research, this study makes the following important contributions. ...
Patent Hotspots and Fronts According to the cross-database retrieval approach, we imported the Derwent format patent data into visual analysis software CiteSpace and performed a text clustering in the ...
doi:10.3390/app9132613
fatcat:souipjsipzcsjpvmbflpaunowq
Near-infrared light-responsive inorganic nanomaterials for photothermal therapy
2016
Asian Journal of Pharmaceutical Sciences
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A B S T R A C T Novel nanomaterials and advanced nanotechnologies prompt the fast development of new protocols for biomedical application. ...
The unique light-to-heat conversion property of nanoscale materials can be utilized to produce novel and effective therapeutics for cancer treatment. ...
Acknowledgments This study was financially supported by the National Natural Science Foundation of China (Grant No. ...
doi:10.1016/j.ajps.2015.11.123
fatcat:uwvongjwhnbbnjy3nlfxgpklty
A systems biology view of cancer
2009
Biochimica et Biophysica Acta. CR. Reviews on Cancer
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They focus on breast cancer, B cell lymphomas, and colorectal cancer. The discussion is centered on key mathematical and computational tools common to a systems biology approach. ...
The goal of this review is to illustrate this approach and its utility for our understanding of cancer. ...
Thanks are due to M. Hatakeyama, the lead author of [19] , for providing Mathematica code to generate Figure 1C . ...
doi:10.1016/j.bbcan.2009.06.001
pmid:19505535
pmcid:PMC2782452
fatcat:vqwiey67wzch5k2r2wxacdhptq
Functional analysis of non-ribosomal peptide synthetases (NRPSs) in Trichoderma virens reveals a polyketide synthase (PKS)/NRPS hybrid enzyme involved in the induced systemic resistance response in maize
2011
Microbiology
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However, a mutation in one of the PKS/NRPS hybrid genes impaired the ability of T. virens to induce the defence response gene pal (phenylalanine ammonia lyase), suggesting a putative role for the associated ...
Plant assays in a hydroponics system revealed that all seven mutants retained the ability to internally colonize maize roots. ...
Increased understanding of the pathways of activated and resistance mechanisms triggered by different agents may lead to the use of a cocktail of elicitors to provide more effective and reliable protection ...
doi:10.1099/mic.0.052159-0
pmid:22075027
fatcat:eee4j6qlaze7ho5yb2k4ieglce
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