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Identification of Therapeutic Targets in Rhabdomyosarcoma through Integrated Genomic, Epigenomic, and Proteomic Analyses

Elizabeth Stewart, Justina McEvoy, Hong Wang, Xiang Chen, Victoria Honnell, Monica Ocarz, Brittney Gordon, Jason Dapper, Kaley Blankenship, Yanling Yang, Yuxin Li, Timothy I. Shaw (+26 others)
2018 Cancer Cell  
We integrated transcriptomic, epigenomic, and proteomic/phosphoproteomic data to elucidate the cellular origins and therapeutic vulnerabilities of rhabdomyosarcoma (RMS).  ...  Comprehensive preclinical testing revealed that targeting the WEE1 kinase in the G 2 /M pathway is the most effective approach in vivo for high-risk RMS.  ...  This work was supported, in part, by Cancer Center Support (CA21765) from the NCI, grants to M.A.D from the NIH (EY014867 and EY018599 and CA168875) and ALSAC.  ... 
doi:10.1016/j.ccell.2018.07.012 pmid:30146332 pmcid:PMC6158019 fatcat:txxtgwgeobbbdj2zrivcn7z6d4

(So) Big Data and the transformation of the city

Gennady Andrienko, Natalia Andrienko, Chiara Boldrini, Guido Caldarelli, Paolo Cintia, Stefano Cresci, Angelo Facchini, Fosca Giannotti, Aristides Gionis, Riccardo Guidotti, Michael Mathioudakis, Cristina Ioana Muntean (+6 others)
2020 International Journal of Data Science and Analytics  
We conclude the paper outlining the main research challenges that urban data science has yet to address in order to help make the smart city vision a reality.  ...  The truth is that we have just scratched the surface of the research challenges that should be tackled in order to make this vision a reality.  ...  Availability of data and materials The data and methods that support the findings described in this paper can be found in the SoBigData catalogue at  ... 
doi:10.1007/s41060-020-00207-3 fatcat:k4eh5k2epjblzf6myc7tiw5gam

Chalcogenides and Carbon Nanostructures: Great Applications for PEM Fuel Cells [chapter]

Yadira Gochi-Ponce, Gabriel Alonso-Núñez, Nicolás Alonso-Vante, Mercedes Teresita Oropeza-Guzmán
2018 Proton Exchange Membrane Fuel Cell  
In this context, new synthesis routes are designed under moderate conditions, which are definitely needed in order to simplify the process, reduce costs, and allow the production of NMCs at lower temperatures  ...  have a significant oxygen reduction activity and remarkable superconducting properties.  ...  Paraguay Delgado for TEM analysis and to Marco Ovalle, student of Nanotechnology Engineering, for their technical support and design of figures and to the National Institute of Technology of México/Technological  ... 
doi:10.5772/intechopen.71994 fatcat:vfto6nw7crcepppxnwq5nqq2xy

Electrophysiological responses to sugars and amino acids in the nucleus of the solitary tract of type 1 taste receptor double knockout mice

B. Kalyanasundar, Ginger D. Blonde, Alan Craig Spector, Susan P. Travers
2020 Journal of Neurophysiology  
Strong evidence supports a major role for heterodimers of the Type 1 taste receptor (T1R) family in the taste transduction of sugars (T1R2+T1R3) and amino acids (T1R1+T1R3), but there are also neural and  ...  In both double-KO strains, responses to sugars and a moderate concentration of an MSG+amiloride+IMP cocktail (0.1M, i.e, umami) were profoundly depressed, whereas a panel of 0.6M amino acids were mostly  ...  GRANTS This work was supported by National Institute of Deafness and Other Communications Disorders Grant DC-004574 (to A. C. Spector).  ... 
doi:10.1152/jn.00584.2019 pmid:31913749 pmcid:PMC7052635 fatcat:qf24tijgkrgklofo4ausgv25je

Occupational cancer in the oncogene era

R D Hamm
1990 British Journal of Industrial Medicine  
The putative oncogene is to be known as "gsp" (pronounced "gasp" for G, protein) and promises to be the first of a new family of oncogenes that will contribute another dimension to cellular mischief.  ...  expertise in order to take part in such multidisciplinary approaches to occupational cancer in the oncogene era.  ... 
pmid:2159771 pmcid:PMC1035140 fatcat:5mmytuq6tbgnlb4aytnsw2ga6m

Some aspects of toxic contaminants in herbal medicines

K Chan
2003 Chemosphere  
The paper also summarises how modernization and progress are being carried out to get the best out of Chinese medicines for public healthcare.  ...  Practice (GSP) and Good Manufacturing Practice (GMP) for producing these medicinal products from herbal or natural sources.  ...  diagnostic agents (Chan, 1996) .  ... 
doi:10.1016/s0045-6535(03)00471-5 pmid:12867165 fatcat:vv2gejuf7vcszpqilktupir3ae

Evaluation of Biological Activity of Natural Compounds: Current Trends and Methods

Carlos Barba-Ostria, Saskya E. Carrera-Pacheco, Rebeca Gonzalez-Pastor, Jorge Heredia-Moya, Arianna Mayorga-Ramos, Cristina Rodríguez-Pólit, Johana Zúñiga-Miranda, Benjamin Arias-Almeida, Linda P. Guamán
2022 Molecules  
These emerging technologies continue to appear due to the urgent need to expand the analysis capacity of a growing number of reported biomolecules.  ...  Metabolites such as tannins, anthocyanins, and alkaloids, among others, serve as a defense mechanism in live organisms and are undoubtedly compounds of interest for the food, cosmetic, and pharmaceutical  ...  Figures 3 and 7 were created with Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/molecules27144490 pmid:35889361 pmcid:PMC9324072 fatcat:x2pbtvfkh5gulmqr6rfumvm32e

Exploring the genomic traits of fungus-feeding bacterial genus Collimonas

Chunxu Song, Ruth Schmidt, Victor de Jager, Dorota Krzyzanowska, Esmer Jongedijk, Katarina Cankar, Jules Beekwilder, Anouk van Veen, Wietse de Boer, Johannes A. van Veen, Paolina Garbeva
2015 BMC Genomics  
Collimonas is a genus belonging to the class of Betaproteobacteria and consists mostly of soil bacteria with the ability to exploit living fungi as food source (mycophagy).  ...  (PKS-NRPS), nonribosomal peptide synthetase (NRPS) gene clusters, a new lipopeptide and type III and type VI secretion systems.  ...  Acknowledgements This research was supported in part by funds from Ecolink (260-45140) and by The Netherlands Organization for Scientific Research (NWO) VIDI personal grant to P.G (864.11.015).  ... 
doi:10.1186/s12864-015-2289-3 pmid:26704531 pmcid:PMC4690342 fatcat:gdv5rraa7jecjor47dghzvp6g4

Gold Nanoparticles in Cancer Theranostics

Qinyue Gao, Jingjing Zhang, Jie Gao, Zhengyang Zhang, Haitao Zhu, Dongqing Wang
2021 Frontiers in Bioengineering and Biotechnology  
Their small size and surface characteristics enable them to extravasate and access the tumor microenvironment (TME), which is a promising solution to realize highly effective treatments.  ...  Moreover, stimuli-responsive properties (respond to hypoxia and acidic pH) of nanoparticles to TME enable GNPs' unrivaled control for effective transport of therapeutic cargos.  ...  The ZIF-8 layer, providing a porous character, was coated onto a self-assembly of gold superparticles (GSPs) to form a GSPs@ZIF-8 SERS substrate, could affect the traveled fashion and process of gaseous  ... 
doi:10.3389/fbioe.2021.647905 pmid:33928072 pmcid:PMC8076689 fatcat:xpue354msnc6xi2tsfkmdgilom

Plant Extracts for Type 2 Diabetes: From Traditional Medicine to Modern Drug Discovery

Jinjoo Lee, Seungjin Noh, Suhyun Lim, Bonglee Kim
2021 Antioxidants  
As numerous plant extracts with antidiabetic effects have been widely reported, they have the potential to be a great therapeutic agent for type 2 diabetes with less side effects.  ...  The anti-inflammatory and antioxidant properties of plant extracts suppressed c-Jun amino terminal kinase (JNK) and nuclear factor kappa B (NF-κB) pathways, which induce insulin resistance.  ...  As such, additional examination is necessary to confirm whether the natural components played a synergistic role.  ... 
doi:10.3390/antiox10010081 pmid:33435282 fatcat:sxvwiplqqzfhtegwd4h32fk7km

Proteomics-based identification of differentially abundant proteins reveals adaptation mechanisms of Xanthomonas citri subsp. citri during Citrus sinensis infection

Leandro M. Moreira, Márcia R. Soares, Agda P. Facincani, Cristiano B. Ferreira, Rafael M. Ferreira, Maria I. T. Ferro, Fábio C. Gozzo, Érica B. Felestrino, Renata A. B. Assis, Camila Carrião M. Garcia, João C. Setubal, Jesus A. Ferro (+1 others)
2017 BMC Microbiology  
Conclusions: This is the first time that a protein repertoire is shown to be active and working in an integrated manner during the infection process in a compatible host, pointing to an elaborate mechanism  ...  Xanthomonas citri subsp. citri (Xac) is the causal agent of citrus canker.  ...  Acknowledgements We acknowledge the Mass Spectrometry Laboratory at Brazilian Biosciences National Laboratory, CNPEM-ABTLuS, Campinas, Brazil for its support with the mass spectrometry analysis.  ... 
doi:10.1186/s12866-017-1063-x pmid:28693412 pmcid:PMC5504864 fatcat:gy5ymzcvgnbrxfdmlji3aoqcom

A Study on Technology Competition of Graphene Biomedical Technology Based on Patent Analysis

Xi Yang, Xin Liu, Jun Song
2019 Applied Sciences  
The main objective of this study is to develop a new and comprehensive method to investigate TC in a given technology field by conducting a patent review and then employing a patent roadmap to dig out  ...  The effectiveness of the approach is verified with the case study on graphene biomedical technology. Compared to previous research, this study makes the following important contributions.  ...  Patent Hotspots and Fronts According to the cross-database retrieval approach, we imported the Derwent format patent data into visual analysis software CiteSpace and performed a text clustering in the  ... 
doi:10.3390/app9132613 fatcat:souipjsipzcsjpvmbflpaunowq

Near-infrared light-responsive inorganic nanomaterials for photothermal therapy

Zhihong Bao, Xuerong Liu, Yangdi Liu, Hongzhuo Liu, Kun Zhao
2016 Asian Journal of Pharmaceutical Sciences  
A B S T R A C T Novel nanomaterials and advanced nanotechnologies prompt the fast development of new protocols for biomedical application.  ...  The unique light-to-heat conversion property of nanoscale materials can be utilized to produce novel and effective therapeutics for cancer treatment.  ...  Acknowledgments This study was financially supported by the National Natural Science Foundation of China (Grant No.  ... 
doi:10.1016/j.ajps.2015.11.123 fatcat:uwvongjwhnbbnjy3nlfxgpklty

A systems biology view of cancer

Reinhard Laubenbacher, Valerie Hower, Abdul Jarrah, Suzy V. Torti, Vladimir Shulaev, Pedro Mendes, Frank M. Torti, Steven Akman
2009 Biochimica et Biophysica Acta. CR. Reviews on Cancer  
They focus on breast cancer, B cell lymphomas, and colorectal cancer. The discussion is centered on key mathematical and computational tools common to a systems biology approach.  ...  The goal of this review is to illustrate this approach and its utility for our understanding of cancer.  ...  Thanks are due to M. Hatakeyama, the lead author of [19] , for providing Mathematica code to generate Figure 1C .  ... 
doi:10.1016/j.bbcan.2009.06.001 pmid:19505535 pmcid:PMC2782452 fatcat:vqwiey67wzch5k2r2wxacdhptq

Functional analysis of non-ribosomal peptide synthetases (NRPSs) in Trichoderma virens reveals a polyketide synthase (PKS)/NRPS hybrid enzyme involved in the induced systemic resistance response in maize

P. K. Mukherjee, N. Buensanteai, M. E. Moran-Diez, I. S. Druzhinina, C. M. Kenerley
2011 Microbiology  
However, a mutation in one of the PKS/NRPS hybrid genes impaired the ability of T. virens to induce the defence response gene pal (phenylalanine ammonia lyase), suggesting a putative role for the associated  ...  Plant assays in a hydroponics system revealed that all seven mutants retained the ability to internally colonize maize roots.  ...  Increased understanding of the pathways of activated and resistance mechanisms triggered by different agents may lead to the use of a cocktail of elicitors to provide more effective and reliable protection  ... 
doi:10.1099/mic.0.052159-0 pmid:22075027 fatcat:eee4j6qlaze7ho5yb2k4ieglce
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