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Agent based modeling of Treg-Teff cross regulation in relapsing-remitting multiple sclerosis

Marzio Pennisi, Abdul-Mateen Rajput, Luca Toldo, Francesco Pappalardo
2013 BMC Bioinformatics  
Conclusions: The presented model allows to capture the essential dynamics of relapsing-remitting MS despite its simplicity.  ...  It gave useful insights that support the hypothesis of a breakdown of Teff-Treg cross balancing mechanisms.  ...  The full contents of the supplement are available online at supplements/14/S16.  ... 
doi:10.1186/1471-2105-14-s16-s9 pmid:24564794 pmcid:PMC3853330 fatcat:2kwmpthxa5aafgjwoxdvmmoci4

Modeling the effector - regulatory T cell cross-regulation reveals the intrinsic character of relapses in Multiple Sclerosis

Nieves Vélez de Mendizábal, Jorge Carneiro, Ricard V Solé, Joaquín Goñi, Jean Bragard, Ivan Martinez-Forero, Sara Martinez-Pasamar, Jorge Sepulcre, Javier Torrealdea, Francesca Bagnato, Jordi Garcia-Ojalvo, Pablo Villoslada
2011 BMC Systems Biology  
The relapsing-remitting dynamics is a hallmark of autoimmune diseases such as Multiple Sclerosis (MS).  ...  studies in patients with Multiple Sclerosis.  ...  JB acknowledges the support of the MEC through the grant: FIS2005-06912-C02, DINCARD. JG is a fellow of Government of Navarra.  ... 
doi:10.1186/1752-0509-5-114 pmid:21762505 pmcid:PMC3155504 fatcat:mrr23fz5frc4jh2vtyrcxlwndm

A computational approach based on the colored Petri net formalism for studying multiple sclerosis

Simone Pernice, Marzio Pennisi, Greta Romano, Alessandro Maglione, Santina Cutrupi, Francesco Pappalardo, Gianfranco Balbo, Marco Beccuti, Francesca Cordero, Raffaele A. Calogero
2019 BMC Bioinformatics  
Relapsing Remitting Multiple Sclerosis (RRMS) is one of the most common form of MS in adults and is characterized by a series of neurologic symptoms, followed by periods of remission.  ...  Multiple Sclerosis (MS) is an immune-mediated inflammatory disease of the Central Nervous System (CNS) which damages the myelin sheath enveloping nerve cells thus causing severe physical disability in  ...  About this supplement This article has been published as part of BMC Bioinformatics Volume 20 Supplement 6, 2019: Towards computational modeling on immune system function.  ... 
doi:10.1186/s12859-019-3196-4 pmid:31822261 pmcid:PMC6904991 fatcat:uyf7xch2wfdutmhklwterdselq

In Silico Modeling of the Immune System: Cellular and Molecular Scale Approaches

Mariagrazia Belfiore, Marzio Pennisi, Giuseppina Aricò, Simone Ronsisvalle, Francesco Pappalardo
2014 BioMed Research International  
For the investigation of the physiology and pathology of the immune responses, computer and mathematical models have been used in the last decades, enabling the representation of biological processes.  ...  In this modeling effort, a major issue is represented by the communication between models that work at cellular and molecular level, that is, multiscale representation.  ...  Conflict of Interests The authors declare that there is no conflict of interests regarding the publishing of this paper.  ... 
doi:10.1155/2014/371809 pmid:24804217 pmcid:PMC3997136 fatcat:6ynhk46pljeqplcm4cegankvem

Computational modeling of the immune response in multiple sclerosis using epimod framework

Simone Pernice, Laura Follia, Alessandro Maglione, Marzio Pennisi, Francesco Pappalardo, Francesco Novelli, Marinella Clerico, Marco Beccuti, Francesca Cordero, Simona Rolla
2020 BMC Bioinformatics  
Results We propose a new model to study the immune response in relapsing remitting MS (RRMS), the most common form of MS that is characterized by alternate episodes of symptom exacerbation (relapses) with  ...  Background Multiple Sclerosis (MS) represents nowadays in Europe the leading cause of non-traumatic disabilities in young adults, with more than 700,000 EU cases.  ...  Acknowledgements Computational resources were provided by the High-Performance Centre for Artificial Intelligence (HPC4AI, https :// hpc4a i.unito .it/) of the University of Torino.  ... 
doi:10.1186/s12859-020-03823-9 pmid:33308135 fatcat:bnb7dylkyrbv7mcbu4llh56xga

T-Regulatory Cells In Tumor Progression And Therapy

Amit Verma, Rohit Mathur, Abdullah Farooque, Vandana Kaul, Seema Gupta, Bilikere S Dwarakanath
2019 Cancer Management and Research  
Regulatory T cells (Tregs) are important members of the immune system regulating the host responses to infection and neoplasms.  ...  Thus, Tregs are a hurdle in achieving the complete potential of anti-cancer therapies including immunotherapy.  ...  Treatment with 2-DG or impaired glycolytic conditions such as relapsed, remitting multiple sclerosis reduces the abundance of Foxp3-E2 isoform, necessary for the Treg function. 139 Since suboptimal  ... 
doi:10.2147/cmar.s228887 pmid:31920383 pmcid:PMC6935360 fatcat:clbx4ersivcahhfrjqp4ejjnma

The mTOR Signaling Pathway in Multiple Sclerosis; from Animal Models to Human Data

Aigli G. Vakrakou, Anastasia Alexaki, Maria-Evgenia Brinia, Maria Anagnostouli, Leonidas Stefanis, Panos Stathopoulos
2022 International Journal of Molecular Sciences  
This article recapitulates the evidence on the role of mammalian targets of rapamycin (mTOR) complex pathways in multiple sclerosis (MS).  ...  Importantly, the study of mTOR pathway contributions to autoimmune inflammatory demyelination and multiple sclerosis illustrates the difficulties in the clinical application of animal model results.  ...  Acknowledgments: We thank the members of Biomed Graphics for professional assistance with Figure 2 design. Conflicts of Interest: The authors declare no relevant conflict of interest.  ... 
doi:10.3390/ijms23158077 pmid:35897651 pmcid:PMC9332053 fatcat:d5gfscvon5bfbhaecxgm5euo5m

Adaptive immune regulation of glial homeostasis as an immunization strategy for neurodegenerative diseases

Lisa M. Kosloski, Duy M. Ha, Jessica A. L. Hutter, David K. Stone, Michael R. Pichler, Ashley D. Reynolds, Howard E. Gendelman, R. Lee Mosley
2010 Journal of Neurochemistry  
This review summarizes advances in immune regulation to achieve a homeostatic glial response for therapeutic gain.  ...  relapsing-remitting multiple sclerosis and induces GA-specific CD4+ cells that attenuate activated microglia and protect against neurodegeneration (Benner et al. 2004 , Laurie et al. 2007 .  ...  In this scenario, regulation of adaptive immunity is carried out by mutually opposing activities of Teffs and Tregs.  ... 
doi:10.1111/j.1471-4159.2010.06834.x pmid:20524958 pmcid:PMC2923270 fatcat:vh5axv3wpnhw7diqz7rowtqxmu

Induction of Antigen-Specific Tolerance in T Cell Mediated Diseases

Laura Passerini, Silvia Gregori
2020 Frontiers in Immunology  
Researchers effort resulted in the development of cell-free strategies, including gene vaccination, protein-based approaches and nanoparticles, and an increasing number of clinical trials tested the ability  ...  indirectly the immunomodulatory properties of antigen presenting cells, the ultimate in vivo mediators of tolerance.  ...  ACKNOWLEDGMENTS We thank Giada Amodio for critical reading of the manuscript.  ... 
doi:10.3389/fimmu.2020.02194 pmid:33133064 pmcid:PMC7550404 fatcat:ko6hgakfvjf2rlbgfd6eu7uwvu

Regulation of T-Cell Immune Responses by Pro-Resolving Lipid Mediators

Javier Perez-Hernandez, Valerio Chiurchiù, Sylvain Perruche, Sylvaine You
2021 Frontiers in Immunology  
conditions, including autoimmunity, in human and experimental models.  ...  Bioactive lipids play a major role in the fine-tuning of this dynamic process in a timely manner.  ...  with relapsing-remitting MS (38) .  ... 
doi:10.3389/fimmu.2021.768133 pmid:34868025 pmcid:PMC8635229 fatcat:qfk373pu4feytopom73ewwpg7q

Update on Dendritic Cell-Induced Immunological and Clinical Tolerance

Carolina Obregon, Rajesh Kumar, Manuel Antonio Pascual, Giuseppe Vassalli, Déla Golshayan
2017 Frontiers in Immunology  
Despite successful experimental studies and ongoing phase I/II clinical trials using autologous tolDCs in patients with type 1 diabetes, rheumatoid arthritis, multiple sclerosis, and in SOT recipients,  ...  In this review, we discuss the characteristics of human DCs and recent advances in their classification, as well as the role of DCs in immune regulation and their susceptibility to in vitro or in vivo  ...  These tolDCs induced antigen-specific hyporesponsiveness in myelin-reactive T cells isolated from relapsing-remitting MS patients (167) .  ... 
doi:10.3389/fimmu.2017.01514 pmid:29250057 pmcid:PMC5715373 fatcat:cnbixbcwpbemdggjjvi7pvwoae

Interleukin-2 Family Members and their Role in Demyelinating Disease

: Mahendra K Bhopale
2020 Annals of Immunology & Immunotherapy  
Based on different roles of each family member in demyelinating disease, bio-agents and therapeutic agents have been attempted in an experimental model to study their role in demyelinating disease is described  ...  This family group of an IL-2 cytokine plays important, but different roles in neurologically related demyelinating disease studied in multiple sclerosis (MS) and it's experimentally induced rodent models  ...  Gardi Medical College for the encouragements, and to establish and develop research in biomedical sciences.  ... 
doi:10.23880/aii-16000125 fatcat:i5d7fe2ufvaarosh5wb7ktig5u

Regulatory T Cells As Supporters of Psychoimmune Resilience: Toward Immunotherapy of Major Depressive Disorder

Pierre Ellul, Encarnita Mariotti-Ferrandiz, Marion Leboyer, David Klatzmann
2018 Frontiers in Neurology  
As the main role of regulatory T cells (Tregs) is to control inflammation, this might denote a Treg insufficiency in MDD.  ...  Here, after reviewing the evidence supporting a relation between Treg insufficiency and MDD, we conclude that a novel therapeutic approach based on Treg stimulation could be valuable in at least the subset  ...  In humans, many but not all autoimmune diseases have been associated with a qualitative or a quantitative defect of Tregs, such as in type 1 diabetes, multiple sclerosis, rheumatoid arthritis, and systemic  ... 
doi:10.3389/fneur.2018.00167 pmid:29615964 pmcid:PMC5869201 fatcat:7ruiusiyjff5fhjdoxjezrb6om

Dual destructive and protective roles of adaptive immunity in neurodegenerative disorders

Kristi M Anderson, Katherine E Olson, Katherine A Estes, Ken Flanagan, Howard E Gendelman, R Mosley
2014 Translational Neurodegeneration  
Inappropriate T cell responses in the central nervous system (CNS) affect the pathogenesis of a broad range of neuroinflammatory and neurodegenerative disorders that include, but are not limited to, multiple  ...  The temporal and spatial mechanisms by which these immune responses occur and are regulated in the setting of active disease have gained significant recent attention.  ...  Venken et al. made similar findings in patients suffering from relapsing-remitting MS. However, FOXP3 expression and Treg functionality was normal during secondary progressive MS [40] .  ... 
doi:10.1186/2047-9158-3-25 pmid:25671101 pmcid:PMC4323229 fatcat:5wfmiv4ikfffdpavknvwqa7o5m

Mesenchymal Stem Cells and Induced Pluripotent Stem Cells as Therapies for Multiple Sclerosis

Juan Xiao, Rongbing Yang, Sangita Biswas, Xin Qin, Min Zhang, Wenbin Deng
2015 International Journal of Molecular Sciences  
Multiple sclerosis (MS) is a chronic, autoimmune, inflammatory demyelinating disorder of the central nervous system that leads to permanent neurological deficits.  ...  and repair process in animal models.  ...  Acknowledgments We thank the funding support from the Bureau of Xiangyang City Science and Technology projects  ... 
doi:10.3390/ijms16059283 pmid:25918935 pmcid:PMC4463588 fatcat:ld2ixd5fw5cnzj4ig2phzbxu3a
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