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Age-Related Changes in Topological Degradation of White Matter Networks and Gene Expression in Chronic Schizophrenia

Fon Powell, Eve LoCastro, Diana Acosta, Mohamed Ahmed, Stefani O'Donoghue, Natalie Forde, Dara Cannon, Cathy Scanlon, Tushar Rao, Colm McDonald, Ashish Raj
2017 Brain Connectivity  
However, age-related topological changes within and between white matter (WM) networks and its relationship to gene expression with disease progression remain incompletely understood.  ...  Lastly, we show several gene expression profiles, including DISC1, are associated with age-related changes in WM disconnectivity.  ...  Acknowledgments We gratefully acknowledge funding from the National University of Ireland Galway Millennium Project Fund (C.M.) and a fellowship award from the Ford Foundation (F.P.).  ... 
doi:10.1089/brain.2017.0519 pmid:28946750 pmcid:PMC5695754 fatcat:xebkgtha4jggvazlcgmc2qdmyu

Disruption of Neurosynaptic Physiology and Neuron Network Dysfunction in Brain Disorders: An Environmental and Occupational Health Perspective

Abhay Kumar Pandey
2017 Alzheimer's & Neurodegenerative Diseases  
Disruptions in structure and function of neurotransmission elements and protein networks contribute to pathogenesis of neuropsychiatric diseases.  ...  Networks of signaling cascades regulate synaptic transmission and morphology.  ...  White matter association tracts and frontopolar cortex are critically included in the network [123] .  ... 
doi:10.24966/and-9608/100009 fatcat:t6fdusaa6fca5gbxvnnjloneb4

Disruption of Neurosynaptic Physiology and Neuron Network Dysfunction in Brain Disorders: an Environmental and Occupational Health Perspective

Abhay Kumar Pandey
2017 Activitas Nervosa Superior  
Disruptions in structure and function of neurotransmission elements and protein networks contribute to pathogenesis of neuropsychiatric diseases.  ...  Networks of signaling cascades regulate synaptic transmission and morphology.  ...  White matter association tracts and frontopolar cortex are critically included in the network [123] .  ... 
doi:10.1007/s41470-017-0007-y fatcat:3kau4o6u7zhe3pexhfuqqzoe2u

Models of Network Spread and Network Degeneration in Brain Disorders

Ashish Raj, Fon Powell
2018 Biological Psychiatry: Cognitive Neuroscience and Neuroimaging  
This is an example of dynamics of networks, since network topology is itself  ...  atop a static structural brain network; and "dynamics of networks," which constitutes a changing structural brain network.  ...  Acknowledgements AR was supported in part by NIH grants R01NS092802 and R01 EB022717.  ... 
doi:10.1016/j.bpsc.2018.07.012 pmid:30170711 pmcid:PMC6219468 fatcat:kfszzb54jrgyjcfmkhmlrhjnni

Reduced Cortical Thickness is Associated with the Glutamatergic Regulatory Gene Risk Variant DAOA Arg30Lys in Schizophrenia

C Christoph Schultz, Igor Nenadic, Kathrin Koch, Gerd Wagner, Martin Roebel, Claudia Schachtzabel, Thomas W Mühleisen, Markus M Nöthen, Sven Cichon, Thomas Deufel, Michael Kiehntopf, Marcella Rietschel (+3 others)
2011 Neuropsychopharmacology  
In light of current etiological concepts the glutamatergic system plays an essential role for the pathophysiology of the disorder offering multiple options for new  ...  The sponsor served no role in the study design; in the collection, analysis and interpretation of data; in the writing of the report; or in the decision to submit the paper for publication.  ...  Acknowledgments This work was supported by the Bundesministerium für Bildung und Forschung, BMBF Grant 01GW0740 and the Interdisciplinary Center for Clinical Research of the University of Jena (IZKF).  ... 
doi:10.1038/npp.2011.56 pmid:21508934 pmcid:PMC3138664 fatcat:6xnkhnzphne5jjykfwa3oagnwy

Neurophysiology of Social Conduct and Impact of Adverse Exposures

Abhay Kumar Pandey, Bajarangprasad L. Pandey
2016 Avicenna Journal of Neuro Psycho Physiology  
Description of neuroanatomical projection paths in the brain white matter and acceptance of "associationistic" models of cognitive function helped develop the concept of network in neurology (2).  ...  This article briefly introduces related neurophysiologic and neurotoxicological perspectives; moreover, the interdisciplinary research perspectives relevant to development of preventive and corrective  ...  The deficits correlate the localization of the substantive white matter changes in parietal and temporal lobe with impaired functions (74) .  ... 
doi:10.5812/ajnpp.12452 fatcat:huceo63gyzg25pi6o6xeuvldfm

Integrative genomics study of microglial transcriptome reveals effect of DLG4 (PSD95) on white matter in preterm infants [article]

Michelle L Krishnan, Juliette Van Steenwinckel, Anne-Laure Schang, Jun Yan, Johanna Arnadottir, Tifenn Le Charpentier, Zsolt Csaba, Pascal Dournaud, Sara Cipriani, Constance Auvynet, Luigi Titomanlio, Julien Pansiot (+9 others)
2017 bioRxiv   pre-print
role of microglia in preterm white matter damage.  ...  We examined preterm neuroinflammation in a mouse model of encephalopathy of prematurity induced by IL1B exposure, carrying out a gene network analysis of the cell-specific transcriptomic response to injury  ...  We charted DLG4 gene 453 expression across tissues and found that it is widely expressed in both grey and white matter in 454 adults (Supplementary Figure 8, panel C).  ... 
doi:10.1101/105288 fatcat:dib44lawr5hd7ehzyx7dmaj3nu

Neuroimmunological Aberrations and Cerebral Asymmetry Abnormalities in Schizophrenia: Select Perspectives on Pathogenesis

Ganesan Venkatasubramanian, Monojit Debnath
2014 Clinical Psychopharmacology and Neuroscience  
immunological changes and subsequently affect developmental programming of cerebral asymmetry in schizophrenia.  ...  Within the wide-ranging gamut of factors that comprise gene-environment interactions postulated to underlie schizophrenia, the crosstalk between environmental factors and feto-maternal immune components  ...  The human IL-6 gene is located on chromosome 7p15-7p21 and IL-6 expression is primarily regulated by alterations in gene transcription.  ... 
doi:10.9758/cpn.2014.12.1.8 pmid:24851116 pmcid:PMC4022772 fatcat:u6ybibs3unealk6g2c756yv5ey

Morphological changes in gray matter volume correlate with catechol-O-methyl transferase gene Val158Met polymorphism in first-episode treatment-naïve patients with schizophrenia

Ming-Li Li, Bo Xiang, Yin-Fei Li, Xun Hu, Qiang Wang, Wan-Jun Guo, Wei Lei, Chao-Hua Huang, Lian-Sheng Zhao, Na Li, Hong-Yan Ren, Hui-Yao Wang (+3 others)
2015 Neuroscience Bulletin  
These findings suggest that the COMT Met variant is associated with the disruption of dopaminergic influence on gray matter in schizophrenia, and the effect of the COMT gene on GMV in schizophrenia is  ...  A common functional polymorphism of this gene, Val158/158Met, has been proposed to infl uence gray matter volume (GMV).  ...  white matter (WM), and cerebrospinal fluid using the 'newsegment' routine implemented in SPM8.  ... 
doi:10.1007/s12264-014-1491-7 pmid:25564193 pmcid:PMC5562642 fatcat:tzqg5fiplbhzhhlkxwfc3q5vlm

Panel Session Co-Morbid Pain and Addiction: Novel Treatments

2006 Neuropsychopharmacology  
The relevance of this upregulation and the failure of it in schizophrenia in relation to clinical symptoms and cognitive deficits is not yet known.  ...  Chronic exposure to cocaine induces long-lasting neuroadaptations within the mesocorticolimbic and mesocorticostriatal pathways that are thought to underlie the emergence and expression of addictive behaviors  ...  The Time Course of Antipsychotics Versus Placebo: On Overall Efficacy, Positive, Negative and Cognitive Symptoms John M. Davis*  ... 
doi:10.1038/sj.npp.1301265 fatcat:6odqjmshuncm5muxk5g5knprui

Poster Session II

2010 Neuropsychopharmacology  
Additional analyses will examine relationships between these functional changes and white matter abnormalities in HRSZ.  ...  This yielded no changes in gene expression, suggesting that TARP g and cornichon gene dysregulation in schizophrenia is likely not due to antipsychotic treatment but rather the illness itself.  ...  Genetic disruption in genes, such as NET, with shared expression in the brain and autonomic nervous system, may explain comorbidity of psychiatric and cardiovascular disease.  ... 
doi:10.1038/npp.2010.217 fatcat:gbcgyi35jbdndlwhlgwio7ts7y

Panel and Study Groups

2013 Neuropsychopharmacology  
Methods: We have studied over 238 normal human brains in both DLPFC and hippocampus ranging in age from week 14 in the fetus to 80 years of age, using Illumina microchip arrays, qRT-PCR and RNA Seq.  ...  Moreover, it appears as if there are differences in expression in a number of transcripts for each of these genes especially NKCC1 and KCC2 that confer neuroanatomical and diagnostic specificity with regard  ...  In addition, we identify an enrichment of cognitive disease related genes that demonstrate unique gene expression changes in the human brain.  ... 
doi:10.1038/npp.2013.278 fatcat:expu2u3f3reypazj7tt7jhybfa

Poster Session II

2005 Neuropsychopharmacology  
Sponsor: Alan Swann Background: Fractional anisotropy (FA) as measured by diffusion tensor imaging (DTI) is becoming increasingly used as a measure of subtle white matter pathology in psychiatric populations  ...  These results will be discussed in light of other studies showing evidence of frontal-subcortical dysfunction in cocaine dependent subjects.  ...  Schizophrenia is Associated with Increased Synaptic Dopamine in Associative Rather than Limbic Regions of the Striatum Marc Laruelle*, Lawrence S Kegeles, Gordon W Frankle, Raj Narendran, Roberto Gil,  ... 
doi:10.1038/sj.npp.1300970 fatcat:ikayo4dkwrdrthgopr2hltn2hi

4th European conference on schizophrenia research: together for better treatment and care

2013 European Archives of Psychiatry and Clinical Neuroscience  
drugs, ICD diagnosis, age, and sex.  ...  topology of some neuronal dysfunctions found, like in olfactory dysfunction, dysautonomia, and even pathology in peripheral tissues, i.e., the muscle lesions found in 50 % of cases.  ...  In line with such gene expression findings, evidence for ultrastructural changes in white matter and oligodendrocytes were reported.  ... 
doi:10.1007/s00406-013-0433-0 pmid:23959132 fatcat:zgntoorsxvbbppkld4nuedpfnm

Premature Birth and Developmental Programming: Mechanisms of Resilience and Vulnerability

Femke Lammertink, Christiaan H. Vinkers, Maria L. Tataranno, Manon J. N. L. Benders
2021 Frontiers in Psychiatry  
Here we will review the impact of stress following premature birth on the programming of neurobiological systems and discuss possible stress-related neural circuits and pathways involved in resilience  ...  As preterm birth interferes with early development of stress-regulatory systems, early interventions might strengthen resilience factors and might help reduce the detrimental effects of chronic stress  ...  CV, MT, and MB provided critical revisions. All authors approved the final version of the paper prior to submission.  ... 
doi:10.3389/fpsyt.2020.531571 pmid:33488409 pmcid:PMC7820177 fatcat:kjxmamyekvgyfgkimahaydp6qe
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