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Affine alignment of compound objects: A direct approach

Csaba Domokos, Zoltan Kato
2009 2009 16th IEEE International Conference on Image Processing (ICIP)  
A direct approach for parametric estimation of 2D affine deformations between compound shapes is proposed. It provides the result as a least-square solution of a linear system of equations.  ...  The basic idea is to fit Gaussian densities over the objects yielding covariant functions, which preserves the effect of the unknown transformation.  ...  CONCLUSION In this paper we proposed a novel approach to estimate 2D affine transformations between compound shapes.  ... 
doi:10.1109/icip.2009.5414195 dblp:conf/icip/DomokosK09 fatcat:li5tz35mgrewzboi5xih6jzn4y

Direct approach to the self-calibration of omnidirectional cameras

A. Salazar-Garibay, E. Malis
2009 2009 IEEE 12th International Conference on Computer Vision Workshops, ICCV Workshops  
Calibrating a camera means determining the geometric properties of the imaging process, i.e., the transformation that maps a three-dimensional point, expressed with respect to a reference frame, onto its  ...  Although the camera calibration problem is well understood, no method allowing the robust direct on-line self-calibration for any central omnidirectional camera is known.  ...  Sometimes the field of view band can be aligned vertically, or in any other plane, usually by means of deploying a circularly symmetrical mirror aligned in the required direction.  ... 
doi:10.1109/iccvw.2009.5457546 dblp:conf/iccvw/Salazar-Garibay09 fatcat:hdluhhwivvbxxkq2pmwpot3h6a

SITE DIRECTED MUTAGENESIS OF HUMAN INTERLEUKIN-2 GENE TO INCREASE THE STABILITY OF THE GENE PRODUCT- A BIOINFORMATICS APPROACH
English

Ashwin Kumar Dakshinamurthi, Manthira Vasagam Chidambaram, Vivek Anand Manivel, Swaminathan Detchanamurthy
2009 International Journal of Bioinformatics Research  
Therefore, with the objective of increasing the stability of the molecule, site directed mutagenesis of human IL-2 gene was carried out.  ...  Due to its presumed role in generating a normal immune response, IL-2 is being evaluated for the treatment of a variety of tumors, in addition to infectious diseases.  ...  The main objective of this study is to induce site directed mutagenesis of human interleukin-2 gene to increase the stability of the gene product.  ... 
doi:10.9735/0975-3087.1.2.4-13 fatcat:yr4emfnwiraprlwbhdym2burnu

Increasing thermal stability and improving biodistribution of VEGFR2-binding affibody molecules by a combination of in silico and directed evolution approaches

Rezan Güler, Siri Flemming Svedmark, Ayman Abouzayed, Anna Orlova, John Löfblom
2020 Scientific Reports  
We designed libraries based on the original monomeric binders with the intention of reducing hydrophobicity, while retaining high affinity for VEGFR2.  ...  The most promising mutations were combined into new monomeric constructs which were finally fused into a dimeric construct, resulting in a 15 °C increase in melting temperature, complete refolding capability  ...  directed evolution for specific and high affinity to various protein target molecules.  ... 
doi:10.1038/s41598-020-74560-5 pmid:33097752 fatcat:455kiesasvf2xavqup5g5zvc2e

Objective models for steroid binding sites of human globulins

J Schnitker, R Gopalaswamy, G M Crippen
1997 Journal of Computer-Aided Molecular Design  
We report the application of a recently developed alignment-free 3D QSAR method [Crippen, G.M., J. Comput. Chem., 16 (1995) 486] to a benchmark-type problem.  ...  The test system involves the binding of 31 steroid compounds to two kinds of human carrier protein.  ...  Acknowledgements Partial support of this work by an Upjohn research award is gratefully acknowledged.  ... 
pmid:9139117 fatcat:majyvc5hyzemrc2chu42aiwnta

Molecular Optimization Using Computational Multi-Objective Methods

C.A. Nicolaou, N. Brown, C.S. Pattichis
2007 Zenodo  
Multi-objective optimization (MOOP) methods introduce a new approach for gaining optimality based on compromises and trade-offs among the various objectives.  ...  This approach, known as single-objective optimization (SOOP), strives to discover a single optimal solution to the optimization problem.  ...  at a time -starting with the binding affinity of a molecule -as part of a process involving the sequential optimization of each biological property, each time followed by screening and a large amount  ... 
doi:10.5281/zenodo.2555799 fatcat:r4d75kodwjatppw2z4yohbdsva

Probing the conformation of the resting state of a bacterial multidrug ABC transporter, BmrA, by a site-directed spin labeling approach

Marie-Ange Do Cao, Serge Crouzy, Miyeon Kim, Michel Becchi, David S. Cafiso, Attilio Di Pietro, Jean-Michel Jault
2009 Protein Science  
Interestingly, one of the single point mutants (Q333C) yielded an immobilized EPR spectrum that could arise from a direct interaction with a vicinal tyrosine residue.  ...  Here, a closely related multidrug bacterial ABC transporter, BmrA, was studied using site-directed spin labeling by focusing on a region connecting the transmembrane domain and the nucleotide-binding domain  ...  Anne Durand for her critical reading of the manuscript.  ... 
doi:10.1002/pro.141 pmid:19479721 pmcid:PMC2775218 fatcat:se7dthhebrauniow2sklwfhvca

Data-Driven Object Manipulation in Images

Chen Goldberg, Tao Chen, Fang-Lue Zhang, Ariel Shamir, Shi-Min Hu
2012 Computer graphics forum (Print)  
Figure 1 : An example of object-based image manipulation: augmenting an object in a scene.  ...  (a) Original image with object (horse) selected in red, and augmentation (jockey) sketched in green (b) The output image containing the added jockey and other regions of the source horse (saddle, reins  ...  Acknowledgements This work was supported by the National Basic Research Project of China (2011CB302205), the Natural Science Foundation of China (61120106007, 61103079), and the Israeli Science Foundation  ... 
doi:10.1111/j.1467-8659.2012.03005.x fatcat:xdzdibt2xne3xi2asfneaywnry

Object recognition on humanoids with poveated vision

A. Ude, G. Gheng
2004 4th IEEE/RAS International Conference on Humanoid Robots, 2004.  
Object recognition requires a robot to perform a number of nontrivial tasks such as finding objects of interest, directing its eyes towards the objects, pursuing them, and identifying the objects once  ...  In this paper we describe a system that makes use of foveated vision to solve the problem of object recognition on a humanoid robot.  ...  so that its principal directions are aligned with the coordinate axes, (3) scale the blob so that its major and minor axis are as long as the sides of a predefined window, (4) translate the blob so that  ... 
doi:10.1109/ichr.2004.1442692 dblp:conf/humanoids/UdeG04 fatcat:xmgok774qzbqpf7qsveeuoe2fu

Objective, Quantitative, Data-Driven Assessment of Chemical Probes

Albert A. Antolin, Joseph E. Tym, Angeliki Komianou, Ian Collins, Paul Workman, Bissan Al-Lazikani
2018 Cell Chemical Biology  
or binding affinities on a logarithmic scale (e.g., pIC 50 or pK d ) for the compound.  ...  We demonstrate that our dataled prioritization of chemical tools aligns well with expert recommendation from the Chemical Probes Portal when both approaches have access to the same information.  ... 
doi:10.1016/j.chembiol.2017.11.004 pmid:29249694 pmcid:PMC5814752 fatcat:pjokuxyu7bbangsfmyipszex4i

Strategies of multi-objective optimization in drug discovery and development

Orazio Nicolotti, Ilenia Giangreco, Antonellina Introcaso, Francesco Leonetti, Angela Stefanachi, Angelo Carotti
2011 Expert Opinion on Drug Discovery  
Multi-objective optimization strategies represent a new approach to capture the occurrence of varying optimal solutions based on trade-offs among the objectives taken into account.  ...  Areas covered: The authors review the potential of multi-objective strategies in a number of fields including: drug library design; substructure mining; the derivation of quantitative structure--activity  ...  The authors state no conflict of interest and have received no payment in preparation of this manuscript.  ... 
doi:10.1517/17460441.2011.588696 pmid:22646211 fatcat:enutgmi3s5hbdeiy4rg7gfymce

Object-based image editing

William A. Barrett, Alan S. Cheney
2002 ACM Transactions on Graphics  
OBIE allows the user to perform interactive, high-level editing of image objects in a few seconds to a few ten's of seconds Figure 1 Animation of a static, digital photo: Mrs.  ...  OBIE gives the user direct, local control over object shape, size, and placement while dramatically reducing the time required to perform image editing tasks.  ...  However, for object-level control, OBIE has much to offer over current pixel-based methods.  ... 
doi:10.1145/566654.566651 fatcat:2tzj2tthfveddmssslzhzkl4va

Object-based image editing

William A. Barrett, Alan S. Cheney
2002 ACM Transactions on Graphics  
OBIE allows the user to perform interactive, high-level editing of image objects in a few seconds to a few ten's of seconds Figure 1 Animation of a static, digital photo: Mrs.  ...  OBIE gives the user direct, local control over object shape, size, and placement while dramatically reducing the time required to perform image editing tasks.  ...  However, for object-level control, OBIE has much to offer over current pixel-based methods.  ... 
doi:10.1145/566570.566651 fatcat:k4poikblqneqnehl7oekspbjru

Differential Object Marking [article]

Giorgio Iemmolo
2020 Zenodo  
It is a typological investigation of Differential Object Marking and Differential Object Indexation, that is the phenomena whereby some direct objects, but not others, are either overtly marked or indexed  ...  This book is a revision of my 2011 dissertation.  ...  Otherwise direct object affixes must be attached to post-cliticised auxiliaries that are usually compounded with the main verb stem, forming thus a sort of serial verb construction (see also Foley 1986  ... 
doi:10.5281/zenodo.4388380 fatcat:ny6dxygtwjftxpoj24ne7deq7e

The Potentials of Learning Object Design in Design Thinking Learning

Can Guvenir, H. Humanur Bagli
2019 Markets, Globalization & Development Review: The Official Journal of the International Society of Markets and Development  
Learning objects are the fundamental part of a learning process that carries the properties of the learning theory and the learning goals.  ...  Design thinking education -as a constructivist learning approach -has skill-based, effective and cognitive learning outcomes.  ...  Compound objects exist on a micro to macro level continuum from material with minimally added context.  ... 
doi:10.23860/mgdr-2019-04-02-03 fatcat:qk5yyctsdzaddoxdh2vw2mqs4m
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