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A case of hyperkeratotic crusted scabies
2020
PLoS Neglected Tropical Diseases
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JA, Martinez-Moreno A,
Jaramillo-Moreno G, Ocampo-Candiani J (2020) A
case of hyperkeratotic crusted scabies. ...
confirming the diagnosis of CS(Fig 0007918 March 5, 2020
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Citation: Cuellar-Barboza A, Cardenas-de la Garza
JA, García-Lozano ...
doi:10.1371/journal.pntd.0007918
pmid:32134911
fatcat:i3dngkp2cnddrhwrn4bcy2lph4
Functional Enrichment Analysis of Regulatory Elements
2022
Biomedicines
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This work is part of Adrian García-Moreno the doctoral thesis. Adrian García-Moreno is enrolled in the Ph.D. program in Biomedicine at the University of Granada, Spain. ...
doi:10.3390/biomedicines10030590
pmid:35327392
pmcid:PMC8945021
fatcat:i55ycjjsvfa2dirmypqdvwrmrm
Macular dysfunction in drusen maculopathy assessed with multifocal electroretinogram and optical coherence tomography
2013
Clinical Ophthalmology
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To study the relationship between macular function assessed by multifocal electroretinogram (mfERG) and morphological changes evaluated with optical coherence tomography (OCT) and fundus photography in patients with drusen maculopathy. Ten patients (age 71 ± 5 years) with drusen maculopathy were compared to fifteen healthy control patients (age 67 ± 7 years). One eye per patient was examined with OCT, color fundus pictures, and mfERG (103 hexagons) recorded in nine areas corresponding to the
doi:10.2147/opth.s39258
pmid:23836959
pmcid:PMC3702544
fatcat:7gs7xk7gdreftgq2odupu4t26u
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... e areas of the OCT retinal map. Drusen density for every separated area was registered. All nine areas in the maculopathy group demonstrated prolonged implicit time compared to healthy controls; the mean value for the maculopathy group was 31.3 milliseconds (95% confidence intervals [CI]: 30.9-31.6) vs 27.9 milliseconds (95% CI: 27.5-28.2; P = 0.006) for the control group. The amplitude in the foveal area was lower in the maculopathy group; the mean value for the maculopathy group was 25.1 nV/deg(2) (95% CI: 18.4-31.7) vs 33.9 nV/deg(2) (95% CI: 27-40.9; P = 0.03) for the control group. mfERG in the maculopathy group demonstrated no differences in areas with or without drusen. There was no correlation between the retinal thickness assessed with OCT and the mfERG response. Eyes with drusen maculopathy demonstrated functional changes compared to healthy controls evaluated with mfERG. Drusen seems to be associated with general macular dysfunction.
Treatment of Pulmonary Disease of Cystic Fibrosis: A Comprehensive Review
2021
Antibiotics
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Cystic fibrosis (CF) is a genetic disease that causes absence or dysfunction of a protein named transmembrane conductance regulatory protein (CFTR) that works as an anion channel. As a result, the secretions of the organs where CFTR is expressed are very viscous, so their functionality is altered. The main cause of morbidity is due to the involvement of the respiratory system as a result of recurrent respiratory infections by different pathogens. In recent decades, survival has been increasing,
doi:10.3390/antibiotics10050486
pmid:33922413
fatcat:m3rk2vdblvdn7j6dmxohwsogte
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... rising by around age 50. This is due to the monitoring of patients in multidisciplinary units, early diagnosis with neonatal screening, and advances in treatments. In this chapter, we will approach the different therapies used in CF for the treatment of symptoms, obstruction, inflammation, and infection. Moreover, we will discuss specific and personalized treatments to correct the defective gene and repair the altered protein CFTR. The obstacle for personalized CF treatment is to predict the drug response of patients due to genetic complexity and heterogeneity of uncommon mutations.
Computational Methods and Software Tools for Functional Analysis of miRNA Data
2020
Biomolecules
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miRNAs are important regulators of gene expression that play a key role in many biological processes. High-throughput techniques allow researchers to discover and characterize large sets of miRNAs, and enrichment analysis tools are becoming increasingly important in decoding which miRNAs are implicated in biological processes. Enrichment analysis of miRNA targets is the standard technique for functional analysis, but this approach carries limitations and bias; alternatives are currently being
doi:10.3390/biom10091252
pmid:32872205
fatcat:u7ehu6nncnbt7pfcbhvb62odpa
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... oposed, based on direct and curated annotations. In this review, we describe the two workflows of miRNAs enrichment analysis, based on target gene or miRNA annotations, highlighting statistical tests, software tools, up-to-date databases, and functional annotations resources in the study of metazoan miRNAs.
Automatic detection of genomic regions with informative epigenetic patterns
2018
BMC Genomics
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Epigenetic phenomena are crucial for explaining the phenotypic plasticity seen in the cells of different tissues, developmental stages and diseases, all holding the same DNA sequence. As technology is allowing to retrieve epigenetic information in a genome-wide fashion, massive epigenomic datasets are being accumulated in public repositories. New approaches are required to mine those data to extract useful knowledge. We present here an automatic approach for detecting genomic regions with
doi:10.1186/s12864-018-5286-5
pmid:30486775
pmcid:PMC6264639
fatcat:r4uxrawes5atvhvxrqdkj7imxa
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... etic variation patterns across samples related to a grouping of these samples, as a way of detecting regions functionally associated to the phenomenon behind the classification. We show that the regions automatically detected by the method in the whole human genome associated to three different classifications of a set of epigenomes (cancer vs. healthy, brain vs. other organs, and fetal vs. adult tissues) are enriched in genes associated to these processes. The method is fully automatic and can exhaustively scan the whole human genome at any resolution using large collections of epigenomes as input, although it also produces good results with small datasets. Consequently, it will be valuable for obtaining functional information from the incoming epigenomic information as it continues to accumulate.
Context-Aware Music Recommender Systems for Groups: A Comparative Study
2021
Information
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Valera, A.; Murciego, A.L.; Moreno-Garcia, M.N. Group Recommender Systems in the Music Domain: A Systematic Literature
Review. ...
Moreno-García *
Department of Computer Science and Automation, Science Faculty, University of Salamanca,
Plaza de los Caídos ...
doi:10.3390/info12120506
fatcat:lqpdktilz5ffdpsfj7cs2wgary
Ecotecnología y sustentabilidad: una aproximación para el Sur global
2015
INTERdisciplina
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Ortiz Moreno, Malagón García y Masera CeruttiEcotecnología y sustentabilidad: una aproximación…D O S S I E R ...
Ortiz Moreno, Malagón García y Masera Cerutti
Ecotecnología y sustentabilidad: una aproximación…
D O S S I E R
Martínez-Alier (2002) propone tres principales corrientes del ambientalismo: " ...
doi:10.22201/ceiich.24485705e.2015.7.52391
fatcat:ng6eg5v6drb5neuf5bzh6hhdey
POTTERY GRAVE GOODS FROM FUNERARY CONTEXTS AT THE ARGARIC SITE OF PEÑALOSA (JAÉN). A METHODOLOGICAL APPROACH
2020
Journal of Ancient History and Archaeology
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, as well as the presence in all the samples of peaks of thermally modified phyllosilicates, indicates that the vessels were 26 WEST 1992; SCHIFFER et alii 1994. 27 GARCÍA-ROSELLÓ/CALVO 2006. 28 LINARES ...
9-octadecenoic acid; 9: Octadecanoic acid; 10: Hexadecane, 2,6,10,14-tetramethyl; 11: Nonadecane; 12: Tetracosanoic acid; 13: Hexacosanoic acid; 14: Octacosanoic acid. 11 SCHIFFER 11 et alii 1994; GARCÍA-ROSELLÓ ...
doi:10.14795/j.v7i3.536
fatcat:s77ix4c775d3vfhyyop4xsvwvq
GeneCodis 4: Expanding the modular enrichment analysis to regulatory elements
[article]
2021
bioRxiv
pre-print
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In this context, different groups are proposing dedicated tools for functional analysis of miRNAs (Garcia-Moreno and Carmona-Saez, 2020) or methylation data (Ren and Kuan, 2019) . ...
Finally, TFs-gene annotations were retrieved from DoRothEA (Garcia-Alonso et al., 2019) which includes curated interactomes for human and mouse. ...
doi:10.1101/2021.04.15.439962
fatcat:a5tnq64lc5dujnzchkwhpw5gpy
Actively Measuring Personal Cloud Storage
2013
2013 IEEE Sixth International Conference on Cloud Computing
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The Personal Cloud model is a mainstream service that meets the growing demand of millions of users for reliable off-site storage. However, despite their broad adoption, very little is known about the quality of service (QoS) of Personal Clouds. In this paper, we present a measurement study of three major Personal Clouds: DropBox, Box and SugarSync. Actively accessing to free accounts through their REST APIs, we analyzed important aspects to characterize their QoS, such as transfer speed,
doi:10.1109/cloud.2013.25
dblp:conf/IEEEcloud/TinedoAACL13
fatcat:buosty7ovze6tfylxogzsyfvkm
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... ility and failure rate. Our measurement, conducted during two months, is the first to deeply analyze many facets of these popular services and reveals new insights, such as important performance differences among providers, the existence of transfer speed daily patterns or sudden service breakdowns. We believe that the present analysis of Personal Clouds is of interest to researchers and developers with diverse concerns about Cloud storage, since our observations can help them to understand and characterize the nature of these services.
Técnica de diafanización con alizarina para el estudio del desarrollo óseo
2015
Revista Colombiana Salud Libre
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La diafanización es una técnica anatómica útil para el estudio del desarrollo óseo y dental, así como para la determinación de los centros de osificación en animales vertebrados. El proceso de diafanización se desarrolla en tres etapas: fijación con formaldehido, tinción con rojo de alizarina, corrosión y conservación. En la diafanización se usan diferentes reactivos como la alizarina roja al 0,1% en agua o alcohol etílico, la solución de KOH 2% en agua y glicerina. Una ventaja importante de la
doi:10.18041/1900-7841/rcslibre.2015v10n2.1430
fatcat:zsktpiwikjfu3dd3dbwkj6rxom
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... diafanización es que los especímenes no son conservados en formaldehido sino en glicerina.
Managing Uncertain Complex Events in Web of Things Applications
[chapter]
2018
Lecture Notes in Computer Science
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A critical issue in the Web of Things (WoT) is the need to process and analyze the interactions of Web-interconnected real-world objects. Complex Event Processing (CEP) is a powerful technology for analyzing streams of information about real-time distributed events, coming from different sources, and for extracting conclusions from them. However, in many situations these events are not free from uncertainty, due to either unreliable data sources and networks, measurement uncertainty, or to the
doi:10.1007/978-3-319-91662-0_28
fatcat:fstoaudy35efzpvo7dkni3damq
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... nability to determine whether an event has actually happened or not. This short research paper discusses how CEP systems can incorporate different kinds of uncertainty, both in the events and in the rules. A case study is used to validate the proposal, and we discuss the benefits and limitations of this CEP extension.
Imputation Performance in Latin American Populations: Improving Rare Variants Representation With the Inclusion of Native American Genomes
2022
Frontiers in Genetics
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We are grateful to Mitzi Flores and Adriana Garmendia for project management support and to Carlos Conde, Victor Guerrero Lemus, Armando Mendez Herrera, Cruz Portugal García, Ma. ...
We also thank Mary Ortega, Cecilia Gutiérrez, and Sara García for technical assistance, Jacob Cervantes for IT support, and Aaron Ragsdale for comments on earlier versions of the manuscript. ...
., 2015) , and facilitated disease stratification (Chatterjee, Shi, and García-Closas 2016) . ...
doi:10.3389/fgene.2021.719791
pmid:35046991
pmcid:PMC8762266
fatcat:hm4xavs5yndtpk3tbw7civokse
Context-Aware Recommender Systems in the Music Domain: A Systematic Literature Review
2021
Electronics
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The design of recommendation algorithms aware of the user's context has been the subject of great interest in the scientific community, especially in the music domain where contextual factors have a significant impact on the recommendations. In this type of system, the user's contextual information can come from different sources such as the specific time of day, the user's physical activity, and geolocation, among many others. This context information is generally obtained by electronic
doi:10.3390/electronics10131555
fatcat:ehnvydv64rfbxghmf2kmrhdndq
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... used by the user to listen to music such as smartphones and other secondary devices such as wearables and Internet of Things (IoT) devices. The objective of this paper is to present a systematic literature review to analyze recent work to date in the field of context-aware recommender systems and specifically in the domain of music recommendation. This paper aims to analyze and classify the type of contextual information, the electronic devices used to collect it, the main outstanding challenges and the possible opportunities for future research directions.
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