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A case of hyperkeratotic crusted scabies

Adrian Cuellar-Barboza, Jesus A. Cardenas-de la Garza, José A. García-Lozano, Adrian Martinez-Moreno, Gildardo Jaramillo-Moreno, Jorge Ocampo-Candiani, Aysegul Taylan Ozkan
2020 PLoS Neglected Tropical Diseases  
JA, Martinez-Moreno A, Jaramillo-Moreno G, Ocampo-Candiani J (2020) A case of hyperkeratotic crusted scabies.  ...  confirming the diagnosis of CS(Fig 0007918 March 5, 2020 1 / 4 a1111111111 a1111111111 a1111111111 a1111111111 a1111111111 OPEN ACCESS Citation: Cuellar-Barboza A, Cardenas-de la Garza JA, García-Lozano  ... 
doi:10.1371/journal.pntd.0007918 pmid:32134911 fatcat:i3dngkp2cnddrhwrn4bcy2lph4

Functional Enrichment Analysis of Regulatory Elements

Adrian Garcia-Moreno, Raul López-Domínguez, Juan Antonio Villatoro-García, Alberto Ramirez-Mena, Ernesto Aparicio-Puerta, Michael Hackenberg, Alberto Pascual-Montano, Pedro Carmona-Saez
2022 Biomedicines  
This work is part of Adrian García-Moreno the doctoral thesis. Adrian García-Moreno is enrolled in the Ph.D. program in Biomedicine at the University of Granada, Spain.  ... 
doi:10.3390/biomedicines10030590 pmid:35327392 pmcid:PMC8945021 fatcat:i55ycjjsvfa2dirmypqdvwrmrm

Macular dysfunction in drusen maculopathy assessed with multifocal electroretinogram and optical coherence tomography

Jose Garcia-Garcia, Monica Lovestam Adrian, Andréasson, Holm, Ruiz-Moreno
2013 Clinical Ophthalmology  
To study the relationship between macular function assessed by multifocal electroretinogram (mfERG) and morphological changes evaluated with optical coherence tomography (OCT) and fundus photography in patients with drusen maculopathy. Ten patients (age 71 ± 5 years) with drusen maculopathy were compared to fifteen healthy control patients (age 67 ± 7 years). One eye per patient was examined with OCT, color fundus pictures, and mfERG (103 hexagons) recorded in nine areas corresponding to the
more » ... e areas of the OCT retinal map. Drusen density for every separated area was registered. All nine areas in the maculopathy group demonstrated prolonged implicit time compared to healthy controls; the mean value for the maculopathy group was 31.3 milliseconds (95% confidence intervals [CI]: 30.9-31.6) vs 27.9 milliseconds (95% CI: 27.5-28.2; P = 0.006) for the control group. The amplitude in the foveal area was lower in the maculopathy group; the mean value for the maculopathy group was 25.1 nV/deg(2) (95% CI: 18.4-31.7) vs 33.9 nV/deg(2) (95% CI: 27-40.9; P = 0.03) for the control group. mfERG in the maculopathy group demonstrated no differences in areas with or without drusen. There was no correlation between the retinal thickness assessed with OCT and the mfERG response. Eyes with drusen maculopathy demonstrated functional changes compared to healthy controls evaluated with mfERG. Drusen seems to be associated with general macular dysfunction.
doi:10.2147/opth.s39258 pmid:23836959 pmcid:PMC3702544 fatcat:7gs7xk7gdreftgq2odupu4t26u

Treatment of Pulmonary Disease of Cystic Fibrosis: A Comprehensive Review

Rosa María Girón Moreno, Marta García-Clemente, Layla Diab-Cáceres, Adrián Martínez-Vergara, Miguel Ángel Martínez-García, Rosa Mar Gómez-Punter
2021 Antibiotics  
Cystic fibrosis (CF) is a genetic disease that causes absence or dysfunction of a protein named transmembrane conductance regulatory protein (CFTR) that works as an anion channel. As a result, the secretions of the organs where CFTR is expressed are very viscous, so their functionality is altered. The main cause of morbidity is due to the involvement of the respiratory system as a result of recurrent respiratory infections by different pathogens. In recent decades, survival has been increasing,
more » ... rising by around age 50. This is due to the monitoring of patients in multidisciplinary units, early diagnosis with neonatal screening, and advances in treatments. In this chapter, we will approach the different therapies used in CF for the treatment of symptoms, obstruction, inflammation, and infection. Moreover, we will discuss specific and personalized treatments to correct the defective gene and repair the altered protein CFTR. The obstacle for personalized CF treatment is to predict the drug response of patients due to genetic complexity and heterogeneity of uncommon mutations.
doi:10.3390/antibiotics10050486 pmid:33922413 fatcat:m3rk2vdblvdn7j6dmxohwsogte

Computational Methods and Software Tools for Functional Analysis of miRNA Data

Adrian Garcia-Moreno, Pedro Carmona-Saez
2020 Biomolecules  
miRNAs are important regulators of gene expression that play a key role in many biological processes. High-throughput techniques allow researchers to discover and characterize large sets of miRNAs, and enrichment analysis tools are becoming increasingly important in decoding which miRNAs are implicated in biological processes. Enrichment analysis of miRNA targets is the standard technique for functional analysis, but this approach carries limitations and bias; alternatives are currently being
more » ... oposed, based on direct and curated annotations. In this review, we describe the two workflows of miRNAs enrichment analysis, based on target gene or miRNA annotations, highlighting statistical tests, software tools, up-to-date databases, and functional annotations resources in the study of metazoan miRNAs.
doi:10.3390/biom10091252 pmid:32872205 fatcat:u7ehu6nncnbt7pfcbhvb62odpa

Automatic detection of genomic regions with informative epigenetic patterns

Florencio Pazos, Adrian Garcia-Moreno, Juan C Oliveros
2018 BMC Genomics  
Epigenetic phenomena are crucial for explaining the phenotypic plasticity seen in the cells of different tissues, developmental stages and diseases, all holding the same DNA sequence. As technology is allowing to retrieve epigenetic information in a genome-wide fashion, massive epigenomic datasets are being accumulated in public repositories. New approaches are required to mine those data to extract useful knowledge. We present here an automatic approach for detecting genomic regions with
more » ... etic variation patterns across samples related to a grouping of these samples, as a way of detecting regions functionally associated to the phenomenon behind the classification. We show that the regions automatically detected by the method in the whole human genome associated to three different classifications of a set of epigenomes (cancer vs. healthy, brain vs. other organs, and fetal vs. adult tissues) are enriched in genes associated to these processes. The method is fully automatic and can exhaustively scan the whole human genome at any resolution using large collections of epigenomes as input, although it also produces good results with small datasets. Consequently, it will be valuable for obtaining functional information from the incoming epigenomic information as it continues to accumulate.
doi:10.1186/s12864-018-5286-5 pmid:30486775 pmcid:PMC6264639 fatcat:r4uxrawes5atvhvxrqdkj7imxa

Context-Aware Music Recommender Systems for Groups: A Comparative Study

Adrián Valera, Álvaro Lozano Murciego, María N. Moreno-García
2021 Information  
Valera, A.; Murciego, A.L.; Moreno-Garcia, M.N. Group Recommender Systems in the Music Domain: A Systematic Literature Review.  ...  Moreno-García * Department of Computer Science and Automation, Science Faculty, University of Salamanca, Plaza de los Caídos  ... 
doi:10.3390/info12120506 fatcat:lqpdktilz5ffdpsfj7cs2wgary

Ecotecnología y sustentabilidad: una aproximación para el Sur global

Jorge Adrián Ortiz Moreno, Sandra Luz Malagón García, Omar Raúl Masera Cerutti
2015 INTERdisciplina  
Ortiz Moreno, Malagón García y Masera CeruttiEcotecnología y sustentabilidad: una aproximación…D O S S I E R  ...  Ortiz Moreno, Malagón García y Masera Cerutti Ecotecnología y sustentabilidad: una aproximación… D O S S I E R Martínez-Alier (2002) propone tres principales corrientes del ambientalismo: "  ... 
doi:10.22201/ceiich.24485705e.2015.7.52391 fatcat:ng6eg5v6drb5neuf5bzh6hhdey

POTTERY GRAVE GOODS FROM FUNERARY CONTEXTS AT THE ARGARIC SITE OF PEÑALOSA (JAÉN). A METHODOLOGICAL APPROACH

Alejandra García-García, Laura Vico-Triguero, Eva Alarcón-García, Eloísa Manzano-Moreno, Antonio Samuel Cantarero-Malagón, Juan Jesús Padilla-Fernández, Adrián Mora-González, Auxilio Moreno-Onorato, Francisco Martín-Peinado, Francisco Contreras-Cortés
2020 Journal of Ancient History and Archaeology  
, as well as the presence in all the samples of peaks of thermally modified phyllosilicates, indicates that the vessels were 26 WEST 1992; SCHIFFER et alii 1994. 27 GARCÍA-ROSELLÓ/CALVO 2006. 28 LINARES  ...  9-octadecenoic acid; 9: Octadecanoic acid; 10: Hexadecane, 2,6,10,14-tetramethyl; 11: Nonadecane; 12: Tetracosanoic acid; 13: Hexacosanoic acid; 14: Octacosanoic acid. 11 SCHIFFER 11 et alii 1994; GARCÍA-ROSELLÓ  ... 
doi:10.14795/j.v7i3.536 fatcat:s77ix4c775d3vfhyyop4xsvwvq

GeneCodis 4: Expanding the modular enrichment analysis to regulatory elements [article]

Adrian Garcia-Moreno, Raul Lopez-Dominguez, Alberto Ramirez-Mena, Alberto Pascual-Montano, Ernesto Aparicio-Puerta, Michael Hackenberg, Pedro Carmona-Saez
2021 bioRxiv   pre-print
In this context, different groups are proposing dedicated tools for functional analysis of miRNAs (Garcia-Moreno and Carmona-Saez, 2020) or methylation data (Ren and Kuan, 2019) .  ...  Finally, TFs-gene annotations were retrieved from DoRothEA (Garcia-Alonso et al., 2019) which includes curated interactomes for human and mouse.  ... 
doi:10.1101/2021.04.15.439962 fatcat:a5tnq64lc5dujnzchkwhpw5gpy

Actively Measuring Personal Cloud Storage

Raul Gracia-Tinedo, Marc Sanchez Artigas, Adrian Moreno-Martinez, Cristian Cotes, Pedro Garcia Lopez
2013 2013 IEEE Sixth International Conference on Cloud Computing  
The Personal Cloud model is a mainstream service that meets the growing demand of millions of users for reliable off-site storage. However, despite their broad adoption, very little is known about the quality of service (QoS) of Personal Clouds. In this paper, we present a measurement study of three major Personal Clouds: DropBox, Box and SugarSync. Actively accessing to free accounts through their REST APIs, we analyzed important aspects to characterize their QoS, such as transfer speed,
more » ... ility and failure rate. Our measurement, conducted during two months, is the first to deeply analyze many facets of these popular services and reveals new insights, such as important performance differences among providers, the existence of transfer speed daily patterns or sudden service breakdowns. We believe that the present analysis of Personal Clouds is of interest to researchers and developers with diverse concerns about Cloud storage, since our observations can help them to understand and characterize the nature of these services.
doi:10.1109/cloud.2013.25 dblp:conf/IEEEcloud/TinedoAACL13 fatcat:buosty7ovze6tfylxogzsyfvkm

Técnica de diafanización con alizarina para el estudio del desarrollo óseo

Guillermo a Adrián Rivera Cardona, Angélica García, Freddy Alonso Moreno Gómez
2015 Revista Colombiana Salud Libre  
La diafanización es una técnica anatómica útil para el estudio del desarrollo óseo y dental, así como para la determinación de los centros de osificación en animales vertebrados. El proceso de diafanización se desarrolla en tres etapas: fijación con formaldehido, tinción con rojo de alizarina, corrosión y conservación. En la diafanización se usan diferentes reactivos como la alizarina roja al 0,1% en agua o alcohol etílico, la solución de KOH 2% en agua y glicerina. Una ventaja importante de la
more » ... diafanización es que los especímenes no son conservados en formaldehido sino en glicerina.
doi:10.18041/1900-7841/rcslibre.2015v10n2.1430 fatcat:zsktpiwikjfu3dd3dbwkj6rxom

Managing Uncertain Complex Events in Web of Things Applications [chapter]

Nathalie Moreno, Manuel F. Bertoa, Gala Barquero, Loli Burgueño, Javier Troya, Adrián García-López, Antonio Vallecillo
2018 Lecture Notes in Computer Science  
A critical issue in the Web of Things (WoT) is the need to process and analyze the interactions of Web-interconnected real-world objects. Complex Event Processing (CEP) is a powerful technology for analyzing streams of information about real-time distributed events, coming from different sources, and for extracting conclusions from them. However, in many situations these events are not free from uncertainty, due to either unreliable data sources and networks, measurement uncertainty, or to the
more » ... nability to determine whether an event has actually happened or not. This short research paper discusses how CEP systems can incorporate different kinds of uncertainty, both in the events and in the rules. A case study is used to validate the proposal, and we discuss the benefits and limitations of this CEP extension.
doi:10.1007/978-3-319-91662-0_28 fatcat:fstoaudy35efzpvo7dkni3damq

Imputation Performance in Latin American Populations: Improving Rare Variants Representation With the Inclusion of Native American Genomes

Andrés Jiménez-Kaufmann, Amanda Y. Chong, Adrián Cortés, Consuelo D. Quinto-Cortés, Selene L. Fernandez-Valverde, Leticia Ferreyra-Reyes, Luis Pablo Cruz-Hervert, Santiago G. Medina-Muñoz, Mashaal Sohail, María J. Palma-Martinez, Gudalupe Delgado-Sánchez, Norma Mongua-Rodríguez (+13 others)
2022 Frontiers in Genetics  
We are grateful to Mitzi Flores and Adriana Garmendia for project management support and to Carlos Conde, Victor Guerrero Lemus, Armando Mendez Herrera, Cruz Portugal García, Ma.  ...  We also thank Mary Ortega, Cecilia Gutiérrez, and Sara García for technical assistance, Jacob Cervantes for IT support, and Aaron Ragsdale for comments on earlier versions of the manuscript.  ...  ., 2015) , and facilitated disease stratification (Chatterjee, Shi, and García-Closas 2016) .  ... 
doi:10.3389/fgene.2021.719791 pmid:35046991 pmcid:PMC8762266 fatcat:hm4xavs5yndtpk3tbw7civokse

Context-Aware Recommender Systems in the Music Domain: A Systematic Literature Review

Álvaro Lozano Murciego, Diego M. Jiménez-Bravo, Adrián Valera Román, Juan F. De Paz Santana, María N. Moreno-García
2021 Electronics  
The design of recommendation algorithms aware of the user's context has been the subject of great interest in the scientific community, especially in the music domain where contextual factors have a significant impact on the recommendations. In this type of system, the user's contextual information can come from different sources such as the specific time of day, the user's physical activity, and geolocation, among many others. This context information is generally obtained by electronic
more » ... used by the user to listen to music such as smartphones and other secondary devices such as wearables and Internet of Things (IoT) devices. The objective of this paper is to present a systematic literature review to analyze recent work to date in the field of context-aware recommender systems and specifically in the domain of music recommendation. This paper aims to analyze and classify the type of contextual information, the electronic devices used to collect it, the main outstanding challenges and the possible opportunities for future research directions.
doi:10.3390/electronics10131555 fatcat:ehnvydv64rfbxghmf2kmrhdndq
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