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Addictive links: the motivational value of adaptive link annotation

Peter Brusilovsky, Sergey Sosnovsky, Michael Yudelson
2009 New Review of Hypermedia and Multimedia  
Adaptive link annotation is a popular adaptive navigation support technology.  ...  In this paper, we present our exploration of a less known effect of adaptive annotation, its ability to significantly increase student motivation to work with non-mandatory educational content.  ...  ACKNOWLEDGEMENT This material is based upon work supported by the National Science Foundation under Grants No. 0310576, 042602, and 0447083.  ... 
doi:10.1080/13614560902803570 fatcat:vatdpkaihjdsxis2zkjmt5rti4

Addictive Links: The Motivational Value of Adaptive Link Annotation in Educational Hypermedia [chapter]

Peter Brusilovsky, Sergey Sosnovsky, Michael Yudelson
2006 Lecture Notes in Computer Science  
Adaptive link annotation is a popular adaptive navigation support technology.  ...  In this paper, we present our exploration of a less known effect of adaptive annotation, its ability to significantly increase student motivation to work with non-mandatory educational content.  ...  ACKNOWLEDGEMENT This material is based upon work supported by the National Science Foundation under Grants No. 0310576, 042602, and 0447083.  ... 
doi:10.1007/11768012_7 fatcat:ytsdpgs6jrfn5iivdnfqjmka4a

Neural and psychological mechanisms underlying appetitive learning: links to drug addiction

Rudolf N Cardinal, Barry J Everitt
2004 Current Opinion in Neurobiology  
Drug addiction, in some way an 'abnormal' set of motivated behaviours, reflects the complexity of instrumental conditioning itself. Addiction is multifactorial.  ...  By contrast, a primary characteristic of human addiction [72] is that responding for non-drug reinforcement decreases relative to that for drug reinforcement (whether because the value of, or motivation  ...  When rats learn to press a lever for food, their actions are initially goal directed and if the value of the reinforcer is subsequently altered, their responding is sensitive to this.  ... 
doi:10.1016/j.conb.2004.03.004 pmid:15082319 fatcat:cuyn7owc3fg5jpefadtvkozpjm

Gene Expression in the Addicted Brain [chapter]

Zhifeng Zhou, Mary-Anne Enoch, David Goldman
2014 International review of neurobiology  
The molecular effects of addiction depend on timing of exposure or withdrawal, the stage of adaptation, the brain region, and the behavioral model, there being many models of addiction.  ...  Addiction is due to changes in the structure and function of the brain, including neuronal networks and the cells that comprise them.  ...  (A) Scatter plot of -log 10 P (uncorrected P value) versus FDR q value for all 16,008 expressed genes.  ... 
doi:10.1016/b978-0-12-801105-8.00010-2 pmid:25172478 pmcid:PMC4427035 fatcat:hhsuvmvvgrgu7hq5i5chk7ihbm

WHAT'S IN A NAME?

2007 Addiction  
We report here on the semantic variations that occur in the sublanguages of two biomedical subdomains, i.e. cell biology and pharmacology, at the level of named entity information.  ...  There are lexical, syntactic, semantic and discourse variations amongst the languages used in various biomedical subdomains.  ...  Acknowledgements We would like to acknowledge the help given by Dr. C.J. Rupp in obtaining the collection of documents from the Open Access section of the UKMPC.  ... 
doi:10.1111/j.1360-0443.2007.01812.x pmid:17493102 fatcat:uia6ruzujnctpkb5d6unxcjr5q

Characterizing intercellular signaling peptides in drug addiction

Elena V. Romanova, Nathan G. Hatcher, Stanislav S. Rubakhin, Jonathan V. Sweedler
2009 Neuropharmacology  
The roles of SPs in the addiction process are highlighted, as are the analytical approaches used to detect and characterize them.  ...  Throughout the past 35 years, the National Institute on Drug Abuse has made significant resources available to scientists that study the mechanisms of drug addiction.  ...  Acknowledgements This material is based upon work supported by the National Institute of Drug Abuse under Award No. DA017940 and No.  ... 
doi:10.1016/j.neuropharm.2008.07.036 pmid:18722391 pmcid:PMC2665169 fatcat:ghcmgldlmrdfnig52n4orynpx4

Addiction-associated genetic variants implicate brain cell type- and region-specific cis-regulatory elements in addiction neurobiology

Chaitanya Srinivasan, BaDoi N. Phan, Alyssa J. Lawler, Easwaran Ramamurthy, Michael Kleyman, Ashley R. Brown, Irene M. Kaplow, Morgan E. Wirthlin, Andreas R. Pfenning
2021 Journal of Neuroscience  
Most genetic variants linked to addiction-associated traits lie in non-coding regions of the genome, likely disrupting cis-regulatory element (CRE) function.  ...  CREs tend to be highly cell type-specific and may contribute to the functional development of the neural circuits underlying addiction.  ...  Our findings link the 910 genetic heritability of addiction-associated behaviors to the OCR profiles of neuronal subtypes 911 and brain regions and present specific hypotheses describing how genetic variants  ... 
doi:10.1523/jneurosci.2534-20.2021 pmid:34462306 pmcid:PMC8549541 fatcat:qkx77xlrfzc3rlpfxfcrsuuqae

Meta-analysis and genome-wide interpretation of genetic susceptibility to drug addiction

Chuan-Yun Li, Wei-Zhen Zhou, Ping-Wu Zhang, Catherine Johnson, Liping Wei, George R Uhl
2011 BMC Genomics  
From meta-data retrieved from 212 publications on candidate gene association studies and 5 GWAS reports, we linked a total of 843 haplotypes to addiction susceptibility.  ...  We mapped the SNPs in these haplotypes to functional and regulatory elements in the genome and estimated the magnitude of the contributions of different molecular mechanisms to their effects on addiction  ...  Signals of recent positive selection provide information about the adaptation of humans to local conditions and have been implicated in phenotypic variations [34] .  ... 
doi:10.1186/1471-2164-12-508 pmid:21999673 pmcid:PMC3215751 fatcat:iun2ybqtdjglphjcomd6qpp3fq

Genetic imaging consortium for addiction medicine [chapter]

Scott Mackey, Kees-Jan Kan, Bader Chaarani, Nelly Alia-Klein, Albert Batalla, Samantha Brooks, Janna Cousijn, Alain Dagher, Michiel de Ruiter, Sylvane Desrivieres, Sarah W. Feldstein Ewing, Rita Z. Goldstein (+35 others)
2016 Progress in Brain Research  
The challenges and achievements of these consortia are considered here with the goal of leveraging these resources to study addiction.  ...  The studies performed on this data should significantly impact our understanding of the genetic and neurobiological basis of addiction.  ...  Adaptation of imaging software to the developing needs of the neuroimaging community and greater automation have been accompanied by tremendous efforts to annotate the software and to educate a large cadre  ... 
doi:10.1016/bs.pbr.2015.07.026 pmid:26822360 pmcid:PMC4820288 fatcat:4k6tgnb4qja7fecgipftwwfu44

A technology prototype system for rating therapist empathy from audio recordings in addiction counseling

Bo Xiao, Chewei Huang, Zac E. Imel, David C. Atkins, Panayiotis Georgiou, Shrikanth S. Narayanan
2016 PeerJ Computer Science  
Scaling up psychotherapy services such as for addiction counseling is a critical societal need. One challenge is ensuring quality of therapy, due to the heavy cost of manual observational assessment.  ...  Our experiments showed that the fully automated system achieved a correlation of 0.643 between expert annotated empathy codes and machine-derived estimations, and an accuracy of 81% in classifying highvs.low  ...  Review Boards at the University of Washington (IRB_36949) and University of Utah (IRB_00058732).  ... 
doi:10.7717/peerj-cs.59 pmid:28286867 pmcid:PMC5344199 fatcat:nmvvr7nwkzbxvctqud5sof5bxm

Addictive Buying: Causes, Processes, and Symbolic Meanings. Thematic Analysis of a Buying Addict's Diary

Irene García Ureta
2007 The Spanish Journal of Psychology  
of values.  ...  On the one hand, to reach an understanding of, and to illustrate the experience of addictive buying and, on the other, to throw some light on the controversial subject of addicts' personal responsibility  ...  Elaborating on the results, I suggest an adaptation of this theory to understand addiction to buying: I propose that personal values, that is, the predominant motivations, can both determine automatic  ... 
doi:10.1017/s1138741600006673 fatcat:bd5mwllkbfcingsm57auzfknzi

Linking emotions to behaviors through deep transfer learning

Haoqi Li, Brian Baucom, Panayiotis Georgiou
2020 PeerJ Computer Science  
Further, we investigate the importance of emotional-context in the expression of behavior by constraining (or not) the neural networks' contextual view of the data.  ...  An important cue of behavior analysis is the dynamical changes of emotions during the conversation.  ...  ACKNOWLEDGEMENTS The authors would like to thank Yi Zhou, Sandeep Nallan Chakravarthula and professor Shrikanth Narayanan for helpful discussions and comments.  ... 
doi:10.7717/peerj-cs.246 pmid:33816898 pmcid:PMC7924597 fatcat:6g5wakxejbajdnriqpzbsuwc2q

Argonaute 2 in dopamine 2 receptor–expressing neurons regulates cocaine addiction

Anne Schaefer, Heh-In Im, Morten T. Venø, Christie D. Fowler, Alice Min, Adam Intrator, Jørgen Kjems, Paul Kenny, Donal O'Carroll, Paul Greengard
2010 Journal of Cell Biology  
Deficiency of Ago2 in dopamine 2 receptor (Drd2)-expressing neurons greatly reduces the motivation to self-administer cocaine in mice.  ...  The multiple changes in gene and protein expression associated with cocaine addiction suggest the existence of a mechanism that facilitates a coordinated cellular response to cocaine.  ...  1850 Argonaute 2 controls cocaine addiction | Schaefer et al. This work was supported in part by National Institutes of Health grants DA10044 and MH074866 (P. Greengard), DA025962 (A.  ... 
doi:10.1083/jcb1902oia4 fatcat:mgvzslwvabem3kxljynsriefcu

Argonaute 2 in dopamine 2 receptor–expressing neurons regulates cocaine addiction

Anne Schaefer, Heh-In Im, Morten T. Venø, Christie D. Fowler, Alice Min, Adam Intrator, Jørgen Kjems, Paul J. Kenny, Donal O'Carroll, Paul Greengard
2010 Journal of Experimental Medicine  
Deficiency of Ago2 in dopamine 2 receptor (Drd2)-expressing neurons greatly reduces the motivation to self-administer cocaine in mice.  ...  The multiple changes in gene and protein expression associated with cocaine addiction suggest the existence of a mechanism that facilitates a coordinated cellular response to cocaine.  ...  Schaefer was the recipient of a German Research Foundation fellowship (SCHA 1482/1-1). H.-I. Im was the recipient of a Ruth L. Kirschstein NARSAD award (DA027281).  ... 
doi:10.1084/jem.20100451 pmid:20643829 pmcid:PMC2931161 fatcat:hkvtccubl5emrkjojntqimn724

Recommendations Based on Social Links [chapter]

Danielle Lee, Peter Brusilovsky
2018 Lecture Notes in Computer Science  
The goal of this chapter is to give an overview of recent works on the development of social link-based recommender systems and to offer insights on related issues and the future direction.  ...  Then, the in-depth understanding of existing recommendations based on users' social links will be addressed.  ...  The value representing the strength of each link was calculated and added separately.  ... 
doi:10.1007/978-3-319-90092-6_11 fatcat:5nhd7rbgu5d3fc563mrhj2nnzi
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