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Ad Retrieval Systems in vitro and in vivo: Knowledge-Based Approaches to Computational Advertising [chapter]

Evgeniy Gabrilovich
2011 Lecture Notes in Computer Science  
In this talk we discuss the unique algorithmic challenges posed by searching the ad corpus, and report on empirical evaluation of large-scale advertising systems in vivo.  ...  Computational advertising also employs a host of NLP techniques, from text summarization for just-in-time ad matching, to machine translation for cross-language ad retrieval, to natural language generation  ...  These studies offer deep insights into how users interact with ads, and facilitate better understanding of the much broader notion of relevance in ad retrieval compared to Web search.  ... 
doi:10.1007/978-3-642-20161-5_2 fatcat:fl2jhe4d4jgxvkjm2cbugk24qi

Targeting miR-21 Inhibits In Vitro and In Vivo Multiple Myeloma Cell Growth

E. Leone, E. Morelli, M. T. Di Martino, N. Amodio, U. Foresta, A. Gulla, M. Rossi, A. Neri, A. Giordano, N. C. Munshi, K. C. Anderson, P. Tagliaferri (+1 others)
2013 Clinical Cancer Research  
Experimental Design: Here, we investigated the in vitro and in vivo anti-multiple myeloma activity of miR-21 inhibitors.  ...  Upregulation of PTEN and downregulation of p-AKT were observed in retrieved xenografts following treatment with miR-21 inhibitors.  ...  Consistent with our in vitro experiments, we found upregulation of PTEN both at mRNA and protein levels in retrieved tumors from animals treated with miR-21 inhibitors ( Fig. 6B and C) .  ... 
doi:10.1158/1078-0432.ccr-12-3325 pmid:23446999 pmcid:PMC4147955 fatcat:ydmquyvwvnarzmotoikhbbonp4

An In Vivo Method to Identify microRNA Targets Not Predicted by Computation Algorithms: p21 Targeting by miR-92a in Cancer

X. Su, H. Wang, W. Ge, M. Yang, J. Hou, T. Chen, N. Li, X. Cao
2015 Cancer Research  
Moreover, inhibition of miR-92a could significantly suppress HCC growth in vitro and in vivo by upregulating p21.  ...  However, how to identify the miRNAs targeting specific mRNA in cells is a significant challenge because of the interaction complexity and the limited knowledge of rules governing these processes.  ...  The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C.  ... 
doi:10.1158/0008-5472.can-14-2218 pmid:26062558 fatcat:skhfm5owerg2pa6rb7ihbrkeiy

Development of an in vivo magnetic resonance imaging and computer modelling platform to investigate the physiological optics of the crystalline lens

Xingzheng Pan, Alyssa L. Lie, Thomas W. White, Paul J. Donaldson, Ehsan Vaghefi
2019 Biomedical Optics Express  
We have developed and validated in vivo magnetic resonance imaging (MRI) protocols to extract parameters (T2 and geometry) of the human lens that, combined with biometric measures of the eye and optical  ...  modelling, enable us to investigate the relative contributions made by the gradient of refractive index (GRIN) and the shape of the lens to the refractive properties of each subject tested.  ...  Disclosures The authors declare that there are no conflicts of interest related to this article. References  ... 
doi:10.1364/boe.10.004462 pmid:31565502 pmcid:PMC6757483 fatcat:ufvyp3zrjjazbhguu2xj6x3lzi

Suppression of Signal Transducer and Activator of Transcription 3 Activation by Butein Inhibits Growth of Human Hepatocellular Carcinoma In Vivo

P. Rajendran, T. H. Ong, L. Chen, F. Li, M. K. Shanmugam, S. Vali, T. Abbasi, S. Kapoor, A. Sharma, A. P. Kumar, K. M. Hui, G. Sethi
2010 Clinical Cancer Research  
both in vitro and in vivo.  ...  Results: We tested an agent, butein, for its ability to suppress STAT3 activation in HCC cells and nude mice model along with prospectively testing the hypothesis of STAT3 inhibition in a virtual predictive  ...  The bottom layer is the computational backplane which enables the system to be dynamic and computes all the mathematics in the middle layer.  ... 
doi:10.1158/1078-0432.ccr-10-1123 pmid:21131551 fatcat:2mu5en7jkvc5vmdljnfkupo2yq

Adaptive support ventilation prevents ventilator-induced diaphragmatic dysfunction: an in vivo piglet study

B Jung, N Rossel, C Le Goff, N Claveiras, M Wysocki, S Matecki, G Chanques, S Jaber
2009 Critical Care  
Methods We conducted a descriptive telephone-based questionnaire study to assess EPs' endotracheal intubation skills through all ERs in Ile de France public hospitals.  ...  Based on our findings, all efforts should be made to verify the tube position with immediate radiographic confirmation after admission to the ER.  ...  Conclusions Over-triage to the ICU is probably unavoidable in MCE.  ... 
doi:10.1186/cc7195 pmcid:PMC4083917 fatcat:ufgt6ac7onaszpmhzi2yyidfqm

Molecular Imaging of N-linked Glycosylation Suggests Glycan Biosynthesis Is a Novel Target for Cancer Therapy

J. N. Contessa, M. S. Bhojani, H. H. Freeze, B. D. Ross, A. Rehemtulla, T. S. Lawrence
2010 Clinical Cancer Research  
Experimental Design: We developed a model system to dynamically monitor NLG in vitro and in vivo using bioluminescent imaging techniques.  ...  Using this molecular imaging approach we carried out serial imaging studies to determine safe and efficacious in vivo dosing of the GlcNAc-1-phosphotransferase inhibitor tunicamycin, which blocks N-glycan  ...  This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.  ... 
doi:10.1158/1078-0432.ccr-09-3331 pmid:20413434 pmcid:PMC3413408 fatcat:x76zl6zjhnd3fi46qrqkqsshpu

HealthAgents: distributed multi-agent brain tumor diagnosis and prognosis

Horacio González-Vélez, Mariola Mier, Margarida Julià-Sapé, Theodoros N. Arvanitis, Juan M. García-Gómez, Montserrat Robles, Paul H. Lewis, Srinandan Dasmahapatra, David Dupplaw, Andrew Peet, Carles Arús, Bernardo Celda (+2 others)
2007 Applied intelligence (Boston)  
The HealthAgents system is implementing novel pattern recognition discrimination methods, in order to analyse in vivo Magnetic Resonance Spectroscopy (MRS) and ex vivo/in vitro High Resolution Magic Angle  ...  HealthAgents is a European Union funded research project, which aims to enhance the classification of brain tumours using such a decision support system based on intelligent agents to securely connect  ...  , and Jan Luts and Javier Vicente for their comments to the machine learning section.  ... 
doi:10.1007/s10489-007-0085-8 fatcat:kefcix5l7zcy7kahfujyjxeq4m

Mastering the scales: a survey on the benefits of multiscale computing software

Derek Groen, Jaroslaw Knap, Philipp Neumann, Diana Suleimenova, Lourens Veen, Kenneth Leiter
2019 Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences  
One contribution of 11 to a theme issue 'Multiscale modelling, simulation and computing: from the desktop to the exascale' .  ...  We are grateful to the organizers and participants of the Lorentz Center workshop 'Multiscale Computing: From the Desktop to the Exascale', for providing an excellent discussion platform, which substantially  ...  We are also grateful to David Coster for providing information on the OMFIT and AiiDA toolkits.  ... 
doi:10.1098/rsta.2018.0147 fatcat:66fvauvyknbwnllsyoe73pqtmi

Enhanced vector space models for content-based recommender systems

Cataldo Musto
2010 Proceedings of the fourth ACM conference on Recommender systems - RecSys '10  
• Implementation and evaluation of system prototypes. The pro- posed models will be evaluated in both in-vitro and in-vivo scenarios.  ...  [RS95] Ray Richardson and Alan F. Smeaton. Using wordnet in a knowledge-based approach to information retrieval.  ... 
doi:10.1145/1864708.1864791 dblp:conf/recsys/Musto10 fatcat:btpepieksvdrtpgdihskllxc34

Computational Creativity

Rania A. Hodhod, Brian S. Magerko
2014 International Journal of Cognitive Informatics and Natural Intelligence  
As the field has continued to grow, the time has come for the creation of a more formal, even archival, forum for work in computational creativity and this year we took the leap.  ...  However, we will take a few more steps towards the development of systems that must eventually be acknowledged as creative themselves, and, in the process, we will, perhaps, ask additional interesting  ...  This research has been supported by an NSF grant (IIS Award #0534266) entitled "Multimodal Case-Based Reasoning in Modeling and Design," by ONR through an NDSEG fellowship, and by the NSF GRFP fellowship  ... 
doi:10.4018/ijcini.2014040101 fatcat:t75r5mrudzckfm3cjskssgadma

Knowledge assets in services across industries and across time

G. Scott Erickson, Helen N. Rothberg
2015 Investigaciones Europeas de Dirección y Economía de la Empresa  
Further, there is considerable evidence of changes in specific service and non-service industries over the time period, adding details to the finding that knowledge development is not static but does vary  ...  Two multi-year, multi-industry datasets are used to directly compare the knowledge asset levels in service industry firms against those in non-service industry firms.  ...  , credit, etc. 3.99 3.29 7371-2 Prepackaged software 5.81 3.70 7373 Computer systems design 4.50 1.65 7374 Computer processing services 4.24 3.26 7375 Info retrieval services 2.49 - 75  ... 
doi:10.1016/j.iedee.2014.09.002 fatcat:cc4rri6rhvcjxdctqrtiq53xzi

Molecular profiling indicates orthotopic xenograft of glioma cell lines simulate a subclass of human glioblastoma

Uma T. Shankavaram, Markus Bredel, William E. Burgan, Donna Carter, Philip Tofilon, Kevin Camphausen
2012 Journal of Cellular and Molecular Medicine  
In this report, we investigated gene expression profiles of three preclinical growth models of glioma cell lines, in vitro and in vivo as subcutaneous and intracerebral xenografts to examine which cell  ...  mice in combination with irradiation, providing an in vivo cell line system of preclinical studies.  ...  The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C.  ... 
doi:10.1111/j.1582-4934.2011.01345.x pmid:21595825 pmcid:PMC3164941 fatcat:5bgoj2yyire2hmfwhctxy6ztuy

AutoMate: Enabling Autonomic Applications on the Grid

M. Parashar, H. Liu, Z. Li, V. Matossian, C. Schmidt, G. Zhang, S. Hariri
2006 Cluster Computing  
by biological systems and deal with similar challenges of complexity, heterogeneity, and uncertainty.  ...  The overall goal of Project Automate is to investigate conceptual models and implementation architectures that can enable the development and execution of such self-managing Grid applications.  ...  conventional and unconventional information for crisis prevention and response, medical applications that use in-vivo and in-vitro sensors and actuators for patient management, and business applications  ... 
doi:10.1007/s10586-006-7561-5 fatcat:pakuaryd3nhgxnrxuvh24wgkke

Empathy and brain evolution

A Gibbons
1993 Science  
Other factors to be considered include experience in in vivo and in vitro hemodynamic monitoring, knowledge of in vivo surgical techniques and experience with computers/software.  ...  Other factors to be considered include experience in in vivo and in vitro cardiac and/or vascular procedures, experience in acute and chronic in vivo studies and knowledge of computer/software data collection  ... 
doi:10.1126/science.8446891 pmid:8446891 fatcat:zamknlo4erazjlteosw7m67lrm
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