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Activity-induced manganese-dependent MRI (AIM-MRI) and functional MRI in awake rabbits during somatosensory stimulation
2016
NeuroImage
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Activity-induced manganese-dependent MRI (AIM-MRI) is a powerful tool to track system-wide neural activity using high resolution, quantitative T 1 -weighted MRI in animal models and has significant advantages ...
Significant BOLD activation in the left somatosensory (SS) cortex and left ventral posteromedial (VPM) thalamic nucleus was detected during whisker vibration. ...
Acknowledgments This work was supported by the National Institutes of Health (National Institute of Neurological Disorders and Stroke Grant NS059879 and the National Institute of Mental Health Grant MH47340 ...
doi:10.1016/j.neuroimage.2015.11.033
pmid:26589332
pmcid:PMC4733628
fatcat:2kxwx5x6rnhwzo6qm7yvevgudy
Activity-induced MEMRI cannot detect functional brain anomalies in the APPxPS1-Ki mouse model of Alzheimer's disease
2019
Scientific Reports
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Activity-induced Manganese-Enhanced Magnetic Resonance Imaging (MEMRI) has been proposed as a powerful approach to visualize evoked brain activity in rodents. ...
We hypothesized that diffuse weakening of the BBB results in an uncontrolled diffusion of the MR contrast agent and a lack of correlation between manganese accumulation and neuronal activity. ...
d'avenir" ANR-11-INBS-0011 -NeurATRIS: Translational Research Infrastructure for Biotherapies in Neurosciences. ...
doi:10.1038/s41598-018-37980-y
pmid:30718666
pmcid:PMC6361936
fatcat:mmirdqgoqvfyzb5uje3qd5dkr4
The rabbit as a behavioral model system for magnetic resonance imaging
2018
Journal of Neuroscience Methods
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The use of rabbits instead of rodents allows much shorter periods of habituation, and the rabbit allows behavior to be observed during the day while the animal is in its normal wake cycle. ...
Visual stimulation was produced by flashing green LEDs and whisker stimulation was done by powering a small coil of wire attached to a fiber band. ...
We thank Matthew Schroeder for the data in Figures 4B, 4C , and 4D which were collected as part of his doctoral dissertation. ...
doi:10.1016/j.jneumeth.2017.05.021
pmid:28552515
pmcid:PMC5702588
fatcat:eafnjqedyrfgdl7tzmbvl2sst4
Quantitative activation-induced manganese-enhanced MRI reveals severity of Parkinson's disease in mice
2015
Scientific Reports
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Hence, MEMRI can non-invasively measure relative levels of neuronal activity and has been termed activation-induced MEMRI (AIM-MRI) 5,6 . ...
We first show that manganese ion-accumulation depends on neuronal activity. ...
Araki for technical assistance, and the Institute for Animal Experimentation and Biomedical Research Core, Tohoku University Graduate School of Medicine for the use of its facilities and their technical ...
doi:10.1038/srep12800
pmid:26255701
pmcid:PMC4530460
fatcat:xal56zhlyfem5heqswnu5nmofa
Technical and Conceptual Considerations for Performing and Interpreting Functional MRI Studies in Awake Rats
2011
Frontiers in Psychiatry
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Our laboratory has used imaging to investigate brain activation in awake rats following cocaine administration and during the presentation of lactation-associated sensory stimuli. ...
The relatively good spatial and temporal resolution and the ever-growing database on the biological and biophysical basis of the blood oxygen level dependent (BOLD) signal make it a unique technique in ...
in neuronal activity in the somatosensory cortex of the awake mouse during fMRI. ...
doi:10.3389/fpsyt.2011.00043
pmid:21808625
pmcid:PMC3137945
fatcat:fu5tf4mi2fgapdru4nxyneywvi
Applications of Manganese-Enhanced Magnetic Resonance Imaging in Ophthalmology and Visual Neuroscience
2019
Frontiers in Neural Circuits
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Among the advanced MRI techniques, manganese-enhanced MRI (MEMRI) involves the use of active manganese contrast agents that positively enhance brain tissue signals in T1-weighted imaging with respect to ...
Magnetic resonance imaging (MRI) offers non-invasive probing of the structure and function of the neural circuits without depth limitation, and can help identify abnormalities in brain tissues in vivo. ...
Manganese-enhanced MRI likely reflects both activity-independent uptake at base levels as well as activity-dependent uptake upon stimulations or interventions . ...
doi:10.3389/fncir.2019.00035
pmid:31156399
pmcid:PMC6530364
fatcat:geartq4yive6rb4bs377ikjl2a
Animal Functional Magnetic Resonance Imaging: Trends and Path Toward Standardization
2020
Frontiers in Neuroinformatics
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A collection of associated methods aims to replicate observations made in humans and to identify the mechanisms underlying the distributed neuronal activity in the healthy and disordered brain. ...
Animal whole-brain functional magnetic resonance imaging (fMRI) provides a non-invasive window into brain activity. ...
Giorgi et al., 2017) , as well as in the case of somatosensory stimulation . ...
doi:10.3389/fninf.2019.00078
pmid:32038217
pmcid:PMC6987455
fatcat:ligl6s7bxzcb7nexjeg7w46c2i
Structural and functional alterations in the retrosplenial cortex following neuropathic pain
2019
Pain
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In addition, we found that the functional RSgA connectivity to the subiculum and the prelimbic system are significantly increased in spared nerve injury animals and correlated with peripheral pain thresholds ...
Using a voxel-based morphometry approach, we showed that neuropathic pain induced a significant increase of the gray matter concentration within the RSgA, associated with a significant activation of both ...
Our aim was to combine structural and functional MRI, pain and emotional/cognitive behavioural assessment to identify the brain territories and brain functional impairments involved in neuropathic pain ...
doi:10.1097/j.pain.0000000000001610
pmid:31145220
fatcat:6g3hlk4zrrawhpubpbvsnhxywq
Oral presentations
2011
Pediatric Radiology
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Purpose: The aim of the pilot study was the assessment of pulmonary valve function during rest and physical activity. ...
The aim of our study was to correlate residual epileptic activity after functional hemispherotomy with conventional magnetic resonance imaging (MRI) findings and Diffusion Tensor Imaging (DTI) including ...
Mean brain values were 27 in the neonate (24.8 without, 28.5 with shields) and 46.54 in other age phantoms (46.4 without, 46.6 with shields). Conclusion: ATCM is a requisite during pediatric head CT. ...
doi:10.1007/s00247-011-2024-4
fatcat:fe3o7eyxdfgu3gwtqtpyawpdce
XXIst CANADIAN CONGRESS OF NEUROLOGICAL SCIENCES Program and Abstracts
1986
Canadian Journal of Neurological Sciences
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In the present study we examine functional interaction between single neurons within such columns during voluntary forelimb movement in awake primates (M. speciosa). ...
The neurotoxic substances manganese (Mn 2 + ) and l-methyl-4phenyl-l, 2, 5, 6-tetrahydropyridine (MPTP) induce parkinsonism in man. ...
doi:10.1017/s0317167100036246
fatcat:qlbhzzpxyjgshdjz5f5xm5pvli
Abstracts from the 45th Annual Meeting of Japanese Association for the Stusy of Taste and Smell (JASTS 2011), Kanazawa, Japan, October 5-7th, 2011 (The president of the meeting was Dr. Takaki Miwa, Kanazawa Medical University)
2012
Chemical Senses
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We compared 6 detergents (Anzergent 3-14, DM, DDM, UDM, Triton-X 100, LDAO) in the T2R16 solubilization step and found the highest solubilizing ability in Anzergent 3-14. ...
In this study, we designed Saccharomyces cerevisiae-aided, large-scale T2R16 purification protocols and examined each step of them by using the GFP tag-added C-terminal fragment for determination of the ...
Before eye opening young rats depend on somatosensory and olfactory function for survival, as they can learn their damÕs odor and approach her without visual information. ...
doi:10.1093/chemse/bjs052
fatcat:stnw3sgsbvaczgzpw3jd76hg6a
Abstracts from the ASENT 17th Annual Meeting
2015
Neurotherapeutics
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Immediately before ultrasound-induced injury and up to 1 h after, we electrically stimulated the median nerve and recorded SSEPs from the somatosensory cortex. ...
We aim to evaluate the feasibility of using novel flexible epidermal electrodes to detect TBI-induced changes in SSEPs. ...
in animals and antiepileptic efficacy in patients with Dravet syndrome, a rare, early-onset catastrophic epileptic encephalopathy often associated with loss of function mutation in the SCN1A gene. ...
doi:10.1007/s13311-015-0362-x
fatcat:i4p5vaie3ffufmncmhewgnpsjm
XXIInd Canadian Congress of Neurological Sciences
1987
Canadian Journal of Neurological Sciences
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NK cell functional activity was significantly elevated in the IF group by 48 hours. ...
We undertook an investigation of posterior column function, using median and posterior column function, using median and posterior tibial nerve somatosensory evoked potential (SEP) studies in 9 patients ...
CSF folate, blood thiamine levels and the percentage of thiamine pyrophosphase activity showed no difference between the groups. ...
doi:10.1017/s0317167100026548
fatcat:regflyqu4ngglnz56oym2yf754
Abstracts for the 13th Turkish Neuroscience Congress April 30th 2015 to May 3rd 2015, Konya, Turkey
2015
Anatomy (International Journal of Experimental and Clinical Anatomy)
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Scientists in biology and neurobiology have thus been compelled and stimulated to initiate profound studies on morphology and function of all organs and their cells. ...
Intensive research activities within the past 200 years have revealed that the central nervous system (CNS) is a heterogeneous, heteromorphic, multidimensional and multifunctional compound organ system ...
The aim of this study is to investigate the effect of memantine and NNC 55-0396 interaction on the penicillin induced epileptiform activity. ...
doi:10.2399/ana.15.001s
fatcat:cc6uyz2r2ve2fcomz3f5ptr5re
Abstracts
2016
Acta Physiologica
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on the activity of the Purpose: Increased H + and hyperactivation of Na + -H + exchanger1 (NHE1) are the causes contracture and cell deaths induced by ischemia reperfusion (I/R) injury. ...
In addition, AgRP-ablated mice present exacerbated stress-induced anorexia and palatable food intakea hallmark of comfort feeding. ...
We aimed to compare MDSPCs with bone marrow mesenchymal stem cells (BM-MSCs) and to evaluate their feasibility for the treatment of AKI. ...
doi:10.1111/apha.12712
pmid:27329970
fatcat:imcxhh3singqdlh7umt4tcj54y
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