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Activity-induced manganese-dependent MRI (AIM-MRI) and functional MRI in awake rabbits during somatosensory stimulation

Matthew P. Schroeder, Craig Weiss, Daniel Procissi, Lei Wang, John F. Disterhoft
2016 NeuroImage  
Activity-induced manganese-dependent MRI (AIM-MRI) is a powerful tool to track system-wide neural activity using high resolution, quantitative T 1 -weighted MRI in animal models and has significant advantages  ...  Significant BOLD activation in the left somatosensory (SS) cortex and left ventral posteromedial (VPM) thalamic nucleus was detected during whisker vibration.  ...  Acknowledgments This work was supported by the National Institutes of Health (National Institute of Neurological Disorders and Stroke Grant NS059879 and the National Institute of Mental Health Grant MH47340  ... 
doi:10.1016/j.neuroimage.2015.11.033 pmid:26589332 pmcid:PMC4733628 fatcat:2kxwx5x6rnhwzo6qm7yvevgudy

Activity-induced MEMRI cannot detect functional brain anomalies in the APPxPS1-Ki mouse model of Alzheimer's disease

Alexandre Androuin, Yah-se Abada, Myriam Ly, Mathieu Santin, Alexandra Petiet, Stéphane Epelbaum, Anne Bertrand, Benoît Delatour
2019 Scientific Reports  
Activity-induced Manganese-Enhanced Magnetic Resonance Imaging (MEMRI) has been proposed as a powerful approach to visualize evoked brain activity in rodents.  ...  We hypothesized that diffuse weakening of the BBB results in an uncontrolled diffusion of the MR contrast agent and a lack of correlation between manganese accumulation and neuronal activity.  ...  d'avenir" ANR-11-INBS-0011 -NeurATRIS: Translational Research Infrastructure for Biotherapies in Neurosciences.  ... 
doi:10.1038/s41598-018-37980-y pmid:30718666 pmcid:PMC6361936 fatcat:mmirdqgoqvfyzb5uje3qd5dkr4

The rabbit as a behavioral model system for magnetic resonance imaging

Craig Weiss, Daniel Procissi, John M. Power, John F. Disterhoft
2018 Journal of Neuroscience Methods  
The use of rabbits instead of rodents allows much shorter periods of habituation, and the rabbit allows behavior to be observed during the day while the animal is in its normal wake cycle.  ...  Visual stimulation was produced by flashing green LEDs and whisker stimulation was done by powering a small coil of wire attached to a fiber band.  ...  We thank Matthew Schroeder for the data in Figures 4B, 4C , and 4D which were collected as part of his doctoral dissertation.  ... 
doi:10.1016/j.jneumeth.2017.05.021 pmid:28552515 pmcid:PMC5702588 fatcat:eafnjqedyrfgdl7tzmbvl2sst4

Quantitative activation-induced manganese-enhanced MRI reveals severity of Parkinson's disease in mice

Satomi Kikuta, Yukiyo Nakamura, Yukio Yamamura, Atsushi Tamura, Noriyasu Homma, Yuchio Yanagawa, Hajime Tamura, Jiro Kasahara, Makoto Osanai
2015 Scientific Reports  
Hence, MEMRI can non-invasively measure relative levels of neuronal activity and has been termed activation-induced MEMRI (AIM-MRI) 5,6 .  ...  We first show that manganese ion-accumulation depends on neuronal activity.  ...  Araki for technical assistance, and the Institute for Animal Experimentation and Biomedical Research Core, Tohoku University Graduate School of Medicine for the use of its facilities and their technical  ... 
doi:10.1038/srep12800 pmid:26255701 pmcid:PMC4530460 fatcat:xal56zhlyfem5heqswnu5nmofa

Technical and Conceptual Considerations for Performing and Interpreting Functional MRI Studies in Awake Rats

Marcelo Febo
2011 Frontiers in Psychiatry  
Our laboratory has used imaging to investigate brain activation in awake rats following cocaine administration and during the presentation of lactation-associated sensory stimuli.  ...  The relatively good spatial and temporal resolution and the ever-growing database on the biological and biophysical basis of the blood oxygen level dependent (BOLD) signal make it a unique technique in  ...  in neuronal activity in the somatosensory cortex of the awake mouse during fMRI.  ... 
doi:10.3389/fpsyt.2011.00043 pmid:21808625 pmcid:PMC3137945 fatcat:fu5tf4mi2fgapdru4nxyneywvi

Applications of Manganese-Enhanced Magnetic Resonance Imaging in Ophthalmology and Visual Neuroscience

Wenyu Deng, Muneeb A. Faiq, Crystal Liu, Vishnu Adi, Kevin C. Chan
2019 Frontiers in Neural Circuits  
Among the advanced MRI techniques, manganese-enhanced MRI (MEMRI) involves the use of active manganese contrast agents that positively enhance brain tissue signals in T1-weighted imaging with respect to  ...  Magnetic resonance imaging (MRI) offers non-invasive probing of the structure and function of the neural circuits without depth limitation, and can help identify abnormalities in brain tissues in vivo.  ...  Manganese-enhanced MRI likely reflects both activity-independent uptake at base levels as well as activity-dependent uptake upon stimulations or interventions .  ... 
doi:10.3389/fncir.2019.00035 pmid:31156399 pmcid:PMC6530364 fatcat:geartq4yive6rb4bs377ikjl2a

Animal Functional Magnetic Resonance Imaging: Trends and Path Toward Standardization

Francesca Mandino, Domenic H. Cerri, Clement M. Garin, Milou Straathof, Geralda A. F. van Tilborg, M. Mallar Chakravarty, Marc Dhenain, Rick M. Dijkhuizen, Alessandro Gozzi, Andreas Hess, Shella D. Keilholz, Jason P. Lerch (+2 others)
2020 Frontiers in Neuroinformatics  
A collection of associated methods aims to replicate observations made in humans and to identify the mechanisms underlying the distributed neuronal activity in the healthy and disordered brain.  ...  Animal whole-brain functional magnetic resonance imaging (fMRI) provides a non-invasive window into brain activity.  ...  Giorgi et al., 2017) , as well as in the case of somatosensory stimulation .  ... 
doi:10.3389/fninf.2019.00078 pmid:32038217 pmcid:PMC6987455 fatcat:ligl6s7bxzcb7nexjeg7w46c2i

Structural and functional alterations in the retrosplenial cortex following neuropathic pain

David André Barrière, Al Mahdy Hamieh, Ricardo Magalhães, Amidou Traoré, Julie Barbier, Jean-Marie Bonny, Denis Ardid, Jérôme Busserolles, Sébastien Mériaux, Fabien Marchand
2019 Pain  
In addition, we found that the functional RSgA connectivity to the subiculum and the prelimbic system are significantly increased in spared nerve injury animals and correlated with peripheral pain thresholds  ...  Using a voxel-based morphometry approach, we showed that neuropathic pain induced a significant increase of the gray matter concentration within the RSgA, associated with a significant activation of both  ...  Our aim was to combine structural and functional MRI, pain and emotional/cognitive behavioural assessment to identify the brain territories and brain functional impairments involved in neuropathic pain  ... 
doi:10.1097/j.pain.0000000000001610 pmid:31145220 fatcat:6g3hlk4zrrawhpubpbvsnhxywq

Oral presentations

2011 Pediatric Radiology  
Purpose: The aim of the pilot study was the assessment of pulmonary valve function during rest and physical activity.  ...  The aim of our study was to correlate residual epileptic activity after functional hemispherotomy with conventional magnetic resonance imaging (MRI) findings and Diffusion Tensor Imaging (DTI) including  ...  Mean brain values were 27 in the neonate (24.8 without, 28.5 with shields) and 46.54 in other age phantoms (46.4 without, 46.6 with shields). Conclusion: ATCM is a requisite during pediatric head CT.  ... 
doi:10.1007/s00247-011-2024-4 fatcat:fe3o7eyxdfgu3gwtqtpyawpdce


1986 Canadian Journal of Neurological Sciences  
In the present study we examine functional interaction between single neurons within such columns during voluntary forelimb movement in awake primates (M. speciosa).  ...  The neurotoxic substances manganese (Mn 2 + ) and l-methyl-4phenyl-l, 2, 5, 6-tetrahydropyridine (MPTP) induce parkinsonism in man.  ... 
doi:10.1017/s0317167100036246 fatcat:qlbhzzpxyjgshdjz5f5xm5pvli

Abstracts from the 45th Annual Meeting of Japanese Association for the Stusy of Taste and Smell (JASTS 2011), Kanazawa, Japan, October 5-7th, 2011 (The president of the meeting was Dr. Takaki Miwa, Kanazawa Medical University)

2012 Chemical Senses  
We compared 6 detergents (Anzergent 3-14, DM, DDM, UDM, Triton-X 100, LDAO) in the T2R16 solubilization step and found the highest solubilizing ability in Anzergent 3-14.  ...  In this study, we designed Saccharomyces cerevisiae-aided, large-scale T2R16 purification protocols and examined each step of them by using the GFP tag-added C-terminal fragment for determination of the  ...  Before eye opening young rats depend on somatosensory and olfactory function for survival, as they can learn their damÕs odor and approach her without visual information.  ... 
doi:10.1093/chemse/bjs052 fatcat:stnw3sgsbvaczgzpw3jd76hg6a

Abstracts from the ASENT 17th Annual Meeting

K. Clarence-Smith
2015 Neurotherapeutics  
Immediately before ultrasound-induced injury and up to 1 h after, we electrically stimulated the median nerve and recorded SSEPs from the somatosensory cortex.  ...  We aim to evaluate the feasibility of using novel flexible epidermal electrodes to detect TBI-induced changes in SSEPs.  ...  in animals and antiepileptic efficacy in patients with Dravet syndrome, a rare, early-onset catastrophic epileptic encephalopathy often associated with loss of function mutation in the SCN1A gene.  ... 
doi:10.1007/s13311-015-0362-x fatcat:i4p5vaie3ffufmncmhewgnpsjm

XXIInd Canadian Congress of Neurological Sciences

1987 Canadian Journal of Neurological Sciences  
NK cell functional activity was significantly elevated in the IF group by 48 hours.  ...  We undertook an investigation of posterior column function, using median and posterior column function, using median and posterior tibial nerve somatosensory evoked potential (SEP) studies in 9 patients  ...  CSF folate, blood thiamine levels and the percentage of thiamine pyrophosphase activity showed no difference between the groups.  ... 
doi:10.1017/s0317167100026548 fatcat:regflyqu4ngglnz56oym2yf754

Abstracts for the 13th Turkish Neuroscience Congress April 30th 2015 to May 3rd 2015, Konya, Turkey

2015 Anatomy (International Journal of Experimental and Clinical Anatomy)  
Scientists in biology and neurobiology have thus been compelled and stimulated to initiate profound studies on morphology and function of all organs and their cells.  ...  Intensive research activities within the past 200 years have revealed that the central nervous system (CNS) is a heterogeneous, heteromorphic, multidimensional and multifunctional compound organ system  ...  The aim of this study is to investigate the effect of memantine and NNC 55-0396 interaction on the penicillin induced epileptiform activity.  ... 
doi:10.2399/ana.15.001s fatcat:cc6uyz2r2ve2fcomz3f5ptr5re


2016 Acta Physiologica  
on the activity of the Purpose: Increased H + and hyperactivation of Na + -H + exchanger1 (NHE1) are the causes contracture and cell deaths induced by ischemia reperfusion (I/R) injury.  ...  In addition, AgRP-ablated mice present exacerbated stress-induced anorexia and palatable food intakea hallmark of comfort feeding.  ...  We aimed to compare MDSPCs with bone marrow mesenchymal stem cells (BM-MSCs) and to evaluate their feasibility for the treatment of AKI.  ... 
doi:10.1111/apha.12712 pmid:27329970 fatcat:imcxhh3singqdlh7umt4tcj54y
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