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FlightTracker: Consistency across Read-Optimized Online Stores at Facebook

Xiao Shi, Scott Pruett, Kevin Doherty, Jinyu Han, Dmitri Petrov, Jim Carrig, John Hugg, Nathan Bronson
2020 USENIX Symposium on Operating Systems Design and Implementation  
FlightTracker delivers these advantages while preserving the efficiency, latency, and availability benefits of asynchronous replication for the underlying systems, managing consistency for billions of  ...  This store must be optimized for read efficiency, availability, and scalability.  ...  Acknowledgements We thank the following people for critical contributions to the systems in this paper: Tina Park, Kevin Ventullo, Christopher Small, Andrew Bass, Tushar Pankaj, David Goode, Soham Shah  ... 
dblp:conf/osdi/ShiPDHPCHB20 fatcat:2xi5qrax5bd6bi2mrwzxom4hgi

An Analysis of Network-Partitioning Failures in Cloud Systems

Ahmed Alquraan, Hatem Takruri, Mohammed Alfatafta, Samer Al-Kiswany
2018 USENIX Symposium on Operating Systems Design and Implementation  
to the Proceedings of the 13th USENIX Symposium on Operating Systems Design and Implementation is sponsored by USENIX.  ...  Acknowledgment We thank the anonymous reviewers and our shepherd, Marcos Aguilera, for their insightful feedback.  ...  We thank Nicholas Lee, Alex Liu, Dian Tang, Anusan Sivakumaran, and Charles Wu for their help in reproducing some of the failures.  ... 
dblp:conf/osdi/AlquraanTAA18 fatcat:eeifmcvfd5b2jpyvg4lydwsvku

Surpassing 10 000 identified and quantified proteins in a single run by optimizing current LC-MS instrumentation and data analysis strategy

Jan Muntel, Tejas Gandhi, Lynn Verbeke, Oliver M. Bernhardt, Tobias Treiber, Roland Bruderer, Lukas Reiter
2019 Molecular Omics  
Optimization of chromatography and data analysis resulted in more than 10 000 proteins in a single shot at a validated FDR of 1% (two-species test) and revealed deep insights into the testis cancer physiology  ...  Acknowledgements We grateful to Ivana Karlovska for preparation of the HeLa sample.  ...  an increase of the proteins involved in replication, suggesting an increased replication rate, that also the mismatch repair pathway was enriched in the IPA analysis (Fig.  ... 
doi:10.1039/c9mo00082h pmid:31465043 fatcat:zpdt7p3xmragle3xf3zzxjzwyy

Impact of exposure to low concentrations of nitric oxide on protein profile in murine and human pancreatic islet cells

Rafael Tapia-Limonchi, Irene Díaz, Gladys M Cahuana, Mario Bautista, Franz Martín, Bernat Soria, Juan R Tejedo, Francisco J Bedoya
2014 Islets  
Keywords: pancreatic b cell, protein profile, nitric oxide, islet survival Homeostatic levels of nitric oxide (NO) protect efficiently against apoptotic death in both human and rodent pancreatic b cells  ...  In addition, metabolic and structural proteins, oxidoreductases and chaperones related with protein metabolism are also regulated by NO treatment.  ...  , molecular transport, cell growth proliferation, free radical scavenging, DNA replication recombination repair, and energy production (Fig. 2B) .  ... 
doi:10.1080/19382014.2014.995997 pmid:25658244 pmcid:PMC4398281 fatcat:oyi3wezzqzdb5ifiddufbvsafy

SoK: Understanding BFT Consensus in the Age of Blockchains [article]

Gang Wang
2021 IACR Cryptology ePrint Archive  
There are many excellent Byzantine-based replicated solutions and ideas that have been contributed to improving performance, availability, or resource efficiency.  ...  Under the hood of blockchain, consensus protocols play the most important role to achieve distributed replication systems.  ...  When applying the Byzantine fault model directly to Raft, the safety and availability of Raft would be compromised in several aspects, e.g., leader election and log replication.  ... 
dblp:journals/iacr/Wang21c fatcat:wggbkbi25fg43fieebp4qzlk3m

Functional Transcriptome Analysis of Bladder Cancer Cell Lines Persistently Infected with Oncolytic Newcastle Disease Virus [article]

Umar Ahmad, Arcana Thirumorthy, De Ming Chau, Suet Lin Chia, Khatijah Yusoff, Syahril Abdullah, Soon Choy Chan, Abhi Veerakumarasivam
2020 bioRxiv   pre-print
As for EJ28Pi, 55 DEGs were upregulated (log2 fold-change ≤ 0) and 79 DEGs were downregulated (log2 fold-change ≥ 0).  ...  Of the 63 DEGs identified for TCCSUPPi cells, 25 DEGs were upregulated (log2 fold-change ≥ 0) and 38 DEGs were downregulated (log2 fold-change ≤ 0).  ...  Acknowledgement This study was supported by the Ministry Energy, Science, Technology, Environment and Climate Change (MESTECC) Malaysia Flagship Fund, reference number: FP0514B0021-2(DSTIN).  ... 
doi:10.1101/2020.12.14.422610 fatcat:p6a4new4pjf2xipiyhiyesgy7q

A Study of Failure Recovery and Logging of High-Performance Parallel File Systems

Runzhou Han, Om Rameshwar Gatla, Mai Zheng, Jinrui Cao, Di Zhang, Dong Dai, Yong Chen, Jonathan Cook
2022 ACM Transactions on Storage  
We hope this study and the resulting tool and dataset can facilitate follow-up research in the communities and help improve PFSs for reliable high-performance computing.  ...  In addition, we characterize the extensive logs generated in the experiments in detail and identify the unique patterns and limitations of PFSs in terms of failure logging.  ...  We also believe that such a study, including the open-source PFault and the extensive PFS logs, can have a long-term impact on the design of large-scale file systems, storage systems, and HPC systems.  ... 
doi:10.1145/3483447 fatcat:kr5oxndbzrbrli5typvcvm7yke

CrossCheck: A Holistic Approach for Tolerating Crash-Faults and Arbitrary Failures

Arthur Martens, Christoph Borchert, Manuel Nieke, Olaf Spinczyk, Rudiger Kapitza
2016 2016 12th European Dependable Computing Conference (EDCC)  
Traditionally, crash faults are addressed using state-machine replication (SMR) and critical data is selectively protected by checksums.  ...  Both techniques can be efficiently combined, however, large parts of a service remain susceptible to transient errors such as bit-flips or more severe state corruptions.  ...  KA 3171/2-3 and SP 968/5-3.  ... 
doi:10.1109/edcc.2016.29 dblp:conf/edcc/MartensBNSK16 fatcat:6jxsa4k3hvdmxfgr2kewsytopm

Transcriptomics and Cell Transformation Assay: an Integrated Approach to Evaluate the Effects of Low Dose Ionizing Radiation

2021 International Journal on Oncology and Radiotherapy  
Results: Cell's transformation was observed at 1.5, 2 and 3Gy doses. The 0.25Gy dose, which was able to induce an increment of clonal efficiency, did not induce cell transformation.  ...  In the last years, great attention has been paid to the effects of IR at low doses and to the non-monotonic dose-response curve for IR exposures.  ...  Daniele Quercioli for his help in the statistical analysis Conflict of Interest Statement The authors declare no conflicts of interest.  ... 
doi:10.51626/ijor.2021.02.00005 fatcat:o5lxzawlbjat5ktd4wmeiui2aq

Altered Protein Expression in the Ileum of Mice Associated with the Development of Chronic Infections with Echinostoma caproni (Trematoda)

Alba Cortés, Javier Sotillo, Carla Muñoz-Antoli, Bernard Fried, J. Guillermo Esteban, Rafael Toledo, John Pius Dalton
2015 PLoS Neglected Tropical Diseases  
These proteins were related to the restoration of the intestinal epithelium and the control of homeostatic dysregulation, mitochondrial and cytoskeletal proteins among others.  ...  These proteins were related to the restoration of the intestinal epithelium and the control of homeostatic dysregulation, concomitantly with mitochondrial and cytoskeletal proteins among others.  ...  The isoelectric focusing was carried out at 20°C in the Ettan IPGphor 3 System (GE Healthcare) as follows: (I) 300 V for 4 h; (II) gradient to 1,000 V for 6 h; (III) gradient to 8,000 V for 3 h; and (IV  ... 
doi:10.1371/journal.pntd.0004082 pmid:26390031 pmcid:PMC4577103 fatcat:m6t2wu3xq5e7xpur6ofakezmpm

Connecting Supplier and DoD Blockchains for Transparent Part Tracking

Francis Asuncion, Adam Brinckman, Dwayne Cole, Jeffrey Curtis, Matt Davis, Timothy Dunlevy, Calvin Farmer, Andrew Harrison, Daniel P. Johnson, Joshua Joyce, Chris Klubertanz, Jonathan Lane (+16 others)
2021 Blockchain: Research and Applications  
on digital technology and critically dependent on secure, timely, accurate, and trusted data.  ...  Blockchains have been around for more than ten years, and since 2015, a plethora of systems have been launched to target more flexible use cases.  ...  The procedure runs as follows. O-level removes the part, and if it cannot be repaired by the local I-Level team, it is shipped to a D-level depot for repair.  ... 
doi:10.1016/j.bcra.2021.100017 fatcat:33665zphyvefdnonmb5p36cmva

The proteome signature of the inflammatory breast cancer plasma membrane identifies novel molecular markers of disease

Ivette J Suárez-Arroyo, Yismeilin R Feliz-Mosquea, Juliana Pérez-Laspiur, Rezina Arju, Shah Giashuddin, Gerónimo Maldonado-Martínez, Luis A Cubano, Robert J Schneider, Michelle M Martínez-Montemayor
2016 American Journal of Cancer Research  
The accurate and early diagnosis of IBC and the development of targeted therapy against this deadly disease remain a great medical challenge.  ...  We identified for the first time the overexpression of the novel plasminogen receptor, PLGRKT in IBC and of the carrier protein, SCAMP3.  ...  Scott Schaffer from the Proteomics and Mass Spectrometry Facility in UMASS for the MS analysis. We would like to acknowledge the UCC-SOM RCMI Common Instrumentation Area.  ... 
pmid:27648361 pmcid:PMC5004075 fatcat:g2tfrms425fefgcoryxokl4aqa

Parvovirus B19 Achievements and Challenges

Giorgio Gallinella
2013 ISRN Virology  
Linked to these issues is the continuous effort to develop better diagnostic algorithms and methods and the need for development of prophylactic and therapeutic options for B19V infections.  ...  environments in terms of tropism and ability to achieve a productive replicative cycle, or, on the contrary, to establish persistence; the consequences of infection in terms of interference with the cell  ...  factors and/or DNA repair proteins.  ... 
doi:10.5402/2013/898730 fatcat:7s4p3ejcofboldzx5dzpqyndra

Leukocyte-Endothelial Cell Adhesion Molecule 2 (LECAM2) [chapter]

2017 Encyclopedia of Cancer  
to be important for the peptide's biological activity.  ...  Interestingly, substantial quantities of lactoferricin are generated in the stomach following the ingestion of lactoferrin-containing milk.  ...  References Agrawal N, Kango M, Mishra A, Sinha P (1995) Neoplastic transformation and aberrant cell-cell interactions in genetic mosaics of lethal (2)  ... 
doi:10.1007/978-3-662-46875-3_101347 fatcat:wq4gqlizr5csfjlwv4opja2jb4

Extracellular vesicles and their nucleic acids for biomarker discovery

Fatemeh Momen-Heravi, Stephen J. Getting, Sterghios Athanasios Moschos
2018 Pharmacology and Therapeutics  
Future implementation of 'omics-based technologies and integration of systems biology approaches for the development of EV-based biomarkers and personalized medicine are also considered. ted : d ted ar  ...  EVs are found in different biofluids and are potential sources for the discovery of novel biomarkers.  ...  Moreover, false positive / negative error rates, in many cases not taken account of, confound data replication in follow-up studies 128 .  ... 
doi:10.1016/j.pharmthera.2018.08.002 pmid:30081050 fatcat:woirqnnhzfgmjco6q2rearexai
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