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Incorporating prognostic imaging biomarkers into clinical practice
2013
Cancer Imaging
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A prognostic imaging biomarker can be defined as an imaging characteristic that is objectively measurable and provides information on the likely outcome of the cancer disease in an untreated individual ...
With appropriate validation within an established evaluation framework, prognostic imaging biomarkers have the potential to contribute to individualized cancer care, in some cases reducing the financial ...
imaging and the use of imaging biomarkers in clinical practice. ...
doi:10.1102/1470-7330.2013.9003
pmid:24060808
pmcid:PMC3781605
fatcat:ncrg2h44offshd3ftzbrerx57m
Comparative Study of Amide Proton Transfer Imaging and Intravoxel Incoherent Motion Imaging for Predicting Histologic Grade of Hepatocellular Carcinoma
2020
Frontiers in Oncology
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The purpose of our study was to investigate the value of amide proton transfer (APT) imaging in predicting the histological grade of HCC, compared with the intravoxel incoherent motion (IVIM) imaging. ...
Conclusion: APT imaging may be a potential noninvasive biomarker for the prediction of histologic grading of HCC and complements IVIM imaging for the more accurate and comprehensive characterization of ...
Recently, conventional diffusion-weighted imaging (DWI) and intravoxel incoherent motion (IVIM) diffusion-weighted MR imaging (5-7) have shown their potential values in providing useful biomarkers for ...
doi:10.3389/fonc.2020.562049
pmid:33194630
pmcid:PMC7659984
fatcat:eellrifuaratfhdzkjmw2u2ccq
Pancreatic imaging: Current status of clinical practices and small animal studies
2017
World Journal of Methodology
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situations in pre-clinical pancreatic imaging studies. ...
The high incidence and mortality of pancreatic diseases have placed diagnostic imaging in a crucial position in daily clinical practice. ...
In this mini-review, current situations of common clinical practices and recent development of pre-clinical rodent studies in pancreatic imaging are inspected and discussed with the emphasis on basic magnetic ...
doi:10.5662/wjm.v7.i3.101
pmid:29026690
pmcid:PMC5618143
fatcat:fjaijb7t5fhu3kuvg5ldsldnuy
Neuroproteomics tools in clinical practice
2015
Biochimica et Biophysica Acta - Proteins and Proteomics
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The application of rapidly emerging technology such as mass spectrometry (MS) in proteomics has opened new avenues to accelerate biomarker discovery, both for diagnostic as well as for prognostic purposes ...
This review summarizes the most recent advances in the mass spectrometry-based neuroproteomics and analyses the current and future directions in the biomarker discovery for the neurodegenerative diseases ...
The 2-DE study [79] revealed altered levels of 47 novel candidate protein biomarkers in AD as compared to control CSF samples. ...
doi:10.1016/j.bbapap.2015.01.016
pmid:25680928
fatcat:yja2tre7yvbj5oa66kgmbxvoly
Image-Based Biomarkers in Clinical Practice
2011
Seminars in Radiation Oncology
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The growth of functional and metabolically informative imaging is eclipsing anatomic imaging alone, in clinical practice. ...
Through these changes and enhancements, image-based biomarkers will enhance clinical decision making and accelerate the progress that is made through clinical trial research. ...
Acknowledgments
Support in part by NIH grant: 1U01 CA140206-01 ...
doi:10.1016/j.semradonc.2010.11.003
pmid:21356483
pmcid:PMC4270476
fatcat:pylxrux2vfaa3ktrcozumfu4pu
Diverse Responses to Vascular Disrupting Agent Combretastatin A4 Phosphate: A Comparative Study in Rats with Hepatic and Subcutaneous Tumor Allografts Using MRI Biomarkers, Microangiography, and Histopathology
2013
Translational Oncology
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Vessel density derived from microangiography was significantly lower in STs compared to HTs without CA4P treatment. ...
Relative to vehicle controls and treated group at baseline, necrosis ratio, apparent diffusion coefficient, and enhancement ratio changed slightly with the STs but significantly with HTs (P < .05) after ...
Apparent diffusion coefficient. ADC values derived from DWI served as an imaging biomarker for tissue viability assessment ( Figure 3C ). ...
doi:10.1593/tlo.12367
pmid:23418616
pmcid:PMC3573653
fatcat:uwciy6gadbda7fvbtzgfgmcxua
Response criteria for glioma
2008
Nature Clinical Practice Oncology
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blood biomarker studies more frequently, and also suggest that investigators recognize the limitations of imaging biomarkers as surrogate end points. ...
We propose that studies report both radiographic and clinical response rates, use volumetric rather than cross-sectional area to measure lesion size, and incorporate findings from mechanistic imaging and ...
Acknowledgments This work was funded by the US Public Health Service (grants M01-RR-01066, 1R21CA117079-01, 5T32CA009502-20, 5P41RR014075 and 5P01CA080124) and The MIND Institute. ...
doi:10.1038/ncponc1204
pmid:18711427
pmcid:PMC4795821
fatcat:gg2wtdngzvbx7bnwbghaslpjhq
Active surveillance as a practical strategy to differentiate lethal and non-lethal prostate cancer subtypes
2012
Asian Journal of Andrology
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used in routine clinical practice. ...
The results of a prospective single institutional study on the combined assessment of 3.0-T endorectal MRI sequences, including T2WI, spectroscopic, dynamic contrast-enhanced and diffusion weighted imaging ...
doi:10.1038/aja.2011.151
pmid:22504873
pmcid:PMC3720161
fatcat:qcppp4xqjnerxialbbabxz5pwi
Liver fibrosis detection and staging: a comparative study of T1ρ MR imaging and 2D real-time shear-wave elastography
2017
Abdominal Radiology
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Purpose: To compare the results of T1q MR imaging and 2D real-time shear-wave elastography (SWE) for liver fibrosis detection and staging. ...
Fibrosis was staged according to the META-VIR scoring system. Correlation test was performed among T1q values, LS values, and fibrosis stage. ...
Further studies are required to move this technology forward and translate it to a clinically applicable imaging biomarker. ...
doi:10.1007/s00261-017-1381-3
pmid:29198003
pmcid:PMC6061497
fatcat:zjea6amp2ndnbknrb64fszzxsu
Alzheimer's Disease: A Clinical Practice-Oriented Review
2012
Frontiers in Neurology
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and to be aware of the implications they have in clinical practice. ...
Biomarkers, namely magnetic resonance imaging, single photon emission tomography, FDG PET, PiB PET, CSF tau, and Aβ analysis, as well as available data on their diagnostic accuracy, are also discussed. ...
These include: functional MRI and diffusion tensor imaging (Hampel et al., 2008) ; diffusion weighted imaging, magnetization transfer MRI and proton magnetic resonance spectroscopy (Kantarci and Jack ...
doi:10.3389/fneur.2012.00063
pmid:22529838
pmcid:PMC3330267
fatcat:tjnyt6ruxbaejprxrcvrn3wlmi
Recommendations for Preclinical Renal MRI: A Comprehensive Open-Access Protocol Collection to Improve Training, Reproducibility, and Comparability of Studies
2021
Msphere
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clinical practice. ...
reproducibility and standardization of renal MRI biomarkers. ...
PARENCHIMA (renalmri.org) is a community-driven Action in the COST program of the European Union, which unites more than 200 experts in renal MRI from 30 countries with the aim to improve the reproducibility ...
doi:10.1007/978-1-0716-0978-1_1
pmid:33475991
fatcat:umgimar2jne5bon7c2arlvwque
MRI of hepatocellular carcinoma: an update of current practices
2014
Diagnostic and Interventional Radiology
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nonspecific gadolinium chelates, hepatobiliary contrast agents, and diffusion weighted imaging. ...
compared with CT and MRI. ...
images compared with the in-phase images. ...
doi:10.5152/dir.2014.13370
pmid:24808419
pmcid:PMC4463351
fatcat:k4uz3ec66jgytgksofcmhtgvve
A practical review of magnetic resonance imaging for the evaluation and management of cervical cancer
2016
Radiation Oncology
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Staging and management of cervical cancer has for many years been based on clinical exam and basic imaging such as intravenous pyelogram and x-ray. ...
a practical approach if access to MRI is limited. ...
Diffusion-weighted MRI (DW-MRI) is a non-contrast imaging methodology that measures water diffusion in tissue typically using apparent diffusion coefficients (ADC) for quantification and comparison. ...
doi:10.1186/s13014-016-0591-0
pmid:26830954
pmcid:PMC4736634
fatcat:z7eoofe6mrhqbgjqrnf6aou62i
Cardiac MR: From Theory to Practice
2022
Frontiers in Cardiovascular Medicine
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Especially in view of recent developments in the field of machine learning that provide novel solutions to address existing problems, it is necessary to bridge the gap between the clinical and scientific ...
Furthermore, an overview of novel deep learning image segmentation and analysis methods is provided with a focus on automatic, fast and reliable extraction of biomarkers and parameters of clinical relevance ...
increasingly important in clinical practice. ...
doi:10.3389/fcvm.2022.826283
pmid:35310962
pmcid:PMC8927633
fatcat:j3vd446nxnajvgajkhazwbvgia
Gaucher Disease in Bone: From Pathophysiology to Practice
2019
Journal of Bone and Mineral Research
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Investing in safe, clinically useful, and better predictive methods for determining bone integrity and fracture risk remains a need. © 2019 The Authors. ...
To develop practical clinical recommendations, an international group of experienced physicians conducted a comprehensive review of 20 years' of the literature, defining terms according to pathophysiological ...
Acknowledgments AK is supported by grants from the Swedish Research Council Formas. PKM is supported by Sanofi-Genzyme Center of ...
doi:10.1002/jbmr.3734
pmid:31233632
pmcid:PMC6852006
fatcat:fkawnfzeqrbc3apancm4ir6zjm
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