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Incorporating prognostic imaging biomarkers into clinical practice

W. Phillip Law, Kenneth A. Miles
2013 Cancer Imaging  
A prognostic imaging biomarker can be defined as an imaging characteristic that is objectively measurable and provides information on the likely outcome of the cancer disease in an untreated individual  ...  With appropriate validation within an established evaluation framework, prognostic imaging biomarkers have the potential to contribute to individualized cancer care, in some cases reducing the financial  ...  imaging and the use of imaging biomarkers in clinical practice.  ... 
doi:10.1102/1470-7330.2013.9003 pmid:24060808 pmcid:PMC3781605 fatcat:ncrg2h44offshd3ftzbrerx57m

Comparative Study of Amide Proton Transfer Imaging and Intravoxel Incoherent Motion Imaging for Predicting Histologic Grade of Hepatocellular Carcinoma

Baolin Wu, Fei Jia, Xuekun Li, Lei Li, Kaiyu Wang, Dongming Han
2020 Frontiers in Oncology  
The purpose of our study was to investigate the value of amide proton transfer (APT) imaging in predicting the histological grade of HCC, compared with the intravoxel incoherent motion (IVIM) imaging.  ...  Conclusion: APT imaging may be a potential noninvasive biomarker for the prediction of histologic grading of HCC and complements IVIM imaging for the more accurate and comprehensive characterization of  ...  Recently, conventional diffusion-weighted imaging (DWI) and intravoxel incoherent motion (IVIM) diffusion-weighted MR imaging (5-7) have shown their potential values in providing useful biomarkers for  ... 
doi:10.3389/fonc.2020.562049 pmid:33194630 pmcid:PMC7659984 fatcat:eellrifuaratfhdzkjmw2u2ccq

Pancreatic imaging: Current status of clinical practices and small animal studies

Ting Yin, Yewei Liu, Ronald Peeters, Yuanbo Feng, Yicheng Ni
2017 World Journal of Methodology  
situations in pre-clinical pancreatic imaging studies.  ...  The high incidence and mortality of pancreatic diseases have placed diagnostic imaging in a crucial position in daily clinical practice.  ...  In this mini-review, current situations of common clinical practices and recent development of pre-clinical rodent studies in pancreatic imaging are inspected and discussed with the emphasis on basic magnetic  ... 
doi:10.5662/wjm.v7.i3.101 pmid:29026690 pmcid:PMC5618143 fatcat:fjaijb7t5fhu3kuvg5ldsldnuy

Neuroproteomics tools in clinical practice

Ganna Shevchenko, Anne Konzer, Sravani Musunuri, Jonas Bergquist
2015 Biochimica et Biophysica Acta - Proteins and Proteomics  
The application of rapidly emerging technology such as mass spectrometry (MS) in proteomics has opened new avenues to accelerate biomarker discovery, both for diagnostic as well as for prognostic purposes  ...  This review summarizes the most recent advances in the mass spectrometry-based neuroproteomics and analyses the current and future directions in the biomarker discovery for the neurodegenerative diseases  ...  The 2-DE study [79] revealed altered levels of 47 novel candidate protein biomarkers in AD as compared to control CSF samples.  ... 
doi:10.1016/j.bbapap.2015.01.016 pmid:25680928 fatcat:yja2tre7yvbj5oa66kgmbxvoly

Image-Based Biomarkers in Clinical Practice

John E. Bayouth, Thomas L. Casavant, Michael M. Graham, Milan Sonka, Manickam Muruganandham, John M. Buatti
2011 Seminars in Radiation Oncology  
The growth of functional and metabolically informative imaging is eclipsing anatomic imaging alone, in clinical practice.  ...  Through these changes and enhancements, image-based biomarkers will enhance clinical decision making and accelerate the progress that is made through clinical trial research.  ...  Acknowledgments Support in part by NIH grant: 1U01 CA140206-01  ... 
doi:10.1016/j.semradonc.2010.11.003 pmid:21356483 pmcid:PMC4270476 fatcat:pylxrux2vfaa3ktrcozumfu4pu

Diverse Responses to Vascular Disrupting Agent Combretastatin A4 Phosphate: A Comparative Study in Rats with Hepatic and Subcutaneous Tumor Allografts Using MRI Biomarkers, Microangiography, and Histopathology

Junjie Li, Feng Chen, Yuanbo Feng, Marlein Miranda Cona, Jie Yu, Alfons Verbruggen, Jian Zhang, Raymond Oyen, Yicheng Ni
2013 Translational Oncology  
Vessel density derived from microangiography was significantly lower in STs compared to HTs without CA4P treatment.  ...  Relative to vehicle controls and treated group at baseline, necrosis ratio, apparent diffusion coefficient, and enhancement ratio changed slightly with the STs but significantly with HTs (P < .05) after  ...  Apparent diffusion coefficient. ADC values derived from DWI served as an imaging biomarker for tissue viability assessment ( Figure 3C ).  ... 
doi:10.1593/tlo.12367 pmid:23418616 pmcid:PMC3573653 fatcat:uwciy6gadbda7fvbtzgfgmcxua

Response criteria for glioma

A Gregory Sorensen, Tracy T Batchelor, Patrick Y Wen, Wei-Ting Zhang, Rakesh K Jain
2008 Nature Clinical Practice Oncology  
blood biomarker studies more frequently, and also suggest that investigators recognize the limitations of imaging biomarkers as surrogate end points.  ...  We propose that studies report both radiographic and clinical response rates, use volumetric rather than cross-sectional area to measure lesion size, and incorporate findings from mechanistic imaging and  ...  Acknowledgments This work was funded by the US Public Health Service (grants M01-RR-01066, 1R21CA117079-01, 5T32CA009502-20, 5P41RR014075 and 5P01CA080124) and The MIND Institute.  ... 
doi:10.1038/ncponc1204 pmid:18711427 pmcid:PMC4795821 fatcat:gg2wtdngzvbx7bnwbghaslpjhq

Active surveillance as a practical strategy to differentiate lethal and non-lethal prostate cancer subtypes

Yoshiyuki Kakehi
2012 Asian Journal of Andrology  
used in routine clinical practice.  ...  The results of a prospective single institutional study on the combined assessment of 3.0-T endorectal MRI sequences, including T2WI, spectroscopic, dynamic contrast-enhanced and diffusion weighted imaging  ... 
doi:10.1038/aja.2011.151 pmid:22504873 pmcid:PMC3720161 fatcat:qcppp4xqjnerxialbbabxz5pwi

Liver fibrosis detection and staging: a comparative study of T1ρ MR imaging and 2D real-time shear-wave elastography

Ruo-kun Li, Xin-pin Ren, Fu-hua Yan, Jin-wei Qiang, Hui-min Lin, Tao Wang, Hong-fei Zhao, Wei-bo Chen
2017 Abdominal Radiology  
Purpose: To compare the results of T1q MR imaging and 2D real-time shear-wave elastography (SWE) for liver fibrosis detection and staging.  ...  Fibrosis was staged according to the META-VIR scoring system. Correlation test was performed among T1q values, LS values, and fibrosis stage.  ...  Further studies are required to move this technology forward and translate it to a clinically applicable imaging biomarker.  ... 
doi:10.1007/s00261-017-1381-3 pmid:29198003 pmcid:PMC6061497 fatcat:zjea6amp2ndnbknrb64fszzxsu

Alzheimer's Disease: A Clinical Practice-Oriented Review

Luísa Alves, Ana Sofia A. Correia, Rita Miguel, Paulo Alegria, Paulo Bugalho
2012 Frontiers in Neurology  
and to be aware of the implications they have in clinical practice.  ...  Biomarkers, namely magnetic resonance imaging, single photon emission tomography, FDG PET, PiB PET, CSF tau, and Aβ analysis, as well as available data on their diagnostic accuracy, are also discussed.  ...  These include: functional MRI and diffusion tensor imaging (Hampel et al., 2008) ; diffusion weighted imaging, magnetization transfer MRI and proton magnetic resonance spectroscopy (Kantarci and Jack  ... 
doi:10.3389/fneur.2012.00063 pmid:22529838 pmcid:PMC3330267 fatcat:tjnyt6ruxbaejprxrcvrn3wlmi

Recommendations for Preclinical Renal MRI: A Comprehensive Open-Access Protocol Collection to Improve Training, Reproducibility, and Comparability of Studies

Andreas Pohlmann, Susan J Back, Andrea Fekete, Iris Friedli, Stefanie Hectors, Neil Peter Jerome, Min-Chi Ku, Dario Livio Longo, Martin Meier, Jason M Millward, João S Periquito, Erdmann Seeliger (+5 others)
2021 Msphere  
clinical practice.  ...  reproducibility and standardization of renal MRI biomarkers.  ...  PARENCHIMA ( is a community-driven Action in the COST program of the European Union, which unites more than 200 experts in renal MRI from 30 countries with the aim to improve the reproducibility  ... 
doi:10.1007/978-1-0716-0978-1_1 pmid:33475991 fatcat:umgimar2jne5bon7c2arlvwque

MRI of hepatocellular carcinoma: an update of current practices

Hina Arif-Twari, Bobby Kalb, Surya Chundru, Puneet Sharma, James Costello, Rainner W. Guessner, Diego R. Martin
2014 Diagnostic and Interventional Radiology  
nonspecific gadolinium chelates, hepatobiliary contrast agents, and diffusion weighted imaging.  ...  compared with CT and MRI.  ...  images compared with the in-phase images.  ... 
doi:10.5152/dir.2014.13370 pmid:24808419 pmcid:PMC4463351 fatcat:k4uz3ec66jgytgksofcmhtgvve

A practical review of magnetic resonance imaging for the evaluation and management of cervical cancer

Emma C. Fields, Elisabeth Weiss
2016 Radiation Oncology  
Staging and management of cervical cancer has for many years been based on clinical exam and basic imaging such as intravenous pyelogram and x-ray.  ...  a practical approach if access to MRI is limited.  ...  Diffusion-weighted MRI (DW-MRI) is a non-contrast imaging methodology that measures water diffusion in tissue typically using apparent diffusion coefficients (ADC) for quantification and comparison.  ... 
doi:10.1186/s13014-016-0591-0 pmid:26830954 pmcid:PMC4736634 fatcat:z7eoofe6mrhqbgjqrnf6aou62i

Cardiac MR: From Theory to Practice

Tevfik F. Ismail, Wendy Strugnell, Chiara Coletti, Maša Božić-Iven, Sebastian Weingärtner, Kerstin Hammernik, Teresa Correia, Thomas Küstner
2022 Frontiers in Cardiovascular Medicine  
Especially in view of recent developments in the field of machine learning that provide novel solutions to address existing problems, it is necessary to bridge the gap between the clinical and scientific  ...  Furthermore, an overview of novel deep learning image segmentation and analysis methods is provided with a focus on automatic, fast and reliable extraction of biomarkers and parameters of clinical relevance  ...  increasingly important in clinical practice.  ... 
doi:10.3389/fcvm.2022.826283 pmid:35310962 pmcid:PMC8927633 fatcat:j3vd446nxnajvgajkhazwbvgia

Gaucher Disease in Bone: From Pathophysiology to Practice

Derralynn Hughes, Peter Mikosch, Nadia Belmatoug, Francesca Carubbi, TimothyM Cox, Ozlem Goker-Alpan, Andreas Kindmark, PramodK Mistry, Ludger Poll, Neal Weinreb, Patrick Deegan
2019 Journal of Bone and Mineral Research  
Investing in safe, clinically useful, and better predictive methods for determining bone integrity and fracture risk remains a need. © 2019 The Authors.  ...  To develop practical clinical recommendations, an international group of experienced physicians conducted a comprehensive review of 20 years' of the literature, defining terms according to pathophysiological  ...  Acknowledgments AK is supported by grants from the Swedish Research Council Formas. PKM is supported by Sanofi-Genzyme Center of  ... 
doi:10.1002/jbmr.3734 pmid:31233632 pmcid:PMC6852006 fatcat:fkawnfzeqrbc3apancm4ir6zjm
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