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Abstinence from Cocaine and Sucrose Self-Administration Reveals Altered Mesocorticolimbic Circuit Connectivity by Resting State MRI

Hanbing Lu, Qihong Zou, Svetlana Chefer, Thomas J. Ross, D. Bruce Vaupel, Karine Guillem, William P. Rea, Yihong Yang, Laura L. Peoples, Elliot A. Stein
2014 Brain Connectivity  
cocaine (IV) or sucrose (orally) followed by an identically enforced 30 day abstinence period.  ...  Moreover, individual differences in cocaine SA escalation predicted connectivity strength only in the Acb-dmPFC circuit.  ...  ALTERED MESOCORTICOLIMBIC CIRCUIT CONNECTIVITY  ... 
doi:10.1089/brain.2014.0264 pmid:24999822 pmcid:PMC4146381 fatcat:7iznrnfsjvdo7g6thxwffusb7q

Functional Connectivity of Chronic Cocaine Use Reveals Progressive Neuroadaptations in Neocortical, Striatal, and Limbic Networks

Caitlin A. Orsini, Luis M. Colon-Perez, Sara C. Heshmati, Barry Setlow, Marcelo Febo
2018 eNeuro  
Notably, there were no changes in strength of functional connectivity at 1 or 14 d after either cocaine or sucrose self-administration.  ...  Functional magnetic resonance imaging was conducted before self-administration and after 1 and 14 d of abstinence (1d and 14d Abs).  ...  Acknowledgments: We thank the Drug Supply Program at the National Institute on Drug Abuse for providing cocaine HCl.  ... 
doi:10.1523/eneuro.0081-18.2018 pmid:30073194 pmcid:PMC6071197 fatcat:22fconf23zgtfkq2jt5zkw7jbe

Effect of cocaine dependence on brain connections: clinical implications

Liangsuo Ma, Joel L. Steinberg, F. Gerard Moeller, Sade E. Johns, Ponnada A. Narayana
2015 Expert Review of Neurotherapeutics  
In cocaine users, some of the altered brain connectivity measures are associated with behavioral performance, history of drug use, and treatment outcome.  ...  The majority of these brain connectivity studies indicated that cocaine use is associated with altered brain connectivity between different structures, including cortical-striatal regions and default mode  ...  Abstinence from cocaine and sucrose self-administration reveals altered mesocorticolimbic circuit connectivity by resting state MRI. Brain Connect. 2014; 4(7): 499-510.  ... 
doi:10.1586/14737175.2015.1103183 pmid:26512421 pmcid:PMC4651809 fatcat:iygjsow4svgxpa7enjcqbbazwe

fMRI response in the medial prefrontal cortex predicts cocaine but not sucrose self-administration history

Hanbing Lu, Svetlana Chefer, Pradeep K. Kurup, Karine Guillem, D. Bruce Vaupel, Thomas J. Ross, Anna Moore, Yihong Yang, Laura L. Peoples, Elliot A. Stein
2012 NeuroImage  
In contrast, both the cocaine and sucrose SA groups demonstrated a very similar initial negative fMRI response followed by an attenuated positive response.  ...  Given that the two SA groups had identical histories of operant training and handling, this region-specific group difference revealed by regression analysis may reflect the development of neuroadaptive  ...  It was also partially supported by P50DA012756, and R01 552981 (L.L.P.), Institute for Translational Medicine and Therapeutics of the University of Pennsylvania, and grant UL1RR024134 from the National  ... 
doi:10.1016/j.neuroimage.2012.05.076 pmid:22664568 pmcid:PMC3875563 fatcat:hgbtkcrg4rdivl35mxjsdncw2m

Top-Down Network Effective Connectivity in Abstinent Substance Dependent Individuals

Michael F. Regner, Naomi Saenz, Keeran Maharajh, Dorothy J. Yamamoto, Brianne Mohl, Korey Wylie, Jason Tregellas, Jody Tanabe, Emmanuel Andreas Stamatakis
2016 PLoS ONE  
(NOI) were selected using template matching to a canonical set of resting state networks.  ...  Methods 50 SDI and 50 controls of similar sex and age completed psychological surveys and resting state fMRI. fMRI results were analyzed using group independent component analysis; 14 networks-of-interest  ...  Acknowledgments This work was supported by the National Institute of Drug Abuse (NIDA) grants DA024104 (JT), DA 027748 (JT), and DA 041011 (MFR).  ... 
doi:10.1371/journal.pone.0164818 pmid:27776135 pmcid:PMC5077096 fatcat:7e7jkxf4z5favhgtixqjto3hya

Increased Alcohol Seeking in Mice Lacking Gpr88 Involves Dysfunctional Mesocorticolimbic Networks

Sami Ben Hamida, Sueli Mendonça-Netto, Tanzil Mahmud Arefin, Md. Taufiq Nasseef, Laura-Joy Boulos, Michael McNicholas, Aliza Toby Ehrlich, Eleanor Clarke, Luc Moquin, Alain Gratton, Emmanuel Darcq, Laura Adela Harsan (+2 others)
2018 Biological Psychiatry  
Keywords Orphan G protein coupled receptor; GPR88 knockout mice; ethanol voluntary drinking; operant self-administration; resting-state functional magnetic resonance imaging; amygdala; prefrontal cortex  ...  Also, effective connectivity from VTA to NAC and AMY was reduced.  ...  Resting-state functional Magnetic Resonance Imaging (Rs-fMRI) MRI data acquisition and Resting-state functional MRI analysis were conducted as described in (35, 36) and effective connectivity (FC) analysis  ... 
doi:10.1016/j.biopsych.2018.01.026 pmid:29580570 pmcid:PMC6054571 fatcat:feiiaiqd2vho5op57dw4cao4gi

Basolateral amygdala and stress-induced hyperexcitability affect motivated behaviors and addiction

B M Sharp
2017 Translational Psychiatry  
Disruption of intrinsic amygdala and BLA regulatory neurocircuits is often caused by dysfunctional neuroplasticity frequently due to molecular alterations in local GABAergic circuits and principal glutamatergic  ...  In this Review, we discuss molecular mechanisms and neural circuits that regulate physiological and stress-induced dysfunction of BLA/amygdala and its principal output neurons.  ...  Repeated stress during abstinence increased the reacquisition of operant nicotine self-administration (SA).  ... 
doi:10.1038/tp.2017.161 pmid:28786979 pmcid:PMC5611728 fatcat:76uatdxjwrbo7l6frrddtndesa

Food addiction A common neurobiological mechanism with drug abuse

Gene-Jack Wang
2018 Frontiers in Bioscience  
cortex after 1 and 12 weeks of abstinence -Increased MOR availability was associated with self-reported cocaine craving and cocaine use severity before admission Heinz et al  ...  We review literature of functional MRI (fMRI), resting-state MRI (rsfMRI) and structural MRI including gray and white matter volumes, fractional anisotropy (FA) and mean diffusivity (MD).  ... 
doi:10.2741/4618 pmid:28930574 fatcat:mjfhvuleyjcyra5lxdsbjheoba

Effects of monoamine releasers with varying selectivity for releasing dopamine/norepinephrine versus serotonin on choice between cocaine and food in rhesus monkeys

Matthew L. Banks, Bruce E. Blough, S. Stevens Negus
2011 Behavioural Pharmacology  
These results extend the range of conditions across which dopamine and norepinephrine-selective releasers have been shown to reduce cocaine self-administration. Banks ML, Blough BE, Negus SS.  ...  Together, these findings reveal a molecular mechanism by which cocaine regulates HDAC5 function to antagonize the rewarding impact of cocaine, likely by putting a brake on drug-stimulated gene expression  ...  This Funding Opportunity Announcement (FOA) issued by the National Institute on Drug Abuse (NIDA) and the National Institute on Alcohol Abuse and Alcoholism (NIAAA) encourages Research Project Grant (R01  ... 
doi:10.1097/fbp.0b013e32834d63ac pmid:22015808 pmcid:PMC3476464 fatcat:wxbgqsqazfegvfnvq6gdvwreua

ACNP 57th Annual Meeting: Poster Session II

2018 Neuropsychopharmacology  
Post-traumatic stress disorder (PTSD) remains a growing and often debilitating psychiatric disorder resulting from severe trauma.  ...  After one week, mice were tested for avoidance behaviors by open field and light-dark box testing.  ...  We hypothesize that cocaine self-administration generates a longlasting epigenetic environment which alters the integration of neural circuit activity within genetically defined cell types in the NAc and  ... 
doi:10.1038/s41386-018-0267-6 fatcat:febeq6uwefgdzm65ccmzrmjwjy

ACNP 58th Annual Meeting: Panels, Mini-Panels and Study Groups

2019 Neuropsychopharmacology  
Recent progress has been made on probes to study interactions between the opioid neuropeptide dynorphin and the kappa opioid receptor, which are implicated in the negative aversive states associated with  ...  In parallel, two analogues were assayed in brain slices using genetically-encoded optical sensors for dynorphin developed by Lin Tian's lab at UC Davis.  ...  Methods: We generated three within-sample, RNA/ChIP datasets from NAc of mice following either SET2 overexpression, 1-day or 28-days of abstinence following cocaine-self administration.  ... 
doi:10.1038/s41386-019-0544-z pmid:31801977 pmcid:PMC6957922 fatcat:hjyvf7fcpbf2fhxit6rlhsvg2y

Poster Session I

2013 Neuropsychopharmacology  
Notably, the deficits following acute administration of 100 mg/kg KYN were fully prevented by co-administration of GAL.  ...  This deficit appears to result from KYNA's negative allosteric modulation of a7nAChRs, as performance accuracy was normalized by GAL.  ...  Abi-Dargham, and S. Kapur, Arch Gen Psychiatry 69, 776 (2012). 2  ... 
doi:10.1038/npp.2013.279 fatcat:54ipecxjarcvljrvn5fgtgif5u

Panel and Study Groups

2013 Neuropsychopharmacology  
Similarly, the switch from GABA as an excitatory to inhibitory neurotransmitter in human brain mediated by two genes, NKCC1 and KCC2, has only recently been explored.  ...  Similarly, the switch from GABA being excitatory to inhibitory is mediated by relative ratios that favor NKCC1 prenatally to ones that favor KCC2 postnatally.  ...  resting state connections. 2.  ... 
doi:10.1038/npp.2013.278 fatcat:expu2u3f3reypazj7tt7jhybfa

Ventral pallidum roles in reward and motivation

Kyle S. Smith, Amy J. Tindell, J. Wayne Aldridge, Kent C. Berridge
2009 Behavioural Brain Research  
We conclude that the ventral pallidum may serve as an important 'limbic final common pathway' for mesocorticolimbic processing of many rewards.  ...  , and (3) activation patterns in ventral pallidum neurons specifically encode reward and motivation signals via phasic bursts of excitation to incentive and hedonic stimuli.  ...  Heimer and Wilson first identified Acknowledgements Research leading to this review was supported by grants from the NIH to KCB (MH63649 and DA015188) and JWA (DA017752).  ... 
doi:10.1016/j.bbr.2008.09.038 pmid:18955088 pmcid:PMC2606924 fatcat:5r7fyp5hvrgopo4lbvz4xkx6bi

Poster Session III

2011 Neuropsychopharmacology  
In sum, our findings reveal a novel role for FMRP in the processes underlying alterations in the brain and behavior that occur in response to repeated cocaine exposure.  ...  Manipulation of dopamine function suggested a general effect on self-administration of both reinforcer solutions, but higher doses of the antagonist may be needed to reveal a significant effect and to  ...  22-hour withdrawal point from the last cocaine self-administration.  ... 
doi:10.1038/npp.2011.293 fatcat:o4t4mbgxcbax7fgl5vb2dzbep4
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