A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2018; you can also visit the original URL.
The file type is application/pdf.
Filters
Ab-origin: An Improved Tool of Heavy Chain Rearrangement Analysis for Human Immunoglobulin
[chapter]
2007
Lecture Notes in Computer Science
Preserved Fulltext
An improved tool to explore the origin of human immunoglobulin heavy chains, named Ab-origin, has been developed. ...
Though only taking the human heavy chain for an example here, the algorithm also suits for the analysis of all immunoglobulin and TCR sequences. ...
technology commission of Shanghai municipality (04DZ19850, 06PJ14072). ...
doi:10.1007/978-3-540-72586-2_52
fatcat:cin2po2eqredbalvvpk4uaobca
Ab-origin: an enhanced tool to identify the sourcing gene segments in germline for rearranged antibodies
2008
BMC Bioinformatics
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2017; you can also visit the original URL.
The file type is application/pdf.
Moreover, none of them give a confidence for immunoglobulin heavy diversity (IGHD) identification. ...
Developing fast, efficient and enhanced tools is always needed with the booming of immunological data. Results: Here, a program named Ab-origin is presented. ...
Yeo WeeKiang for helping us improving the English writing, and the anonymous reviewers for their constructive comments. We also thank Dr. Wu Wei for fruitful and helpful discussion. ...
doi:10.1186/1471-2105-9-s12-s20
pmid:19091020
pmcid:PMC2638160
fatcat:daeylty7cvczzbpb2rfqb2jbye
Benchmarking the performance of human antibody gene alignment utilities using a 454 sequence dataset
2010
Computer applications in the biosciences : CABIOS
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2019; you can also visit the original URL.
The file type is application/pdf.
Motivation: Immunoglobulin heavy chain genes are formed by recombination of genes randomly selected from sets of IGHV, IGHD and IGHJ genes. ...
The Stanford_S22 dataset and an evaluation tool is available at ...
Conflict of Interest: none declared. ...
doi:10.1093/bioinformatics/btq604
pmid:21036814
fatcat:ogxlmhcdevdxtlg4iphdchbjdy
Clustering-based identification of clonally-related immunoglobulin gene sequence sets
2010
Immunome Research
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2017; you can also visit the original URL.
The file type is application/pdf.
Results: We have developed and implemented an algorithm for identifying sets of clonally-related sequences in large human immunoglobulin heavy chain gene variable region sequence sets. ...
The identification of groups of rearranged immunoglobulin gene sequences descended from the same rearrangement (clonally-related sets) in very large sets of sequences is facilitated by the availability ...
Acknowledgements The authors thank Michael Bain and Katherine Jackson for helpful comments and feedback. This article has been published as part of Immunome Research ...
doi:10.1186/1745-7580-6-s1-s4
pmid:20875155
pmcid:PMC2946782
fatcat:2kkcexky3bgexmz5zrtgwqklby
Assigning and visualizing germline genes in antibody repertoires
2015
Philosophical Transactions of the Royal Society of London. Biological Sciences
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2019; you can also visit the original URL.
The file type is application/pdf.
datasets of human immunoglobulin heavy chain sequences. ...
Identifying the germline genes involved in immunoglobulin rearrangements is an essential first step in the analysis of antibody repertoires. ...
We thank the two anonymous reviewers for their comments, which helped to improve the manuscript. ...
doi:10.1098/rstb.2014.0240
pmid:26194754
pmcid:PMC4528417
fatcat:d7ybn2675vfmdc3sh6mp7xsbze
Recovery of a human natural antibody against the noncollagenous-1 domain of type IV collagen using humanized models
2015
Journal of Translational Medicine
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2017; you can also visit the original URL.
The file type is application/pdf.
Ab target the noncollagenous 1 (NC1) domain of alpha3(IV) collagen, but little is known about Ab origins or structure. ...
The aim of this study was to assess the suitability of two humanized models for this purpose. ...
We thank Divino Deoliveira for help with humanized models, Michael Cook for help with flow cytometry, Emma Zhao for help with immunoassays and animal husbandry, Julie Fuller of the Surgical Sciences Histopathology ...
doi:10.1186/s12967-015-0539-4
pmid:26048777
pmcid:PMC4467618
fatcat:p2wyhhw3r5gdro4tbyhjqbbv6y
Multispecificity of a recombinant anti-ras monoclonal antibody
2017
Journal of Molecular Recognition
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2018; you can also visit the original URL.
The file type is application/pdf.
Whilst studying the cellular molecular switch protein m-ras, a recombinant monoclonal antibody to m-ras was generated for use as a research tool. ...
The cross reactive binding of the monoclonal Ab to h-ras was defined by peptide array blot revealing that the Ab showed preference for peptide sequences containing multiple positively charged amino acid ...
Conflicts of Interests: The authors declare they have no conflicts of interests. ...
doi:10.1002/jmr.2683
pmid:29115701
fatcat:oog2ybuexve3bmevzma7pvnana
Ontogeny of Recognition Specificity and Functionality for the Broadly Neutralizing Anti-HIV Antibody 4E10
2014
PLoS Pathogens
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2017; you can also visit the original URL.
The file type is application/pdf.
The process of antibody ontogeny typically improves affinity, on-rate, and thermostability, narrows polyspecificity, and rigidifies the combining site to the conformer optimal for binding from the broader ...
The ontogeny of 4E10, an autoreactive antibody with unexpected combining site flexibility, was delineated through structural and biophysical comparisons of the mature antibody with multiple potential precursors ...
Acknowledgments We would like to thank Tim Vanden Bos and Madeline LaPatra for assistance with protein production.
Author Contributions ...
doi:10.1371/journal.ppat.1004403
pmid:25254371
pmcid:PMC4177983
fatcat:hjjydmof35aqjdvhtgzipmobcy
Abstract Book, XIII International Congress of Histochemistry and Cytochemistry ICHC2008, Imaging of Cell Dynamics, 23rd-27th August 2008, Medical University of Gdansk, Poland
2008
Folia Histochemica et Cytobiologica
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2020; you can also visit the original URL.
The file type is application/pdf.
line (Ab) originated from the melanotic form by a spontaneous alteration, differing in many biological properties. ...
We will describe a new tool for the high-throughput analysis of alternative splicing. ...
To reach this goal, changes in the chemical coding of sympathetic neurons supplying porcine urinary bladder, an animal which can be used as a very good model for human lower urinary tract, have been elucidated ...
doi:10.5603/4388
doaj:cdebe86bf2604301b2401e99ae9a504c
fatcat:7j6nazvgnjf2bhooy5awdzq7uy
Immunoregulation in myasthenia gravis
1989
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2020; you can also visit the original URL.
The file type is application/pdf.
Additionally, in order to gain access to an appropriate patient base for our study, we established a further modification with improved sensitivity for detection of serum nAchR Ab. ...
Myasthenia Gravis (MG) is an autoimmune disorder of neuromuscular transmission. Clinically, the disease is manifested by abnormal muscle fatigue with recovery on resting. ...
We have established two modifications of the nAchR Ab originally described by Lindstrom et al (1977) . ...
doi:10.14288/1.0100307
fatcat:szzwzbhof5fetf75d2d4mffbly