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This article examines American Protestant anti-lynching advocacy in the early twentieth century. ... of lynching regularly downplayed race and framed the crime in terms of its threat to American civilization and national law and order. ... "The best way to stop lynchings is to stop the crimes that provoke the lynchings." ...doi:10.3390/rel10020116 fatcat:ebwbrhwihrekxfv227i5jm7bfy
Background Sebaceous neoplasms of the skin (SN) are described in the Muir Torre variant of Lynch syndrome (LS). ... Results 24 individuals with a personal history of SN underwent a genetic evaluation for Lynch syndrome (LS) at Dana-Farber Cancer Institute. 10 had family histories which met Amsterdam criteria, 8 had ...doi:10.1186/1897-4287-9-s1-p7 pmcid:PMC3288897 fatcat:v74hgg2wfndotbnqruckss5hwu
Journal of Gastrointestinal & Digestive System
The cancer risk for patients with Lynch syndrome is not limited to the colorectum; women with Lynch syndrome are at risk for endometrial cancer, and Lynch patients of both genders are at risk for other ... This article reviews these novel mechanisms and mutations, their clinical significance, and the pathogenesis of these Lynch causing mutations. ... similar to Lynch cannot be excluded [1, 16] . ...doi:10.4172/2161-069x.1000151 fatcat:somohvjsz5cxhixspbwznjwaea
Mutual information maximization has emerged as a powerful learning objective for unsupervised representation learning obtaining state-of-the-art performance in applications such as object recognition, speech recognition, and reinforcement learning. However, such approaches are fundamentally limited since a tight lower bound of mutual information requires sample size exponential in the mutual information. This limits the applicability of these approaches for prediction tasks with high mutualarXiv:1903.11780v1 fatcat:x27to7vs3fe6zdpxrqtl4p5djm
more »... rmation, such as in video understanding or reinforcement learning. In these settings, such techniques are prone to overfit, both in theory and in practice, and capture only a few of the relevant factors of variation. This leads to incomplete representations that are not optimal for downstream tasks. In this work, we empirically demonstrate that mutual information-based representation learning approaches do fail to learn complete representations on a number of designed and real-world tasks. To mitigate these problems we introduce the Wasserstein dependency measure, which learns more complete representations by using the Wasserstein distance instead of the KL divergence in the mutual information estimator. We show that a practical approximation to this theoretically motivated solution, constructed using Lipschitz constraint techniques from the GAN literature, achieves substantially improved results on tasks where incomplete representations are a major challenge.
Charlesworth 1990; Lynch et al. 1995) . ... et al. 1995; Schultz and Lynch 1997) . ...doi:10.1554/0014-3820(2000)054[1234:tfeosm]2.0.co;2 fatcat:dy5lazehqjbdjoyfhef3wwgmse
Conclusion : Treize pour cent de la population présentaient des mutations concordant avec un syndrome de Lynch. ... We investigated the prevalence of Lynch syndrome as a hereditary cause of colon cancer in the young Jamaican colorectal cancer (CRC) population. ... In addition, the at-risk family members of those with diagnosed Lynch syndrome were all offered colonoscopic surveillance. ...doi:10.1503/cjs.037410 pmid:22854115 pmcid:PMC3468640 fatcat:thi3e5nparhi7da5yng2njlte4
INTRODUCTION Lynch syndrome or hereditary nonpolyposis colorectal cancer (HNPCC; MIM 120435), is the most common colorectal cancer predisposition syndrome. ... Alternatively, it is possible that these tumors are sporadic in nature and not associated with the Muir-Torre/Lynch syndrome spectrum. ...doi:10.1038/jhg.2009.119 pmid:19911012 fatcat:2kwxtwlyczc7nnmkxrnztlonlu
BACKGROUND: Cyanazine is a common pesticide used frequently in the United States during the 1980s and 1990s. Animal and human studies have suggested that triazines may be carcinogenic, but results have been mixed. We evaluated cancer incidence in cyanazine-exposed pesticide applicators among the 57,311 licensed pesticide applicators in the Agricultural Health Study (AHS). METHODS: We obtained detailed pesticide exposure information from a self-administered questionnaire completed at enrollmentdoi:10.1289/ehp.8997 pmid:16882534 pmcid:PMC1552023 fatcat:byuzxt77mzg6zeycslxzzd62ni
more »... 1993-1997). Cancer incidence was followed through January 2002. Over half of cyanazine-exposed applicators had ≥ 6 years of exposure at enrollment, and approximately 85% had begun using cyanazine before the 1990s. We used adjusted Poisson regression to calculate rate ratios (RRs) and 95% confidence intervals (CIs) of multiple cancer sites among cyanazine-exposed applicators. We calculated p trend values, and all statistical tests were twosided. Two exposure metrics were used: tertiles of lifetime days of exposure (LD) and intensityweighted LD. RESULTS: A total of 20,824 cancer-free AHS applicators reported ever using cyanazine at enrollment. Cancer incidence comparisons between applicators with the lowest cyanazine exposure and those with the highest exposure yielded the following for the LD metric: all cancers, RR = 0.99 (95% CI, 0.80-1.24); prostate cancer, RR = 1.23 (95% CI, 0.87-1.70); all lymphohematopoietic cancers, RR = 0.92 (95% CI, 0.50-1.72); non-Hodgkin lymphoma, RR = 1.25 (95% CI, 0.47-3.35); lung cancer, RR = 0.52 (95% CI, 0.22-1.25). CONCLUSIONS: We did not find any clear, consistent associations between cyanazine exposure and any cancer analyzed. The number of sites was small for certain cancers, limiting any conclusion with regard to ovarian, breast, and some other cancers.
Charlesworth 1990; Lynch et al. 1995) . ... et al. 1995; Schultz and Lynch 1997) . ...doi:10.1111/j.0014-3820.2000.tb00557.x pmid:11005291 fatcat:vjgwkxxx7nes3jpbaq5jevnfmu
The development of bladder cancer is still not as well understood in Lynch syndrome as other classical Lynch syndrome associated cancers, such as colorectal and endometrial cancer. ... Screening of patients with known Lynch syndrome is also important to evaluate for development of new primary tumors. ... Screening for urothelial cancers in patients with diagnosed Lynch syndrome Patients with Lynch syndrome require a number of distinct considerations in regard to screening for Lynch syndrome associated ...doi:10.2217/fon-2017-0346 pmid:29345160 fatcat:bfkmcsnpbneoho5oqoavioriwq
Lynch et al. ... SECONDARY ANALYSIS Reference Mapping and Variant Calling One of the most common types of analysis performed on newly generated HTS data is to compare them with and identify the Lynch et al. ... Aaron Petkau is a bioinformatician at the CSCHAH in Winnipeg, Manitoba, Canada. ...doi:10.1128/cmr.00001-16 pmid:28590251 pmcid:PMC5010755 fatcat:7q5tsfxyzvgtrjfa6buww6pfi4
JAAD Case Reports
Lynch, MB BCh BAO, 5 The Maples, Clonskeagh, D14 F821, Ireland. E-mail: firstname.lastname@example.org. ...doi:10.1016/j.jdcr.2019.08.024 pmid:31687463 pmcid:PMC6820251 fatcat:zluq6tqfi5bmhdqrll5r5pezby
et al, 2013; Lynch et al, 2016; Lynch et al, 2014) . ... However, generalization can also occur under timeindependent mechanisms, such as those that modulate the retrieval of contextual cues (Lynch et al, 2013; Lynch et al, 2016; Lynch et al, 2014) . ...doi:10.1038/npp.2016.255 pmid:27834391 pmcid:PMC5312073 fatcat:qyntcyjy4fallaf3jrasjcppnm
Measuring the evolutionary rate of reproductive isolation is essential to understanding how new species form. Tempo calculations typically rely on fossil records, geological events, and molecular evolution analyses. The speed at which genetically-based hybrid mortality arises, or the "incompatibility clock", is estimated to be millions of years in various diploid organisms and is poorly understood in general. Owing to these extended timeframes, seldom do biologists observe the evolution ofdoi:10.1186/s12862-017-0879-1 pmid:28125957 pmcid:PMC5270250 fatcat:jweqvfj3rrakrfd2d7g6bdim3a
more »... d mortality in real time. Results: Here we report the very recent spread and fixation of complete asymmetric F 1 hybrid mortality within eight years of laboratory maintenance in the insect model Nasonia. The asymmetric interspecific hybrid mortality evolved in an isogenic stock line of N. longicornis and occurs in crosses to N. vitripennis males. The resulting diploid hybrids exhibit complete failure in dorsal closure during embryogenesis. Conclusion: These results comprise a unique case whereby a strong asymmetrical isolation barrier evolved in real time. The spread of this reproductive isolation barrier notably occurred in a small laboratory stock subject to recurrent bottlenecks.
drug law enforcement because it is substantially proactive, and explicitly reflects institutional policies and practices with respect to resource deployment, more so than most law enforcement efforts (Lynch ... practices as part of a global neo-liberal project, or as an effort to prop up the 'myth of a sovereign state' (Garland, 2001: 109) necessarily oversimplify, but in the process lose explanatory power (Lynch ... Aaron Roussell is an Assistant Professor at Washington State University. ...doi:10.1177/1362480613476986 fatcat:452kbhazdbcfnjfhv5siuveljm
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