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APL in the Nordic Countries [chapter]

Gitte Christensen
2015 IFIP Advances in Information and Communication Technology  
An introduction to the early years of APL and its use in the Nordic countries. The different applications of APL are described in the context of changing conditions through the last 50 years.  ...  The evolution of APL is outlined and the current state established. In summary this is a story of computing driven by end-users.  ...  The recent realisation that successful software implementation depends on close user involvement has been successfully proven by APL users through the last 50 years.  ... 
doi:10.1007/978-3-319-17145-6_35 fatcat:gnwsiq6idjhovlgko6ze2zntsq

Abstracts

1971 IBM Systems Journal  
A financial analysis model has been implemented within the framework of the APL time-sharing system.  ...  Computer- aided translation (CAT) is a storage and retrieval operation carried out on line with a computer during the time in which a translation is produced.  ... 
doi:10.1147/sj.104.0327 fatcat:dtcvtkg7hnfyzj7whaqb7kojni

The Significant Contribution of Small-Sized and Spherical Aerosol Particles to the Decreasing Trend in Total Aerosol Optical Depth over Land from 2003 to 2018

Ke Gui, Huizheng Che, Lei Li, Yu Zheng, Lei Zhang, Hujia Zhao, Junting Zhong, Wenrui Yao, Yuanxin Liang, Yaqiang Wang, Xiaoye Zhang
2021 Engineering  
However, the effects of different APLs on TAOD changes are regionally dependent and their extent of correlation varied spatially.  ...  in the frequency-of-occurrences (FoOs) of these APLs.  ...  interest or financial conflicts to disclose.  ... 
doi:10.1016/j.eng.2021.05.017 fatcat:ayg3q7jt5bhvrlz6oipuaguj6e

Thrombosis with Thrombocytopenia - A Vascular Paradox
English

Veena Nanjappa, Lachikarathman Devegowda, Abhishek Rathore, Sadanand K.S, Manjunath Cholenahally Nanjappa
2020 Journal of Evidence Based Medicine and Healthcare  
Since there are no guidelines regarding this subset, most of the treatment is based on few anecdotal reports and consensus data.  ...  METHODS It is a descriptive study of four cases collected over one-year period including patients of thrombosis with thrombocytopenia.  ...  Since there are no guidelines regarding this subset, most of the treatment is based on few anecdotal reports and consensus data.  ... 
doi:10.18410/jebmh/2020/634 fatcat:m4hooo7rnbgyxamrafqqwusppa

A general management business simulation in APL

P. N. Wahi
1972 IBM Systems Journal  
There is a trade-off Figure 2 APL system setup for game between the number of work spaces and their sizes; increasing —a cycle one reduces the other. DATA BASE DATA.  ...  subject to a limit on the line of credit.  ... 
doi:10.1147/sj.112.0169 fatcat:6bwvjvkjyjahbaamaiaa3as2m4

Antiphospholipid Antibodies in Inflammatory and Autoimmune Rheumatic and Musculoskeletal Diseases Beyond Lupus: A Systematic Review of the Available Evidence

Georges El Hasbani, Mario Viola, Savino Sciascia, Ali T. Taher, Imad Uthman
2021 Rheumatology and Therapy  
The role of aPL has been largely investigated in systemic lupus erythematosus (SLE) with minimal data on other autoimmune rheumatic diseases.  ...  However, there was a large heterogeneity among the retrieved studies. Available data supporting a general screening for aPL in all inflammatory and autoimmune RMDs are still insufficient.  ...  This article is based on previously conducted studies and does not contain any new studies with human participants or animals performed by any of the authors. Data Availability.  ... 
doi:10.1007/s40744-020-00273-w pmid:33420626 fatcat:ju56g6x5b5fazgt5v7upd2gmum

Scalable approach for lensless imaging at x-ray wavelengths

S. Eisebitt, M. Lörgen, W. Eberhardt, J. Lüning, S. Andrews, J. Stöhr
2004 Applied Physics Letters  
A special design of a sample holder allows recovery of the low spatial frequency information of the sample from the Patterson map of the measured diffraction.  ...  As the sample holder provides this functionality due to a suitable reference hole, the technique is applicable to a wide variety of samples and can be easily scaled to investigate large arrays of samples  ...  S.A. would like to thank the Fannie and John Hertz Foundation for financial support. The research of J.L. and J.S. is supported by the Office of Basic Energy Sciences of the U.S. Department of Energy.  ... 
doi:10.1063/1.1728320 fatcat:nvfdcryj6zeovccb5xwrpfzi7y

Longitudinal Analysis of Anti-cardiolipin and Anti-β2-glycoprotein-I Antibodies in Recent-Onset Systemic Lupus Erythematosus: A Prospective Study in Swedish Patients

Martina Frodlund, Tomas Walhelm, Charlotte Dahle, Christopher Sjöwall
2021 Frontiers in Medicine  
of IgG/IgA/IgM anti-cardiolipin (aCL) and anti-β2-glycoprotein-I (anti-β2GPI) antibodies, using both the manufacturer's cut-off and a cut-off based on the 99th percentile of 400 apparently healthy donors  ...  Samples were obtained at 0, 6, 12, 24, 36, 48, 60, 72, 84, and 96 months after SLE diagnosis.Results: Depending on the cut-off applied, 61.1 or 44.4% showed a positive result for at least one aPL isotype  ...  Regardless of whether APS appears on its own or concomitantly with (secondary to) other autoimmune conditions, it is classified based on the presence of one or more repeated aPL tests and at least one  ... 
doi:10.3389/fmed.2021.646846 pmid:33732724 pmcid:PMC7959716 fatcat:33lioo7gjbg67f7dnlwxpf6dp4

APAview: A web-based platform for alternative polyadenylation analyses in hematological cancers

Xi Hu, Jialin Song, Jacqueline Chyr, Jinping Wan, Xiaoyan Wang, Jianqiang Du, Junbo Duan, Huqin Zhang, Xiaobo Zhou, Xiaoming Wu
2022 Frontiers in Genetics  
Using APAview, we explored APA features in two hematological cancers, APL and AML. APAview can also be applied to other diseases by uploading different experimental data.  ...  APAview server runs on Python3 with a Flask framework and a Jinja2 templating engine. For visualization, APAview client is built on Bootstrap and Plotly.  ...  Acknowledgments The authors would like to thank Hongxing Liu and Panxiang Cao of Hebei Yanda Lu Daopei Hospital for valuable discussion on hematological cancers.  ... 
doi:10.3389/fgene.2022.928862 pmid:36035147 pmcid:PMC9411867 fatcat:ewfvpkjvojgmdpxy4hrlhwqymu

Tumour-derived PGD2 and NKp30-B7H6 engagement drives an immunosuppressive ILC2-MDSC axis

Sara Trabanelli, Mathieu F. Chevalier, Amaia Martinez-Usatorre, Alejandra Gomez-Cadena, Bérengère Salomé, Mariangela Lecciso, Valentina Salvestrini, Grégory Verdeil, Julien Racle, Cristina Papayannidis, Hideaki Morita, Irene Pizzitola (+30 others)
2017 Nature Communications  
Upon treating APL with all-trans retinoic acid and achieving complete remission, the levels of PGD2, NKp30, ILC2s, IL-13 and M-MDSCs are restored.  ...  Here we show that, in acute promyelocytic leukaemia (APL), ILC2s are increased and hyper-activated through the interaction of CRTH2 and NKp30 with elevated tumour-derived PGD2 and B7H6, respectively.  ...  Romero for insightful discussions and support of this study. We thank Prof. H. de Thé for providing the PML-RARA APL mice, Dr A. Donda for help with the TRAMP model, P. Reichenbach and S.  ... 
doi:10.1038/s41467-017-00678-2 pmid:28928446 pmcid:PMC5605498 fatcat:pa4qfbghfjfmrk3nggzhv7m5vy

Phase retrieval in x-ray coherent Fresnel projection-geometry diffraction

Liberato De Caro, Cinzia Giannini, Alessia Cedola, Daniele Pelliccia, Stefano Lagomarsino, Werner Jark
2007 Applied Physics Letters  
The phase was retrieved, by using a Fourier-based iterative phasing algorithm, consistent with measured diffraction data and known constraints in real space, with a submicrometer spatial resolution.  ...  Coherent x-ray diffraction experiments were performed in Fresnel regime, within a line-projection geometry.  ...  Thus, one can realize a suitable Fourier-based iterative phasing program for retrieving the unknown function f͑r͒, as schematically summarized in the following steps, with u and r the variables of the  ... 
doi:10.1063/1.2431457 fatcat:n5rt4h6ncraz7mgvmzptt254ly

M2-polarized macrophages control LSC fate by enhancing stemness, homing, immune evasion and metabolic reprogramming [article]

Isabel Weinhauser, Diego Pereira-Martins, Luciana Almeida, Jacobien Hilberink, Cesar Ortiz, Douglas Silveira, Lynn Quek, Cleide Araujo, Thiago Bianco, Antonio Lucena-Araujo, Nienke Visser, Shanna Hogeling (+5 others)
2022 bioRxiv   pre-print
Intra bone marrow co-injection of M2d-macrophages together with leukemic blasts that fail to engraft on their own now induce fatal leukemia in mice.  ...  We developed an M2d-based biomarker panel that outperforms currently used AML prognosis predictors.  ...  Co-culture of primary APL patient cells on M2d macrophages allows the development of full-blown leukemia in a xenograft model Based on the premise that macrophage-injected NSGS mice enabled APL engraftment  ... 
doi:10.1101/2022.05.06.489506 fatcat:z6mtijjsjngwzp5hlye3uc36zm

Modeling dynamics and alternative treatment strategies in acute promyelocytic leukemia

Gerson Hiroshi Yoshinari, Artur César Fassoni, Luis Fernando Mello, Eduardo M. Rego, Dominik Wodarz
2019 PLoS ONE  
We collected clinical data from 38 patients treated for APL under the International Consortium on Acute Leukemia (ICAL) protocol and laboratory data during induction therapy.  ...  Acute Promyelocytic Leukemia (APL) is a rare and potentially lethal condition in which risk-based therapy often leads to better outcomes.  ...  (TIF) presents the clinical data retrieved from 38 patients with APL treated at HCRP under the International Consortium on Acute Promyelocytic Leukemia (IC-APL) [4] protocol of the ICAL from 2007-2017  ... 
doi:10.1371/journal.pone.0221011 pmid:31415632 pmcid:PMC6695187 fatcat:thi3sofadrebhehpaz3rznsxtu

Characteristics and predictors of early hospital deaths in newly diagnosed APL: a 13-year population-wide study

Harinder Gill, Yammy Yung, Hiu-Tung Chu, Wing-Yan Au, Pui-Kwan Yip, Emily Lee, Rita Yim, Paul Lee, Daniel Cheuk, Shau-Yin Ha, Rock Y. Y. Leung, Edmond S. K. Ma (+2 others)
2021 Blood Advances  
Despite therapeutic advances, early death (ED) remains a major factor curtailing survival of acute promyelocytic leukemia (APL).  ...  We performed a cohort analysis of nonselect patients with newly diagnosed APL who presented to the health care system in Hong Kong, where oral arsenic trioxide was used.  ...  The impact of oral As 2 O 3 -based induction on ED remains to be evaluated prospectively.  ... 
doi:10.1182/bloodadvances.2021004789 pmid:34269798 fatcat:7svqe2n7rzfota62vskdzo3bqq

CDK6 Is a Potential Prognostic Biomarker in Acute Myeloid Leukemia

Wei Liu, Jin-Mou Yi, Yi Liu, Cong Chen, Kai-Xuan Zhang, Cheng Zhou, Hui-En Zhan, Liang Zhao, Stephanie Morales, Xie-Lan Zhao, Hui Zeng
2021 Frontiers in Genetics  
However, the clinical significance and effects of CDK6 expression on the prognosis of non-APL AML patients remain uncertain.  ...  By analyzing public databases, we observed that the messenger RNA (mRNA) levels of CDK6 were significantly overexpressed in AML cell lines and non-acute promyelocytic leukemia (non-APL) AML patients when  ...  Guan-Teng Yang for collecting the clinical data. We also thank Dr. Juan Du for providing helpful comments.  ... 
doi:10.3389/fgene.2020.600227 pmid:33597968 pmcid:PMC7882723 fatcat:dkaxl5rferbbxfatlfhzfbvt2i
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