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The AFHSC-Division of GEIS Operations Predictive Surveillance Program: a multidisciplinary approach for the early detection and response to disease outbreaks
2011
BMC Public Health
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The program's ultimate goal is pro-active public health practice through pre-event preparedness, prevention and control, and response decision-making and prioritization. ...
The Armed Forces Health Surveillance Center, Division of Global Emerging Infections Surveillance and Response System Operations (AFHSC-GEIS) initiated a coordinated, multidisciplinary program to link data ...
Green barsnatural events in an outbreak's emergence. Blue barsthe predictive surveillance program activities. Red bars -predictive surveillance program products. ...
doi:10.1186/1471-2458-11-s2-s10
pmid:21388561
pmcid:PMC3092411
fatcat:schxqs4szfh4th2kugski2bghe
Page 344 of British Journal of Clinical Pharmacology Vol. 62, Issue 3
[page]
2006
British Journal of Clinical Pharmacology
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In Program and LPV/r should provide an APL AUC)», in excess of the re AER hi ai tS A ;
2 on Clinical
antiviral target (1900 ng h' ml’) determined from the exposure—antiviral response relationship in the ...
References '
pharmacokinetic
Program and Abstract
Br J Clin Pharmacol ...
Atheroma: links with antiphospholipid antibodies, Hughes syndrome and lupus
1999
QJM: Quarterly journal of medicine
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independent risk factor for myocardial infarctions8 and cerebral strokes.9 These if aPL can be found to possess proatherogenic properties, population screening programs may char-findings have prompted ...
The association of 'autoimmune' aPL with throm-induced by immunization with human b2GPI affect atherosclerosis.17 Indeed, transgenic mice lacking botic events has been documented so consistently that their ...
doi:10.1093/qjmed/92.1.57
pmid:10209673
fatcat:4homzmberrdvpaofgte5wsmx7e
A variant t(14;17) in acute promyelocytic leukemia Positive response to retinoic acid treatment
1995
Cancer Genetics and Cytogenetics
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We present a case of acute promyelocytic leukemia (APL) carrying an atypical translocation involving chromosomes 14 and 17. ...
Positive response to retinoic acid treatment suggests molecular rearrangement of retinoic acid receptor a. From the Department of Genetics (M. J. C., M. D. 0., A. G.), ...
The patient then left the hospital and underwent a bone marrow transplantation program. ...
doi:10.1016/0165-4608(94)00182-b
pmid:7736436
fatcat:wgyso2mxx5ezzbwlocr3twwuey
Is there a role for immunosuppression in antiphospholipid syndrome?
2019
Hematology ASH Education Program
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Conventional APS treatment focuses on antithrombotic strategies, which are usually ineffective for the microvascular and nonthrombotic manifestations of aPL. ...
syndrome (APS) is a systemic autoimmune disorder characterized by thrombosis, pregnancy morbidity, or nonthrombotic manifestations in patients with persistently positive antiphospholipid antibodies (aPL ...
is common to a majority of aPL-b 2 GPI receptor interactions. aPL-mediated events likely occur owing to various signaling mechanisms activated independently by different aPL specificities. ...
doi:10.1182/hematology.2019000073
pmid:31808842
pmcid:PMC6913487
fatcat:sr6hoqjkjjfd7iin7opwggd334
Orchestration of multiple arrays of signal cross-talk and combinatorial interactions for maturation and cell death: another vision of t(15;17) preleukemic blast and APL-cell maturation
2001
Oncogene
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After an overview of reported experimental data on APL-cell maturation and apoptosis, we apply our current knowledge on signaling pathways to underline those which might generate signal cross-talks. ...
suitable to decipher the integration of signal cross-talks at the transcriptional level should be our ®rst priority today, to generate some realistic therapeutic approaches After'Ten Years of Molecular APL ...
Transfusion Department, St-Louis Hospital, Paris, France) for helpful discussions and passing on Claude Bernard's statement that corresponds so well to the research situation after ten years of molecular APL ...
doi:10.1038/sj.onc.1204760
pmid:11704845
fatcat:jrvbp7eyc5c23nfxys3fr73de4
Evaluation of arsenic trioxide by the pediatric preclinical testing program with a focus on Ewing sarcoma
2012
Pediatric Blood & Cancer
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Arsenic trioxide did not induce significant differences in EFS distribution compared to control in any of the Ewing sarcoma xenografts studied, and no objective responses were observed. ...
Kaplan-Meier event free survival data are presented as Supplemental Figure 1 . ...
Regression has not been observed for preclinical in vivo testing outside of the APL setting, with best response limited to tumor growth inhibition that generally has been of limited extent [6, 7] . ...
doi:10.1002/pbc.23391
pmid:22315235
pmcid:PMC3612422
fatcat:la2nqmspovfxrlfgurjjmxxdii
Antiphospholipid syndrome
2013
Hematology ASH Education Program
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to be at increased risk for thrombosis and pregnancy complications, whereas isolated positivity for aPLs appears to be associated with low risk. ...
The antiphospholipid syndrome (APS) is defined by venous or arterial thrombosis and/or pregnancy morbidity in patients with persistent presence of antiphospholipid antibodies (aPLs). ...
at least 12 weeks apart due to the early death of a patient who had never been tested for aPLs before the CAPS event Criteria 1, 2, and 4 Criteria 1, 3, and 4 and the development of a third event after ...
doi:10.1182/asheducation-2013.1.675
pmid:24319251
fatcat:6ksjszo5fbbx3hojgy5r5ybywy
Risk Markers for Significant Bleeding and Thrombosis in Pediatric Acute Promyelocytic Leukemia; Report From the Children's Oncology Group Study AAML0631
2018
Journal of pediatric hematology/oncology
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In pediatric APL patients, the presenting WBC is a marker for risk of early death. ...
Thus, there is a strong need to identify other biomarkers that can predict APL-associated coagulopathy. ...
The contents of this report are solely the responsibility of the authors and do not necessarily represent the official views of the NIH. ...
doi:10.1097/mph.0000000000001280
pmid:30095694
pmcid:PMC6419515
fatcat:mvkjp5tex5ajvjsvic5zerayci
Guideline development for the management of gout: role of combination therapy with a focus on lesinurad
2017
Drug Design, Development and Therapy
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response. ...
versus APL
monotherapy in patients with active gout and an inadequate
response to APL (defined as an SUA consistently $6 mg/d). ...
doi:10.2147/dddt.s97959
pmid:29123379
pmcid:PMC5661481
fatcat:w7csvkcsznby5lua7ctf4w3mpy
Can hydroxychloroquine be protective against COVID-19-associated thrombotic events ?
2021
Journal of Microbiology, Immunology and Infection
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Recently, antiphospholipid (aPL) antibodies were found increased in a large number of COVID-19 patients. ...
SARS-CoV-2 is considered a lung-tropic virus, severe COVID-19 is not just a viral pulmonary infection, clinically it is a multi-organ pathology with major coagulation abnormalities and thromboembolism events ...
Among aPL antibodies, Lupus anticoagulant (LA) are more associated to thrombotic events. ...
doi:10.1016/j.jmii.2020.12.010
pmid:33500211
pmcid:PMC7783458
fatcat:qhlux6rah5bqzd5hjmd4jw6v2m
Page 215 of Behavior Research Methods Vol. 11, Issue 2
[page]
1979
Behavior Research Methods
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Programming Languages
We chose APL as the language to develop experi¬ mental control programs because of its extensive capabilities for manipulating character strings and data arrays. ...
Tuning
For example, the difficulty in timing stimulus and response events with sufficient precision is probably most often cited as an inherent limitation of large-scale timesharing systems for computerized ...
A Review of Agent-Based Programming for Multi-Agent Systems
2021
Computers
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make use of agent programming. ...
In this paper, we focus on agent programming and we provide a systematic review of the literature in agent-based programming for multi-agent systems. ...
Jason is used for programming the agent level, CArtAgO is responsible for the environment level, and Moise for the organisation level. ...
doi:10.3390/computers10020016
fatcat:z6ebckw62javvfbi6dgobmpd4m
Programming Deliberation Strategies in Meta-APL
[chapter]
2015
Lecture Notes in Computer Science
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A key advantage of BDI-based agent programming is that agents can deliberate about which course of action to adopt to achieve a goal or respond to an event. ...
We show how both agent programs and the agent's deliberation strategy can be encoded in the agent programming language meta-APL. ...
In the BDI approach, agents select plans in response to changes in their environment, or to achieve goals. In most BDI-based agent programming languages, plan selection follows four steps. ...
doi:10.1007/978-3-319-25524-8_27
fatcat:meqkyogi45adxadgpu3lxbzbzy
APS ACTION – AntiPhospholipid Syndrome Alliance For Clinical Trials and InternatiOnal Networking
2012
Lupus
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clinical events limits the optimal clinical study design 1 . ...
for prevention and management of aPL-related clinical events; 2) maintaining a repository that will help us standardize aPL tests and perform mechanistic studies; and 3) generating private and government ...
doi:10.1177/0961203312437810
pmid:22635205
pmcid:PMC5733706
fatcat:zetrec42rvdiplk3e4jo3xp4pu
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