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The AFHSC-Division of GEIS Operations Predictive Surveillance Program: a multidisciplinary approach for the early detection and response to disease outbreaks

Clara J Witt, Allen L Richards, Penny M Masuoka, Desmond H Foley, Anna L Buczak, Lillian A Musila, Jason H Richardson, Michelle G Colacicco-Mayhugh, Leopoldo M Rueda, Terry A Klein, Assaf Anyamba, Jennifer Small (+4 others)
2011 BMC Public Health  
The program's ultimate goal is pro-active public health practice through pre-event preparedness, prevention and control, and response decision-making and prioritization.  ...  The Armed Forces Health Surveillance Center, Division of Global Emerging Infections Surveillance and Response System Operations (AFHSC-GEIS) initiated a coordinated, multidisciplinary program to link data  ...  Green barsnatural events in an outbreak's emergence. Blue barsthe predictive surveillance program activities. Red bars -predictive surveillance program products.  ... 
doi:10.1186/1471-2458-11-s2-s10 pmid:21388561 pmcid:PMC3092411 fatcat:schxqs4szfh4th2kugski2bghe

Page 344 of British Journal of Clinical Pharmacology Vol. 62, Issue 3 [page]

2006 British Journal of Clinical Pharmacology  
In Program and LPV/r should provide an APL AUC)», in excess of the re AER hi ai tS A ; 2 on Clinical antiviral target (1900 ng h' ml’) determined from the exposure—antiviral response relationship in the  ...  References ' pharmacokinetic Program and Abstract Br J Clin Pharmacol  ... 

Atheroma: links with antiphospholipid antibodies, Hughes syndrome and lupus

D. Harats
1999 QJM: Quarterly journal of medicine  
independent risk factor for myocardial infarctions8 and cerebral strokes.9 These if aPL can be found to possess proatherogenic properties, population screening programs may char-findings have prompted  ...  The association of 'autoimmune' aPL with throm-induced by immunization with human b2GPI affect atherosclerosis.17 Indeed, transgenic mice lacking botic events has been documented so consistently that their  ... 
doi:10.1093/qjmed/92.1.57 pmid:10209673 fatcat:4homzmberrdvpaofgte5wsmx7e

A variant t(14;17) in acute promyelocytic leukemia Positive response to retinoic acid treatment

J.C Cigudosa, M.J Calasanz, M.D Odero, J Marin, E Bengoechea, A Gullon
1995 Cancer Genetics and Cytogenetics  
We present a case of acute promyelocytic leukemia (APL) carrying an atypical translocation involving chromosomes 14 and 17.  ...  Positive response to retinoic acid treatment suggests molecular rearrangement of retinoic acid receptor a. From the Department of Genetics (M. J. C., M. D. 0., A. G.),  ...  The patient then left the hospital and underwent a bone marrow transplantation program.  ... 
doi:10.1016/0165-4608(94)00182-b pmid:7736436 fatcat:wgyso2mxx5ezzbwlocr3twwuey

Is there a role for immunosuppression in antiphospholipid syndrome?

Ecem Sevim, Rohan Willis, Doruk Erkan
2019 Hematology ASH Education Program  
Conventional APS treatment focuses on antithrombotic strategies, which are usually ineffective for the microvascular and nonthrombotic manifestations of aPL.  ...  syndrome (APS) is a systemic autoimmune disorder characterized by thrombosis, pregnancy morbidity, or nonthrombotic manifestations in patients with persistently positive antiphospholipid antibodies (aPL  ...  is common to a majority of aPL-b 2 GPI receptor interactions. aPL-mediated events likely occur owing to various signaling mechanisms activated independently by different aPL specificities.  ... 
doi:10.1182/hematology.2019000073 pmid:31808842 pmcid:PMC6913487 fatcat:sr6hoqjkjjfd7iin7opwggd334

Orchestration of multiple arrays of signal cross-talk and combinatorial interactions for maturation and cell death: another vision of t(15;17) preleukemic blast and APL-cell maturation

Gérard Benoit, Mathilde Roussel, Frédério Pendino, Evelyne Ségal-Bendirdjian, Michel Lanotte
2001 Oncogene  
After an overview of reported experimental data on APL-cell maturation and apoptosis, we apply our current knowledge on signaling pathways to underline those which might generate signal cross-talks.  ...  suitable to decipher the integration of signal cross-talks at the transcriptional level should be our ®rst priority today, to generate some realistic therapeutic approaches After'Ten Years of Molecular APL  ...  Transfusion Department, St-Louis Hospital, Paris, France) for helpful discussions and passing on Claude Bernard's statement that corresponds so well to the research situation after ten years of molecular APL  ... 
doi:10.1038/sj.onc.1204760 pmid:11704845 fatcat:jrvbp7eyc5c23nfxys3fr73de4

Evaluation of arsenic trioxide by the pediatric preclinical testing program with a focus on Ewing sarcoma

Malcolm A. Smith, Min H. Kang, C. Patrick Reynolds, Raushan T. Kurmasheva, Denise Alexander, Catherine A. Billups, Jeffrey A. Toretsky, Peter J. Houghton
2012 Pediatric Blood & Cancer  
Arsenic trioxide did not induce significant differences in EFS distribution compared to control in any of the Ewing sarcoma xenografts studied, and no objective responses were observed.  ...  Kaplan-Meier event free survival data are presented as Supplemental Figure 1 .  ...  Regression has not been observed for preclinical in vivo testing outside of the APL setting, with best response limited to tumor growth inhibition that generally has been of limited extent [6, 7] .  ... 
doi:10.1002/pbc.23391 pmid:22315235 pmcid:PMC3612422 fatcat:la2nqmspovfxrlfgurjjmxxdii

Antiphospholipid syndrome

W. Lim
2013 Hematology ASH Education Program  
to be at increased risk for thrombosis and pregnancy complications, whereas isolated positivity for aPLs appears to be associated with low risk.  ...  The antiphospholipid syndrome (APS) is defined by venous or arterial thrombosis and/or pregnancy morbidity in patients with persistent presence of antiphospholipid antibodies (aPLs).  ...  at least 12 weeks apart due to the early death of a patient who had never been tested for aPLs before the CAPS event Criteria 1, 2, and 4 Criteria 1, 3, and 4 and the development of a third event after  ... 
doi:10.1182/asheducation-2013.1.675 pmid:24319251 fatcat:6ksjszo5fbbx3hojgy5r5ybywy

Risk Markers for Significant Bleeding and Thrombosis in Pediatric Acute Promyelocytic Leukemia; Report From the Children's Oncology Group Study AAML0631

Madhvi Rajpurkar, Todd A. Alonzo, Yi-Cheng Wang, Robert B. Gerbing, Alan S. Gamis, James H. Feusner, John Gregory, Matthew A. Kutny
2018 Journal of pediatric hematology/oncology  
In pediatric APL patients, the presenting WBC is a marker for risk of early death.  ...  Thus, there is a strong need to identify other biomarkers that can predict APL-associated coagulopathy.  ...  The contents of this report are solely the responsibility of the authors and do not necessarily represent the official views of the NIH.  ... 
doi:10.1097/mph.0000000000001280 pmid:30095694 pmcid:PMC6419515 fatcat:mvkjp5tex5ajvjsvic5zerayci

Guideline development for the management of gout: role of combination therapy with a focus on lesinurad

Graeme Jones, Elena Panova, Richard Day
2017 Drug Design, Development and Therapy  
response.  ...  versus APL monotherapy in patients with active gout and an inadequate response to APL (defined as an SUA consistently $6 mg/d).  ... 
doi:10.2147/dddt.s97959 pmid:29123379 pmcid:PMC5661481 fatcat:w7csvkcsznby5lua7ctf4w3mpy

Can hydroxychloroquine be protective against COVID-19-associated thrombotic events ?

Christian A. Devaux, Laurence Camoin-Jau, Jean-Louis Mege, Didier Raoult
2021 Journal of Microbiology, Immunology and Infection  
Recently, antiphospholipid (aPL) antibodies were found increased in a large number of COVID-19 patients.  ...  SARS-CoV-2 is considered a lung-tropic virus, severe COVID-19 is not just a viral pulmonary infection, clinically it is a multi-organ pathology with major coagulation abnormalities and thromboembolism events  ...  Among aPL antibodies, Lupus anticoagulant (LA) are more associated to thrombotic events.  ... 
doi:10.1016/j.jmii.2020.12.010 pmid:33500211 pmcid:PMC7783458 fatcat:qhlux6rah5bqzd5hjmd4jw6v2m

Page 215 of Behavior Research Methods Vol. 11, Issue 2 [page]

1979 Behavior Research Methods  
Programming Languages We chose APL as the language to develop experi¬ mental control programs because of its extensive capabilities for manipulating character strings and data arrays.  ...  Tuning For example, the difficulty in timing stimulus and response events with sufficient precision is probably most often cited as an inherent limitation of large-scale timesharing systems for computerized  ... 

A Review of Agent-Based Programming for Multi-Agent Systems

Rafael C. Cardoso, Angelo Ferrando
2021 Computers  
make use of agent programming.  ...  In this paper, we focus on agent programming and we provide a systematic review of the literature in agent-based programming for multi-agent systems.  ...  Jason is used for programming the agent level, CArtAgO is responsible for the environment level, and Moise for the organisation level.  ... 
doi:10.3390/computers10020016 fatcat:z6ebckw62javvfbi6dgobmpd4m

Programming Deliberation Strategies in Meta-APL [chapter]

Sam Leask, Brian Logan
2015 Lecture Notes in Computer Science  
A key advantage of BDI-based agent programming is that agents can deliberate about which course of action to adopt to achieve a goal or respond to an event.  ...  We show how both agent programs and the agent's deliberation strategy can be encoded in the agent programming language meta-APL.  ...  In the BDI approach, agents select plans in response to changes in their environment, or to achieve goals. In most BDI-based agent programming languages, plan selection follows four steps.  ... 
doi:10.1007/978-3-319-25524-8_27 fatcat:meqkyogi45adxadgpu3lxbzbzy

APS ACTION – AntiPhospholipid Syndrome Alliance For Clinical Trials and InternatiOnal Networking

D Erkan, MD Lockshin
2012 Lupus  
clinical events limits the optimal clinical study design 1 .  ...  for prevention and management of aPL-related clinical events; 2) maintaining a repository that will help us standardize aPL tests and perform mechanistic studies; and 3) generating private and government  ... 
doi:10.1177/0961203312437810 pmid:22635205 pmcid:PMC5733706 fatcat:zetrec42rvdiplk3e4jo3xp4pu
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