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ACGT: advancing clinico-genomic trials on cancer - four years of experience
2011
Studies in Health Technology and Informatics
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Advancing Clinico-Genomic Trials (ACGT) was a European Commission funded Integrated Project that aimed at providing tools and methods to enhance the efficiency of clinical trials in the -omics era. ...
The project, now completed after four years of work, involved the development of both a set of methodological approaches as well as tools and services and its testing in the context of real-world clinico-genomic ...
The vision of the Advancing Clinico-Genomic Trials on Cancer (ACGT) project (www.eu-acgt.org) was to tackle the above issues by developing a semantically rich grid infrastructure platform in support of ...
pmid:21893844
fatcat:m5qggzte4vhvjbdxo44ie3axwu
Post-genomic clinical trials - the perspective of ACGT
2009
ecancermedicalscience
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Acknowledgement The authors would like to thank all members of the ACGT consortium who are actively contributing to addressing the R&D challenges faced. ...
The ACGT project (FP6-2005-IST-026996) is partly funded by the EC and the authors are grateful for this support. ...
These clinico-genomic trials are scenario based and driven by clinicians. Today, two main clinico-genomic trials and an in silico experiment are interconnected within the ACGT project. ...
doi:10.3332/ecms.2008.66
pmid:22275963
pmcid:PMC3234044
fatcat:vdjnfxvaenbebit4hmgnusltde
Building a European biomedical grid on cancer: the ACGT Integrated Project
2006
Studies in Health Technology and Informatics
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This paper presents the needs and requirements that led to the formation of the ACGT (Advancing Clinico Genomic Trials) integrated project, its vision and methodological approaches of the project. ...
The ultimate objective of the ACGT project is the development of a European biomedical grid for cancer research, based on the principles of open access and open source, enhanced by a set of interoperable ...
Acknowledgements The authors wish to express their gratitude to the whole of the ACGT consortium for their contributions with various ideas on which the ACGT project was developed. ...
pmid:16823143
fatcat:y5z67zykjfeydiemgb6emr5oou
The ACGT project in retrospect: Lessons learned and future outlook
2011
Procedia Computer Science
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The objective of the ACGT (Advancing Clinico-Genomic Trials on Cancer: Open Grid Services for improving Medical Knowledge Discovery, www.eu-acgt.org) project that has recently concluded successfully was ...
and services in support of multicentric, post-genomic clinical trials. ...
Acknowledgements The authors gratefully acknowledge the financial support of the European Commission for the Project ACGT, FP6/2004/IST-026996. ...
doi:10.1016/j.procs.2011.04.119
fatcat:ls5emmpmrrfwnhnkscbpazorge
The ACGT Master Ontology and its applications – Towards an ontology-driven cancer research and management system
2011
Journal of Biomedical Informatics
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Objective: This paper introduces the objectives, methods and results of ontology development in the EU co-funded project Advancing Clinico-genomic Trials on Cancer -Open Grid Services for Improving Medical ...
scientific workflows in the context of multi-centric, post-genomic clinical trials. ...
Acknowledgments The authors thank all members of the ACGT consortium who are actively contributing to addressing the R&D challenges faced. ...
doi:10.1016/j.jbi.2010.04.008
pmid:20438862
pmcid:PMC5755590
fatcat:r5o5r66xazh7dfxh4pfzchb46m
Section 7: Bioinformatics: Bioinformatics Linkage of Heterogeneous Clinical and Genomic Information in Support of Personalized Medicine
2007
IMIA Yearbook of Medical Informatics
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These in turn will enable the faster advancement of personalized medicine. ...
In order to achieve this, heterogeneous clinical and genomic data source must be integrated in scientifically meaningful and productive systems. ...
for discussions on the cancer data standards repository. ...
doi:10.1055/s-0038-1638533
fatcat:m47yswixvzb2vjoznsfdtdbgxq
ONTOLOGY BASED INTEGRATION OF DISTRIBUTED AND HETEROGENEOUS DATA SOURCES IN ACGT
english
2008
Proceedings of the First International Conference on Health Informatics
unpublished
english
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In this work, we describe the set of tools comprising the Data Access Infrastructure within Advancing Clinico-genomic Trials on Cancer (ACGT), a R&D Project funded in part by the European. ...
Two experiments have been carried out in order to test the suitability of the selected approach, integrating clinical and DICOM image databases. ...
ACKNOWLEDGEMENTS The authors would like to thank all members of the ACGT consortium who are actively contributing to addressing the R&D challenges faced. ...
doi:10.5220/0001045503010306
fatcat:bjrwg42bqbe4xkep5o662dhrze
Metadata extraction using text mining
2009
Studies in Health Technology and Informatics
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In particular, we investigate the semi-automatic conversion of functions of the statistical environment R into Grid services as implemented by the GridR tool by the generation of appropriate metadata. ...
In this paper, we investigate how relevant metadata can be extracted from a semi-structured textual documentation of the algorithm that is underlying the service, by the use of text mining methods. ...
This is the aim of the Advancing Clinico-Genomics Trials on Cancer (ACGT) project. ...
pmid:19593048
fatcat:pr73olvlwbbz3k3m7lr5ywfbxq
p-Medicine: From data sharing and integration via VPH models to personalized medicine
2011
ecancermedicalscience
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oncologist to researchers, industrial partners, and tools developers; a famous patient was present: Janelle Hail, a 30-year breast cancer survivor, founder and CEO of the National Breast Cancer Foundation ...
3rd symposium (Paris, 6-8 July 2011) to discussion on gateways to increase the efficacy of cancer diagnostics and therapeutics (http://www.winconsortium.org/symposium.html).Speakers ranged from clinical ...
) heterogeneous data management and experience gained during the ACGT project (http://www.eu-acgt.org/) in the field of quality assurance. ...
doi:10.3332/ecancer.2011.218
pmid:22276060
pmcid:PMC3223941
fatcat:y4dgvllw4nbzrbls6nwye7q7ce
Establishing and harmonizing ontologies in an interdisciplinary health care clinical research environment
2008
Studies in Health Technology and Informatics
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An example of such harmonization within the ACGT project is described, which draws on ontology-based computing as a basis for sharing clinical and laboratory data on cancer research. ...
The authors argue that one key foundation for both ontology evaluation and harmonization is the adoption of a realist paradigm in ontology development. ...
One such initiative financed by the European Union within its 6th Framework Programme is the Advancing Clinico-Genomic Trials on Cancer (ACGT) project. ...
pmid:18376049
fatcat:vjsdk2yfzzdodf4p4zeaemtg5e
Navigating Multi-scale Cancer Systems Biology towards Model-driven Personalized Therapeutics
[article]
2021
bioRxiv
pre-print
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Rapid advancements in high-throughput omics technologies and experimental protocols have led to the generation of vast amounts of biomolecular data on cancer that now populates several online databases ...
Cancer systems biology models built on top of this data have the potential to provide specific insights into complex multifactorial aberrations underpinning tumor initiation, development, and metastasis ...
Evolution of multiscale modeling software for abstracting and simulating the spatiotemporal biomolecular complexity.
) such as Advancing Clinico-Genomic Trials on Cancer (ACGT) (312), Clinically Oriented ...
doi:10.1101/2021.05.17.444410
fatcat:vbfvmtb5irdapglgkmh5na73je
Automatic Generation of Integration and Preprocessing Ontologies for Biomedical Sources in a Distributed Scenario
2008
2008 21st IEEE International Symposium on Computer-Based Medical Systems
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To test the method, experiments were carried out with four biomedical databases -containing rheumatoid arthritis, gene expression patterns, biological processes and breast cancer patients-proving the performance ...
Access to a large number of remote data sources has boosted research in biomedicine, where different biological and clinical research projects are based on collaborative efforts among international organizations ...
They were developed and used by the authors in the context of two projects funded by the European Commission, the INFOBIOMED Network of Excellence and the ACGT project -Advanced Clinico-Genomic Trials ...
doi:10.1109/cbms.2008.71
dblp:conf/cbms/AnguitaPCM08
fatcat:74m6eocqgremzl2ohfhuozwjpi
Guest Editorial Introduction to the Special Section on BioGrid: Biomedical Computations on the Grid
2008
IEEE Transactions on Information Technology in Biomedicine
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limited to, the following: 1) computational genomics; computational proteomics; 2) systems biology, biological information integration; 3) storage of biomedical information; 4) retrieval of distributed ...
The power of the grids lies not only in the aggregate computing ability, data storage, and network bandwidth that can readily be brought to bear on a particular problem, but also on its ease of use. ...
Article [27] reports on original results of the Advancing Clinico Genomic Trials (ACGT) integrated project focusing on the design and development of a European Biomedical Grid infrastructure in support ...
doi:10.1109/titb.2008.918585
pmid:18416025
fatcat:tmlicpixnbeljbaut7mhays2zm
biomarkers (clinical)
2009
Annals of Oncology
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The underlying motivation of the EU-funded Advancing Clinico-Genomic Clinical Trials on Cancer project (ACGT; www.eu-acgt.org) is to provide researchers and clinicians with optimal computational, IT, legal ...
and ethical, as well as security means and resources to facilitate clinico-genomic research, with a particular focus on breast cancer and nephroblastoma. ...
doi:10.1093/annonc/mdp103
fatcat:megr7qvczrfmzbpqqqwfd7ndby
Article Commentary: Dealing with Diversity in Computational Cancer Modeling
2013
Cancer Informatics
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Human initiative projects on cancer. ...
We briefly review current interoperability efforts drawing upon our experiences with the development of in silico models for predictive oncology within a number of European Commission Virtual Physiological ...
Acknowledgements The authors would like to thank the participating institutions of the project consortium and its members. ...
doi:10.4137/cin.s11583
pmid:23700360
pmcid:PMC3653811
fatcat:gr2li3oeynarxpgc422bd5p6iu
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