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The Rectal Cancer microRNAome - microRNA Expression in Rectal Cancer and Matched Normal Mucosa

J. Gaedcke, M. Grade, J. Camps, R. Sokilde, B. Kaczkowski, A. J. Schetter, M. J. Difilippantonio, C. C. Harris, B. M. Ghadimi, S. Moller, T. Beissbarth, T. Ried (+1 others)
2012 Clinical Cancer Research  
miRNAs play a prominent role in a variety of physiologic and pathologic biologic processes, including cancer.  ...  This comprehensive analysis of the rectal cancer miRNAome uncovered novel miRNAs and pathways associated with rectal cancer. This information contributes to a detailed view of this disease.  ...  Acknowledgments The authors thank Dara Wangsa and Chang-Rong Lai for their assistance with the PCR assays, and Yue Hu for help with the miRNA target correlation analysis.  ... 
doi:10.1158/1078-0432.ccr-12-0016 pmid:22850566 pmcid:PMC6298229 fatcat:jz33bgfuyfexrmbq4favwip6iu

Identifying Complex lncRNA/Pseudogene–miRNA–mRNA Crosstalk in Hormone-Dependent Cancers

Dulari K. Jayarathna, Miguel E. Rentería, Emilie Sauret, Jyotsna Batra, Neha S. Gandhi
2021 Biology  
This study is the first to investigate pseudogene-associated ceRNAs across a group of related cancers and highlights the value of this approach to understanding the shared molecular pathogenesis in a group  ...  We performed a functional enrichment analysis for differentially expressed genes in the shared ceRNA network of HD cancers, followed by a survival analysis to determine their prognostic ability.  ...  Acknowledgments: The datasets reported in this work originated from the TCGA Research Network: https://www.cancer.gov/tcga (accessed on 16 May 2020).  ... 
doi:10.3390/biology10101014 pmid:34681112 fatcat:locz5m745fhg5d3goy4idyzucy

Identification of Unique miRNA Biomarkers in Colorectal Adenoma and Carcinoma Using Microarray: Evaluation of Their Putative Role in Disease Progression

Kothandaraman Narasimhan, Kalamegam Gauthaman, Peter Natesan Pushparaj, Govindasamy Meenakumari, Adeel Gulzar Ahmed Chaudhary, Adel Abuzenadah, Mamdooh Abdullah Gari, Mohammed Al Qahtani, Jayapal Manikandan
2014 ISRN Cell Biology  
MicroRNAs (miRNAs) are known to be dysregulated and play a key role in cancer progression.  ...  Moreover, the association of miR135b and MB gene is very unique and can be considered as a lead candidate for novel cancer therapeutics.  ...  This project ISRN Cell Biology 9 was supported by the NSTIP strategic technologies program in the Kingdom of Saudi Arabia, Award no. 11-MED1550-03, and the authors, therefore, acknowledge with thanks STU  ... 
doi:10.1155/2014/526075 fatcat:yenncyn57vembc5lhy3fpshype

Genome-Wide Sex and Gender Differences in Cancer

Camila M. Lopes-Ramos, John Quackenbush, Dawn L. DeMeo
2020 Frontiers in Oncology  
In particular, we will explore some of the emerging analytical approaches, such as the use of network methods, that are providing a deeper understanding of the drivers of differences based on sex and gender  ...  Better understanding these complex factors and their interactions will improve cancer prevention, treatment, and outcomes for all individuals.  ...  In a study modeling gene regulatory networks for each of 1,308 patients with colon cancer, although gene expression only differed significantly in sex chromosome genes, gene regulatory networks exhibited  ... 
doi:10.3389/fonc.2020.597788 pmid:33330090 pmcid:PMC7719817 fatcat:bytrmguqn5fkbanyfihf7pw65q

Preoperative chemoradiotherapy for rectal cancer: the sensitizer role of the association between miR-375 and c-Myc

Raquel Conde-Muiño, Carlos Cano, Victoria Sánchez-Martín, Antonio Herrera, Ana Comino, Pedro P. Medina, Pablo Palma, Marta Cuadros
2017 OncoTarget  
According to these findings, miRNA-375 and its targeted c-Myc may be useful as a predictive biomarker of the response to neoadjuvant treatment in patients with locally advanced rectal cancer.  ...  In the present study, integrated analysis of miRNA and mRNA expression profiles was conducted in 45 pretreatment rectal tumors in order to analyze the expressions of miRNAs and c-Myc and their relationship  ...  Better knowledge of c-Myc function could increase our understanding of the biology of the responder rectal cancer patients but may also provide a novel therapeutic molecular target for clinical practice  ... 
doi:10.18632/oncotarget.19393 pmid:29137264 pmcid:PMC5669890 fatcat:3lox2pshjbgmtfw5bi3265sdiu

Editorial: Advances in Mathematical and Computational Oncology

George Bebis, Doron Levy, Russell Rockne, Ernesto Augusto Bueno Da Fonseca Lima, Panayiotis V. Benos
2022 Frontiers in Physiology  
Understanding the origins and growth of cancer requires understanding the role of genetics in encoding proteins that form phenotypes and molecular alterations at multiple levels (e.g., gene, cell, and  ...  Cancer is not a single disease, it is a complex and heterogeneous disease which leads to the second cause of death worldwide.  ...  Network Using a Systems Biology Model).  ... 
doi:10.3389/fphys.2022.889198 pmid:35464082 pmcid:PMC9021698 fatcat:f6mocy3oebhvxmn675bzbyfvuq

Epigenetics Meets Radiation Biology as a New Approach in Cancer Treatment

Joong-Gook Kim, Moon-Taek Park, Kyu Heo, Kwang-Mo Yang, Joo Yi
2013 International Journal of Molecular Sciences  
Especially, colon cancer is a great model system for investigating the epigenetic mechanism for aberrant gene expression alteration.  ...  Even though there is growing evidence on the importance of epigenetics and biological processes induced by radiation exposure in various cancer types including colon cancer, specific epigenetic alterations  ...  Epigenetic approaches (DNA methylation and histone modification) could be a critical research field to understand the biological effects of IR in cancer.  ... 
doi:10.3390/ijms140715059 pmid:23873297 pmcid:PMC3742287 fatcat:5nuzaflccffkfmeznpw4g4tj34

miRNAs as biomarkers in colorectal cancer diagnosis and prognosis

Jingfang Ju
2010 Bioanalysis  
The potential roles of miRNAs in cancer were reported almost a decade later, opening up a new paradigm for discoveries in cancer research.  ...  Since the discovery of noncoding small miRNAs and their function in controlling mRNA translational rate, the small non-coding miRNA world has become a research wonderland for cancer and other human diseases  ...  A more comprehensive systems biology approach is needed to fully understand the impact of miRNA in terms of signaling pathways and targets associated with each pathway.  ... 
doi:10.4155/bio.10.45 pmid:20543966 pmcid:PMC2883182 fatcat:mc43u4fvvreo5af6ag6u7wnooe

Identification of biomarker microRNAs for predicting the response of colorectal cancer to neoadjuvant chemoradiotherapy based on microRNA regulatory network

Yaqun Zhu, Qiliang Peng, Yuxin Lin, Li Zou, Peipei Shen, Feifei Chen, Ming Min, Li Shen, Jiajia Chen, Bairong Shen
2016 OncoTarget  
Preoperative radiotherapy or chemoradiotherapy has become a standard procedure for treatment of patients with locally advanced colorectal cancer (CRC).  ...  MicroRNAs (miRNAs) are promising biomarkers for predicting personalized responses. In this study, we collected 30 publicly reported miRNAs associated with chemoradiotherapy of CRC.  ...  The model was enriched for frail sites in miRNA-mRNA networks and focused on the independent regulatory power of miRNAs.  ... 
doi:10.18632/oncotarget.13659 pmid:27903980 pmcid:PMC5356795 fatcat:c5lwhk5eefesrhby7xyagkc7nq

Role of MicroRNA Molecules in Colon Cancer Etiology

Farid E Ahmed
2014 Biology and Medicine  
The expression of several miRNAs in noninvasive body fluids/excrements has been linked to development of colorectal cancer (CRC) and its progression.  ...  between miRNAs and their targets is required only in the first six to eight bases from the 5′ end of the miRNA.  ...  Differences between colon and rectal cancer Epidemiologic evidence suggests that colon cancers (CCs) and rectal cancers (RCs) differ in their morbidities and etiologies.  ... 
doi:10.4172/0974-8369.1000201 fatcat:qfxrzms6y5bmvacx3m3fztj5qq

The functional role of miRNAs in colorectal cancer: insights from a large population-based study

E. Mullany Lila, L. Slattery Martha
2019 Cancer Biology and Medicine  
Identification of causal microRNAs (miRNAs) in colorectal cancer (CRC) is elusive, due to our lack of understanding of how specific miRNAs affect biological pathways and outcomes.  ...  The aim of the paper is to compile results from a population-based study (n = 1,954 cases with matched carcinoma/normal tissue) of miRNAs in CRC.  ...  Acknowledgements This study was supported in part by National Cancer Institute (NCI, Grant No.CA163683). Partial support for this manuscript came form the Huntsman Cancer Institute.  ... 
doi:10.20892/j.issn.2095-3941.2018.0514 pmid:31516743 pmcid:PMC6713639 fatcat:hyw2vtjrlvgojh2henxfdrnk4u

A gene browser of colorectal cancer with literature evidence and pre-computed regulatory information to identify key tumor suppressors and oncogenes

Min Zhao, Yining Liu, Fuda Huang, Hong Qu
2016 Scientific Reports  
Only 11% (colon cancer) and 12% (rectal cancer) of patients with distant metastases survive the first five years 2 .  ...  There is a poor understanding of the heterogeneity of CRC with regard to causative genetic mutations and gene regulatory mechanisms.  ...  Acknowledgements This work was supported by the National Natural Science Foundation of China (No. 31171270) and a research start-up fellowship from the University of the Sunshine Coast to MZ.  ... 
doi:10.1038/srep30624 pmid:27477450 pmcid:PMC4967895 fatcat:qe4tvs2y45an3cplfy3xlkn3vy

Tumor microRNAs Identified by Small RNA Sequencing as Potential Response Predictors in Locally Advanced Rectal Cancer Patients Treated With Neoadjuvant Chemoradiotherapy

TANA MACHACKOVA, KAROLINA TRACHTOVA, VLADIMIR PROCHAZKA, TOMAS GROLICH, MARTINA FARKASOVA, LUKAS FIALA, ROMAN SEFR, IGOR KISS, MATEJ SKROVINA, MICHAL DOSOUDIL, IOANA BERINDAN-NEAGOE, MAREK SVOBODA (+2 others)
2020 Cancer Genomics & Proteomics  
Rectal cancer accounts for approximately one-third of all colorectal cancers.  ...  Currently, the standard treatment for locally advanced rectal cancer (LARC) is neoadjuvant chemoradiotherapy (CRT) with capecitabine or 5-fluorouracil followed by curative surgery.  ...  Acknowledgements This study was supported by the Ministry of Health of the Czech Republic by the Czech Health Research Council project No. 16-31765A.  ... 
doi:10.21873/cgp.20185 pmid:32345666 pmcid:PMC7259892 fatcat:dqvyg7rpzrebzff6rgzx5fackm

Systems approach for the selection of micro-RNAs as therapeutic biomarkers of anti-EGFR monoclonal antibody treatment in colorectal cancer

Avisek Deyati, Shweta Bagewadi, Philipp Senger, Martin Hofmann-Apitius, Natalia Novac
2015 Scientific Reports  
Among the 20 molecules listed by the National Cancer Institute for the treatment of mCRC (http://www.cancer.gov/cancertopics/treatment/colon-and-rectal), cetuximab is one of the most successful monoclonal  ...  However, little is known regarding the role of miRNAs as a therapeutic biomarker for cetuximab treatment in CRC.  ...  Moreover, this research will also provide a valuable background for colorectal cancer investigators to identify critical miRNA regulatory elements for better understanding regulatory mechanisms or designing  ... 
doi:10.1038/srep08013 pmid:25622824 pmcid:PMC5389028 fatcat:6rwamo7etnattfnhccswczgjcu

circlncRNAnet: An integrated web-based resource for mapping functional networks of long or circular forms of non-coding RNAs

Shao-Min Wu, Hsuan Liu, Po-Jung Huang, Ian Yi-Feng Chang, Chi-Ching Lee, Chia-Yu Yang, Wen-Sy Tsai, Bertrand Chin-Ming Tan
2017 GigaScience  
In summary, circlncRNAnet is the first of its kind in the regulatory RNA research field, providing a "one-stop" resource for in-depth analyses of ncRNA biology. circlncRNAnet is freely available at  ...  Given their widespread target spectrum as well as extensive modes of action, a complete understanding of their biological relevance will depend on integrative analyses of systems data at various levels  ...  In summary, 40 circlncRNAnet is the first of its kind in the regulatory RNA research field, providing a 41 "one-stop" resource for in-depth analyses of ncRNA biology.  ... 
doi:10.1093/gigascience/gix118 pmid:29194536 pmcid:PMC5765557 fatcat:7e4l2evnfrbgvf4ako5xxilyfi
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