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Dhanya R. Krishnan, Do Le Quoc, Pramod Bhatotia, Christof Fetzer, Rodrigo Rodrigues
2016 Proceedings of the 25th International Conference on World Wide Web - WWW '16  
Approximate computation returns an approximate output for a job instead of the exact output.  ...  Incremental computation updates the output incrementally instead of re-computing everything from scratch for successive runs of a job with input changes.  ...  Rodrigo Rodrigues is partially supported by FCT with reference UID/CEC/50021/2013 and an ERC Starting Grant (ERC-2012-StG-307732).  ... 
doi:10.1145/2872427.2883026 dblp:conf/www/KrishnanQBFR16 fatcat:ukywbrylyjfkxepyksllsfryka

Electronic health records-driven phenotyping: challenges, recent advances, and perspectives

Jyotishman Pathak, Abel N Kho, Joshua C Denny
2013 JAMIA Journal of the American Medical Informatics Association  
The information driven approach demonstrated performance comparable to physician chart reviews, and represents a promising new approach for future computerized decision support applications.  ...  Understanding the inherent complexities associated with the healthcare process is vital for achieving scalable and high-throughput phenotyping.  ... 
doi:10.1136/amiajnl-2013-002428 pmid:24302669 pmcid:PMC3861925 fatcat:spyyo2cku5ec7fwdskountbgru

Enhancing Cancer Drug Discovery through Novel Cell Signaling Pathway Panel Strategy

Liang Schweizer, Litao Zhang
2013 Cancer Growth and Metastasis  
Here, we propose to apply cell signaling pathway panel approaches for oncology drug discovery.  ...  The strategies and guiding principles of the pathway panel approach are discussed. 2 pathway analysis examples with related processes and technology platforms are illustrated to identify cancer drugs that  ...  Acknowledgements We thank members from LEMBC for their contributions to cancer pathway screening efforts under this panel strategy, as well as collaborations with automation and IT groups.  ... 
doi:10.4137/cgm.s11134 pmid:24665207 pmcid:PMC3941151 fatcat:4f6db6cml5f5dnsh3czaljvte4

A Multidimensional Model for Monitoring Cloud Services [chapter]

Nuno Palhares, Solange Rito Lima, Paulo Carvalho
2013 Advances in Intelligent Systems and Computing  
Taking a stratified view of the problem, this study contributes to achieve a clearer and more efficient approach to cloud services monitoring.  ...  This process involves the identification of relevant parameters and metrics for each monitoring dimension, focusing on monitoring of resources, quality of service, security and service contracts.  ...  This work is funded by FEDER through the Competitiveness Factors Operational Programme -COMPETE and Portuguese National Funds through FCT -Foundation for Science and Technology under the Project: FCOMP  ... 
doi:10.1007/978-3-642-36981-0_87 fatcat:tzm4o6cz5nh4zhxcibtpdfw7um

Challenges and opportunities for oncology biomarker discovery

Avisek Deyati, Erfan Younesi, Martin Hofmann-Apitius, Natalia Novac
2013 Drug Discovery Today  
Novel high throughput text-mining approaches are absolutely essential for automated biomarker knowledge processing.  ...  In the next section, we provide an analytic view on existing biomarker knowledge bases and their applications in interpretation of high-throughput data.  ... 
doi:10.1016/j.drudis.2012.12.011 pmid:23280501 fatcat:efrzfpjpxbaa5pon6i4jmq5vg4

Future of Personalized Medicine in Oncology: A Systems Biology Approach

Ana Maria Gonzalez-Angulo, Bryan T.J. Hennessy, Gordon B. Mills
2010 Journal of Clinical Oncology  
Systems biology integrates engineering, physics, and mathematical approaches with biologic and medical insights in an iterative process to visualize the interconnected events within a cell that determine  ...  The masses of data generated by high-throughput technologies are challenging to manage, visualize, and convert to the knowledge required to improve patient outcomes.  ...  High throughput DNA sequencing offers a new approach to gene resequencing.  ... 
doi:10.1200/jco.2009.27.0777 pmid:20406928 pmcid:PMC2881854 fatcat:27csfbhzdbfqtaqlhbwptgqvua

Approximate Stream Analytics in Apache Flink and Apache Spark Streaming [article]

Do Le Quoc, Ruichuan Chen, Pramod Bhatotia, Christof Fetze, Volker Hilt, Thorsten Strufe
2017 arXiv   pre-print
Thus, they are not well-suited for stream analytics. This motivated the design of StreamApprox - a stream analytics system for approximate computing.  ...  processing such as Apache Flink.  ...  Apache Flink [2] implements the pipelined stream processing model to support a truly native stream processing engine.  ... 
arXiv:1709.02946v1 fatcat:ejcj5eugkjbxpo5bet22dhv7jq

Single-Cell Analysis in Cancer Genomics

Assieh Saadatpour, Shujing Lai, Guoji Guo, Guo-Cheng Yuan
2015 Trends in Genetics  
Current theories propose that cancer development involves both a process of clonal evolution from mutated cells of origin and a differentiation hierarchy from cancer stem cells [2] .  ...  In this paper we review the recent single-cell technological and computational advances at the genomic, transcriptomic, and proteomic levels, and discuss their applications in cancer research.  ...  Acknowledgments This work was supported in part by a Claudia Adams Barr Award to G-C.Y.  ... 
doi:10.1016/j.tig.2015.07.003 pmid:26450340 pmcid:PMC5282606 fatcat:zgp7okmxrfdmfd6mqrrbc4qpce

BigSR: an empirical study of real-time expressive RDF stream reasoning on modern Big Data platforms [article]

Xiangnan Ren and Olivier Curé and Hubert Naacke and Guohui Xiao
2018 arXiv   pre-print
Our experiments show that BigSR over both BSP and RAT generally scales up to high throughput beyond million-triples per second (with or without recursion), and RAT attains sub-millisecond delay for stateless  ...  For the sake of generality and to cover a wide variety of use cases, BigSR relies on the two main execution models adopted by major distributed execution frameworks: Bulk Synchronous Processing (BSP) and  ...  The support for recursive rules was not a difficult problem.  ... 
arXiv:1804.04367v1 fatcat:up2rgtt4bbc67ohpy3qwzsyn6y

WhiteWater: Distributed Processing of Fast Streams

Ioana Stanoi, George Mihaila, Themis Palpanas, Christian Lang
2007 IEEE Transactions on Knowledge and Data Engineering  
The distribution of query operators over a network of processors, as well as their processing sequence, form a query configuration with inherent constraints on the throughput that it can support.  ...  In this paper, we discuss the implications of measuring and optimizing for output throughput, as well as its limitations.  ...  Her current research focuses on scalable, correct, and efficient event processing techniques to support event-driven applications.  ... 
doi:10.1109/tkde.2007.1056 fatcat:i7rr3fyu2jhn5labxvhll5k5qq

The Marriage of Incremental and Approximate Computing [article]

Dhanya R Krishnan
2016 arXiv   pre-print
The high level idea is to: design a sampling algorithm that biases the sample selection to the memoized data items from previous runs.  ...  Approximate computation returns an approximate output for a job instead of the exact output.  ...  It is based on publish/subscribe model and is a distributed, high-throughput messaging system.  ... 
arXiv:1611.08573v1 fatcat:nj72wfi3kfer5czembdas24y3q

Exploratory failure time analysis in large scale genomics

Cheng Cheng
2016 Computational Statistics & Data Analysis  
CPT is a general approach to testing the null hypothesis of stochastic independence between a failure event point process and any random variable; thus it is widely applicable beyond genomic studies.  ...  Motivated by a special case in a GWAS, a novel test procedure called correlation profile test (CPT) is developed for testing genomic associations with failure-time phenotypes subject to right censoring  ...  Many thanks are due two reviewers, an associate editor and a co-editor, for their constructive critiques and suggestions that substantially helped improve this paper.  ... 
doi:10.1016/j.csda.2015.10.004 pmid:26681817 pmcid:PMC4677332 fatcat:kc4c2sibifdgfccibsjnaywpwa

Apoptosis goes on a chip: advances in the microfluidic analysis of programmed cell death

Donald Wlodkowic, Khashayar Khoshmanesh, John C. Sharpe, Zbigniew Darzynkiewicz, Jonathan M. Cooper
2011 Analytical Chemistry  
Currently he is a Chief Executive Officer of Cytonome/ST, LLC an innovative startup company developing enabling microfluidic technologies for a number of high throughput cell analysis and sorting applications  ...  Professor Jon Cooper's interests lie in the application of micro-and nanotechnology in the biomedical sciences.  ...  Therefore, microfluidic live-cell arrays are an emerging technique with substantial applications in high-throughput screening.  ... 
doi:10.1021/ac200588g pmid:21630641 pmcid:PMC3251906 fatcat:s75hpm5fj5cuzhugv2nqhrgynq

Big Data Analytics for Concurrent Data Processing

A Samydurai, C Vijayakumaran, G Kumaresan, B Muthusenthil
2015 International Journal of Computer Applications  
The solution indexes the streamed documents in main recollection with a structure predicate on the principles of the inverted file, and processes document advent and expiration events with an incremental  ...  Also the first solution for processing perpetual text queries efficiently to address the above challenges is given.  ...  Our resolution indexes the streamed documents in main memory with a structure supported the principles of the inverted file; processes file appearance and running out events with a progressive threshold-based  ... 
doi:10.5120/21211-3912 fatcat:drzhu3ntnjd4fjc4dianmsc55i

Intelligent biology and medicine in 2015: advancing interdisciplinary education, collaboration, and data science

Kun Huang, Yunlong Liu, Yufei Huang, Lang Li, Lee Cooper, Jianhua Ruan, Zhongming Zhao
2016 BMC Genomics  
It included eight scientific sessions, three tutorials, four keynote presentations, three highlight talks, and a poster session that covered current research in bioinformatics, systems biology, computational  ...  Yan Guo, Xiaowen Liu, and others for organizing the tutorials in ICIBM 2015. We thank Indiana University and many volunteers for the local support.  ...  We thank the National Science Foundation (NSF grant IIS-1451135) for financial support of previous ICIBM conferences. Declarations  ... 
doi:10.1186/s12864-016-2893-x pmid:27556295 pmcid:PMC5001210 fatcat:6mg4iddjhrbjfooguf45hvj77u
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