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A simple integrative electrophysiological model of bursting GnRH neurons

Dávid Csercsik, Imre Farkas, Erik Hrabovszky, Zsolt Liposits
2011 Journal of Computational Neuroscience  
In this paper a modular model of the GnRH neuron is presented.  ...  The model is able to reproduce the depolarizing afterpotentials, afterhyperpolarization, periodic bursting behavior and the corresponding calcium transients observed in the case of GnRH neurons.  ...  models of GnRH neuronal bursting.  ... 
doi:10.1007/s10827-011-0343-y pmid:21667154 fatcat:yhx2rdat7vdgjih6f54i4ruvza

Genetic Targeting of Green Fluorescent Protein to Gonadotropin-Releasing Hormone Neurons: Characterization of Whole-Cell Electrophysiological Properties and Morphology

K. J. Suter
2000 Endocrinology  
The expression of GFP allowed identification of 84 -94% of immunofluorescently-detected GnRH neurons.  ...  GnRH neurons form the final common pathway for central control of reproduction, with regulation achieved by changing the pattern of GnRH pulses.  ...  James Roberts for the GnRH promoter; Dr.  ... 
doi:10.1210/en.141.1.412 pmid:10614664 fatcat:n544peaafbbgtp3usrvjhq3jeu

Multitasking in Gonadotropin-Releasing Hormone Neuron Dendrites

Karl J. Iremonger, Allan E. Herbison
2014 Neuroendocrinology  
nectivity and function of the upstream neurons that project to GnRH neurons, this review will focus specifically on how GnRH neurons are adapted to integrate and process afferent synaptic inputs.  ...  This knowledge has been synthesized through a variety of methods including morphological, electrophysiological, functional imaging and computational studies.  ...  The excitability of GnRH neurons and hence the secretion of GnRH peptide are controlled by a distributed and complex neural network.  ... 
doi:10.1159/000368364 pmid:25300776 fatcat:a22ydpd7cnboviovoicb5y7ydu

Dendritic Processing of Excitatory Synaptic Input in Hypothalamic Gonadotropin Releasing-Hormone Neurons

C. B. Roberts, J. A. Best, K. J. Suter
2006 Endocrinology  
We thank Dieter Jaeger for permitting the use of his laboratory for the electrophysiological components of this work. We thank Dr.  ...  A preliminary report of these data was presented in abstract form (2004 Endocrine Society Meeting).  ...  Surprising new insights into the morphology of GnRH neurons: The morphology of GnRH neurons is generally described as simple bipolar with a vertical orientation in the hypothalamus.  ... 
doi:10.1210/en.2005-1350 pmid:16373415 fatcat:avmy2nmwzzgmbluvxs5pocf3xu

Multiple functions of non-hypophysiotropic gonadotropin releasing hormone neurons in vertebrates

Chie Umatani, Yoshitaka Oka
2019 Zoological Letters  
The functional role of non-hypophysiotropic GnRH neurons may thus be in the global modulation of neural circuits in a manner dependent on internal conditions or the external environment.  ...  This hormone is produced by hypothalamic GnRH neurons and stimulates the secretion of gonadotropins.  ...  Acknowledgements The authors wish to express their thanks to all the members of the Laboratory of Biological Signaling, Department of Biological Sciences, Graduate School of Science, the University of  ... 
doi:10.1186/s40851-019-0138-y pmid:31367467 pmcid:PMC6647275 fatcat:vgdkpai6zzg2rhjdsh5bheqso4

Initiation and Propagation of Action Potentials in Gonadotropin-Releasing Hormone Neuron Dendrites

K. J. Iremonger, A. E. Herbison
2012 Journal of Neuroscience  
Gonadotropin-releasing hormone (GnRH) neurons are the final output neurons in a complex neuronal network that regulates fertility.  ...  The morphology of GnRH neuron dendrites is very different to other central neurons in that they are very long, thin, and unbranched.  ...  That study also generated a morphologically based computer model of a GnRH neuron soma and dendrite.  ... 
doi:10.1523/jneurosci.3739-11.2012 pmid:22219278 pmcid:PMC6621316 fatcat:onfo52ugjneereqywms2y37e2i

Physiology of the Gonadotrophin-Releasing Hormone (GnRH) Neurone: Studies from Embryonic GnRH Neurones

S. Constantin
2011 Journal of neuroendocrinology  
Taking advantage of the unique developmental feature of GnRH neurons, the nasal explant model allows primary GnRH neurons to be maintained within a micro-network where pulsatile secretion is preserved  ...  Although it has been known for decades that the efficiency of communication between the hypothalamus and the pituitary depends on the pulsatile profile of GnRH secretion, how GnRH neuronal activity is  ...  This work was supported, in part, by the Intramural Research Program of the National Institutes of Health, National Institute of Neurological Disorders and Stroke and by the New Zealand Research Council  ... 
doi:10.1111/j.1365-2826.2011.02130.x pmid:21443528 pmcid:PMC3101116 fatcat:etj6e5ofrfajxp6sd4vybqmbaa

Progress and Challenges in the Search for the Mechanisms of Pulsatile Gonadotropin-Releasing Hormone Secretion

Stephanie Constantin
2017 Frontiers in Endocrinology  
For reproductive success, GnRH neurons, the final output of this network, must integrate and translate a wide range of cues, both environmental and physiological, to the gonadotrophs via pulsatile GnRH  ...  However, the caveat of the techniques supporting either one of the two hypotheses is the gap between events recorded at a single-cell level and GnRH secretion measured at the population level.  ...  In both models, GnRH neurons exhibit action potentials (APs) (71, 73, 74) and fluctuations of intracellular calcium concentration ([Ca 2+ ]i) (75) (76) (77) , concomitant with bursts of APs (78) .  ... 
doi:10.3389/fendo.2017.00180 pmid:28790978 pmcid:PMC5523686 fatcat:pnsoswopa5hlpfmcr4vgmikkzm

Mechanisms of Neuromodulation by a Nonhypophysiotropic GnRH System Controlling Motivation of Reproductive Behavior in the Teleost Brain

Hideki ABE, Yoshitaka OKA
2011 Journal of reproduction and development  
By taking advantage of the teleost brains in which all three GnRH systems are well developed, the anatomical and electrophysiological properties of all three groups of GnRH neurons have been studied.  ...  GnRH neuron using our newly developed primary culture system of isolated TN-GnRH3 neurons.  ...  Acknowledgments The authors wish to thank all the members of the Laboratory of Biological Signaling, Department of Biological Sciences, Graduate School of Science, The University of Tokyo, for collaboration  ... 
doi:10.1262/jrd.11-055e pmid:22277963 fatcat:7azgg66q4bgpplhuxy45h3s53u

Mathematical Modelling of Endocrine Systems

Eder Zavala, Kyle C.A. Wedgwood, Margaritis Voliotis, Joël Tabak, Francesca Spiga, Stafford L. Lightman, Krasimira Tsaneva-Atanasova
2019 Trends in endocrinology and metabolism  
Combined mathematical modelling and experimental approaches have shown that these rhythms result from regulatory processes occurring at multiple levels of organisation and require continuous dynamic equilibration  ...  Ultimately, we envisage that the insight provided by mathematical models could lead to novel experimental tools able to continuously adapt parameters to gradual physiological changes and the design of  ...  We also discuss an example of a new class of hybrid approaches: the dynamic clamp in electrophysiology, where real-time integration of mathematical modelling with experimental techniques can be used to  ... 
doi:10.1016/j.tem.2019.01.008 pmid:30799185 pmcid:PMC6425086 fatcat:pab4gejagvhtddoigaaqz2o6de

Dendro-dendritic bundling and shared synapses between gonadotropin-releasing hormone neurons

R. E. Campbell, G. Gaidamaka, S.-K. Han, A. E. Herbison
2009 Proceedings of the National Academy of Sciences of the United States of America  
The other interaction was one in which a GnRH neuron dendrite intercepted other GnRH neuron dendrites in a perpendicular fashion.  ...  The observation of shared synaptic input to bundled GnRH neuron dendrites suggests a mechanism of GnRH neuron synchronization. dendrite ͉ fertility ͉ LHRH ͉ mouse ͉ GnRH  ...  The authors declare no conflict of interest. This article is a PNAS Direct Submission. ACKNOWLEDGMENTS. We thank Mr. Andrew McNaughton (Otago Centre for Confocal Microscopy), Mr.  ... 
doi:10.1073/pnas.0903463106 pmid:19541658 pmcid:PMC2705602 fatcat:pnp22m7xi5evtj6ze4iw447dqi

Motivations and Methods for Analyzing Pulsatile Hormone Secretion

Johannes D. Veldhuis, Daniel M. Keenan, Steven M. Pincus
2008 Endocrine reviews  
Model-Free Evaluation of Endocrine Networks A. Concept of model-free assessment B. Rationale for ensemble statistics  ...  Analyses of Multihormone (Ensemble) Interactions A. Ensemble concept B. Ensemble modeling requirements C. Examples of ensemble-control models in endocrine systems D. Simplifying assumptions VIII.  ...  Acknowledgments We thank Kay Nevinger and Donna Scott for support of manuscript preparation, Ashley Bryant for data analysis and graphics, the Mayo Immunochemical Laboratory for assay assistance, and the  ... 
doi:10.1210/er.2008-0005 pmid:18940916 pmcid:PMC2647703 fatcat:nfh3m7x64ne25ojtyyv77zg3zu

Integrative Neuro-Endocrine Pathways in the Control of Reproduction in Lamprey: A Brief Review

Mihael Freamat, Stacia A. Sower
2013 Frontiers in Endocrinology  
It is also part of a network of brain structures and pathways that integrate information from the internal and external milieu and coordinate the adaptive behavioral and physiological responses to social  ...  In this paper we review the state of knowledge of the GnRH system in relation to the behavior, external, and internal factors that control reproduction in one of the oldest lineage of vertebrates, the  ...  Centrifugal neuromodulatory input to GnRH neurons of the nervus terminalis convey integrative signals to the chemosensory neurons in the nasal cavity thus adjusting the olfactory sensitivity to reproductive  ... 
doi:10.3389/fendo.2013.00151 pmid:24151489 pmcid:PMC3798812 fatcat:wgpyeezq3fdk7hpyxecsr222rm

Ion Channels and Signaling in the Pituitary Gland

Stanko S. Stojilkovic, Joël Tabak, Richard Bertram
2010 Endocrine reviews  
Other members of this receptor family can activate calcium channels in the endoplasmic reticulum, leading to a cell type-specific modulation of electrical activity.  ...  In others, the function of these action potentials is to maintain the cells in a responsive state with cytosolic calcium near, but below, the threshold level.  ...  This bursting behavior is illustrated in Fig. 15 using a simple mathematical model from Ref. 716 ; a more detailed model can be found in Ref. 711 .  ... 
doi:10.1210/er.2010-0005 pmid:20650859 pmcid:PMC3365841 fatcat:e6wqvhrvcjebbaviwhgib4x2h4

Control of anterior pituitary cell excitability by calcium-activated potassium channels

Michael J. Shipston
2018 Molecular and Cellular Endocrinology  
A major challenge for the future is to determine the cell-type specific molecular composition of calcium-activated potassium channels and how they control anterior pituitary hormone secretion as well as  ...  BK channels can, paradoxically, both promote electrical bursting as well as terminate bursting and spiking dependent upon intrinsic BK channel properties and proximity to voltage gated calcium channels  ...  Acknowledgements This work was generously supported by a Medical Research Council grant to MJS.  ... 
doi:10.1016/j.mce.2017.06.003 pmid:28596131 fatcat:f2zoe33eivetvjaijhoucuwsva
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