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MicroRNA Predictors of Longevity in Caenorhabditis elegans

Zachary Pincus, Thalyana Smith-Vikos, Frank J. Slack, Stuart K. Kim
2011 PLoS Genetics  
We quantitatively examined Caenorhabditis elegans reared individually in a novel apparatus and observed throughout their lives.  ...  Though correlated, markers of growth/muscle maintenance and of metabolic by-products ("age pigments") report independently on lifespan, suggesting that graceful aging is not a single process.  ...  Alexandre de Lencastre, Seth Pincus, and Rachael Nimmo for helpful discussions and comments. Author Contributions Conceived the experiments: ZP FJS.  ... 
doi:10.1371/journal.pgen.1002306 pmid:21980307 pmcid:PMC3183074 fatcat:cenoqgjo2bahvildzxgbektpii

ÉCole De Physique Des Houches [chapter]

2007 Les Houches  
Established in 1951, the Physics School is located in a group of chalets surrounded by meadows and woods, at an altitude of 1150 m facing the Mont-Blanc range -a very favourable environment for intellectual  ...  It rises 4,810.45 m above sea level and is ranked 11th in the world in topographic prominence. ecole de Physique des houches la côte des chavants 74310 les houches, france +33 (0)4 50 54 40 69  ...  M., and Schaaf, A. (2003). Math. Geol. 35, 853-872. 2. Clauss, F., Maniere, M.  ... 
doi:10.1016/s0924-8099(13)60020-7 fatcat:jydcwidbbnf3nppqp4x3pyu6ga

École de Physique des Houches [chapter]

2008 Les Houches  
Established in 1951, the Physics School is located in a group of chalets surrounded by meadows and woods, at an altitude of 1150 m facing the Mont-Blanc range -a very favourable environment for intellectual  ...  It rises 4,810.45 m above sea level and is ranked 11th in the world in topographic prominence. ecole de Physique des houches la côte des chavants 74310 les houches, france +33 (0)4 50 54 40 69  ...  M., and Schaaf, A. (2003). Math. Geol. 35, 853-872. 2. Clauss, F., Maniere, M.  ... 
doi:10.1016/s0924-8099(13)60004-9 fatcat:nxiezedqabbbtnfqonvw6c3doi

École de Physique des Houches [chapter]

2006 Les Houches  
Established in 1951, the Physics School is located in a group of chalets surrounded by meadows and woods, at an altitude of 1150 m facing the Mont-Blanc range -a very favourable environment for intellectual  ...  It rises 4,810.45 m above sea level and is ranked 11th in the world in topographic prominence. ecole de Physique des houches la côte des chavants 74310 les houches, france +33 (0)4 50 54 40 69  ...  M., and Schaaf, A. (2003). Math. Geol. 35, 853-872. 2. Clauss, F., Maniere, M.  ... 
doi:10.1016/s0924-8099(06)80084-3 fatcat:6w7diik2k5af7cpowh4xz3nsky

Society for Development Biology 64th Annual Meeting

2005 Developmental Biology  
Additional studies showed that the RNAi-like mechanism by which IESs are identified for elimination involves methylation of K9 on histone H3 and has other features of a highly conserved pathway for gene  ...  We proposed a "scan RNA model" based on our discovery of conjugationspecific 28 nt (scn)RNAs that hybridized to IESs and an argonaute family protein, Twi1p, that migrated from the old to the new MAC and  ...  The National Academies have been focused on ''making a science out of education'', which means creating continuously improving education systems based on evidence-based analyses of how people learn and  ... 
doi:10.1016/j.ydbio.2005.04.040 fatcat:jj63lzrujnfx7pt3uxl57spp4i

Eu Us Roadmap Nanoinformatics 2030 [article]

Haase, Klaessig
2018 Zenodo  
This roadmap has been jointly developed in trustful cooperation among scientists of the European Union, the United States of America and a few other countries.  ...  In particular it should be noted that some of the terms might be defined and used differently in the US versus the EU, also within different scientific disciplines and within different regulatory frameworks  ...  Smaller community size and a more pressing need to leverage limited research funding are advantages to Caenorhabditis elegans and Arabidopsis thaliana progress, while selecting one strain for preferred  ... 
doi:10.5281/zenodo.1486012 fatcat:yll2tsodjbgmlmyoyjfkcptxja

Artificial intelligence and molecular biology

1994 ChoiceReviews  
This work benefited greatly from many discussions with Peter Friedland, Charles Yanofsky, Bruce Buchanan, and Edward Feigenbaum. Dan Weld contributed comments on a draft of this article.  ...  Often experimenters both establish initial experimental conditions, and perturb the system at later times (often using a complex protocol) by adding reagents, applying heat or cold, etc.  ...  C. elegans One of the most exciting model organisms to emerge recently has been the nematode worm Caenorhabditis elegans.  ... 
doi:10.5860/choice.31-3826 fatcat:5jmryy7mkbcrvifz6ahlbbdceu

HGM 2010 Programme / Abstract

2010 The HUGO Journal  
The identification of an EYS mutation in a dog affected with retinal progressive atrophy would provide a useful model for establishing future therapies for retinitis pigmentosa.  ...  We would like to extend our utmost appreciation to them for all of their support.  ...  His current research interests include system-level understanding of biological time, space and information, and systems-based medicine on human disease.  ... 
doi:10.1007/s11568-010-9143-0 fatcat:oykxd6u7snfi5o7m6tst7wi6yq

Functional Genomics, Proteomics, Bioinformatics

2005 The FEBS Journal  
The scientific work carried out at our laboratory based on a number of research objects (bean harricot butterfly, pea shoot, infusorian, rat lactic gland) confirm that the intensively growing plants and  ...  Cells compromised for mortalin expression by hammerhead ribozymes, antisense and siRNA showed growth arrest suggesting that a threshold level of mortalin is essential for cell proliferation.  ...  We have made a semi-automated disease gene finding pipeline based on this assumption. Central to this pipeline is identification of genes in model organisms, which resemble the human disease genes.  ... 
doi:10.1111/j.1742-4658.2005.4739_3.x fatcat:njbcgznnxnb4la3yddlzpq4gr4

Toxicity Testing in the 21st Century: A Vision and a Strategy

Daniel Krewski, Daniel Acosta, Melvin Andersen, Henry Anderson, John C. Bailar, Kim Boekelheide, Robert Brent, Gail Charnley, Vivian G. Cheung, Sidney Green, Karl T. Kelsey, Nancy I. Kerkvliet (+11 others)
2010 Journal of Toxicology and Environmental Health. Part B, Critical Reviews  
Extrapolation of in vitro results to in vivo human blood and tissue concentrations would be based on pharmacokinetic models for the given exposure condition.  ...  Implementation of these strategies would result in a new toxicity testing paradigm firmly based on human biology.  ...  Phase I would focus on elucidating toxicity pathways; developing a data-storage, -access, and -management system; developing standard protocols for research methods and reporting; and planning a strategy  ... 
doi:10.1080/10937404.2010.483176 pmid:20574894 pmcid:PMC4410863 fatcat:v2wmp6tq4jbxxoztw3re2mwzfy

A Mathematical Model of Influence of the Interaction between Civilization Center and Barbarian Periphery on the World System Development

Grinin Leonid, Korotayev Andrey
2019 Zenodo  
One of the directions of this interdisciplinary search for the unity of the world in its diversity is Universal Evolutionism (Big History).  ...  In no way will it be a digression from the direction which we have initially defined for our Yearbook, but just an extension of the scope of the research.  ...  Rautian, and A. A. Fomin for discussion of ideas considered in this paper and valuable recommendations. Alexander V. Markov et al.  ... 
doi:10.5281/zenodo.3685877 fatcat:iq6hwb4l3bbnnlchdxmimazrya

Candidate gene and high throughput genetic analysis of habituation in Caenorhabditis elegans

Andrew Christopher Giles
2012
Using this tracking system, I examined many mutants and discovered hundreds of novel phenotypic variants for habituation in C. elegans.  ...  To accomplish this I studied habituation of the tap withdrawal response in Caenorhabditis elegans; an organism with a tractable nervous system, well characterized habituation and availability of genetic  ...  I have collected extensive behavioural and morphological data for a mutant library of Caenorhabditis elegans.  ... 
doi:10.14288/1.0072619 fatcat:5mpxa6eeinexhmqg7aj2qbrgou

Abstracts

2016 Acta Physiologica  
We used a genetically encoded synaptic marker for electron microscopy (GESEM) based on intra-vesicular generation of electron-dense labeling in axonal boutons.  ...  We used the dystrophic cardiac calcification phenotype as a marker in Abcc6 -/mice to determine the effect of 4-PBA on mineralization.  ...  Physiological and histological kidney parameters were determined on day 0, 8, 14, 21, 28, 35 (6  ... 
doi:10.1111/apha.12712 pmid:27329970 fatcat:imcxhh3singqdlh7umt4tcj54y

in Venice, Italy, covered BIOTECHNO 2011 Chairs Olivier Bodenreider, National Institutes of Health-Bethesda, USA Andreas Dress, Shanghai Institutes for Biological Sciences (SIBS) / Chinese Academy of Sciences (CAS) , China Victor Felea

Pei-Yuan Qian, Kaust, Cristina Seceleanu, Ravi Radhakrishnan, Olivier Bodenreider, Ravi Radhakrishnan, Luis Alexandre, Basim Alhadidi, Albalqa, Christine Amaldas, Nizamettin Aydin, Olivier Bodenreider (+45 others)
2011 Romania Attila Kertesz-Farkas   unpublished
Bioinformatics deals with the system-level study of complex interactions in biosystems providing a quantitative systemic approach to understand them and appropriate tool support and concepts to model them  ...  Current human mechanisms seem to offer significant ways for improving theories, algorithms, technologies, products and systems.  ...  We hope that BIOTECHNO 2011 was a successful international forum for the exchange of ideas and results between academia and industry and to promote further progress in biotechnology.  ... 
fatcat:26cfmxqebbcovmvktfkc4gqeyu

Molecular and genetic studies into the formation of lateral roots in Eucalyptus and Arabidopsis

Pelosi, Assunta, 1969-
2017
of a partial loss of capacity for indetenninate root growth post germination.  ...  Alternatively, APl:l/extensin may function in a capacity that is similar to that speculated for HRGPnt3 by Keller and Lamb (1989) .  ...  A feature of this RNA polymerase II subunit is the high, level of ainino acid conservation and an invariable CX 2 CXi2RCX 2 CGXR motif which represents a Zn-binding domain (Shpakovski et aL, 1995  ... 
doi:10.4225/03/59d44a1ca3148 fatcat:kumhm3qw4ng3la6urasgnvz224