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Whole integration of neural connectomics, dynamics and bio-mechanics for identification of behavioral sensorimotor pathways in Caenorhabditis elegans [article]

Jimin Kim, Julia A Santos, Mark J Alkema, Eli Shlizerman
2019 bioRxiv   pre-print
Specifically, we introduce a model that computationally emulates the activity of the complete somatic nervous system and its response to stimuli.  ...  We propose such a comprehensive framework to investigate the interaction between the nervous system and the body for the nematode Caenorhabditis elegans (C. elegans).  ...  Results We utilize the recently established computational neuronal network dynamical model of C. elegans to simulate responses of the nervous system to stimuli (22, 23, 26) .  ... 
doi:10.1101/724328 fatcat:zoaztswt4jguhagfojvqydgihm

Page 4180 of Psychological Abstracts Vol. 86, Issue 10 [page]

1999 Psychological Abstracts  
Carpenter and S Grossberg (1987) can account for the dopamine responses to novelty, general zation, and discrimination of appetitive and aversive stimuli.  ...  Journal of Computational Neuroscience, 1999(May—Jun), Vol 6(3), 263-277 Derived a linear neural network model of the chemotaxis control circuit in the nematode Caenorhabditis elegans and demonstrated INTELLIGENT  ... 

Reward from bugs to bipeds: a comparative approach to understanding how reward circuits function

Kristin M. Scaplen, Karla R. Kaun
2016 Journal of neurogenetics  
In a complex environment, animals learn from their responses to stimuli and events. Appropriate response to reward and punishment can promote survival, reproduction and increase evolutionary fitness.  ...  In part, this is a result of the sheer diversity of neurons, the heterogeneity of their responses and the complexity of neural circuits within which they are found.  ...  Disclosure statement The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article.  ... 
doi:10.1080/01677063.2016.1180385 pmid:27328845 pmcid:PMC4926782 fatcat:7hmttjpjcnhthnjw24lkrrlbmu

Corollary Discharge Promotes a Sustained Motor State in a Neural Circuit for Navigation [article]

Ni Ji, Vivek Venkatachalam, Hillary Rodgers, Wesley Hung, Taizo Kawano, Christopher M. Clark, Maria Lim, Mark J. Alkema, Mei Zhen, Aravinthan D.T. Samuel
2019 biorxiv/medrxiv   pre-print
Here, we report that C. elegans uses corollary discharge to sustain motor responses during thermotactic navigation.  ...  We propose that corollary discharge underlies a positive feedback mechanism to generate persistent neural activity and sustained behavioral patterns in a sensorimotor transformation.  ...  Acknowledgements We thank Daniel Witvliet for insights on C. elegans connectomes and generating Figure 2B .  ... 
doi:10.1101/861559 fatcat:ikhy7nvixjej5cefoomcudhavy

Discriminating Gourmets, Lovers, and Enophiles? Neural Nets Tell All About Locusts, Toads, and Roaches [chapter]

Wayne M. Getz, William C. Lemon
2000 Artificial Neural Networks in Medicine and Biology  
The third is a study of the response characteristics of a recurrent Hopfield-type neural network to input that represents olfactory stimuli.  ...  In this study the fitness of individuals depends on their response to signals from plants and the density of individuals using those plants [1] .  ...  Other simple neural nets have been developed that learn to avoid aversive stimuli by trial and error or by imitation [12] .  ... 
doi:10.1007/978-1-4471-0513-8_5 dblp:conf/annimab/GetzL00 fatcat:vhxvibgzzncubhiwec57lk7qvq

Fluctuation-Driven Neural Dynamics Reproduce Drosophila Locomotor Patterns

Andrea Maesani, Pavan Ramdya, Steeve Cruchet, Kyle Gustafson, Richard Benton, Dario Floreano, Aldo A Faisal
2015 PLoS Computational Biology  
To shed light on the influence of activity fluctuations on action timing, we developed a computational approach for automatically generating neural network models that reproduce large-scale, high-resolution  ...  To examine how fluctuating activity can contribute to action timing, we paired high-resolution measurements of freely walking Drosophila melanogaster with data-driven neural network modeling and dynamical  ...  Acknowledgments We thank members of the Benton and Floreano laboratories, Valerio Giacomo Iungo, Francesco Viola, Matthieu Louis, and Andrew Straw for helpful discussions.  ... 
doi:10.1371/journal.pcbi.1004577 pmid:26600381 pmcid:PMC4657918 fatcat:4dgpdazhjjbwrfhl7lwq46x3wa

Nematode locomotion: dissecting the neuronal–environmental loop

Netta Cohen, Tom Sanders
2014 Current Opinion in Neurobiology  
With a fully reconstructed and extensively characterized neural circuit, the nematode Caenorhabditis elegans is a promising model system for integrating our understanding of neuronal, circuit and whole-animal  ...  Here we review significant advances in our understanding of proprioceptive control of locomotion, and more abstract models of spatial orientation and navigation.  ...  References and recommended reading Papers of particular interest, published within the period of review, have been highlighted as: of special interest of outstanding interest  ... 
doi:10.1016/j.conb.2013.12.003 pmid:24709607 fatcat:4cmhud5hondsjk7pcpic73fca4

Polarity-specific high-level information propagation in neural networks

Yen-Nan Lin, Po-Yen Chang, Pao-Yueh Hsiao, Chung-Chuan Lo
2014 Frontiers in Neuroinformatics  
In the present study, we analyzed two neural networks: the somatic nervous system of Caenorhabditis elegans (C. elegans) and the partial central complex network of Drosophila, in light of these properties  ...  Our result provides insights into how the complex functions of natural neural networks may arise from a design that allows them to efficiently transform and combine input signals.  ...  The work was supported by the Aim for the Top University Project of the Ministry of Education and by National Science Council.  ... 
doi:10.3389/fninf.2014.00027 pmid:24672472 pmcid:PMC3955877 fatcat:zleysi5ky5ggvp4yrfye4xz3wq

Toxic stress-specific cytoprotective responses regulate learned behavioral decisions in C. elegans

Gábor Hajdú, Eszter Gecse, István Taisz, István Móra, Csaba Sőti
2021 BMC Biology  
Previous studies have shown that exposure of Caenorhabditis elegans to pathogens or toxins simultaneously stimulates cellular stress and detoxification responses and aversive behavior.  ...  Results Here, we show that exposure of C. elegans to high concentrations of naturally attractive food-derived odors, benzaldehyde and diacetyl, induces toxicity and food avoidance behavior.  ...  Keith Blackwell, Johji Miwa and Tibor Vellai for the C. elegans strains; T. Keith Blackwell, Keith P.  ... 
doi:10.1186/s12915-021-00956-y pmid:33563272 fatcat:u4nlac2m6neodgu7o2xxhhzg3q

Neural mechanisms underlying the temporal organization of naturalistic animal behavior [article]

Luca Mazzucato
2022 arXiv   pre-print
We crystallize recent studies which converge on an emergent mechanistic theory of temporal variability based on attractor neural networks and metastable dynamics, arising from the coordinated interactions  ...  In this review, we provide a critical assessment of the existing behavioral and neurophysiological evidence for these sources of temporal variability in naturalistic behavior.  ...  Acknowledgments I would like to thank Zach Mainen, James Murray, Cris Niell, Matt Smear, Osama Ahmed, the participants of the Computational Neuroethology Workshop 2021 in Jackson, and the members of the  ... 
arXiv:2203.02151v1 fatcat:m3cnresdcndz7hhr2qizhrmxlu

Serotonin in Affective Control

Peter Dayan, Quentin J.M. Huys
2009 Annual Review of Neuroscience  
We first describe a range of its effects in invertebrates, in endowing specific structurally fixed networks with plasticity at multiple spatial and temporal scales to aspects of homeostatic state.  ...  We argue that this is associated with a more unified representational and functional role to do with aversive processing that is amenable to computational analyses with the kinds of reinforcement learning  ...  Acknowledgements We are very grateful to Björn Brembs, Y-Lan Boureau, Roshan Cools, Bill Deakin, Nathaniel Daw, Kenji Doya, Michael Frank, Robert Huber  ... 
doi:10.1146/annurev.neuro.051508.135607 pmid:19400722 fatcat:vtvhnv4tjjef5ia7iapbkw2bri

Neural Architecture of Hunger-Dependent Multisensory Decision Making in C. elegans

D. Dipon Ghosh, Tom Sanders, Soonwook Hong, Li Yan McCurdy, Daniel L. Chase, Netta Cohen, Michael R. Koelle, Michael N. Nitabach
2016 Neuron  
Here we confronted C. elegans worms with the decision whether to cross a hyperosmotic barrier presenting the threat of desiccation to reach a source of food odor.  ...  These studies reveal a potentially general neural circuit architecture for internal state control of threat-reward decision making.  ...  Mitani, C. Bargmann, and the Caenorhabditis Genetics Center for strains, K.  ... 
doi:10.1016/j.neuron.2016.10.030 pmid:27866800 pmcid:PMC5147516 fatcat:tsyortz4trak3m6w5gej5lvpey

Corollary discharge promotes a sustained motor state in a neural circuit for navigation

Ni D Ji, Vivek Venkatachalam, Hillary Denise Rodgers, Wesley Hung, Taizo Kawano, Christopher M Clark, Maria Lim, Mark J Alkema, Mei Zhen, Aravinthan DT Samuel
2021 eLife  
Here, we report that C. elegans uses feedback from the motor circuit to a sensory processing interneuron to sustain its motor state during thermotactic navigation.  ...  Animals exhibit behavioral and neural responses that persist on longer time scales than transient or fluctuating stimulus inputs.  ...  A. Schematic of the circuit model. B. Dynamics of the model in response to an oscillating input stimulus. Top, temporal profile of the input signal.  ... 
doi:10.7554/elife.68848 fatcat:vupcwebn4nf5xnbueyidrtipcu

Vulnerability-Based Critical Neurons, Synapses, and Pathways in the Caenorhabditis elegans Connectome

Seongkyun Kim, Hyoungkyu Kim, Jerald D. Kralik, Jaeseung Jeong, Kim T. Blackwell
2016 PLoS Computational Biology  
We believe our study provides a significant advance in the understanding of the network topology of the C. elegans connectome, and provides insights into the fundamental architectural design of complex  ...  To determine this, the nematode roundworm Caenorhabditis elegans is an attractive model system.  ...  The nematode C. elegans is a valuable model system to identify potentially fundamental design elements of nervous systems.  ... 
doi:10.1371/journal.pcbi.1005084 pmid:27540747 pmcid:PMC4991803 fatcat:xjve5ruxkrc6xnchurowximbjy

The Cellular Organization of Zebrafish Visuomotor Circuits

Michael B. Orger
2016 Current Biology  
Recent studies have made considerable progress towards understanding the underlying neural circuit basis of these innate responses, at two fundamental levels.  ...  systems, but is now becoming feasible in a vertebrate model.  ...  Similarly, several groups have investigated learned fear responses and processing of aversive stimuli in the habenula [19] [20] [21] , a conserved structure implicated in the regulation of neuromodulatory  ... 
doi:10.1016/j.cub.2016.03.054 pmid:27166700 fatcat:qek2a5z6rjft7fyxqgd22amove
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