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Magnetic Resonance Imaging in (Near-)Term Infants with Hypoxic-Ischemic Encephalopathy

Corline E. J. Parmentier, Linda S. de Vries, Floris Groenendaal
2022 Diagnostics  
Hypoxic-ischemic encephalopathy (HIE) is a major cause of neurological sequelae in (near-)term newborns.  ...  In this review, the main brain injury patterns of infants with HIE, the application of conventional and advanced MRI techniques in these newborns, and HIE mimics, will be described.  ...  Acknowledgments: The authors thank the neonatologists, physician assistants and nurses of the NICU of the Wilhelmina Children's Hospital in Utrecht for their devoted use of the aEEG and MRI.  ... 
doi:10.3390/diagnostics12030645 pmid:35328199 pmcid:PMC8947468 fatcat:e36sdnpbu5cgtga2p2sjcmn6pm

Early Changes in Glutamate Metabolism and Perfusion in Basal Ganglia following Hypoxia-Ischemia in Neonatal Piglets: A Multi-Sequence 3.0T MR Study

Yu-xue Dang, Kai-ning Shi, Xiao-ming Wang
2017 Frontiers in Physiology  
The excitotoxicity of glutamate metabolism as well as hemodynamic disorders of the brain are both risk factors for neonatal hypoxic-ischemic brain damage (HIBD).  ...  Our study results revealed that Glu level is closely associated with the microcirculatory perfusion changes in the acute stage of HIBD.  ...  ACKNOWLEDGMENTS We would like to thank our colleagues in the Department of Radiology, Shengjing Hospital of China Medical University and MR Engineers whose efforts make this work possible.  ... 
doi:10.3389/fphys.2017.00237 pmid:28487658 pmcid:PMC5404207 fatcat:puranum2qval7lk6auyybrc6uq

Basic Principles and Concepts Underlying Recent Advances in Magnetic Resonance Imaging of the Developing Brain

Ashok Panigrahy, Matthew Borzage, Stefan Blüml
2010 Seminars in Perinatology  
This article will review basic principles and concepts underlying recent advances in MR spectroscopy, diffusion, perfusion and volumetric MR imaging.  ...  Knowledge of normal developmental changes in quantitative MR values is also essential to interpret pathologic cases.  ...  Acknowledgments The authors thank Hari Keshava and Arabhi Nagasunder (quantitative diffusion tensor measurements); Marvin D.  ... 
doi:10.1053/j.semperi.2009.10.001 pmid:20109968 pmcid:PMC2887750 fatcat:72csqanjhva3lpgbvfv52z65qe

Multimodality Monitoring in Neurocritical Care

Katja Elfriede Wartenberg, J. Michael Schmidt, Stephan A. Mayer
2007 Critical care clinics  
The thermal diffusion method provides a quantitative estimate of regional CBF in milliliters per 100 g per minute by using thermal diffusion based on the tissue's ability for dissipation of heat [31]  ...  Furthermore, MRI detects ischemia early by an increase in signal on diffusion-weighted imaging (DWI) and reduction of the apparent diffusion coefficient within 30 minutes of onset of symptoms.  ... 
doi:10.1016/j.ccc.2007.06.002 pmid:17900483 fatcat:poac3krpm5bffbmz2y6xbdibo4

Cerebral Near Infrared Spectroscopy Monitoring in Term Infants With Hypoxic Ischemic Encephalopathy—A Systematic Review

Subhabrata Mitra, Gemma Bale, Judith Meek, Ilias Tachtsidis, Nicola J. Robertson
2020 Frontiers in Neurology  
Optical measurements of brain metabolism using broadband NIRS and cerebral blood flow using diffuse correlation spectroscopy add additional pathophysiological information.  ...  Objective: To perform a systematic review of cerebral NIRS monitoring in term and near-term infants with HIE.  ...  ACKNOWLEDGMENTS The authors would like to acknowledge the help from Simon Coats, Clinical Support librarian in UCL medical library for this systematic review.  ... 
doi:10.3389/fneur.2020.00393 pmid:32536901 pmcid:PMC7267214 fatcat:jnc7gasnmfdivheocbmwcbe6n4

Morphological and hemodynamic magnetic resonance assessment of early neonatal brain injury in a piglet model

Berit H. Munkeby, Kristin Lyng, Jahn Frederik Frøen, Eldrid H. Winther-Larssen, Jan Henrik Rosland, Hans-Jørgen Smith, Ola Didrik Saugstad, Atle Bjørnerud
2004 Journal of Magnetic Resonance Imaging  
Morphological and haemodynamic MR assessment of early neonatal brain injury in a piglet model A linear correlation was observed between the relative cerebral perfusion reduction and the cerebral apparent  ...  In particular, the combination of PWI and DWI has been shown to be a very sensitive and non-invasive method for identifying the ischemic penumbra as the area of mismatch between perfusion and diffusion  ... 
doi:10.1002/jmri.20084 pmid:15221803 fatcat:xmopmz5ewjgvtom6cvbvketueq

A neuroradiologist's guide to arterial spin labeling MRI in clinical practice

M. Grade, J. A. Hernandez Tamames, F. B. Pizzini, E. Achten, X. Golay, M. Smits
2015 Neuroradiology  
Studies on ASL in brain tumour imaging indicate a high correlation between areas of increased CBF as measured with ASL and increased cerebral blood volume as measured with dynamic susceptibility contrast-enhanced  ...  Arterial spin labeling (ASL) is a non-invasive MRI technique to measure cerebral blood flow (CBF).  ...  Pienaar R, Paldino MJ, Madan N et al (2012) A quantitative method for correlating observations of decreased apparent diffusion coefficient with elevated cerebral blood perfusion in newborns presenting  ... 
doi:10.1007/s00234-015-1571-z pmid:26351201 pmcid:PMC4648972 fatcat:wbmxvor3pzdpjgs2jwh3z5c2ru

The measurement of diffusion and perfusion in biological systems using magnetic resonance imaging

David L Thomas, Mark F Lythgoe, Gaby S Pell, Fernando Calamante, Roger J Ordidge
2000 Physics in Medicine and Biology  
Diffusion MRI measures the molecular mobility of water in tissue, while perfusion MRI measures the rate at which blood is delivered to tissue.  ...  D G, Frackowiak R S, Proctor E, Allen K L, Williams S R and Ross Russell R W 1987 Acute cerebral ischaemia: concurrent changes in cerebral blood flow, energy metabolism, pH, and lactate measured with  ...  Interestingly, in the periphery of the lesion, a diffusion-perfusion mismatch was observed, that is, a decrease in CBF without a change in diffusion.  ... 
doi:10.1088/0031-9155/45/8/201 pmid:10958179 fatcat:bcmcktedgjb6rcsdlctuc3bhtq

Clinical applications of diffusion tensor imaging

Qian Dong, Robert C. Welsh, Thomas L. Chenevert, Ruth C. Carlos, Pia Maly-Sundgren, Diana M. Gomez-Hassan, Suresh K. Mukherji
2003 Journal of Magnetic Resonance Imaging  
Quantitative apparent diffusion coefficients and fractional anisotropy have emerged from being primarily research tools to methods enabling valuable clinical applications.  ...  This review describes the clinical utility of diffusion tensor imaging, including the basic principles of the technique, acquisition, data analysis, and the major clinical applications.  ...  ACKNOWLEDGMENTS We thank Suzanne Murphy for assistance with preparation of the manuscript.  ... 
doi:10.1002/jmri.10424 pmid:14696215 fatcat:ku3ltpqncrdppotxnmqn5kdcza

New means to assess neonatal inflammatory brain injury

Chen Jin, Irene Londono, Carina Mallard, Gregory A. Lodygensky
2015 Journal of Neuroinflammation  
and vulnerability of developing oligodendrocytes to cerebral insults.  ...  has emerged as a promising candidate for such purpose.  ...  Acknowledgements The authors wish to thank the following institutions for their support: the CIHR, Institute of Human Development, Child and Youth Health (IHDCYH) (grant nos. 126790 and 136908) the Fonds  ... 
doi:10.1186/s12974-015-0397-2 pmid:26407958 pmcid:PMC4583178 fatcat:jgv5hqv54ffari2zl7nv72x6ty


1978 Stroke  
Abstracts A B-4609-78 How Much Physical Therapy for Patients With Stroke?  ...  Stiff and painful shoulders were present in 21 of the patients by two weeks and had developed in a further 37 by one year. Physiotherapy did not prevent this.  ...  In 9 of 10 animals studied at the end of the ischemic insult and not allowed to recover, blood flow in the cerebral hemispheres was greatly reduced, with minimal flow (0.01 to 0.11 ml gm~l min 1 ) persisting  ... 
doi:10.1161/01.str.9.6.604 fatcat:7kb2frougve7tpna27kjlup6ci

Injury to the Preterm Brain and Cerebral Palsy: Clinical Aspects, Molecular Mechanisms, Unanswered Questions, and Future Research Directions

Michael A. Babcock, Felina V. Kostova, Donna M. Ferriero, Michael V. Johnston, Jan E. Brunstrom, Henrik Hagberg, Bernard L. Maria
2009 Journal of Child Neurology  
Cerebral palsy will affect nearly 10% of the 60,000 very-low-birth-weight infants born in the United States in the next year, and an even greater percentage will display some form of permanent neurological  ...  A complex interplay of both destructive and developmental forces is responsible for injury to the preterm brain.  ...  Endotoxintreated animals show a significant decrease both in parallel diffusion and in fractional anisotropy, with no change in apparent diffusion coefficient.  ... 
doi:10.1177/0883073809338957 pmid:19745084 pmcid:PMC3695641 fatcat:ltvufqoo7nab3jne5jq3fipite

Poster Viewing Session III

2017 Journal of Cerebral Blood Flow and Metabolism  
Methods: We have used diffuse correlation spectroscopy (DCS) [2] to follow microvascular cerebral blood flow (CBF) changes in the frontal lobes during a HOB challenge.  ...  Journal of Cerebral Blood Flow & Metabolism 37(1S) correlates the NIRS results with the pre-surgery CT, and the six months treatment and CT outcomes.  ...  Acknowledgement: This research has been funded by Acknowledgements: T.Hollyer is grateful the financial and technical support for this project from SINAPSE, ReNeuron, and The University of Glasgow  ... 
doi:10.1177/0271678x17695987 pmid:28366135 pmcid:PMC5441165 fatcat:m4mfdovmpzasbh5brx26kp4ho4

Systemic, Local, and Imaging Biomarkers of Brain Injury: More Needed, and Better Use of Those Already Established?

Keri L. H. Carpenter, Marek Czosnyka, Ibrahim Jalloh, Virginia F. J. Newcombe, Adel Helmy, Richard J. Shannon, Karol P. Budohoski, Angelos G. Kolias, Peter J. Kirkpatrick, Thomas Adrian Carpenter, David K. Menon, Peter J. Hutchinson
2015 Frontiers in Neurology  
A broad definition of a biomarker is any observable feature that can be used to inform on the state of the patient, e.g., a molecular species, a feature on a scan, or a monitoring characteristic, e.g.,  ...  Biomarkers are usually quantitative measures, which can be utilized in diagnosis and monitoring of response to treatment.  ...  The theory of the importance of autoregulation is related to the presumed dual control mechanism of cerebral blood flow, whereby, in physiological conditions, a single insult such as reduced cerebral perfusion  ... 
doi:10.3389/fneur.2015.00026 pmid:25741315 pmcid:PMC4332345 fatcat:pdvtd4m4erb25f2u5wtyjggsrq

Cerebral blood flow and cerebrovascular autoregulation in a swine model of pediatric cardiac arrest and hypothermia*

Jennifer K. Lee, Ken M. Brady, Jennifer O. Mytar, Kathleen K. Kibler, Erin L. Carter, Karen G. Hirsch, Charles W. Hogue, Ronald B. Easley, Lori C. Jordan, Peter Smielewski, Marek Czosnyka, Donald H. Shaffner (+1 others)
2011 Critical Care Medicine  
Conclusions-In a pediatric model of cardiac arrest and resuscitation, delayed induction of hypothermia decreased cerebral perfusion and decreased the lower limit of autoregulation.  ...  We determined the relationship of cerebral blood flow to cerebral perfusion pressure in a swine model of pediatric hypoxic-asphyxic cardiac arrest during normothermia and hypothermia and tested novel measures  ...  Validation of diffuse correlation spectroscopy measurements of rodent cerebral blood flow with simultaneous arterial spin labeling MRI; towards MRI-optical continuous cerebral metabolic monitoring.  ... 
doi:10.1097/ccm.0b013e318223b910 pmid:21705904 pmcid:PMC3178742 fatcat:xguhjvrafzgonozjx64sp54kmm
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