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A protocol for use of medetomidine anesthesia in rats for extended studies using task-induced BOLD contrast and resting-state functional connectivity
2009
NeuroImage
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Keywords Medetomidine anesthesia; rat; blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMRI); physiological fluctuations; resting-state functional connectivity magnetic resonance ...
In the secondary infusion period using 300 μg/kg/hr, resting-state functional connectivity is enhanced. ...
The authors thank Hanbing Lu and B. Douglas Ward for their helpful comments. The authors would also like to thank Abbie Amadio and Karen Hyde for manuscript editing and figure preparation. ...
doi:10.1016/j.neuroimage.2009.03.004
pmid:19285560
pmcid:PMC2693293
fatcat:copxq2ttkzdedikgr67fsnlyfi
The power of using functional fMRI on small rodents to study brain pharmacology and disease
2015
Frontiers in Pharmacology
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Functional magnetic resonance imaging (fMRI) is an excellent tool to study the effect of pharmacological modulations on brain function in a non-invasive and longitudinal manner. ...
Respectively, these techniques permit the assessment of functional connectivity during rest as well as brain activation triggered by sensory stimulation and/or a pharmacological challenge. ...
ACKNOWLEDGMENTS The authors acknowledge the Institute for the Promotion of Innovation by Science and Technology (IWT) in Flanders grant agreement 131060, Molecular Imaging of Brain Pathophysiology ...
doi:10.3389/fphar.2015.00231
pmid:26539115
pmcid:PMC4612660
fatcat:vxu45hrsn5hchn46yitjtt76my
Functional imaging evidence for task-induced deactivation and disconnection of a major default mode network hub in the mouse brain
2020
Proceedings of the National Academy of Sciences of the United States of America
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The default mode network (DMN) has been defined in functional brain imaging studies as a set of highly connected brain areas, which are active during wakeful rest and inactivated during task-based stimulation ...
These results validate an imaging technique for the study of activation and connectivity in the lightly sedated awake mouse brain and provide evidence supporting an evolutionary preserved function of the ...
Discussion Our study developed and validated a fUS protocol, which uses a head-fixed configuration and light medetomidine sedation in awake and behaving mice, to study sensory task-induced changes of FC ...
doi:10.1073/pnas.1920475117
pmid:32541017
fatcat:ows44dtsrfglfdwt52nzhkqe4u
Time-dependent effects of isoflurane and dexmedetomidine on functional connectivity, spectral characteristics, and spatial distribution of spontaneous BOLD fluctuations
2014
NMR in Biomedicine
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Eleven rats were anesthetized with 2% isoflurane anesthesia; four rats were anesthetized for a short period (30min, simulating induction and fMRI setup) and seven rats were anesthetized for a long period ...
Anesthesia is often necessary to perform fMRI experiments in the rodent model; however, commonly used anesthetic protocols may manifest changing brain conditions over the duration of the study. ...
In 2006, Weber et al. presented a protocol using medetomidine sedation allowing for longitudinal fMRI studies to be performed in rats (10) . ...
doi:10.1002/nbm.3062
pmid:24449532
pmcid:PMC4465547
fatcat:f4hlshxwbnffpi7jzo6oojtytu
Resting-state functional connectivity of the rat brain
2008
Magnetic Resonance in Medicine
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Success in these studies is attributed in part to the use of medetomidine hydrochloride (Domitor) for anesthesia. ...
Regional-specific average time courses of spontaneous fluctuations in blood oxygen level dependent (BOLD) MRI contrast at 9.4T in lightly anesthetized resting rat brain are formed, and correlation coefficients ...
Douglas Ward, Hanbing Lu, Shi-Jiang Li, and Jay Neitz for their helpful comments and careful review of the manuscript. ...
doi:10.1002/mrm.21524
pmid:18429028
pmcid:PMC2562321
fatcat:out4vce7rbcxtemmgsjdlbjqx4
The (Un)Conscious Mouse as a Model for Human Brain Functions: Key Principles of Anesthesia and Their Impact on Translational Neuroimaging
2020
Frontiers in Systems Neuroscience
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Based on this, a simple and comprehensive functional neurosignature pattern can be determined for use in defining brain states and anesthetic depth in rest and in response to stimuli. ...
Low-dose anesthetic protocols are commonly applied in murine functional brain studies to prevent stress and facilitate a calm and relaxed condition among animals. ...
Molecular Medicine, Berlin, Germany), and Nikoloz Sirmpilatze (Functional Imaging Laboratory, Deutsches Primatenzentrum, Göttingen, Germany) for valuable discussions, reading and commenting on the manuscript ...
doi:10.3389/fnsys.2020.00008
pmid:32508601
pmcid:PMC7248373
fatcat:eelkqgl3ybbchpbxeiamp54jea
Preserved Modular Network Organization in the Sedated Rat Brain
2014
PLoS ONE
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In this study, we characterized the properties of resting-state FCN in an extensive number of Sprague-Dawley rats (n = 40) under medetomidine sedation by evaluating its modular organization and centrality ...
modularity contrasting from the one reported for deep anesthesia but closely resembles the organization described for the rat in conscious state. ...
Acknowledgments The authors would like to thank the following persons for a) suggestions and feedback on the analysis and interpretation of the data: Onur Guentuerkuen, Johan Van Audekerke, Murray Shanahan ...
doi:10.1371/journal.pone.0106156
pmid:25181007
pmcid:PMC4152194
fatcat:cqvc5p5b5rejzohnszuedxmqjm
Functional Connectivity of the Brain Across Rodents and Humans
[article]
2022
arXiv
pre-print
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Resting-state functional magnetic resonance imaging (rs-fMRI), which measures the spontaneous fluctuations in the blood oxygen level-dependent (BOLD) signal, is increasingly utilized for the investigation ...
Rodents, as a typical animal model in neuroscience, play an important role in the studies that examine the neuronal processes that underpin the spontaneous fluctuations in the BOLD signal and the functional ...
Acknowledgments The authors would like to thank Harry Watters for helpful discussions, and acknowledge funding from 1R01MH111416, 1R01NS078095, and 1R01EB029857. ...
arXiv:2111.05912v5
fatcat:6vqseyf5qvgdjdbhy5esnpjrse
Noise and non-neuronal contributions to the BOLD signal: applications to and insights from animal studies
2017
NeuroImage
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The use of anesthesia, common in animal studies, alters neural activity, vascular tone, and neurovascular coupling. ...
This review discusses different types of noise and non-neuronal contributors to the BOLD signal, sources of variability for animal studies, and insights to be gained from animal models. ...
and Improved Cognition (BIONIC), and the Center for Systems Imaging at Emory. ...
doi:10.1016/j.neuroimage.2016.12.019
pmid:28017922
pmcid:PMC5481494
fatcat:cfjnbrsikzhglpfgml4mmikq24
Functional Connectivity fMRI of the Rodent Brain: Comparison of Functional Connectivity Networks in Rat and Mouse
2011
PLoS ONE
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Moreover, by acquiring rsfMRI data with a comparable protocol for anesthesia, scanning and analysis, in both rats and mice we were able to compare findings obtained in both species. ...
At present, resting state functional MRI (rsfMRI) is increasingly used in human neuropathological research. ...
Introduction The interest in resting state functional Magnetic Resonance Imaging (rsfMRI), a method commonly used to study functional connectivity in the brain has recently shown a marked increase and ...
doi:10.1371/journal.pone.0018876
pmid:21533116
pmcid:PMC3078931
fatcat:wz6i2nothzcjxfy4elljq5nbdm
Long-term vascular access ports as a means of sedative administration in a rodent fMRI survival model
2011
Journal of Neuroscience Methods
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Functional MRI during nerve stimulation and resting-state functional connectivity MRI (fcMRI) were performed at times 0, 2, 4, 8, and 12 weeks postoperatively using a 9.4 T scanner. ...
The purpose of this study is to develop a rodent functional magnetic resonance imaging (fMRI) survival model with the use of heparin-coated vascular access devices. ...
Acknowledgments This work was supported by grant EB000215 of the National Institutes of Health. ...
doi:10.1016/j.jneumeth.2011.06.018
pmid:21726581
pmcid:PMC3156352
fatcat:aauq2x5wwbbrlkojvfttn2gray
Dexmedetomidine − commonly used in resting-state and neurovascular coupling studies − is prone to inducing seizures in rats but not in wild type mice
[article]
2019
bioRxiv
pre-print
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For correct interpretation of spontaneous fluctuations and functional connectivity in the resting-state, it is important to characterize the neuronal mechanisms of fMRI in animal models. ...
Animal studies of the evoked response and resting-state commonly use dexmedetomidine sedation. ...
Optimization of anesthesia protocol for resting-state fMRI in mice based on differential effects of anesthetics on functional connectivity patterns. Neuroimage 102 Pt 2, 838-847. ...
doi:10.1101/2019.12.29.890525
fatcat:yspvge2meze3dbb4glkwm4oi6i
Functional Connectivity of the Brain Across Rodents and Humans
2022
Frontiers in Neuroscience
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Resting-state functional magnetic resonance imaging (rs-fMRI), which measures the spontaneous fluctuations in the blood oxygen level-dependent (BOLD) signal, is increasingly utilized for the investigation ...
Rodents, as a typical animal model in neuroscience, play an important role in the studies that examine the neuronal processes that underpin the spontaneous fluctuations in the BOLD signal and the functional ...
similar to resting-state networks seen in functional connectivity-based analysis can be obtained using only a very small fraction of the data. ...
doi:10.3389/fnins.2022.816331
pmid:35350561
pmcid:PMC8957796
fatcat:kkfqmlxlyncbzinrgrqtu6p4ia
Olfactory Information Storage Engages Subcortical and Cortical Brain Regions That Support Valence Determination
2021
Cerebral Cortex
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Significantly stronger BOLD responses occurred in the PrL-IL, PC, and AON during 100 Hz compared with 20 Hz OB stimulation. LTP in the aPC was concomitantly induced by 100 Hz stimulation. ...
Here, we compared functional magnetic resonance imaging BOLD responses triggered during 20 or 100 Hz stimulation of the OB. ...
Another study using fMRI compared changes in BOLD responses to local field potentials recorded in the aPC and revealed state-dependent functional connectivity in the olfactory system . ...
doi:10.1093/cercor/bhab226
pmid:34379749
pmcid:PMC8841565
fatcat:xzxsecfqqjfbzicpapljrg2uie
Combined rTMS/fMRI Studies: An Overlooked Resource in Animal Models
2018
Frontiers in Neuroscience
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This review summarizes the main studies combining different rTMS protocols with fMRI in humans, in both healthy and patient populations, providing a foundation for the design of equivalent studies in animals ...
choice for examining both short and long term functional connectivity changes in large-scale networks and is becoming increasingly popular in animal research because of its high translatability, but, ...
The high reproducibility and minimal impact on network connectivity of the medetomidine/isoflurane combination anesthesia make it a preferred anesthetic regime for prolonged and longitudinal rs-fMRI studies ...
doi:10.3389/fnins.2018.00180
pmid:29628873
pmcid:PMC5876299
fatcat:s7dibpbuureifksyn6ez7thn2i
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