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A process model of Rho GTP-binding proteins

Luca Cardelli, Emmanuelle Caron, Philippa Gardner, Ozan Kahramanoğulları, Andrew Phillips
2009 Theoretical Computer Science  
Based on the structure of a published ordinary differential equations (ODE) model, we first present a generic process model for the Rho GTP-binding proteins, and compare it with the ODE model.  ...  Rho GTP-binding proteins play a key role as molecular switches in many cellular activities.  ...  Acknowledgements The authors would like to thank Vassily Lyutsarev from Microsoft Research, for implementing and managing the parameter exploration process on a cluster of machines and the anonymous referees  ... 
doi:10.1016/j.tcs.2009.04.029 fatcat:sfwpt35ekbhxvpv2xai3gksdlq

A Process Model of Rho GTP-binding Proteins in the Context of Phagocytosis

Luca Cardelli, Philippa Gardner, Ozan Kahramanoğulları
2008 Electronical Notes in Theoretical Computer Science  
We present a generic process model for the Rho GTP-binding proteins, and compare it with a previous model that uses ordinary differential equations.  ...  At the early stages of the phagocytic signalling, Rho GTP-binding proteins play a key role.  ...  A Process Calculus Model We compositionally build a process model of Rho GTP-binding proteins by treating the components of the Rho GTP cycle as components of a stochastic π-calculus process (see, e.g.  ... 
doi:10.1016/j.entcs.2007.12.007 fatcat:moqf7x77gzck7pkhunzkgn5xfu

Rho effectors and reorganization of actin cytoskeleton

Shuh Narumiya, Toshimasa Ishizaki, Naoki Watanabe
1997 FEBS Letters  
Recently, several GTP-Rho binding proteins were isolated.  ...  The small GTPase Rho regulates several actomyosinbased cellular processes such as cell adhesion, cytokinesis and contraction. The biochemical mechanisms of these actions remain unknown.  ...  This work was supported in part by a Grant-in-aid for Specially Promoted Research from the Ministry of Education, Science and Culture of Japan and by a grant from HFSP.  ... 
doi:10.1016/s0014-5793(97)00317-7 pmid:9247125 fatcat:izdtg7hn4rb63my5yeknmjbf6i

Functional and Therapeutic Relevance of Rho GTPases in Innate Immune Cell Migration and Function during Inflammation: An In Silico Perspective

Pankaj Dipankar, Puneet Kumar, Shiba Prasad Dash, Pranita P. Sarangi, Rohit Gundamaraju
2021 Mediators of Inflammation  
Systematic regulation of leukocyte migration to the site of infection is a vital step during immunological responses.  ...  Rho GTPases act as molecular switches during inflammatory cell migration by cycling between Rho-GDP (inactive) to Rho-GTP (active) forms and play an essential role in the precise regulation of actin cytoskeletal  ...  Acknowledgments This work is funded by the Department of Biotechnology, Govt. of India (BT/010/IYBA/2017/04), to PPS; UGC fellowship to SPD, and ICMR fellowship to PD.  ... 
doi:10.1155/2021/6655412 pmid:33628114 pmcid:PMC7896857 fatcat:o33wsjxh7bccbc5bwx6luouqdy

Coordination of Rho and Rac GTPase Function via p190B RhoGAP

Rodrigo I. Bustos, Marie-Annick Forget, Jeffrey E. Settleman, Steen H. Hansen
2008 Current Biology  
control of Rho signaling in a broad range of physiological processes.  ...  Rnd proteins, a unique branch of Rho-like G proteins, bind the p190-MD directly to promote RhoGAP activity of p190 molecules [5] .  ...  Acknowledgments We are grateful to Tobias Meyer, Martin A. Schwartz, and Arthur S. Alberts for providing reagents, to Ashley D.  ... 
doi:10.1016/j.cub.2008.09.019 pmid:18948007 pmcid:PMC4084715 fatcat:ff6ygujdlrgdvoahbbenzrndti

Rho: theme and variations

Anne J. Ridley
1996 Current Biology  
In addition to their roles in organizing the actin cytoskeleton, members of the Rho family of GTPbinding proteins have recently been implicated in a plethora of other functions, including the activation  ...  Alongside this expansion in proposed functions has been the identification of multiple target proteins that interact directly with Rho, Rac or Cdc42.  ...  All of the proteins encoded by these genes belong to the superfamily of Ras-related GTP-binding proteins.  ... 
doi:10.1016/s0960-9822(02)70711-2 pmid:8939567 fatcat:q4vubvf7dneavkt2ssayqnygqe

Guanine nucleotide exchange regulates membrane translocation of Rac/Rho GTP-binding proteins

G M Bokoch, B P Bohl, T H Chuang
1994 Journal of Biological Chemistry  
GTP-binding proteins of the Rho family are maintained as cytosolic complexes with RhoGDI in resting cells, but are released and translocate to the membrane during the course of cell activation.  ...  Membrane association of Rac/Rho/CDC42 was specifically induced by GTP analogs and required a heat- and trypsin-labile membrane component.  ...  Knaus for preparation of Rac antisera used in this study, as well as for helpful discussions. The Rho antibody was a kind gift of J. Bertoglio, INSERM, Paris, France.  ... 
pmid:7989340 fatcat:uxcprulehvetfpac2htxu4yfmy

Conformational Selection in G-Proteins: Lessons from Ras and Rho

Barry J. Grant, J. Andrew McCammon, Alemayehu A. Gorfe
2010 Biophysical Journal  
The induced fit model has traditionally been invoked to describe the activating conformational change of the monomeric G-proteins, such as Ras and Rho.  ...  Furthermore, the pattern of correlated motions revealed by these simulations predicts a preserved allosteric coupling of the nucleotide-binding site with the membrane interacting C-terminus in both Rho  ...  Ana Rodrigues for valuable discussions, and acknowledge the Center for Theoretical Biological Physics, the National Science Founda-tion, National Institutes of Health, Howard Hughes Medical Institute,  ... 
doi:10.1016/j.bpj.2010.10.020 pmid:21112273 pmcid:PMC2998626 fatcat:j2zqp5pwqbhdjngaqc5q55oyji

Rho GTPase regulation by miRNAs and covalent modifications

Ming Liu, Feng Bi, Xuan Zhou, Yi Zheng
2012 Trends in Cell Biology  
To date, most studies of Rho GTPase regulation have focused on the classic GTPase cycle -GTP binding and hydrolysis -controlled by guanine nucleotide exchange factors (GEFs), GTPaseactivating proteins  ...  cycle regulatory model.  ...  Acknowledgments We thank members of our laboratory for critical readings of the manuscript and productive discussions.  ... 
doi:10.1016/j.tcb.2012.04.004 pmid:22572609 pmcid:PMC3383930 fatcat:ebvcxseqjbfmtcih2gf2dthokq

Crystal structure of Rnd3/RhoE: functional implications1

Dennis Fiegen, Lars Blumenstein, Patricia Stege, Ingrid R Vetter, Mohammad Reza Ahmadian
2002 FEBS Letters  
This is the ¢rst GTP-structure of a Rho family member which reveals a similar fold but striking di¡erences from RhoA concerning (i) GTPase center, (ii) charge distribution at several surface areas, (iii  ...  Herein, we report the crystal structure of the Rnd3/RhoE G-domain (amino acids 19^200) at 2.0 A î resolution.  ...  Swart for providing the cDNA of human Rnd3, Klaus Sche¡zek and Oliver Daumke for critical reading of the manuscript, and Andreas Arndt for expert technical help.  ... 
doi:10.1016/s0014-5793(02)03094-6 pmid:12163169 fatcat:kh6wdusbsnexxbea2ofddiavr4

High Throughput strategies Aimed at Closing the GAP in Our Knowledge of Rho GTPase Signaling

Manel Dahmene, Laura Quirion, Mélanie Laurin
2020 Cells  
Throughout development, Rho GTPases choregraph a plethora of cellular processes essential for cellular migration, cell–cell junctions, and cell polarity assembly.  ...  Recently, several groups have tackled this challenge by using proteomic approaches to map the full repertoire of Rho GTPases and Rho regulators protein interactions.  ...  Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/cells9061430 pmid:32526908 fatcat:nvliyqeqdfcv7lz66xdjumcagq

The Function of the p190 Rho GTPase-activating Protein Is Controlled by Its N-terminal GTP Binding Domain

Nia Tatsis, Deborah A. Lannigan, Ian G. Macara
1998 Journal of Biological Chemistry  
At its N terminus, p190 contains a GTP binding domain of unknown significance.  ...  p190 is a GTPase-activating protein (GAP) for the Rho family of GTPases. The GAP domain of p190 is at the C terminus of the protein.  ...  Settleman for providing the p190 cDNA and Sara Bush for construction of the pKH3 vector and of the pKH3-p190 construct.  ... 
doi:10.1074/jbc.273.51.34631 pmid:9852136 fatcat:ahvlymizunafva2irkhubcjwlu

The Role of Mg2+Cofactor in the Guanine Nucleotide Exchange and GTP Hydrolysis Reactions of Rho Family GTP-binding Proteins

Baolin Zhang, Yaqin Zhang, Zhi-xin Wang, Yi Zheng
2000 Journal of Biological Chemistry  
Differing from Ras and Rab proteins, which require Mg 2؉ for GDP and GTP binding, the Rho GTPases bind the nucleotides in the presence or absence of Mg 2؉ similarly, with dissociation constants in the  ...  Here we have investigated the role of Mg 2؉ cofactor in the guanine nucleotide binding and hydrolysis processes of the Rho family members, Cdc42, Rac1, and RhoA.  ...  Kejin Zhu and Yuan Gao for providing the GST-Dbl and Trio proteins.  ... 
doi:10.1074/jbc.m001027200 pmid:10843989 fatcat:nujpc7rwqvd47fbjx53god2pja

Cell motility: The necessity of Rac1 GDP/GTP flux

Maria Carla Parrini, Jacques Camonis
2011 Communicative & Integrative Biology  
regulation of Rac1 throughout motility, supporting the notion of a general GTPase flux model for Rho-family GTPases.  ...  We showed that the Ral-effector exocyst directly binds to a negative regulator of Rac1: the SH3BP1 protein.  ... 
doi:10.4161/cib.17772 pmid:22446552 pmcid:PMC3306356 fatcat:nuiqozdy3zhs3emladt6gufm7i

Small G-protein networks:

Takashi Matozaki, Hiroyuki Nakanishi, Yoshimi Takai
2000 Cellular Signalling  
Small GTP-binding proteins (G-proteins) exist in eukaryotes from yeast to human and constitute a superfamily consisting of more than 100 members.  ...  It has become clear that multiple small G-proteins form signalling cascades that are involved in various cellular functions, such as budding processes of the yeast and regulation of the actin cytoskeleton  ...  The activity of this protein kinase is stimuconsisting of Raf protein kinase (c-Raf-1, A-Raf, and lated by GTP-Rho proteins.  ... 
doi:10.1016/s0898-6568(00)00102-9 pmid:11027944 fatcat:aqd2anq2sfaxhbhlbq6mkgfyu4
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