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Towards Patient-Specific Finite-Element Simulation of MitralClip Procedure [chapter]

T. Mansi, I. Voigt, E. Assoumou Mengue, R. Ionasec, B. Georgescu, T. Noack, J. Seeburger, D. Comaniciu
2011 Lecture Notes in Computer Science  
A biomechanical model of the MV, constrained by the observed motion of the mitral annulus and papillary muscles, is employed to simulate valve closure and MitralClip intervention.  ...  We propose an integrated framework for personalized simulation of MV function and apply it to simulate Mitral-Clip procedure.  ...  We then apply a biomechanical model to simulate valve closure (Sec. 2.2) and valve clipping (Sec. 2.3).  ... 
doi:10.1007/978-3-642-23623-5_57 fatcat:vrdbaolfpndpdekmdscwfprjoq

Multi-modal Validation Framework of Mitral Valve Geometry and Functional Computational Models [chapter]

Sasa Grbic, Thomas F. Easley, Tommaso Mansi, Charles H. Bloodworth, Eric L. Pierce, Ingmar Voigt, Dominik Neumann, Julian Krebs, David D. Yuh, Morten O. Jensen, Dorin Comaniciu, Ajit P. Yoganathan
2015 Lecture Notes in Computer Science  
Computational models of the mitral valve (MV) exhibit significant potential for patient-specific surgical planning.  ...  Despite advances, only limited ground-truth data exists to validate their ability to accurately simulate MV closure and function.  ...  Geometric comparison of clinical measurements derived from the mitral valve (MV) model at systole from µCT, old (atrial) Echo acquisition, new (ventricular) Echo acquisition and simulated closure model  ... 
doi:10.1007/978-3-319-14678-2_25 fatcat:2p7ygormjvdmncintytljj3tu4

An integrated framework for finite-element modeling of mitral valve biomechanics from medical images: Application to MitralClip intervention planning

Tommaso Mansi, Ingmar Voigt, Bogdan Georgescu, Xudong Zheng, Etienne Assoumou Mengue, Michael Hackl, Razvan I. Ionasec, Thilo Noack, Joerg Seeburger, Dorin Comaniciu
2012 Medical Image Analysis  
Keywords: Mitral valve apparatus Patient-specific anatomy Machine-learning Finite-element biomechanical models Mitral valve therapy planning a b s t r a c t Treatment of mitral valve (MV) diseases requires  ...  Comparisons between the simulated closed valve and ground truth show encouraging results (average point-to-mesh distance: 1.49 ± 0.62 mm) but also the need for personalization of tissue properties, as  ...  a b s t r a c t Treatment of mitral valve (MV) diseases requires comprehensive clinical evaluation and therapy personalization to optimize outcomes.  ... 
doi:10.1016/j.media.2012.05.009 pmid:22766456 fatcat:5irc6hs6frh6zd5zc6k7kod2vy

Multi-modal Pipeline for Comprehensive Validation of Mitral Valve Geometry and Functional Computational Models [chapter]

Dominik Neumann, Sasa Grbic, Tommaso Mansi, Ingmar Voigt, Jean-Pierre Rabbah, Andrew W. Siefert, Neelakantan Saikrishnan, Ajit P. Yoganathan, David D. Yuh, Razvan Ioan Ionasec
2014 Lecture Notes in Computer Science  
Mitral Valve (MV) Regurgitation, a disorder in which the MV does not close properly during systole, is among its most common forms. Traditionally, it has been treated with MV replacement.  ...  Hence, there is a need for efficient tools for training and planning of MV repair interventions. Computational models of valve function have been developed for these purposes.  ...  Biomechanical Model of the Mitral Valve MV closure is calculated from the TEE anatomy based on the model proposed in [6] .  ... 
doi:10.1007/978-3-642-54268-8_22 fatcat:jbuesfdnobhdlmdz5quudrnpla

Estimation of patient-specific material properties of the mitral valve using 4D Transesophageal Echocardiography

Jingjing Kanik, Tommaso Mansi, Ingmar Voigt, Puneet Sharma, Razvan Ioan Ionasec, Dorin Comaniciu, James Duncan
2013 2013 IEEE 10th International Symposium on Biomedical Imaging  
Quantitative patient-specific modeling of the mitral valve is demanded since it allows for the reliable predictive simulation of medical intervention.  ...  As a step closer to a fully personalized model, an estimation algorithm is presented in this paper.  ...  The colored pointwise distances for Patient 2 (Fig. 3) show that the personalized parameters result in better closure of the mitral valve.  ... 
doi:10.1109/isbi.2013.6556690 dblp:conf/isbi/KanikMVSICD13 fatcat:3lxfjys3c5gzhi66tbui53jasi

4D-transesophageal echocardiography and emerging imaging modalities for guiding mitral valve repair

Alison M Pouch, Benjamin M Jackson, Paul A Yushkevich, Joseph H Gorman, Robert C Gorman
2015 Annals of Cardiothoracic Surgery  
biomechanical simulations.  ...  Optimizing this match may prevent patients with repairable valves (in the hands of a surgeon with subspecialty expertise) from undergoing unnecessary valve replacement (in the hands of a surgeon with a  ...  (3) present an integrated framework for estimating personalized geometrical mitral valve models from 4D-TEE images and using these models as input to finite element analysis to simulate valve closure  ... 
doi:10.3978/j.issn.2225-319x.2015.02.01 pmid:26539351 pmcid:PMC4598460 fatcat:6pjwbk4r6vfohcvhcknv4vesnq

Finite element analysis for edge-to-edge technique to treat post-mitral valve repair systolic anterior motion

Qi Zhong, Wenhua Zeng, Xiaoyang Huang, Xiaojia Zhao
2014 Acta of Bioengineering and Biomechanics  
And the simulated results were compared with echocardiography and measurement data of the patients under the mitral valve surgery, which shows good agreement.  ...  Systolic anterior motion of the mitral valve is an uncommon complication of mitral valve repair, which requires immediate supplementary surgical action.  ...  Model personalization is a big challenge for mitral valve repair simulation using finite element method, but this in-vitro and noninvasive method is very attractive for researchers to study the effects  ... 
pmid:25597231 fatcat:l5cflbvqgrgrrm22nrbo6f7pgq

Page 57 of The American Journal of the Medical Sciences Vol. 116, Issue 1 [page]

1898 The American Journal of the Medical Sciences  
In a large proportion of cases the answer is affirmative. Simulated reduplication of the first sound caused by late closure of the mitral valve.  ...  In a previous section it has been stated that Hayden considers isolated, audible valve closure to be the normal cause of reduplication.  ... 

Effect of Edge-to-Edge Mitral Valve Repair on Chordal Strain: Fluid-Structure Interaction Simulations

Milan Toma, Daniel R. Einstein, Keshav Kohli, Sheridan L. Caroll, Charles H. Bloodworth, Richard P. Cochran, Karyn S. Kunzelman, Ajit P. Yoganathan
2020 Biology  
Hence, it is important to quantitatively evaluate the effect of edge-to-edge repair on chordal integrity. in this study, we employ a computational mitral valve model to simulate functional mitral regurgitation  ...  area, until a two fold increase in the inter-papillary muscle distance as compared to the normal mitral valve.  ...  Altering our existing model with patient specific MV parameters is the next step towards personalizing these simulations.  ... 
doi:10.3390/biology9070173 pmid:32708356 fatcat:4k3rous4yfcihf5ji63p6rmsmy

Interactive editing of virtual chordae tendineae for the simulation of the mitral valve in a decision support system

Lars Walczak, Lennart Tautz, Mathias Neugebauer, Joachim Georgii, Isaac Wamala, Simon Sündermann, Volkmar Falk, Anja Hennemuth
2020 International Journal of Computer Assisted Radiology and Surgery  
Purpose Decision support systems for mitral valve disease are an important step toward personalized surgery planning. A simulation of the mitral valve apparatus is required for decision support.  ...  Building a model of the chordae tendineae is an essential component of a mitral valve simulation.  ...  As a first step, the closure of the valve can be simulated using the parameterization described above.  ... 
doi:10.1007/s11548-020-02230-y pmid:33098536 fatcat:vji2yf2cvbhslo2si5mb4iwaha

Patient-Specific Mitral Valve Closure Prediction Using 3D Echocardiography

Philippe Burlina, Chad Sprouse, Ryan Mukherjee, Daniel DeMenthon, Theodore Abraham
2013 Ultrasound in Medicine and Biology  
This paper presents an approach to modeling the closure of the mitral valve using patient-specific anatomical information derived from 3D transesophageal echocardiography (3D TEE).  ...  The method utilizes a tensile shape finding approach based on energy minimization. This method is used to predict the aptitude of the mitral valve leaflets to coapt.  ...  This includes the work by Hammer et al. (2008) , who reported a valve closure simulation method using a linear mass-spring mesh model to predict the MV closure.  ... 
doi:10.1016/j.ultrasmedbio.2012.11.009 pmid:23497987 pmcid:PMC3760036 fatcat:jidcfzqannab7lylckj42jz25q

Page 1169 of Circulation Vol. 14, Issue 6 [page]

1956 Circulation  
Its importance is that it may simulate pathologic murmurs. KITCHELL Miller, A. J., and Texidor, T. A.: “Precordial Catch.”” A Neglected Syndrome of Precordial Pain. J. A. M.  ...  Asynchronism of valve closures is the fundamental basis for splitting of heart sounds and may have 2 general bases designated as electric (asynchronism resulting from ventricular activation abnormality  ... 

Page 95 of Modern Concepts of Cardiovascular Disease Vol. 39, Issue 4 [page]

1970 Modern Concepts of Cardiovascular Disease  
A LSC followed by a late systolic murmur may simulate A, followed by the mur- mur of semilunar valve regurgitation, whereas a LSC followed by A, may simulate A, followed by an S, gallop.  ...  Reversed splitting of S. occurs when aortic valve closure is inor- dinately delayed, with A, following P, during all phases of respiration.  ... 

Comparison of Artificial Neochordae and Native Chordal Transfer in the Repair of a Flail Posterior Mitral Leaflet: An Experimental Study

Muralidhar Padala, Benedicte Cardinau, Lazarina I. Gyoneva, Vinod H. Thourani, Ajit P. Yoganathan
2013 Annals of Thoracic Surgery  
BACKGROUND-Surgical reconstruction of a flail posterior leaflet is a routine mitral valve repair, the techniques for which have evolved from leaflet resection to leaflet preservation.  ...  METHODS-Adult porcine mitral valves (N =7) were studied in a pulsatile left heart experimental model in which isolated P2 flail was mimicked by marginal chordal transection.  ...  M.P was supported by an American Heart Association Pre-doctoral Fellowship during the study, and the study was partially supported by a National Institute of Health grant to A.P.Y (R01-HL090661).  ... 
doi:10.1016/j.athoracsur.2012.09.055 pmid:23291143 pmcid:PMC3631597 fatcat:uglbz2ng7jbo7pth4hxp7qhkka

Physiologic Basis for the Heart Sounds and Their Clinical Significance

Mortimer L. Schwartz, Robert C. Little
1961 New England Journal of Medicine  
A third sound may be normal in a young person but may suggest constrictive pericarditis, heart failure or mitral insufficiency or both in an older person.  ...  A patient who has mitral stenosis without auscultatory evidence of an opening snap probably has a rigid, calcified mitral valve.  ... 
doi:10.1056/nejm196102092640606 pmid:13749114 fatcat:dgijswqoqvaijjs62zdrn34a74
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