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Towards droplet size-aware biochemical application compilation for AM-EWOD biochips
2015
2015 Symposium on Design, Test, Integration and Packaging of MEMS/MOEMS (DTIP)
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Our routing algorithm is developed for a novel digital microfluidic biochip architecture based on Active Matrix Electrowetting on Dielectric, which uses a thin film transistor array for the electrodes. ...
Several approaches have been proposed for the compilation of digital microfluidic biochips, which, starting from a biochemical application and a given biochip architecture, determine the allocation, resource ...
However, recently, a novel digital microfluidic biochip architecture has been developed based on Active Matrix Electrowetting on Dielectric (AM-EWOD), which uses a thin film transistor (TFT) array for ...
doi:10.1109/dtip.2015.7161024
fatcat:yxbzpyddvfdv7ehsvod6ogtdna
Drug Discovery Acceleration Using Digital Microfluidic Biochip Architecture and Computer-aided-design Flow
2019
International Journal of Engineering
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A Digital Microfluidic Biochip (DMFB) offers a promising platform for medical diagnostics, DNA sequencing, Polymerase Chain Reaction (PCR), and drug discovery and development. ...
There is an urgent need for collaboration between experts of drug discovery, microfluidic platform architecture and also machine learning to design a data-driven microfluidic architecture which improves ...
steps on a digital microfluidic biochip [5] . ...
doi:10.5829/ije.2019.32.08b.13
fatcat:7qezfhg7evenvjc4cby7wnk45a
Design of Microfluidic Biochips (Dagstuhl Seminar 15352)
2016
Dagstuhl Reports
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The goal of the seminar was to bring together experts in order to present and to develop new ideas and concepts for design automation algorithms and tools for microfluidic biochips. ...
Advances in microfluidic technologies have led to the emergence of biochip devices for automating laboratory procedures in biochemistry and molecular biology. ...
Algorithms for Automated Sample Preparation using Digital Microfluidic Biochips Our research envisions the algorithmic microfluidics and it expands the computer-aideddesign (CAD) research to develop DMF ...
doi:10.4230/dagrep.5.8.34
dblp:journals/dagstuhl-reports/ChakrabartyHW15
fatcat:ysb7qihxujdwtoh4xp36rwviau
Design and optimization of a digital microfluidic biochip for protein crystallization
2008
2008 IEEE/ACM International Conference on Computer-Aided Design
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We present the design of a multi-well plate microfluidic biochip for protein crystallization; this biochip can transfer protein samples, prepare candidate solutions, and carry out crystallization automatically ...
To reduce the manufacturing cost of such devices, we present an efficient algorithm to generate a pin-assignment plan for the proposed design. ...
We have also described efficient droplet-routing algorithms for defect-tolerant well-loading. Fig. 1 : 1 Fabricated digital microfluidic arrays. ...
doi:10.1109/iccad.2008.4681589
dblp:conf/iccad/XuCP08
fatcat:5gaqew3it5ejfp5c34mh3ycbmu
Droplet-trace-based array partitioning and a pin assignment algorithm for the automated design of digital microfluidic biochips
2006
Proceedings of the 4th international conference on Hardware/software codesign and system synthesis - CODES+ISSS '06
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We propose a partitioning algorithm based on the concept of "droplet trace", which is extracted from the scheduling and droplet routing results produced by a synthesis tool. ...
Most prior work on CAD for biochips has assumed independent control of electrodes using a large number of (electrical) input pins. ...
Thus, this novel technology is referred to as "digital microfluidics". ...
doi:10.1145/1176254.1176283
dblp:conf/codes/XuC06
fatcat:cukyfh3mfnc2vk3hdxex43qkri
Integrated droplet routing and defect tolerance in the synthesis of digital microfluidic biochips
2008
ACM Journal on Emerging Technologies in Computing Systems
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Postsynthesis droplet routing does not guarantee that feasible droplet pathways can be found for area-constrained biochip layouts; nonroutable fabricated biochips must be discarded. ...
As high-throughput bioassays are mapped to digital microfluidic platforms, the need for design automation techniques is being increasingly felt. ...
In Section 3 we discuss related prior work on automated synthesis tools and postsynthesis droplet routing for digital microfluidic biochips. ...
doi:10.1145/1389089.1389091
fatcat:pseusgpvz5e6rfrcbrrzi2zbze
A high-performance droplet router for digital microfluidic biochips
2008
Proceedings of the 2008 international symposium on Physical design - ISPD '08
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In this paper, we propose a high-performance droplet router for digital microfluidic biochip (DMFB) design. ...
When multiple droplets form a deadlock, our algorithm resolves it by backing off some droplets for concession. ...
Yao-Wen Chang from National Taiwan University for providing experimental results of the network-flow based algorithm on our test designs. ...
doi:10.1145/1353629.1353672
dblp:conf/ispd/ChoP08
fatcat:qfeqw5gnwbhspjvqe23p4pay4a
System-level design automation tools for digital microfluidic biochips
2005
Proceedings of the 3rd IEEE/ACM/IFIP international conference on Hardware/software codesign and system synthesis - CODES+ISSS '05
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Biochips based on digital microfluidics offer a powerful platform for massively parallel biochemical analysis such as clinical diagnosis and DNA sequencing. ...
Current full-custom design techniques for digital microfluidic biochips do not scale well for increasing levels of system integration. ...
Following the analogy of microelectronics, this novel approach is referred to as "digital microfluidics". ...
doi:10.1145/1084834.1084887
dblp:conf/codes/ChakrabartyS05
fatcat:swxbvv2wsbfejb2yyrpsfyjbsq
Defect-Tolerant Design and Optimization of a Digital Microfluidic Biochip for Protein Crystallization
2010
IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems
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Recently, droplet-based "digital" microfluidics have been used for executing protein assays on a chip. ...
We present the design of a multi-well-plate microfluidic biochip for protein crystallization; this biochip can transfer protein samples, prepare candidate solutions, and carry out crystallization automatically ...
Index Terms-Digital microfluidics, droplet routing, lab-onchip, pin-constrained biochip design, route scheduling, well-plate chip.
I. ...
doi:10.1109/tcad.2010.2042888
fatcat:cxopih2dojhgzbomsw6sykmvrq
A Novel Double Fault Diagnosis and Detection Technique in Digital Microfluidic Biochips
[chapter]
2015
Lecture Notes in Computer Science
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This paper presents a rigorous offline double fault diagnosis as well as a detection technique for Digital Microfluidic Biochips (DMFBs). ...
In this paper, the proposed algorithm detects double faults anywhere in the chip satisfying the dynamic fluidic constraints and improves the fault diagnosis time to an extent. ...
A network flow based routing algorithm has been proposed in [12] for the droplet routing problem on biochips [13] . ...
doi:10.1007/978-3-319-24369-6_15
fatcat:jcj3mmcn2vhxhhkka2wgrmer2i
A droplet routing technique for fault-tolerant digital microfluidic devices
2008
2008 IEEE 14th International Mixed-Signals, Sensors, and Systems Test Workshop
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This paper describes a droplet routing technique for a fault-tolerant digital microfluidic platform. ...
Efficient droplet routing is one of the key approaches for realizing fault-tolerant microfluidic biochips. It requires that run-time diagnosis and fault recovery can be made possible in such systems. ...
CONCLUSIONS This paper presented a novel method for routing droplets on a digital microfluidic device to ensure a fault-tolerant behavior. ...
doi:10.1109/ims3tw.2008.4581596
fatcat:dw6z5la7zfeurccw2zmmtihuoa
Automated design of pin-constrained digital microfluidic biochips under droplet-interference constraints
2007
ACM Journal on Emerging Technologies in Computing Systems
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We propose a design automation method for pin-constrained biochips that manipulate nanoliter volumes of discrete droplets on a microfluidic array. ...
The design procedure relies on a droplet-trace-based array partitioning scheme and an efficient pin assignment technique, referred to as the "Connect-5 algorithm." ...
Thus, this novel technology is referred to as "digital microfluidics." ...
doi:10.1145/1295231.1295235
fatcat:t6luimczujfqjjysoaoj724kka
High-level synthesis of digital microfluidic biochips
2008
ACM Journal on Emerging Technologies in Computing Systems
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Current techniques for full-custom design of droplet-based "digital" biochips do not scale well for concurrent assays and for next-generation system-on-chip (SOC) designs that are expected to include microfluidic ...
We propose a system design methodology that attempts to apply classical high-level synthesis techniques to the design of digital microfluidic biochips. ...
ACKNOWLEDGMENTS We thank Tao Xu of Duke University for helping with the simulations. ...
doi:10.1145/1324177.1324178
fatcat:mwygtsi5sjewtdz4uhyvtygpne
Design Automation for Digital Microfluidic Biochips
2014
IPSJ Transactions on System LSI Design Methodology
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The "digital" microfluidic biochips (DMFBs) are manipulating liquids not as a continuous flow, but as discrete droplets on a two-dimensional array of electrodes. ...
Basic microfluidic operations, such as mixing and dilution, are performed on the array, by routing the corresponding droplets on a series of electrodes. ...
Therefore, microfluidic research is witnessing a paradigm shift from the continuous-flowbased architecture to droplet-based architecture or, in particular, the digital microfluidic biochip (DMFB) [6] ...
doi:10.2197/ipsjtsldm.7.16
fatcat:6cskxmi2szbrtiyyiabqpry4uy
Defect-Aware High-Level Synthesis and Module Placement for Microfluidic Biochips
2008
IEEE Transactions on Biomedical Circuits and Systems
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As chemists adapt more bioassays for concurrent execution on such "digital" droplet-based microfluidic platforms, system integration, design complexity, and the need for defect tolerance are expected to ...
Recent advances in microfluidics technology have led to the emergence of miniaturized biochip devices, also referred to as lab-on-a-chip, for biochemical analysis. ...
Schematic of a digital microfluidic biochip [14] . As in traditional IC design, the automated design of a digital microfluidic biochip can be divided into two major phases. ...
doi:10.1109/tbcas.2008.918283
pmid:23852633
fatcat:z6imlaefzvhwhh5ez4lt4hbs5a
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