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Connectome imaging for mapping human brain pathways

Y Shi, A W Toga
2017 Molecular Psychiatry  
With the fast advance of connectome imaging techniques, we have the opportunity of mapping the human brain pathways in vivo at unprecedented resolution.  ...  Characterization of the microstructural environment in the human brain is discussed from the tensor model to the general fiber orientation distribution (FOD) models that can resolve crossing fibers in  ...  ACKNOWLEDGMENTS This work was in part supported by NIH Grants R01EB022744, K01EB013633, P41EB015922, U54EB020406 and R01MH094343.  ... 
doi:10.1038/mp.2017.92 pmid:28461700 pmcid:PMC5568931 fatcat:lev7cxkifzbp3ksgj6n4pu6she

Cartography and Connectomes

David C. Van Essen
2013 Neuron  
This is embodied in the concept of a connectome as a ''comprehensive'' map of brain connectivity (Sporns et al., 2005) .  ...  In order to resolve these issues, it is important to complement diffusion imaging with high-resolution anatomical methods that provide direct evidence on the statistical pattern of fiber fanning, dispersion  ... 
doi:10.1016/j.neuron.2013.10.027 pmid:24183027 pmcid:PMC3855872 fatcat:nsrernbfkvctlbgaigmef7bedy

Opportunities of Connectomic Neuromodulation

Andreas Horn, Michael D. Fox
2020 NeuroImage  
In this article, we review studies combining neuromodulation and brain connectomics, highlighting opportunities where this approach may prove particularly valuable.  ...  Deep brain stimulation in particular has provided clinical benefit to over 150,000 patients. However, our understanding of how neuromodulation impacts the brain is evolving.  ...  a map of the human connectome.  ... 
doi:10.1016/j.neuroimage.2020.117180 pmid:32702488 pmcid:PMC7847552 fatcat:lssuhyivljc4vbt5irin3gxigu

Imaging human connectomes at the macroscale

R Cameron Craddock, Saad Jbabdi, Chao-Gan Yan, Joshua T Vogelstein, F Xavier Castellanos, Adriana Di Martino, Clare Kelly, Keith Heberlein, Stan Colcombe, Michael P Milham
2013 Nature Methods  
Successful annotation of phenotypic associations with variation in the connectome and cataloguing of neurophenotypes promise to transform our understanding of the human brain.  ...  At macroscopic scales, the human connectome is composed of anatomically distinct brain areas, the structural pathways connecting them, and their functional interactions.  ...  Thanks to Daniel Lurie for his assistance in the preparation of the manuscript and references, as well as to Zarrar Shehzad, Zhen Yang and Sebastian Urchs for their helpful comments.  ... 
doi:10.1038/nmeth.2482 pmid:23722212 pmcid:PMC4096321 fatcat:ahp5n642fzahpdjl2nke67dwxq

The quest for the human connectome: a progress report [article]

Andrew Reid
2016 Zenodo  
The term "connectome" was introduced in a seminal 2005 PNAS article, as a sort of analogy to the genome.  ...  In particular, the use of diffusion-weighted imaging approaches to estimate physical connectivity is fraught with inherent limitations, which are often overlooked in the quest to publish "connectivity"  ...  I know of at least one ongoing attempt to use ultra-high-field (9.4T) MRI to obtain DWI images from postmortem brains, with unprecedented spatial and angular resolution -see this page.  ... 
doi:10.5281/zenodo.5608543 fatcat:i75lxtsmqjdktlxmpq2hrpfbx4

Genetics of the connectome

Paul M. Thompson, Tian Ge, David C. Glahn, Neda Jahanshad, Thomas E. Nichols
2013 NeuroImage  
Connectome-wide genome-wide scans have also been conducted, and we review the multivariate methods required to handle the extremely high dimension of the genomic and network data.  ...  specific variants in the genome for brain-related traits.  ...  Acknowledgments P.M.T. is supported, in part, by NIH R01 grants NS080655, MH097268, AG040060, EB008432, MH089722, HD050735 and P41 EB015922.  ... 
doi:10.1016/j.neuroimage.2013.05.013 pmid:23707675 pmcid:PMC3905600 fatcat:dv26qigaovc4vdpm6jkealvoly

Rich-Club Organization of the Human Connectome

M. P. van den Heuvel, O. Sporns
2011 Journal of Neuroscience  
We discuss the potential functional implications of the rich-club organization of the human connectome, particularly in light of its role in information integration and in conferring robustness to its  ...  The human brain is a complex network of interlinked regions.  ...  Indeed, using a regional approach, we were not able to replicate high positive assortativity of the connectome as reported in high-resolution networks (Eguíluzet al., 2005; Hagmann et al., 2008) (high-resolution  ... 
doi:10.1523/jneurosci.3539-11.2011 pmid:22049421 pmcid:PMC6623027 fatcat:ibvmbv4jn5fsvbmaediq333gea

The Human Connectome Project: A Retrospective

Jennifer Stine Elam, Matthew F. Glasser, Michael P. Harms, Stamatios N. Sotiropoulos, Jesper L.R. Andersson, Gregory C. Burgess, Sandra W. Curtiss, Robert Oostenveld, Linda J. Larson-Prior, Jan-Mathijs Schoffelen, Michael R. Hodge, Eileen A. Cler (+6 others)
2021 NeuroImage  
The Human Connectome Project (HCP) was launched in 2010 as an ambitious effort to accelerate advances in human neuroimaging, particularly for measures of brain connectivity; apply these advances to study  ...  We conclude with a look forward at opportunities and challenges facing the human neuroimaging field from the perspective of the HCP consortium.  ...  ( HCP-A: Mapping the Human  ... 
doi:10.1016/j.neuroimage.2021.118543 pmid:34508893 pmcid:PMC9387634 fatcat:qzxs43vy7reavhdqkn2f5yhw6u

Towards an MRI-based mesoscale connectome of the squid brain

Wen-Sung Chung, Nyoman D. Kurniawan, N. Justin Marshall
2020 iScience  
Using high-resolution diffusion magnetic resonance imaging (dMRI) and a suite of old and new staining techniques, the beginnings of a multi-scale connectome map of the squid brain is erected.  ...  a level of complexity and sub-division in the basal lobe supporting ideas of convergence with the vertebrate basal ganglia, and (3) differential lobe-dependent growth rates that mirror complexity and transitions  ...  We erect the start of a connectome for the squid brain, the first of its kind for the cephalopods with input from high-resolution dMRI, previous histology, new histology with old (Cajal-Golgi silver impregnation  ... 
doi:10.1016/j.isci.2019.100816 pmid:31972515 pmcid:PMC6974791 fatcat:ii4xqpup5nff3nrjncy7evpuzm

Multimodal image registration and connectivity analysis for integration of connectomic data from microscopy to MRI

Maged Goubran, Christoph Leuze, Brian Hsueh, Markus Aswendt, Li Ye, Qiyuan Tian, Michelle Y. Cheng, Ailey Crow, Gary K. Steinberg, Jennifer A. McNab, Karl Deisseroth, Michael Zeineh
2019 Nature Communications  
3D histology, slice-based connectivity atlases, and diffusion MRI are common techniques to map brain wiring.  ...  We develop an automated resource that combines histologically cleared volumes with connectivity atlases and MRI, enabling the analysis of histological features across multiple fiber tracts and networks  ...  Acknowledgements The authors thank Newton Cho, Jordan Squair, Vanessa Sochat, Masaki Ito, Stéphane Pagès, and Yu Wang for their help with pipeline optimization, testing, and validation experiments.  ... 
doi:10.1038/s41467-019-13374-0 pmid:31796741 pmcid:PMC6890789 fatcat:6amqk6fsojcgzjalhqvxp7wqym

Multi-scale graph principal component analysis for connectomics [article]

Steven Winter, Zhengwu Zhang, David Dunson
2020 arXiv   pre-print
We obtain a simple and efficient algorithm for implementation, and illustrate substantial advantages over single scale approaches in simulations and analyses of the Human Connectome Project dataset.  ...  In brain connectomics, the cortical surface is parcellated into different regions of interest (ROIs) prior to statistical analysis.  ...  A critical first step in analyzing structural connectomes is pre-processing of the raw imaging data to obtain a reconstruction of the white matter fiber tracts in each individual's brain, while also aligning  ... 
arXiv:2010.02332v1 fatcat:5g3qrug44ba47mak25xepi73mu

A case study in connectomics: the history, mapping, and connectivity of the claustrum

Carinna M. Torgerson, John D. Van Horn
2014 Frontiers in Neuroinformatics  
the shift from micro-connectomics to macro-connectomics advances the field of neuroscience and improves our capacity to understand the brain.  ...  In this literature review, we provide background details on the claustrum and the history of its study in the human and in other animal species.  ...  Sporns and Tononi, in their noteworthy paper introducing the concept of the connectome, have argued that scientists would not be able to map structure to function in the human brain without a comprehensive  ... 
doi:10.3389/fninf.2014.00083 pmid:25426062 pmcid:PMC4227511 fatcat:rqz4wuabdna27nizj2uc627j2m

A review of structural neuroimaging in schizophrenia: from connectivity to connectomics

Anne L. Wheeler, Aristotle N. Voineskos
2014 Frontiers in Human Neuroscience  
However, even with the advent of these newer analyses, a large amount of variability in findings remains, likely partially due to the considerable heterogeneity present in this disorder.  ...  Examining neurocircuitry, diffusion-weighted imaging studies have identified altered structural integrity of white matter in frontal and temporal brain regions and tracts such as the cingulum bundles,  ...  ACKNOWLEDGMENTS Canadian Institutes of Health Research, Brain and Behavior Research Foundation, CAMH and the CAMH Foundation (thanks to the Kimel family, the Koerner New Scientist Award, and the Paul E  ... 
doi:10.3389/fnhum.2014.00653 pmid:25202257 pmcid:PMC4142355 fatcat:tdcsuyufgzgwflmwrcokyxg7ki

Simulating disease propagation across white matter connectome reveals anatomical substrate for neuropathology staging in amyotrophic lateral sclerosis

Ruben Schmidt, Marcel A. de Reus, Lianne H. Scholtens, Leonard H. van den Berg, Martijn P. van den Heuvel
2016 NeuroImage  
in neuropathology (p = 0.02), a pattern in favor of the hypothesis of pTDP-43 pathology to spread across the brain along axonal pathways.  ...  Our findings thus provide computational evidence of disease spread in ALS to be directed and constrained by the topology of the anatomical brain network.  ...  the mammalian brain as derived from ultra-high resolution in vivo diffusion weighted imaging (DWI) data of the Human Connectome Project .  ... 
doi:10.1016/j.neuroimage.2015.04.005 pmid:25869856 fatcat:zxvzrsy4i5gg5hh65prabodj4e

Glial Regulation of the Neuronal Connectome through Local and Long-Distant Communication

R. Douglas Fields, Dong Ho Woo, Peter J. Basser
2015 Neuron  
If "the connectome" represents a complete map of anatomical and functional connectivity in the brain, it should also include glia.  ...  Glia define and regulate both the brain's anatomical and functional connectivity over a broad range of length scales, spanning the whole brain to subcellular domains of synaptic interactions.  ...  ACKNOWLEDGMENTS This work was supported by the Intramural Research Program, The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), NIH.  ... 
doi:10.1016/j.neuron.2015.01.014 pmid:25905811 pmcid:PMC4426493 fatcat:kg7weldd7fgoxelvicz2cdiimy
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